The San Francisco 49ers are massive favorites over the Las Vegas Raiders ahead of their 4:25 p.m. ET kickoff at Levi's Stadium on Sunday, Nov. 8.
However, my favorite Raiders vs. 49ers prediction and NFL picks call for Las Vegas to cover the number in this Week 9 showdown.
TOP Pick
Raiders vs 49ers prediction: Raiders +9.5
This is too many points for the Las Vegas Raiders, and I’m comfortable recommending them to cover down to +8.5.
NFL favorites of at least seven points are just 6-20-3 against the spread this season, including teams trading at -9.5 or higher going 3-6.
The Raiders have scored the sixth-most points per game (27.6), and quarterback Kirk Cousins is Top 10 in both EPA per play and success rate.
There is a bevy of injury question marks on both sides of the ball for the San Francisco 49ers, and they ranked 14th in EPA per dropback and 15th in dropback success rate across their four games leading into their Week 8 bye.
As a result, I expect Vegas to hang around on Sunday afternoon.
COVERS INTEL: The 49ers are overvalued in the market because they’ve played the 11th-easiest schedule by DVOA and ninth-easiest schedule per PFF.
Raiders vs 49ers combo
In addition to the noted case for Cousins, he’s also thrown for 280.6 yards per game after a quiet Week 1, and I’m particularly impressed that his 8.8 aDOT is his highest mark since the 2016 season.
Turning to Raiders wide receiver Tre Tucker, he’s topped 40 receiving yards in six of eight games with an impressive 16.3 yards per reception and 13.4 aDOT this season. Cousins also has a high-end 115.0 NFL passer rating when targeting the big-play threat.
Raiders vs 49ers combo
- Raiders +9.5
- Kirk Cousins 250+ passing yards
- Tre Tucker 40+ receiving yards
Raiders vs 49ers touchdown scorer: Kaelon Black
I recommend this touchdown prop up to 30%.
49ers running back Kaelon Black is going to be involved this week with star rusher Christian McCaffrey returning from a hamstring injury.
Black scored in Week 7 while rushing for 5.3 yards per carry and an impressive 3.92 yards after contact per attempt. The Raiders have surrendered a rushing score in five consecutive games for seven total.
- Top picks: 47-42, +6.13 units
- Combos: 1-18, -12.0 units
Raiders vs 49ers odds
For help understanding probabilities, see our odds calculator.
- Spread: Raiders +9.5 | 49ers -9.5
- Over/Under: Over 52.5 (53%) | Under 52.5 (48%)
- Moneyline: Raiders 20% | 49ers 80%
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Raiders vs 49ers weather
The forecast calls for sunny, clear skies and a comfortable kickoff temperature of 70°F with light 3 mph winds and no chance of precipitation Sunday afternoon in Santa Clara.
Check out our NFL weather page for up-to-date info on every matchup.
Raiders vs 49ers trend to know
The Raiders have hit the Over in 12 of their last 20 games (+3.20 Units / 15% ROI). Find more NFL betting trends for Raiders vs. 49ers.
or our BET99 promo code COVERS99 if you're in Canada.
How to watch Raiders vs 49ers
| Location | Levi's Stadium, Santa Clara, Calif. |
| Date | Sunday, Nov. 8, 2026 |
| Kickoff | 4:25 p.m. ET |
| TV | FOX |
Raiders vs 49ers latest injuries
Check out our NFL injuries page for updates on every team.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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