NFL Week 6 Odds: Bills and Chiefs Light Fireworks

We're just four months away from the 2022 NFL season, with the full season's schedule released on Thursday night. Week 6 will have no shortage of drama as the headliner will be Josh Allen and the Bills taking on Mahomes and the Chiefs.

Last Updated: May 13, 2022 11:18 AM ET Read Time: 5 min
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Although Week 6 signifies the first bye week for some teams, that doesn't mean we aren't left with plenty of NFL action to bet on.

The Week 6 NFL odds bring us a rematch of the AFC Divisional game last year between the Buffalo Bills and the Kansas City Chiefs. Although they may not reach that level of insanity, this week also provides matchups between the Cowboys and Eagles as well as the Broncos and Chargers.

Here is the list of all the NFL Week 6 matchups, times, and spreads.

These are the NFL odds for Week 6, headlined by the AFC Divisional rematch between the Bills and Chiefs.

Matchup Time Spread Over/Under
Commanders at Bears Thurs, 8:15 p.m. ET PK OTB
49ers at Falcons Sun, 1 p.m. ET Falcons +5.5 OTB
Patriots at Browns Sun, 1 p.m. ET OTB OTB
Jets at Packers Sun, 1 p.m. ET Packers -7.5 OTB
Jaguars at Colts Sun, 1 p.m. ET Colts -7 OTB
Vikings at Dolphins Sun, 1 p.m. ET Dolphins -3 OTB
Bengals at Saints Sun, 1 p.m. ET Saints +1 OTB
Ravens at Giants Sun, 1 p.m. ET Giants +3.5 OTB
Buccaneers at Steelers Sun, 1 p.m. ET Steelers +3.5 OTB
Panthers at Rams Sun, 4:05 p.m. ET Rams -9 OTB
Cardinals at Seahawks Sun, 4:05 p.m. ET Seahawks +2.5 OTB
Bills at Chiefs Sun, 4:25 p.m. ET Chiefs +1.5 OTB
Cowboys at Eagles Sun, 8:20 p.m. ET PK OTB
Broncos at Chargers Mon, 8:15 p.m. ET Cardinals -3 OTB

Teams on bye this week: Lions, Texans, Raiders, Titans.
Odds courtesy of 
DraftKings as of May 13, 2022

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