NFL Week 6 Odds and Betting Lines: Bills Narrow to -1 on MNF

And just like that — POOF! — we're a third of a way through the season with NFL Week 6 odds on the board.

The Week 6 odds started with San Francisco covering in an NFC West war against Seattle on Thursday Night Football, and we're down to our final prime time affair of the week with a Monday matchup between Buffalo and the N.Y. Jets.

Here's a look at the NFL odds and where the lines have moved since opening.

NFL Week 6 odds, lines, and spreads

These are the latest odds for Week 6, headlined by the Bills battling the Jets at MetLife Stadium.

Matchup	Time (E.T.)	Odds
49ers vs Seahawks	Thursday 8:15 p.m. Prime	Seahawks +3.5 O/U 48.5
Jaguars vs Bears	Sunday 1:00 p.m. NFL Network	Bears -1.5 O/U 44.5
Cardinals vs Packers	Sunday 1:00 p.m. FOX	Packers -5 O/U 47.5
Colts vs Titans	Sunday 1:00 p.m. CBS	Titans -2.5 O/U 43
Texans vs Patriots	Sunday 1:00 p.m. CBS	Patriots +7 O/U 37.5
Buccaneers vs Saints	Sunday 1:00 p.m. FOX	Saints +3.5 O/U 41.5
Browns vs Eagles	Sunday 1:00 p.m. FOX	Eagles -9.5 O/U 42.5
Commanders vs Ravens	Sunday 1:00 p.m. CBS	Ravens -6.5 O/U 51.5
Chargers vs Broncos	Sunday 4:05 p.m. CBS	Broncos +3 O/U 35.5
Steelers vs Raiders	Sunday 4:05 p.m. CBS	Raiders +3 O/U 36.5
Lions vs Cowboys	Sunday 4:25 p.m. FOX	Cowboys +3 O/U 52.5
Falcons vs Panthers	Sunday 4:25 p.m. FOX	Panthers +6 O/U 47
Bengals vs Giants	Sunday 8:20 p.m. NBC	Giants +3.5 O/U 47
Bills vs Jets	Monday 8:15 p.m. ESPN	Jets +1 O/U 41

Odds courtesy of BetMGM as of 10-14.

Jaguars vs. Bears odds

Opening line

• Bears -1.5
• Over/Under 43
• View full Jaguars vs. Bears odds and matchup
• Read our Jaguars vs. Bears picks and predictions 

Chicago opened as a 1.5-point neutral-site favorite and that spread jumped as high as -2.5 but has since slimmed to as low as Bears -1 on game day. The Bears are coming off a one-sided win over Carolina while the Jaguars finally cracked the win column with a close one versus Indianapolis. This total opened at 43 points and is up to 43.5 O/U. 

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Cardinals vs. Packers odds

Opening line

• Packers -5.5
• Over/Under 50.5
• View full Cardinals vs. Packers odds and matchup
• Read our Cardinals vs. Packers picks and predictions

Most books opened Green Bay -5.5 and some shops are now as low as -4.5 after Arizona’s upset over San Francisco. However, the spread is back to Packers -5.5 on Sunday morning. This total hit the board at 49 points and jumped up to 50.5 but has since slimmed to 47 with wind and rain in the forecast.

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Colts vs. Titans odds

Opening line

• Titans +1
• Over/Under 42
• View full Colts vs. Titans odds and matchup
• Read our Colts vs. Titans picks and predictions

Colts QB Anthony Richardson will play but RB Jonathan Taylor is sidelined for this AFC South showdown. Tennessee is coming off a bye after a win in Week 4. Bookies opened the Titans as 1-point home underdogs but this spread has swung all the way to Tennessee -3. The total hit the board at 42 points and is up to 43.5 O/U on gameday.

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Texans vs. Patriots odds

Opening line

• Patriots +7
• Over/Under 38.5
• View full Texans vs. Patriots odds and matchup
• Read our Texans vs. Patriots picks and predictions

Houston was able to edge Buffalo at home in Week 5 but is hurting on offense, with WR Nico Collins going down with a hamstring. The Texans opened as touchdown favorites in Foxborough but dropped to -6.5 in the first few hours of action. You can find Houston -6.5 to -7 on Sunday morning. This total opened at 38.5 O/U and is now as low as 37 points.

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Buccaneers vs. Saints odds

Opening line

• Saints +1.5
• Over/Under 42.5
• View full Buccaneers vs. Saints odds and matchup
• Read our Buccaneers vs. Saints picks and predictions

The Saints are coming off a loss on a short week and now have a heat NFC South showdown with the Bucs in Week 6. Tampa Bay opened as a 1.5-point road favorite in NOLA with the total at 42.5 O/U. New Orleans QB Derek Carr will not play, putting rookie Spencer Rattler under center. That drove this spread to Bucs -3.5 with the total at 42 O/U.

