NFL Week 6 Odds: MNF Bettors Backing the Bills

The Bills are getting upwards of 90 percent of both tickets and money at some books for their Week 6 MNF matchup against the Tennessee Titans get the latest NFL odds and line movements for that Monday Night Football matchup, leading right up to kickoff.

Last Updated: Oct 14, 2021 12:25 PM ET Read Time: 5 min

A busy Week 6 Sunday in the NFL kicks off across the pond in London, England with the Dolphins vs. Jaguars and continues through the afternoon and evening, where the Steelers and Seahawks share the Sunday night spotlight.

The Week 6 NFL odds have been on the move since hitting the board a week ago, and we look at the biggest line adjustments, sharp action, and most popular public picks as we get closer to kickoff.

Here is the list of all the NFL Week 6 matchups, times and spreads.

These are the NFL odds for Week 6, headlined by Cleveland giving 3.5 points to the 5-0 Cardinals and the Bills and Titans getting it on in a Monday night matchup in the Music City.

Matchup Time Spread Over/Under
Buccaneers at Eagles Thurs, 8:20 p.m. ET Eagles +7 53
Dolphins at Jaguars* Sun, 9:30 a.m. ET Jaguars +3 46.5
Chiefs at Washington Sun, 1 p.m. ET Washington +7 54.5
Rams at Giants Sun, 1 p.m. ET Giants +8 49.5
Texans at Colts Sun, 1 p.m. ET Colts -10 43.5
Bengals at Lions Sun, 1 p.m. ET Lions +3.5 46.5
Packers at Bears Sun, 1 p.m. ET Bears +6 44
Chargers at Ravens Sun, 1 p.m. ET Ravens -3 51.5
Vikings at Panthers Sun, 1 p.m. ET Panthers +2.5 45.5
Cardinals at Browns Sun, 4:05 p.m. ET Browns -3.5 48.5
Raiders at Broncos Sun, 4:25 p.m. ET Broncos -4.5 43.5
Cowboys at Patriots Sun, 4:25 p.m. ET Patriots +3.5 50.5
Seahawks at Steelers Sun, 8:20 p.m. ET Steelers -4.5 42.5
Bills at Titans Mon, 8:15 p.m. ET Titans +5.5 53.5

Teams on bye this week: Falcons, Saints, Jets, 49ers.
*This game will be played at a neutral location in London, England.
Odds courtesy of FanDuel Sportsbook as of October 17, 2021

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Opening line

Eagles +6.5, O/U 53.5

Why the line moved

UPDATE 7:00 P.M. ET THURSDAY, OCT. 14: The Bucs remain 7-point road favorites at most books for this Thursday Night Football clash, but they can be found at -6.5 at some places. The total has moved around a bit and rose during Thursday afternoon to 53.0 with an hour to go until kickoff and the Covers Consensus showing 63 percent of picks backing the Over.

Opening line

Jaguars +3, O/U 44.5

Why the line moved

UPDATE 7:30 A.M. ET SUNDAY, OCT. 17: This spread has slimmed from Jaguars +3.5 to +3 and now books have the vig on Jacksonville +3 as high as -120, which could indicate a move below a field goal for the London game. Covers Consensus is showing 54 percent of picks on the Jags in this neutral-site matchup and sportsbooks are reporting similar splits at the window. Tua Tagovailoa is expected back for Miami but WR DeVante Parker and top CB Xavien Howard are not in action in Week 6.

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Opening line

Washington +6.5, 54.5 O/U

Why the line moved

UPDATE 7:30 A.M. ET SUNDAY, OCT. 17: Steady money on the Chiefs has bumped this spread from Washington +6.5 to +7, with Covers Consensus showing 73 percent of picks on Kansas City. Sportsbooks like WynnBet are reporting more than 90 percent of ticket count and handle on the visiting Chiefs. Washington has some notable injuries on offense with WR Curtis Samuel and Cam Sims out and WR Terry McLaurin and RB Antonio Gibson listed as questionable. 

Opening line

Giants +10.5, O/U 47.5

Why the line moved

UPDATE 7:40 A.M. ET SUNDAY, OCT. 17: With Giants QB Daniel Jones expected to play in Week 6, this line dipped to New York +8 and the total climbed to 49.5 points. However, the G-Men will be without RB Saquon Barkley and WR Kenny Golladay. DraftKings sportsbooks was seeing heavy action on the visiting Rams, with close to 90 percent of handle on L.A. and more than 90 percent of ticket count on the Rams. 

Opening line

Colts -10, O/U 42.5

Why the line moved

UPDATE 7:40 A.M. ET SUNDAY, OCT. 17:  Some books are dealing Indianapolis -10 as high as -115 vig, which could indicate a move to -10.5 if more money continues to show on the Colts, while some online shops have already made the move with the half-point hook. Covers Consensus is showing just 41 percent of picks on Indianapolis while sportsbooks are reporting a similar lean to Houston, with WynnBet seeing 67 percent of bets and 57 percent of bets on the Texans.

