My Oregon vs. Ohio State prediction favors the Buckeyes to rebound from last weekend's loss to USC when they welcome the Ducks to Ohio Stadium for a crucial Big Ten showdown with College Football Playoff implications.
Ohio State is a 7.5-point favorite with the total at 45.5, and Kalshi gives the Buckeyes a 72% chance to win outright. Kickoff is set for 3:30 p.m. ET on CBS this Saturday, Nov. 7. Check out more of our college football picks.
Oregon vs Ohio State predictions for Week 10
| Market | Pick |
|---|---|
| ⭐ Spread prediction | Ohio State -7.5 |
| Over/Under prediction | Over 45.5 |
| Combo | 1.5x |
TOP PICK
Who will win Oregon vs Ohio State: Ohio State -7.5
Playable to 53%.
The Buckeyes' five-game winning streak ended against USC last weekend, with backup quarterback Luke Fahey leading the team to just 18 points.
Starting quarterback Julian Sayin will be sidelined once again this weekend as he continues to rehab an elbow injury suffered in the team's Week 7 win over Indiana. However, there are reasons to believe Ohio State will get back into the win column.
Scoring just 18 points looks bad on the surface, but Fahey played relatively well against the Trojans in Week 9. He completed 15 of 25 passes from a clean pocket and held his own under pressure, completing 6 of 13 attempts without any turnover-worthy throws.
Fahey looked much better than he did during his relief appearance against the Hoosiers, and it stands to reason that he'll look even better at home after another full week of practice.
Oregon's defense allowed 456 yards of total offense to Northwestern last weekend, despite playing at home. The Ducks could struggle in a hostile environment this Saturday against an Ohio State team that's more talented than last week's result suggests.
Our Week 10 Top 25 predictions and Brad Powers' college football best bets also lay the points with the Buckeyes. However, our college football picks against the spread take the other side and back Oregon +7.5, so compare both cases before you bet the side.
COVERS INTEL: Ohio State is 11-4 ATS against ranked opponents over the last three years, including 4-0 ATS as a home favorite.Oregon vs Ohio State Over/Under pick: Over 45.5
Playable to 53%.
Defense has been a pain point for both teams for much of 2026. Oregon allowed Northwestern 26 points and 456 yards of total offense at home last weekend. The Wildcats went 7-for-17 on third down, moving the chains both through the air and on the ground.
USC carved up Ohio State in the first half last weekend, scoring 20 points. The Buckeyes surrendered a 69-yard touchdown pass on the opening possession and forced just one punt on six true offensive possessions by the Trojans in the first half.
Offense was less of an issue for Ohio State, despite the 18 points. The Buckeyes recorded 25 first downs and 464 yards of total offense, but one long drive ended with a fumble and another stalled on a turnover on downs.
Expect plenty of points in Columbus. Our college football Over/Under picks and Top 25 predictions take the other side and back the Under 45.5, so compare both cases before you bet the total.
Oregon vs Ohio State combo
Playable to 41%.
The game script got away from Ohio State last weekend against USC, leading to a final score that made the game look more lopsided than it truly was.
The Buckeyes moved the ball with ease for much of the contest but couldn't execute in key moments near the goal line. Returning home for Week 10, they carry the weight of a loss, but a more normal game script is likely to reveal a team that still has plenty of talent, including Heisman Trophy contender Jeremiah Smith at wide receiver.
This total has moved too aggressively toward the Under with Ohio State starting a backup quarterback. Expect the Buckeyes to have success throwing the football, helping them earn a win in a high-scoring affair.
Oregon vs Ohio State combo
- Ohio State moneyline
- Over 45.5
Oregon vs Ohio State market trends
Here is how trusted traders at Kalshi are dealing on today’s matchup. Follow the smart money via the widget below to help inform your Oregon vs. Ohio State prediction.
- Top picks: 9-6, +2.36 units
- Combos: 7-10, +5.72 units
Oregon vs Ohio State odds
For help understanding probabilities, see our odds calculator.
- Spread: Oregon +7.5 | Ohio State -7.5
- Over/Under: Over 45.5 (51%) | Under 45.5 (50%)
- Moneyline: Oregon 28% | Ohio State 72%
For the full slate of college football matchups, check out our college football odds board!
More Week 10 college football coverage
- Miami vs. Notre Dame prediction, picks, and odds
- BYU vs. Utah prediction, picks, and odds
- Alabama vs. LSU prediction, picks, and odds
- Kentucky vs. Tennessee prediction, picks, and odds
- Texas vs. Missouri prediction, picks, and odds
- Michigan State vs. Michigan prediction, picks, and odds
- College football Top 25 predictions for Week 10
- Week 10 college football picks against the spread
- Week 10 college football moneyline picks
- Week 10 college football Over/Under picks
- College football AI predictions for Week 10
- Brad Powers' college football best bets for Week 10
- College Football Playoff odds
- College football national championship odds
- Heisman Trophy odds
Oregon vs Ohio State weather
The weather in Columbus this weekend is expected to be chilly, with temperatures in the mid-50s around kickoff. However, the elements shouldn't play a major role, with no precipitation expected and minimal winds in the forecast.
Check out our college football weather page for up-to-date information on every matchup.
Oregon vs Ohio State trend to know
The Over is 4-0 in the Buckeyes' last four games as a home favorite. Find more college football betting trends for Oregon vs. Ohio State.
How to watch Oregon vs Ohio State
| Location | Ohio Stadium, Columbus, Ohio |
| Date | Saturday, Nov. 7, 2026 |
| Kickoff | 3:30 p.m. ET |
| TV | CBS |
Oregon vs Ohio State latest injuries
Check out our college football injuries page for updates on every team.
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