The NFL schedule is finally released! We now know what each team's matchups will be in this new 18-week season, including the game list for Week 16.
The NFL Week 16 matchups begin with a Thursday Night clash between the San Francisco 49ers and Tennessee Titans, features a Christmas Day tilt between the Cleveland Browns and Green Bay Packers, sees the Buffalo Bills travel to Foxborough to play the New England Patriots, and is capped off by a Monday Night Football matchup between the Miami Dolphins and New Orleans Saints.
Here is the list of all the NFL Week 16 matchups, times and opening spreads.
NFL Week 16 Odds
These are the opening NFL odds for Week 16, headlined by the Bills opening as 3.5-point road favorites over New England and Green Bay as a pick'em at home against Cleveland.
| Matchup | Time | Spread | Over/Under |
|---|---|---|---|
| 49ers at Titans | Thurs, 8:20 p.m. ET | Titans +2 | 46.5 |
| Browns at Packers | Sat, 4:30 p.m. ET | PK | 45 |
| Colts at Cardinals | Sat, 8:15 p.m. ET | Cardinals -1 | 50 |
| Giants at Eagles | Sun, 1 p.m. ET | Eagles -1.5 | 46 |
| Rams at Vikings | Sun, 1 p.m. ET | Vikings +2.5 | 48 |
| Bills at Patriots | Sun, 1 p.m. ET | Patriots +3.5 | 47.5 |
| Buccaneers at Patriots | Sun, 1 p.m. ET | Panthers +6.5 | 51 |
| Jaguars at Jets | Sun, 1 p.m. ET | Jets -1.5 | 44.5 |
| Lions at Falcons | Sun, 1 p.m. ET | Falcons -7.5 | 49 |
| Chargers at Texans | Sun, 1 p.m. ET | Texans +4.5 | 47 |
| Ravens at Bengals | Sun, 1 p.m. ET | Bengals +6.5 | 47.5 |
| Bears at Seahawks | Sun, 4:05 p.m. ET | Seahawks -5.5 | 45 |
| Steelers at Chiefs | Sun, 4:25 p.m. ET | Chiefs -8.5 | 50 |
| Broncos at Raiders | Sun, 4:25 p.m. ET | Raiders -2.5 | 47 |
| Washington at Cowboys | Sun, 8:20 p.m. ET | Cowboys -5.5 | 48 |
| Dolphins at Saints | Mon, 8:15 p.m. ET | Saints -3.5 | 46.5 |
Odds courtesy of The SuperBook as of May 16, 2021
More weekly NFL odds content
- Week 1 odds
- Week 2 odds
- Week 3 odds
- Week 4 odds
- Week 5 odds
- Week 6 odds
- Week 7 odds
- Week 8 odds
- Week 9 odds
- Week 10 odds
- Week 11 odds
- Week 12 odds
- Week 13 odds
- Week 14 odds
- Week 15 odds
- Week 17 odds
- Week 18 odds
Where can I bet on the NFL?
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