Opening line

Lions +3.5, O/U 48.5

Why the line moved

UPDATE 7:45 A.M. ET SUNDAY, OCT. 17: Some shops are showing Lions +3.5 at a flat -110 and others are higher on Detroit with the juice as high as -120. Covers Consensus is showing 56 percent of picks on the visiting Bengals while bookmakers like DraftKings sportsbooks are reporting more than 70 percent of bets and money on Cincinnati. The Lions do have some key injuries to RBs D'Andre Swift and Jamaal Williams, as well as TE T.J. Hockenson, but all three are expected to suit up in Week 6.

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Opening line

Bears +4.5, O/U 46.5

Why the line moved

UPDATE 7:50 A.M. ET SUNDAY, OCT. 17: The Bears climbed to +6 at home hosting the Packers and books have either priced that spread with -115 vig or already moved down to +5.5 with some late play on Chicago at the key number. The Packers are drawing 63 percent of picks with Covers Consensus and books are reporting heavier leans on the Cheeseheads, with WynnBet showing 86 percent of bets on Green Bay and 77.5 percent of the handle on the visitor.

Opening line

Ravens -3.5, O/U 50.5

Why the line moved

UPDATE 7:55 A.M. ET SUNDAY, OCT. 17: This spread dropped to Baltimore -2.5 at many books before the weekend and while that spread is still on the board at Ravens -2.5 (-120), other books have received buyback on Baltimore after the move and are dealing a field goal on this interesting AFC clash.

The total has moved down from 52.5 to as low as 50.5 on Sunday morning. The forecast for Baltimore is showing wind gusts of 20 mph or more for this 1 p.m. ET kickoff. 

Opening line

Panthers -1, O/U 47.5

Why the line moved

UPDATE 8:00 A.M. ET SUNDAY, OCT. 17: The Vikings continue to climb, now flirting with -3 after opening as 1.5-point underdogs on the road in Carolina. Minnesota is on the board at -2.5 (-115), indicating a possible move to -3 if money keeps coming in on the visitor. Covers Consensus is showing only 41 percent of picks on the Vikes and bookmakers have some strange splits on this matchup as well, with almost 55 percent of money on Carolina yet the bet count sitting dead even. 

Opening line

Browns -3, O/U 53.5

Why the line moved

UPDATE 8:15 A.M. ET SUNDAY, OCT. 17: With news that Arizona head coach Kliff Kingsbury would miss Week 6 due to COVID-19, the line jumped from Cleveland -3 to -3.5. As of Sunday morning, Arizona +3.5 is priced as high as -120 which could indicate a move back down to a field goal. The Browns will be without RB Nick Chubb and Kareem Hunt is playing through wrist and knee injuries.

Covers Consensus shows 56 percent of picks on the visiting Cardinals while sportsbooks are reporting a near even count on tickets but more money – 62 percent – on the Browns.

The total for this game was one of the bigger adjustments of the week, plummeting from 54 points to as low as 48.5 as of Sunday morning. The weather in Cleveland is calling for wind gusts of 20 mph or higher for this late-afternoon kickoff. 

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Opening line

Broncos -3, O/U 44.5

Why the line moved

UPDATE 8:25 A.M. ET SUNDAY, OCT. 17:  This spread has climbed from Denver -3.5 to as high as -4.5 with more than 60 percent of bets and money fading the drama within the Raiders organization. Covers Consensus is showing 56 percent of picks on the Broncos. 

Opening line

Patriots +3, O/U 47.5

Why the line moved

UPDATE 8:30 A.M. ET SUNDAY, OCT. 17: Most books are dealing Dallas -3.5 (-105) but some online books still have Cowboys -3 (-125) on the board as of Sunday morning. This spread was as high as -4.5 before buyback on the Patriots trimmed it to a field goal before the weekend. Covers Consensus is showing 71 percent of picks on Dallas while sportsbooks are reporting heavier action on the Cowboys, with WynnBet taking more than 90 percent of tickets and money on the visitor.  

Opening line

Steelers -3.5, O/U 43.5

Why the line moved

UPDATE 8:35 A.M. ET SUNDAY, OCT. 17: The Sunday nighter has seen Pittsburgh inch up from -3.5 to as high as -5 with the vig at -115 and with the spread on that dead number book will move quickly to -6 if money shows up on the Steelers on Sunday. With teasers and parlays rolling into the Sunday finale, this game will hold a lot of liability for bookmakers. WynnBet is reporting 82 percent of bets and more than 75 percent of the handle on the host Steelers while Covers Consensus shows 59 percent of picks on Pittsburgh.

Opening line

Titans +3.5, O/U 53

Why the line moved

UPDATE 8:35 A.M. ET SUNDAY, OCT. 17: Bills bettors may want to shop around and grab Buffalo under the key number of -6, with plenty of shops still hanging Bills -5.5. Titans fans, on the other hand, should either wait for the move to +6 or shop for a book dealing that bigger spread on the home side for the Monday nighter. Covers Consensus shows 62 percent of picks on the visiting Bills while DraftKings sportsbook is reporting 90 percent-plus in terms of tickets and total handle on Buffalo.    

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