NFL Moneyline Picks for Every Week 10 Game

Trevor Knapp - Betting Analyst at Covers.com
Trevor Knapp • Betting Analyst 7+ years betting experience
Updated: Nov 10, 2026 , 11:26 AM ET • 4 min read

Fresh off a 12-2 heater, we're rolling into Week 10 with the G-Men on TNF, Joe Cool on SNF, and moneyline picks for every NFL game.

NFL Moneyline Picks for Every Week 10 Game. Arvell Reese, Jordan Love, and Joe Burrow.
Photo By - Reuters Connect. Arvell Reese, Jordan Love, and Joe Burrow.

I finally put the belt to ass in last week's NFL moneyline picks, finishing with a 12-2 record (+4.04 units) and building plenty of momentum heading into a new slate.

Let's keep stacking wins as we kick things off with the New York Giants taking care of business against the Washington Commanders on TNF.

Here are my latest NFL picks for Week 10.

My NFL moneyline record is 85-50 this season for +4.23 units.

For help understanding Kalshi probabilities, see our odds calculator.

Matchup Kalshi
Probability
Commanders Commanders vs Giants Giants Giants 56%
Patriots Patriots vs Lions Lions Lions 58%
Jaguars Jaguars vs Titans Titans Jaguars 84%
Texans Texans vs Browns Browns Texans 68%
Vikings Vikings vs Packers Packers Packers 67%
Chiefs Chiefs vs Falcons Falcons Chiefs 64%
Dolphins Dolphins vs Colts Colts Dolphins 45%
Panthers Panthers vs Saints Saints Saints 52%
Bills Bills vs Jets Jets Bills 80%
Rams Rams vs Cardinals Cardinals Rams 80%
Seahawks Seahawks vs Raiders Raiders Seahawks 63%
49ers 49ers vs Cowboys Cowboys 49ers 67%
Steelers Steelers vs Bengals Bengals Bengals 65%
Chargers Chargers vs Ravens Ravens Ravens 67%

Percentages courtesy of Kalshi, one of the best prediction market apps.

Start trading with Kalshi today!

Sign up now using our exclusive Kalshi promo code 'MAX60' and trade $25 on any event contracts to get $60!

*Eligible U.S. locations only

Expert Week 10 NFL moneyline picks

Commanders vs. Giants: Giants Giants 

While Washington's pathetic offensive line continues to hold Jayden Daniels back, the Giants are coming off a big road win in Philly.

Rookie linebacker Arvell Reese led the way with three sacks and a forced fumble, and I like this pass rush to give Daniels fits on TNF. 

Patriots vs. Lions: Lions Lions

With RB1 Rhamondre Stevenson banged up and A.J. Brown still sidelined, the Lions have the edge in Munich. 

New England's defense is coming off allowing 45 points at home, and Detroit’s offense will be able to capitalize overseas.

Jaguars vs. Titans: Jaguars Jaguars 

Jacksonville just hung 33 points on Baltimore, ranks third in both offensive and defensive EPA, and added Pro Bowl safety Jessie Bates and star defensive tackle Jordan Davis on Monday.

Another double-digit win is in store against the basement-dwelling Titans.

Texans vs. Browns: Texans Texans

C.J. Stroud quietly boasts a 104.8 passer rating on the season, fresh off a five-touchdown performance against the Chargers, while Houston's pass rush was just as lethal, sacking Justin Herbert eight times.

Cleveland's run defense has cratered since losing Maliek Collins (155 rushing yards allowed to the Saints), and Deshaun Watson is set to return behind a struggling O-line that the Texans will feast on.

Vikings vs. Packers: Packers Packers

Jordan Love is playing lights out right now, and the Packers made a statement in Foxborough with a double-digit rout.

With the Vikings' QB situation a complete mess following a Carson Wentz disaster class, I'm rolling with the Packers at home. 

Chiefs vs. Falcons: Chiefs Chiefs 

Patrick Mahomes' elbow scare ended with an MRI that revealed no major damage, and he's expected to play after leading a 35-12 rout of the Jets.

Atlanta was just embarrassed overseas by Cincinnati, and its offense ranks 25th in EPA per play. I'm riding with the Chiefs.


Enjoying Covers content? Add us as a preferred source on your Google account Add as a preferred source on Google

More Covers NFL trading tools


Dolphins vs. Colts: Dolphins Dolphins

Indy went three-and-out on four of its first five drives against a terrible Cowboys defense, and I'm done giving the Shoe any grace whatsoever.

Miami's defense showed some fight by holding Detroit to a season-low 270 yards, so the plus money is worth a shot.

Panthers vs. Saints: Saints Saints

New Orleans has won five of the last six meetings between these teams, and I can't go back to the Carolina well with linebackers Bobby Okereke and Jaelan Phillips both listed as questionable.

Who Dat Nation prevails in this NFC South showdown.

Bills vs. Jets: Bills Bills 

New York has dropped four straight and allowed 28+ points in three consecutive games, so now's not the time to get cute looking for a divisional upset.

Good luck against Josh Allen and the Bills' No. 1-ranked offense.

Rams vs. Cardinals: Rams Rams 

Arizona managed just three points against Seattle, and now Gardner Minshew has reportedly torn the UCL in his throwing arm.

With Carson Beck potentially making his first career start, the Rams' fourth-ranked defense by EPA will make things ugly in the desert.

Seahawks vs. Raiders: Seahawks Seahawks

I'm convinced Drew Lock is actually an upgrade over Sam Darnold, and he once again did an effective job managing the Seahawks' offense against Arizona.

Now facing a Raiders defense allowing a league-high 29.8 points per game, expect Seattle to pull away in Sin City.

49ers vs. Cowboys: 49ers 49ers

Dallas' defense ranks last in third-down defense (48.3%), and it committed 14 penalties while needing a late INT to survive a Colts team that went 3-for-13 on third down. 

Bang Bang Niner Gang is set to invade Jerry World, and the 49ers will make it five straight wins over the Cowboys dating back to 2022.

Steelers vs. Bengals: Bengals Bengals

I'm inclined to side with the best player on the field, and Joe Burrow has emerged as the favorite in the latest NFL MVP odds.

With Pittsburgh's offense remaining stagnant, I have a hard time seeing old man Rodgers keeping pace with Joe Cool.

Chargers vs. Ravens: Ravens Ravens 

Baltimore is a mess, but Los Angeles is 0-8, ranks last in offensive EPA, and just bled 44 points to Houston.

Justin Herbert ranks dead last among qualifying quarterbacks in EPA per dropback, so even the Ravens' QB carousel (enter Jacoby Brissett!) shouldn't be an issue at home.

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.

Pages related to this topic

Trevor Knapp - Covers
Betting Analyst

Trevor joined the Covers content team as a publishing editor in early 2022. Growing up in Vancouver, he studied Broadcast and Online Journalism at the British Columbia Institute of Technology (BCIT), and interned with TSN and Sportsnet Radio while also writing for the Daily Hive.

An avid bettor of the MLB, NFL, and CFL, Trevor advises his fellow sports bettors to leave their hearts at the door and not hesitate to fade their favorite team. It's a strategy he follows regularly as an apathetic Indianapolis Colts and Toronto Blue Jays fan.

Popular Content

Covers is verified safe by: Evalon Logo GPWA Logo GDPR Logo GeoTrust Logo