The Jacksonville Jaguars are massive road favorites over the Tennessee Titans ahead of their 1 p.m. kickoff at Nissan Stadium on Sunday, Nov. 15.
My favorite Jaguars vs. Titans prediction and NFL picks expect the Jacksonville defense to show off in Nashville to keep this total Under the number Sunday afternoon.
TOP Pick
Jaguars vs Titans prediction: Under 46.5
The Under is my preferred play in this game down to 44.5.
The Jacksonville Jaguars have allowed the second-fewest points per game (15.1) and third-lowest EPA per play to rank third in defensive DVOA.
It’s a similar story on offense with the Jags scoring the fourth-most points per game (28.6) and generating the fifth-highest EPA per play to rank fifth in offensive DVOA.
Jacksonville won’t hit this Over on its own, though, and blowouts are where Overs go to die.
With the Tennessee Titans averaging the third-fewest plays per game while ranking 28th in points per game (18.0) and 25th in offensive DVOA, I’m expecting the Jags to hold the Titans in check to keep this total Under the number.
COVERS INTEL: The Jacksonville Jaguars have allowed the second-fewest points per drive, and the Tennessee Titans have scored the fifth-fewest points per drive.
Jaguars vs Titans combo
Jacksonville is superior on both sides of the ball and has covered the spread in 15 of its past 20 games (+9.60 Units / 44% ROI).
The Titans have allowed seven different quarterbacks to reach double-digit rushing yards, and Jags QB Trevor Lawrence is a capable rusher, with 79 yards on the season and 3.14 yards after contact per attempt.
Turning to Jacksonville No. 1 running back Bhayshul Tuten, he’s scored in each of the past three games to climb to seven touchdowns for the season, and he’s also handled 51.4% of the red-zone carries through eight games for the Jags.
Jaguars vs Titans combo
- Jaguars -10.5
- Trevor Lawrence 10+ rushing yards
- Bhayshul Tuten anytime touchdown
Jaguars vs Titans touchdown scorer: Bhayshul Tuten
This touchdown prop is in play to 58%.
It’s not just Tuten’s role that has my attention this week. He boasts a rock-solid 3.65 YCO/A and 98.5 PFF elusive rating, and he’s equally dangerous through the air with 15.1 yards after the catch per reception.
The Titans rank 29th in run defense DVOA, too, so the matchup checks out.
- Top picks: 55-46, +10.44 units
- Combos: 2-21, -10.1 units
Jaguars vs Titans odds
For help understanding probabilities, see our odds calculator.
- Spread: Jaguars -10.5 | Titans +10.5
- Over/Under: Over 46.5 (49%) | Under 46.5 (52%)
- Moneyline: Jaguars 84% | Titans 17%
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Jaguars vs Titans weather
The forecast calls for sunny skies, 52°F temperatures, and light 5 mph winds Sunday afternoon.
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Jaguars vs Titans trend to know
The Jacksonville Jaguars have covered the spread in 15 of their last 20 games (+9.60 Units / 44% ROI). Find more NFL betting trends for Jaguars vs. Titans.
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How to watch Jaguars vs Titans
| Location | Nissan Stadium, Nashville, Tenn. |
| Date | Sunday, Nov. 15, 2026 |
| Kickoff | 1 p.m. ET |
| TV | FOX |
Jaguars vs Titans latest injuries
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