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College Football Picks

Free College Football Expert and Computer Picks For Every Game Nov. 21, 2025

Louisiana Ragin' Cajuns logo ULL @ Arkansas State Red Wolves logo ARST Thu, Nov 20 • 7:30 PM ET
1 Expert Pick 10 Computer Picks
Total
Louisiana Ragin' Cajuns logo Arkansas State Red Wolves logo u54.5 (-125)
Best Odds
Pick made: yesterday
Douglas Farmer image
Douglas Farmer
Betting Analyst

The Ragin’ Cajuns have played better of late, most notably their rushing offense. Louisiana runs the ball at the 11th-highest relative rate in the country, only more so of late, and that should yield some success. But it should also slow down this game, particularly against a decent Sun Belt rush defense.

Receptions
CC
Chauncy Cobb u6.5 Receptions (-128)
Projection 5.1301 (Under)
Best Odds
Pick made: 2 hours ago
EV Model Rating
Star rating: 4 out of 5
View 11 Picks
Florida State Seminoles logo FSU @ North Carolina State Wolfpack logo NCST Fri, Nov 21 • 8:00 PM ET
1 Expert Pick 10 Computer Picks
Passing Yards
TC Tommy Castellanos o235.5 Passing Yards (-114)
Best Odds
Pick made: yesterday
Andrew Caley image
Andrew Caley
Senior Betting Analyst

Tommy Castellanos is averaging 246.1 passing yards over his last seven games, going Over 235.5 yards six times during that period. He should cook a North Carolina State secondary that is struggling. The Wolfpapck have been torched for 367 passing yards to Miami, 408 to Georgia Tech, 423 to Pitt, and 342 to Notre Dame over the last four games. 

Passing Yards
TC
Tommy Castellanos u235.5 Passing Yards (-114)
Projection 211.9657 (Under)
Best Odds
Pick made: 3 days ago
EV Model Rating
Star rating: 5 out of 5
View 11 Picks
Hawai'i Rainbow Warriors logo HAW @ UNLV Rebels logo UNLV Fri, Nov 21 • 10:30 PM ET
2 Expert Picks 9 Computer Picks
Passing Yards
MA Micah Alejado o315.5 Passing Yards (-114)
Best Odds
Pick made: 10 hours ago
JD Yonke image
JD Yonke
Betting Analyst

Micah Alejado is averaging 358.8 passing yards across his last five games, and he stands a good chance of continuing his lucrative run against a miserable UNLV defense that surrenders 6.6 yards per play.

Spread
Hawai'i Rainbow Warriors logo HAW +3.0 (-115)
Best Odds
Pick made: yesterday
Brad Powers image
Brad Powers
Betting Analyst

I like this spot for Hawaii. They're off a bye, catching UNLV off an overtime game on a short week. I actually think Hawaii is the slightly better team and there's some prior perception built into this line. Also, don't underestimate the "hidden homefield," don't be surprised to see Hawaii have 40% or 50% of the crowd based on my experience of attending this game in Las Vegas in past years.

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Rutgers Scarlet Knights logo RUTG @ Ohio State Buckeyes logo OSU Sat, Nov 22 • 12:00 PM ET
1 Expert Pick 6 Computer Picks
Total
Rutgers Scarlet Knights logo Ohio State Buckeyes logo o55.5 (-110)
Best Odds
Pick made: an hour ago
Ed Scimia image
Ed Scimia
Betting Analyst

Ohio State will run up the score against Rutgers, and I'm confident that the Scarlet Knights can contribute enough to get us to the Over on Saturday.

TD Passes
Julian Sayin logo
Julian Sayin o2.5 TD Passes (+100)
Projection 2.8416 (Over)
Best Odds
Pick made: yesterday
EV Model Rating
Star rating: 3 out of 5
View 7 Picks
Missouri Tigers logo MIZZ @ Oklahoma Sooners logo OKLA Sat, Nov 22 • 12:00 PM ET
3 Expert Picks 10 Computer Picks
Spread
Missouri Tigers logo MIZZ +7.5 (-120)
Best Odds
Pick made: 2 hours ago
Douglas Farmer image
Douglas Farmer
Betting Analyst

For all of Oklahoma's thrilling qualities, the Sooners struggle where it matters most, averaging just 3.05 points per quality drive, No. 102 in the country. That kind of struggle ruins any confidence in Oklahoma covering a spread of more than a touchdown against a quality opponent, a position the Sooners actually have not been in yet this season.

Total
Missouri Tigers logo Oklahoma Sooners logo u42.5 (-110)
Best Odds
Pick made: 3 days ago
Jeremy Jones image
Jeremy Jones
Betting Analyst

The Sooners keep almost every opponent below their season average of points allowed and the Tigers have been struggling on offense against good teams.

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Baylor Bears logo BAY @ Arizona Wildcats logo ARIZ Sat, Nov 22 • 1:00 PM ET
1 Expert Pick 10 Computer Picks
Spread
Arizona Wildcats logo ARIZ -5.5 (-115)
Best Odds
Pick made: 3 days ago
Douglas Farmer image
Douglas Farmer
Betting Analyst

Baylor's rush defense has become a laughingstock. Admittedly, it started the year as a joke, giving up 307 yards to Auburn in the opener. Utah ran for nearly 400 late on Saturday, just a few weeks after Cincinnati took 50 carries for more than five yards per carry. Enter Arizona and a top-25 rushing offense. The Wildcats should gash the Bears.