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Browns vs. Eagles odds

Opening line

• Eagles -8.5
• Over/Under 45
• View full Browns vs. Eagles odds and matchup
• Read our Browns vs. Eagles picks and predictions

Philadelphia opened between -8.5 and -9.5 for this Week 6 non-conference clash with Cleveland and the spread is still bouncing between those numbers on Sunday morning. The Browns look horrible on both sides of the ball and watched several defensive starters leave Week 5 with injuries.

Cleveland is also sticking with struggling starting QB Deshaun Watson for Week 6. This total opened at 45 and is down to 42.5 points. Philadelphia is coming off a bye week and will have WRs A.J. Brown and DeVonta Smith back in action. 

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Commanders vs. Ravens odds

Opening line

• Ravens -6.5
• Over/Under 51
• View full Commanders vs. Ravens odds and matchup
• Read our Commanders vs. Ravens picks and predictions

The Ravens opened as high as -7 with most books dealing Baltimore -6.5 in this Battle of the Beltway. The touchdown is the most common spread on gameday. The total opened at 51 points and climbed to 52 O/U - one of the highest of the 2024 season. 

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Chargers vs. Broncos odds

Opening line

• Broncos +2.5
• Over/Under 37
• View full Chargers vs. Broncos odds and matchup
• Read our Chargers vs. Broncos picks and predictions

Los Angeles is coming off a bye and opened as a 2.5-point road favorite in Denver. That spread is up to a field goal. The total is on the shorter end, opening at 37 points and books coming down to 36.5 O/U.

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Steelers vs. Raiders odds

Opening line

• Raiders +3
• Over/Under 36.5
• View full Steelers vs. Raiders odds and matchup
• Read our Steelers vs. Raiders picks and predictions

The Steelers couldn't squeeze out a win on Sunday night and open as 3-point road favorites in Sin City, with the Raiders in distress. Las Vegas is making a switch at quarterback, which has this spread as high as +3.5 and the total on the low end at 36.5 points.

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Lions vs. Cowboys odds

Opening line

• Cowboys +3
• Over/Under 51.5
• View full Lions vs. Cowboys odds and matchup
• Read our Lions vs. Cowboys picks and predictions

Dallas won a long ugly game in Pittsburgh on Sunday night and now face the Lions, who are fresh off the bye week. Bookies opend Detroit as a field goal fave with the total among the tallest on the Week 6 board at 51.5 O/U. As of Sunday morning, Detroit -3 is the consensus with the total at 52.5 O/U.

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Falcons vs. Panthers odds

Opening line

• Panthers +5.5
• Over/Under 48.5
• View full Falcons vs. Panthers odds and matchup
• Read our Falcons vs. Panthers picks and predictions

The Falcons have the rest and momentum edge over their NFC South foes in Week 6, with Atlanta opening as a 5.5-point favorite and jumping to -6 after a big win over Tampa Bay last Thursday. This total opened at 48.5 with the Panthers missing a lot of pieces on defense but is down to 46.5 O/U on gameday.

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Bengals vs. Giants odds

Opening line

• Giants +3.5
• Over/Under 47.5
• View full Bengals vs. Giants odds and matchup
• Read our Bengals vs. Giants picks and predictions

The Giants are 3.5-point home underdogs coming off an upset victory in Seattle in Week 5 but will once again be without WR Malik Nabers (concussion). The Bengals are in desperation mode after an OT loss to Baltimore dropped them to 1-4 SU. This total hit the board at 47.5 and instantly drew Over money to 49.5 O/U but took buyback on the Under and is now at 45 points.

Also see: full Sunday Night Football odds

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Bills vs. Jets odds

Opening line

• Jets +2
• Over/Under 42
• View full Bills vs. Jets odds and matchup
• Read our Bills vs. Jets picks and predictions

The Jets fly back after a Week 5 loss in London, having fired head coach Robert Saleh shortly after landing, and opened between +2 and +2.5 for this Monday Night Football matchup with Buffalo. That spread has tightened considerably, with Bills -1 the consensus 12 hours before kickoff.

Both QBs suffered ankle injuries this past weekend, but Josh Allen and Aaron Rodgers played through those ailments. This total opened at 42 points and is at 41 O/U on Monday morning.

Also see: full Monday Night Football odds

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More weekly NFL odds content

• Week 1 odds
• Week 2 odds
• Week 3 odds
• Week 4 odds
• Week 5 odds
• Week 7 odds
• Week 8 odds
• Week 9 odds
• Week 10 odds
• Week 11 odds
• Week 12 odds
• Week 13 odds
• Week 14 odds
• Week 15 odds
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• Week 17 odds
• Week 18 odds

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