Week 10 NFL Picks for Sunday, Nov. 15: Best Bets From Every Game Preview

Robert Criscola - Betting Analyst at Covers.com
Robert Criscola • Betting Analyst 11+ years betting experience
Updated: Nov 15, 2026 , 05:00 AM ET • 4 min read

We've rounded up all of our experts' NFL Top Picks for Sunday's complete Week 10 slate.

Week 10 NFL Picks
Photo By - Reuters Connect. Jared Goff, Jaxon Smith-Njigba, and Aaron Rodgers.

Get our experts' Week 10 NFL picks for Sunday, Nov. 15, with top plays from Covers analysts across all 12 games!

From the early international matchup between the Patriots and Lions, to Sunday Night Football between the Steelers and Bengals, we've gathered the best picks and analysis for the full Sunday slate.

Check out our NFL picks for more expert predictions throughout the season.

Week 10 top picks at a glance (Sunday, Nov. 15)

Matchup & kickoff Top pick & analyst
Patriots vs. Lions
9:30 a.m.
Lions moneyline
Jason Logan
Chiefs vs. Falcons
1 p.m.
Chiefs -3.5
Neil Parker
Bills vs. Jets
1 p.m.
Over 50.5
Tom Oldfield
Dolphins vs. Colts
1 p.m.
Under 38.5
Dustin Saracini
Vikings vs. Packers
1 p.m.
Green Bay moneyline
Jason Logan
Panthers vs. Saints
1 p.m.
Panthers +2.5
Shawn Krest
Jaguars vs. Titans
1 p.m.
Under 46.5
Neil Parker
Texans vs. Browns
1 p.m.
Texans -4.5
Dustin Saracini
Seahawks vs. Raiders
4:05 p.m.
Seahawks -6.5
Neil Parker
Rams vs. Cardinals
4:05 p.m.
Under 39.5
Jason Logan
49ers vs. Cowboys
4:25 p.m.
Cowboys +4.5
Neil Parker
Steelers vs. Bengals
8:20 p.m.
Steelers +3.5
Jason Logan

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9:30 a.m. kickoff

Patriots vs. Lions

  • Kickoff: 9:30 a.m. ET
  • TV: NFL Network
  • Analyst: Jason Logan

Top pick: Lions moneyline

New England is dealing with significant injuries along its offensive line and could also be without its top two running backs. Detroit ranks third in pass rush win rate and has recorded 27 sacks, giving the Lions a favorable matchup against a Patriots offense that could struggle to protect Drake Maye. Logan likes Detroit to win outright and would take the Lions moneyline as high as 62%.

Read Logan's full Patriots vs. Lions predictions.

1 p.m. kickoffs

Chiefs vs. Falcons

Top pick: Chiefs -3.5

Kansas City's defense has been strong on third downs and in the red zone, while Atlanta has struggled to sustain drives and finish scoring opportunities. The Chiefs also have an edge in limiting explosive plays, a concern for a Falcons offense led by Michael Penix Jr.

Read Parker's full Chiefs vs. Falcons predictions.

Bills vs. Jets

Top pick: Over 50.5

Buffalo's offense leads the league in both yards and points per game, and the Bills have scored at least 30 points in four of their last five meetings with the Jets. New York's passing game gets a boost with Garrett Wilson back, while Geno Smith has connected on a pass of at least 40 yards in four straight games.

Read Oldfield's full Bills vs. Jets predictions.

Dolphins vs. Colts

Top pick: Under 38.5

Neither offense has inspired much confidence, making a low total the focus in Indianapolis. Miami ranks 13th in total defense, and the Dolphins have scored a touchdown on just 47% of their red-zone trips this season.

Read Saracini's full Dolphins vs. Colts predictions.

Vikings vs. Packers

Top pick: Green Bay moneyline

Kirk Cousins' return gives Minnesota a boost, but the Vikings defense is coming off a heavy workload and faces a short week. Green Bay has been one of the league's better two-way teams since Week 6, ranking in the top 10 in EPA per play on both sides of the ball.

Read Logan's full Vikings vs. Packers predictions.

Panthers vs. Saints

Top pick: Panthers +2.5

Carolina and New Orleans are tied atop the NFC South at 3-5, and the Panthers get several contributors back from injured reserve. Those reinforcements should help on both sides of the ball against a Saints defense that has struggled for much of the season.

Read Krest's full Panthers vs. Saints predictions.

Jaguars vs. Titans

Top pick: Under 46.5

Jacksonville has been strong on both sides of the ball, allowing the second-fewest points per game while ranking among the league's top offenses. Tennessee has struggled to move the ball consistently, averaging the third-fewest plays per game and ranking near the bottom of the league in scoring.

Read Parker's full Jaguars vs. Titans predictions.

Texans vs. Browns

Top pick: Texans -4.5

Houston's pass rush has a favorable matchup against a Cleveland offensive line that has allowed the most sacks per game in the league. C.J. Stroud is also coming off a five-touchdown performance, and the Texans' passing offense has a clear statistical edge over a Browns unit that ranks near the bottom of the league.

Read Saracini's full Texans vs. Browns predictions.

4:05 p.m. kickoffs

Seahawks vs. Raiders

Top pick: Seahawks -6.5

Seattle ranks among the league's best defenses in DVOA and pressure rate, setting up a difficult first start for Raiders rookie quarterback Fernando Mendoza. Las Vegas has struggled on defense, allowing the highest EPA per play over the past seven weeks.

Read Parker's full Seahawks vs. Raiders predictions.

Rams vs. Cardinals

Top pick: Under 39.5

Both teams are dealing with major injuries to their top wide receivers, while Arizona is turning to rookie quarterback Carson Beck. The Rams have also leaned more heavily on the run during their recent winning streak, a shift that could shorten the game and limit scoring opportunities.

Read Logan's full Rams vs. Cardinals predictions.

4:25 p.m. kickoff

49ers vs. Cowboys

Top pick: Cowboys +4.5

Dallas has made significant defensive improvements over the past month, moving from near the bottom of several key metrics toward the middle of the pack. The Cowboys' offense ranks sixth in EPA per play and offensive DVOA, giving them the firepower to keep pace with San Francisco.

Read Parker's full 49ers vs. Cowboys predictions.

Sunday Night Football

Steelers vs. Bengals

Top pick: Steelers +3.5

Pittsburgh enters this AFC North matchup with a rest advantage after its bye, while Cincinnati is coming off a demanding trip to Spain. The Steelers' defense has improved considerably during the team's winning streak, and its strong ground game could help keep Joe Burrow and the Bengals offense on the sideline.

Read Logan's full Steelers vs. Bengals predictions.

More NFL Week 10 picks

Check the NFL weather report and the NFL injury report, compare numbers across football betting sites, and brush up with our guide to betting on football before finalizing today's picks.

All of today's matchups are also on the NFL scores and matchups page, and the full pick archive lives in free NFL picks.

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Robert Criscola - Covers.com
Betting Analyst

Robert M. Criscola’s road to becoming a Covers publishing editor began with an internship at Metro New York, which eventually turned into a freelance job at MetroBet covering many sports from a wagering angle, including horse racing. He continued to focus on “The Sport of Kings” by writing for shapperdacapper.com, danonymousracing.com, and informer.fanxt.com before joining the team at the TwinSpires Edge in 2019 as a regular contributor and weekend editor. “Crisco” began writing game previews for Covers in 2022 and joined the editing team in 2023.

His best advice for sports bettors? Bet with your head, not over it.

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