NFL Week 6 Odds and Betting Lines: Niners Favored On Road Against Seahawks

And just like that — POOF! — we're a third of a way through the season with NFL Week 6 odds on the board.

The Week 6 odds get started tonight with a NFC West war between Seattle and San Francisco on Thursday Night Football. Chicago and Jacksonville jump the pond for a London game, setting up a busy Sunday featuring the Beltway Bowl between Washington and Baltimore, and an NFC showcase between Dallas and Detroit. 

Primetime slots belong to the N.Y. Giants and Cincinnati on Sunday night and a Monday matchup between Buffalo and the N.Y. Jets.

Here's a look at the opening NFL Week 6 odds and the early line moves.

NFL Week 6 odds, lines, and spreads

These are the NFL odds for Week 6, headlined by the Bears facing the Jaguars in London.

Matchup	Time (E.T.)	Odds
49ers vs Seahawks	Thursday 8:15 p.m. Prime	Seahawks +3.5 O/U 48.5
Jaguars vs Bears	Sunday 1:00 p.m. NFL Network	Bears -2.5 O/U 44.5
Cardinals vs Packers	Sunday 1:00 p.m. FOX	Packers -5.5 O/U 47.5
Colts vs Titans	Sunday 1:00 p.m. CBS	Titans +2.5 O/U 43
Texans vs Patriots	Sunday 1:00 p.m. CBS	Patriots +7 O/U 38
Buccaneers vs Saints	Sunday 1:00 p.m. FOX	Saints -3.5 O/U 41.5
Browns vs Eagles	Sunday 1:00 p.m. FOX	Eagles -9.5 O/U 42.5
Commanders vs Ravens	Sunday 1:00 p.m. CBS	Ravens -6.5 O/U 51
Chargers vs Broncos	Sunday 4:05 p.m. CBS	Broncos +3 O/U 35.5
Steelers vs Raiders	Sunday 4:05 p.m. CBS	Raiders +3 O/U 36.5
Lions vs Cowboys	Sunday 4:25 p.m. FOX	Cowboys +3.5 O/U 52.5
Falcons vs Panthers	Sunday 4:25 p.m. FOX	Panthers +6 O/U 37
Bengals vs Giants	Sunday 8:20 p.m. NBC	Giants +3.5 O/U 49.5
Bills vs Jets	Monday 8:15 p.m. ESPN	Jets +2.5 O/U 41

Odds as of 10-10.

49ers vs. Seahawks odds

Opening line

• Seahawks +3
• Over/Under 47.5
• View full 49ers vs. Seahawks odds and matchup
• Read our 49ers vs. Seahawks picks and predictions (coming soon)

Both the Seahawks and 49ers were stunned in Week 5. Books opened San Francisco as a 3-point road favorite with some placed higher at -3.5. The total opened 47.5 O/U. Both defenses are hoping to have key contributors back for this mid-week matchup.

Also see: full Thursday Night Football odds

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Jaguars vs. Bears odds

Opening line

• Bears -1.5
• Over/Under 43
• View full Jaguars vs. Bears odds and matchup
• Read our Jaguars vs. Bears picks and predictions (coming soon)

Chicago opened as a 1.5-point neutral-site favorite and that spread jumped as high as -2.5 on Sunday night. The Bears are coming off a one-sided win over Carolina while the Jaguars finally cracked the win column with a close one versus Indianapolis. This total opened at 43 points. 

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Cardinals vs. Packers odds

Opening line

• Packers -5.5
• Over/Under 50.5
• View full Cardinals vs. Packers odds and matchup
• Read our Cardinals vs. Packers picks and predictions (coming soon)

Most books opened Green Bay -5.5 but some shops are now as low as -4.5 after Arizona’s upset over San Francisco. This total hit the board at 49 points and jumped up to 50.5 on Sunday night.

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Colts vs. Titans odds

Opening line

• Titans +1
• Over/Under 42
• View full Colts vs. Titans odds and matchup
• Read our Colts vs. Titans picks and predictions (coming soon)

The health of QB Anthony Richardson and RB Jonathan Taylor will be front and center for this AFC South showdown. Tennessee is coming off a bye after a win in Week 4. Bookies opened the Titans as 1-point home underdogs while the total hit the board at 42 points.

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Texans vs. Patriots odds

Opening line

• Patriots +7
• Over/Under 38.5
• View full Texans vs. Patriots odds and matchup
• Read our Texans vs. Patriots picks and predictions (coming soon)

Houston was able to edge Buffalo at home in Week 5 but is hurting on offense, with WR Nico Collins going down with a hamstring. The Texans opened as touchdown favorites in Foxborough but dropped to -6.5 in the first few hours of action. This total opened at 38.5 O/U.

