The San Francisco 49ers are road favorites over the Dallas Cowboys ahead of their 4:25 p.m. ET kickoff in America’s Game of the Week at AT&T Stadium on Sunday, Nov. 15.
My top 49ers vs. Cowboys prediction and NFL picks expect Dallas to cover the number in a back-and-forth bout.
TOP Pick
49ers vs Cowboys prediction: Cowboys +4.5
The Dallas Cowboys are the side I want above the key number of 4.
After allowing the highest EPA per play and second-highest explosive play rate while ranking 32nd in defensive DVOA to start the year, Dallas' defense has improved to allow the 17th-highest EPA per play and 20th-highest explosive play rate while sitting 17th in defensive DVOA over the past four games.
While those are still middling marks, they represent a huge improvement for the Cowboys, and the Dallas offense can keep pace Sunday.
Dallas ranks sixth in EPA per play and offensive DVOA, while the San Francisco 49ers have faced the eighth-easiest schedule by DVOA and fifth-easiest according to PFF.
With San Francisco starting cornerbacks Renardo Green (back) and Deommodore Lenoir (foot) both nursing injuries, I expect Dallas to put up enough points to cover the spread.
COVERS INTEL: The Cowboys offense ranks fifth in both third-down conversion rate and points per drive.
49ers vs Cowboys combo
The Dallas one-two punch of quarterback Dak Prescott and No. 1 wide receiver CeeDee Lamb is going to be on full display Sunday afternoon.
Both San Francisco starting cornerbacks are nursing the noted injuries, and Prescott has thrown for 275 or more yards in five of eight games, while Lamb has garnered 57 targets over the past four weeks.
Additionally, Prescott sports an impressive 110.9 NFL passer rating when targeting his go-to receiver, and Lamb’s 46.6% air yards share ranks in the 87th percentile among wideouts.
49ers vs Cowboys combo
- Cowboys +4.5
- Dak Prescott 275+ passing yards
- CeeDee Lamb 90+ receiving yards
49ers vs Cowboys touchdown scorer: George Kittle
This touchdown prop is in play down to 50%.
San Fran tight end George Kittle has been a force this season with a high-end 12.7 yards per reception, 8.5 aDOT, and five touchdowns, while quarterback Brock Purdy has a rock-solid 115.5 NFL passer rating when targeting him. With the Cowboys surrendering the fourth-highest catch rate to the position, this is a great matchup for Kittle to score.
He's also garnered 30% of the red-zone targets for the 49ers, including at least one red-zone look in seven of eight games.
- Top picks: 55-46, +10.44 units
- Combos: 2-21, -101 units
49ers vs Cowboys odds
For help understanding probabilities, see our odds calculator.
- Spread: 49ers -4.5 | Cowboys +4.5
- Over/Under: Over 55.5 (50%) | Under 55.5 (51%)
- Moneyline: 49ers 66% | Cowboys 35%
For the full slate of NFL matchups, check out our NFL odds board!
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49ers vs Cowboys weather
AT&T Stadium's retractable roof is expected to be closed for Sunday's game due to cold, wet weather in Arlington.
The Cowboys typically decide on the roof status approximately 90 minutes before kickoff.
Check out our NFL weather page for up-to-date info on every matchup.
49ers vs Cowboys trend to know
Dallas has hit the game total Over in 15 of its last 20 games (+9.50 Units / 43% ROI). Find more NFL betting trends for 49ers vs. Cowboys.
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How to watch 49ers vs Cowboys
| Location | AT&T Stadium, Arlington, Texas |
| Date | Sunday, Nov. 15, 2026 |
| Kickoff | 4:25 p.m. ET |
| TV | FOX |
49ers vs Cowboys latest injuries
Check out our NFL injuries page for updates on every team.
Odds are correct at the time of publishing and are subject to change.
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