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Washington State Cougars logo WSU @ James Madison Dukes logo JMU Sat, Nov 22 • 1:00 PM ET
1 Expert Pick
Spread
James Madison Dukes logo JMU -12.5 (-115)
Best Odds
Pick made: 3 days ago
Douglas Farmer image
Douglas Farmer
Betting Analyst

Going strictly by the numbers, James Madison should be a full two-touchdown favorite. Going by the motivation at hand as the Dukes try to make a case for a College Football Playoff bid, expect James Madison to press the gas for the whole game. This is one moment in which there should be on risk of a backdoor cover.

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Syracuse Orange logo SYR @ Notre Dame Fighting Irish logo ND Sat, Nov 22 • 3:30 PM ET
1 Expert Pick
Spread
Notre Dame Fighting Irish logo ND -34.5 (-118)
Best Odds
Pick made: 3 days ago
Douglas Farmer image
Douglas Farmer
Betting Analyst

Notre Dame has won three Senior Days under Marcus Freeman by a combined score of 124-21. Some of that reflects the quality of opponents, but much of it reflects Freeman's tendency of bettering his team as the season goes along. That was evident as Pittsburgh's supposedly dynamic offense went 2-of-13 on late-down situations last weekend. This aggressive defense now faces a bottom-25 offense in late-down situations, one that has so scuffled for a quarterback since Steve Angeli's injury that it at one point turned to the lacrosse team.

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Duke Blue Devils logo DUKE @ North Carolina Tar Heels logo UNC Sat, Nov 22 • 3:30 PM ET
1 Expert Pick 9 Computer Picks
Passing Yards
GL Gio Lopez o191.5 Passing Yards (-114)
Best Odds
Pick made: 5 hours ago
Chris Hatfield image
Chris Hatfield
Betting Analyst

We’re betting Gio Lopez’s passing yards over again (up to 199.5) because he’s cleared 200 in four straight games, Duke’s pass defense is atrocious, and a likely pass-friendly game script sets him up to exploit it.

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USC Trojans logo USC @ Oregon Ducks logo ORE Sat, Nov 22 • 3:30 PM ET
3 Expert Picks 10 Computer Picks
Total
USC Trojans logo Oregon Ducks logo o59.5 (-105)
Best Odds
Pick made: 2 hours ago
Douglas Farmer image
Douglas Farmer
Betting Analyst

USC's defense has received some faint praise this season, but it has reverted back to its true self in recent weeks. Oregon's defense has also fallen off in recent weeks, slight defensive letdowns against Iowa and Minnesota that the Trojans' offense should delight in exploiting. Expect this to turn into a shootout, perhaps a moment of assuming whoever has the ball last will win.

Total
USC Trojans logo Oregon Ducks logo u59.5 (-105)
Best Odds
Pick made: 3 days ago
JD Yonke image
JD Yonke
Betting Analyst

Neither team plays at a fast tempo, the pace should be relatively slow. The Ducks will run the ball, keeping the clock ticking, and USC's vaunted offense will be slowed by Oregon's elite defense.

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Michigan Wolverines logo MICH @ Maryland Terrapins logo MD Sat, Nov 22 • 4:00 PM ET
1 Expert Pick 10 Computer Picks
Spread
Maryland Terrapins logo MD +13.5 (-105)
Best Odds
Pick made: 7 hours ago
Jeremy Jones image
Jeremy Jones
Betting Analyst
TD Passes
BU
Bryce Underwood u1.5 TD Passes (-182)
Projection 0.9547 (Under)
Best Odds
Pick made: 22 hours ago
EV Model Rating
Star rating: 4 out of 5
View 11 Picks
Pittsburgh Panthers logo PITT @ Georgia Tech Yellow Jackets logo GT Sat, Nov 22 • 7:00 PM ET
1 Expert Pick 10 Computer Picks
Spread
Georgia Tech Yellow Jackets logo GT -2.5 (-110)
Best Odds
Pick made: yesterday
Brad Powers image
Brad Powers
Betting Analyst

I think Georgia Tech is the slightly better team and if they win, they're in the ACC Championsip game. They're at home with the much more experienced and better quarterback. They also have the much better coaching staff. I question where Pittsburgh is at phycologically and think Georgia Tech is feeling good about themselves after that big 4th quarter rally against Boston College. 

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BYU Cougars logo BYU @ Cincinnati Bearcats logo CIN Sat, Nov 22 • 8:00 PM ET
1 Expert Pick 10 Computer Picks
MoneyLine
BYU Cougars logo BYU (-138)
Best Odds
Pick made: yesterday
Phil Naessens image
Phil Naessens
Betting Analyst

Defensively, BYU is built to shut down what Cincinnati does best. The Cougars allow just 191.5 passing yards per game and only eight passing touchdowns all season, making life difficult for Bearcats quarterback Brendan Sorsby. 

 

Receptions
CR
Chase Roberts u4.5 Receptions (-114)
Projection 4.0697 (Under)
Best Odds
Pick made: 2 days ago
EV Model Rating
Star rating: 4 out of 5
View 11 Picks

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