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Buccaneers vs. Saints odds

Opening line

• Saints +1.5
• Over/Under 42.5
• View full Buccaneers vs. Saints odds and matchup
• Read our Buccaneers vs. Saints picks and predictions (coming soon)

The Saints are coming off a loss on a short week and now have a heat NFC South showdown with the Bucs in Week 6. Tampa Bay opened as a 1.5-point road favorite in NOLA with the total at 42.5 O/U. New Orleans QB Derek Carr left Monday’s loss to Kansas City with an oblique injury and has a quick turnaround, testing his health in Week 6.

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Browns vs. Eagles odds

Opening line

• Eagles -8.5
• Over/Under 45
• View full Browns vs. Eagles odds and matchup
• Read our Browns vs. Eagles picks and predictions (coming soon)

Philadelphia opened between -8.5 and -9.5 for this Week 6 non-conference clash with Cleveland. The Browns look horrible on both sides of the ball and watched several defensive starters leave Week 5 with injuries, including corner Denzel Ward.

Cleveland is also sticking with struggling starting QB Deshaun Watson for Week 6. This total opened at 45 and is down to 44 points. Philadelphia is coming off a bye week and hopes to have injured WRs A.J. Brown and DeVonta Smith back in action. 

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Commanders vs. Ravens odds

Opening line

• Ravens -6.5
• Over/Under 51
• View full Commanders vs. Ravens odds and matchup
• Read our Commanders vs. Ravens picks and predictions (coming soon)

The Ravens opened as high as -7 with most books dealing Baltimore -6.5 in this Battle of the Beltway. The total opened at 51 points and is one of the highest of the 2024 season. 

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Chargers vs. Broncos odds

Opening line

• Broncos +2.5
• Over/Under 37
• View full Chargers vs. Broncos odds and matchup
• Read our Chargers vs. Broncos picks and predictions (coming soon)

Los Angeles is coming off a bye and opened as a 2.5-point road favorite in Denver. The total is on the shorter end, opening at 37 points and some books down to 36.5 O/U.

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Steelers vs. Raiders odds

Opening line

• Raiders +3
• Over/Under 36.5
• View full Steelers vs. Raiders odds and matchup
• Read our Steelers vs. Raiders picks and predictions (coming soon)

The Steelers couldn't squeeze out a win on Sunday night and open as 3-point road favorites in Sin City, with the Raiders in distress. Las Vegas could be making a switch at quarterback, which has this total on the low end at 36.5 points.

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Lions vs. Cowboys odds

Opening line

• Cowboys +3
• Over/Under 51.5
• View full Lions vs. Cowboys odds and matchup
• Read our Lions vs. Cowboys picks and predictions (coming soon)

Dallas won a long ugly game in Pittsburgh on Sunday night and now face the Lions, who are fresh off the bye week. Bookies opend Detroit as a field goal fave with the total among the tallest on the Week 6 board at 51.5 O/U.

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Falcons vs. Panthers odds

Opening line

• Panthers +5.5
• Over/Under 48.5
• View full Falcons vs. Panthers odds and matchup
• Read our Falcons vs. Panthers picks and predictions (coming soon)

The Falcons have the rest and momentum edge over their NFC South foes in Week 6, with Atlanta opening as a 5.5-point favorite after a big win over Tampa Bay last Thursday. This total opened at 48.5 with the Panthers missing a lot of pieces on defense.

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Bengals vs. Giants odds

Opening line

• Giants +3.5
• Over/Under 47.5
• View full Bengals vs. Giants odds and matchup
• Read our Bengals vs. Giants picks and predictions (coming soon)

The Giants are 3.5-point home underdogs coming off an upset victory in Seattle in Week 5. The Bengals are in desperation mode after an OT loss to Baltimore dropped them to 1-4 SU. This total hit the board at 47.5 and instantly drew Over money to 49.5 O/U.

Also see: full Sunday Night Football odds

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Bills vs. Jets odds

Opening line

• Jets +2
• Over/Under 42
• View full Bills vs. Jets odds and matchup
• Read our Bills vs. Jets picks and predictions (coming soon)

The Jets fly back after a Week 5 loss in London and opened between +2 and +2.5 for this Monday Night Football matchup with Buffalo. Both QBs suffered ankle injuries this past weekend, but Josh Allen and Aaron Rodgers played through those ailments. This total opened at 42 points.

Also see: full Monday Night Football odds

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More weekly NFL odds content

• Week 1 odds
• Week 2 odds
• Week 3 odds
• Week 4 odds
• Week 5 odds
• Week 7 odds
• Week 8 odds
• Week 9 odds
• Week 10 odds
• Week 11 odds
• Week 12 odds
• Week 13 odds
• Week 14 odds
• Week 15 odds
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• Week 17 odds
• Week 18 odds

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