Commanders vs Packers Predictions, Picks & Best Bets for Thursday Night Football Week 2

Deebo Samuel proved to be Commanders QB Jayden Daniels' favorite target in Week 1, and we expect more of the same on Thursday Night Football. The Packers will answer with a heavy workload for RB Josh Jacobs.

Joe Osborne: Senior Betting Analyst at Covers
Joe Osborne • Senior Betting Analyst
Sep 10, 2025 • 11:19 ET • 4 min read

NFL

Match starts: 28 hrs
GB
64 %
WAS
36 %
EXPERT PICK - PROP
Deebo Samuel o4.5  Receptions Made (-118) Deebo Samuel o4.5 Receptions Made (-118)
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Deebo Samuel Washington Commanders NFL
Photo By - Imagn Images. Commanders WR Deebo Samuel takes it to the house in Week 1.

A couple of rising stars at the quarterback position will lead their teams into Thursday Night Football action, with Jordan Love and the Green Bay Packers playing host to Jayden Daniels and the Washington Commanders.

Both squads got off to great starts in Week 1 with Green Bay dominating the Lions 27-13 and Washington easily defeating the Giants 21-6.

Green Bay's favored by 3.5, but my Commanders vs. Packers predictions and NFL picks expect one of Washington's new stars to have a big impact on the game and fill up the stat sheet on Thursday, September 11.

Commanders vs Packers prediction

Commanders vs Packers Best bet: Deebo Samuel Over 4.5 receptions (-118)

Make no mistake about it, a healthy Deebo Samuel is still one of the top weapons in the NFL.

This was on full display last week as he was a major factor in both the passing and running games for the Washington Commanders in their beatdown of the Giants.

While his touchdown came on his lone carry – a 19-yard run in the fourth quarter – he was Jayden Daniels’ favorite target. Deebo was on the receiving end of 10 targets, leading to seven receptions and 77 yards.

While Daniels spread the ball around with eight separate players receiving a target, the 10 in Samuel's direction were five more than any of his teammates.

It's clear that Kliff Kingsbury plans to use Samuel to his full extent and will take creative measures to get him involved in the offense, as seen on the reverse sweep handoff that led to his TD.

The Green Bay Packers defense was strong in Week 1 against Detroit, but it did allow Jared Goff to complete 31 passes on 39 attempts.

Commanders vs Packers TNF same-game parlay

With lots of potential touches in both the passing and running games, don’t be shocked to see Deebo in the end zone. Meanwhile, this game sets up nicely for Josh Jacobs against a Commanders defense that allowed the second-most rushing yards per game last season.

Commanders vs Packers SGP

  • Samuel Over 4.5 receptions
  • Jacobs Over 77.5 rushing yards
  • Samuel anytime TD

Our big-ticket SGP: Double the fun for Josh Jacobs

With a big day potentially on the way for Jacobs, let’s take him to get into the end zone twice. He had three multi-TD games last season.

Commanders vs Packers SGP

  • Jacobs 2+ TDs
  • Samuel anytime TD
  • Jacobs Over 77.5 rushing yards
  • Samuel Over 4.5 receptions

Commanders vs Packers odds

  • Spread: Washington +3.5 | Green Bay -3.5
  • Moneyline: Washington +155 | Green Bay -185
  • Over/Under: Over 48 | Under 48

Commanders vs Packers betting trend to know

The Washington Commanders have hit the Moneyline in 7 of their last 11 away games (+8.75 Units / 52% ROI)

Find more NFL betting trends for Commanders vs. Packers.

How to watch Commanders vs Packers

Location Lambeau Field, Green Bay, WI
Date Thursday, September 11, 2025
Kickoff 8:15 p.m. ET
TV Amazon Prime

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Joe Osborne Senior Betting Analyst Covers.com
Senior Betting Analyst

Joe is an industry veteran who loves the entertainment aspect of the sports betting industry. His opinions are always backed by data and he enjoys digging into the numbers and coming up with interesting nuggets to share with sports bettors.

Joe takes a high-energy and fun approach to covering his favorite sports which include the NFL, MLB, UFC, NBA and NHL, and there’s no bet type he loves more than an NFL six-point teaser. Joe is the host of our daily sports betting program, Before You Bet, while he also leads our weekly UFC show, P4P Picks, and our 'Covers on the Ground' series where he's covered many UFC, NFL and NBA games in person. A monthly highlight for Joe is conducting interviews with UFC legend Georges St-Pierre ahead of every UFC PPV.

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