NFL Week 16 Odds and Betting Lines: Chargers Favored by More Than a FG on MNF

NFL Sunday on Christmas Day has come and gone, with the lone Week 16 contest remaining being a Monday Night Football clash between the Los Angeles Chargers and Indianapolis Colts. L.A. is the favorite, but most money is on Indy.

Last Updated: Dec 26, 2022 1:04 PM ET Read Time: 8 min
Austin Ekeler Los Angeles Chargers NFL
Photo By - USA TODAY Sports

Christmas Eve was set up as a football fan's heaven, with not eight games, not nine, not 10, but 11. The Seahawks and Chiefs promised plenty of scoring, while the Eagles and Cowboys was anything but boring. 

There was a trio of NFL games on Christmas Day, starting with Miami at home to Green Bay. And Week 16 betting finishes up just right, with the Bolts and the Colts on Monday night.

If it's NFL Week 16 odds that you seek, we lay it all out for you now — take a peek! 

These are the live NFL odds for Week 16, highlighting the best odds available from regulated sportsbooks within your area.

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Falcons at Ravens odds

Opening line

Ravens -7, 40.5 O/U

Why the line moved

9:53 A.M. ET, FRIDAY, DEC. 23: Ravens' quarterback Lamar Jackson has officially been ruled out and Tyler Huntley, despite being listed as Questionable, is on track to start Saturday's game at home against the Falcons. With no chance of a surprise Lamar start, sportsbooks have shortened the pointspread from Baltimore -7/-7.5 to -6.5. The total is down from 35.5/36 to 34.5.

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Lions at Panthers odds

Opening line

Panthers +3, 44 O/U

Why the line moved

10:00 A.M. ET, FRIDAY, DEC. 23: As of Friday morning, the pointspread for this Sunday afternoon game is holding at Lions -2.5. Sportsbooks are taking a lot of action on the Lions, so there is a chance this number gets to -3 by kickoff. BetMGM is reporting 85% of the bets and 79% of the money wagered on the road favorite Lions. The total is holding at 43.5/44.

Bills at Bears odds

Opening line

Bears +9, 42 O/U

Why the line moved

10:49 A.M. ET, SATURDAY, DEC. 24: It's gameday morning and the pointspread for this chilly contest at Soldier Field has slimmed from Friday's number of Bills -8.5 to -8. Books have taken some big bets on the Bears, with shops like DraftKings reporting 56% of the bets and 81% of the money wagered on the home underdogs. The total is at 40/40.5.

Saints at Browns odds

Opening line

Browns -3, 35.5 O/U

Why the line moved

10:17 A.M. ET, FRIDAY, DEC. 23: As of Friday morning, most sportsbooks are dealing Browns -3 for this messy Saturday afternoon contest. The total is at 32/32.5, which will be the lowest Over/Under of the season in the NFL. The weather forecast for Cleveland is calling for 1-2 inches of snow with wind gusts reaching 50-60 MPH, so blowing snow will be an issue. Keep your eyes on all potential weather issues on our NFL Weather page.

Seahawks at Chiefs odds

Opening line

Chiefs -9.5, 48 O/U

Why the line moved

10:58 A.M. ET, SATURDAY, DEC. 24: As kickoff approaches the pointspread for this Saturday afternoon game is at Chiefs -10, but there are a few books flirting with -10.5 (juiced to the underdogs). DraftKings is reporting some big bets on Kansas City, with 66% of their pointspread bets on the Seahawks but an even 50/50 split on money wagered. The total is up slightly from 49/49.5 to 50.5.

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Giants at Vikings odds

Opening line

Vikings -3.5, 47.5 O/U

Why the line moved

11:06 A.M. ET, SATURDAY, DEC. 24: The status of the pointspread for this game hasn't changed much over the last couple of days, despite seemingly steady action on the favored Vikings. Minnesota is still 4-point favorites at most sportsbooks, with a couple of outliers touching -4.5 (juiced to the underdogs). DraftKings is still reporting dominant betting action on the home side with 58% of the bets and 71% of the money wagered on the Vikings. The total is at 48.5.

Bengals at Patriots odds

Opening line

Patriots +3, 40 O/U

Why the line moved

10:33 A.M. ET, FRIDAY, DEC. 23: As of Friday morning, most sportsbooks have slimmed the pointspread for this Saturday afternoon game from Bengals -3.5 to -3. BetMGM is reporting 70% of the bets and 57% of the money wagered on the Bengals, so we're definitely seeing some reverse line movement for this game. The total is at 41.5.

Texans at Titans odds

Opening line

Titans -7, 40 O/U

Why the line moved

10:39 A.M. ET, FRIDAY, DEC. 23: Titans' quarterback Ryan Tannehill has officially been ruled out for Week 16 and will be replaced by QB2 Malik Willis. The Titans will also be without starting center Ben Jones which can sometimes create some issue on the offensive side of the ball. The pointspread for this game is either a heavily juiced Titans -3 or a more even -3.5. BetMGM is reporting 64% of the bets and 68% of the money wagered on Tennessee. The total is holding at 35.5.

Commanders at 49ers odds

Opening line

49ers -6.5, 41 O/U

Why the line moved

11:16 A.M. ET, SATURDAY, DEC. 24: It's gameday morning and the industry consensus on the pointspread is 49ers -6.5. There are a couple of outliers hanging on at -7, but they are heavily juiced on the Commanders side so their move to -6.5 could be coming. The total is at 37.5 as of Saturday morning.

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Eagles at Cowboys odds

Opening line

Cowboys -1, 50 O/U

Why the line moved

11:23 A.M. ET, SATURDAY, DEC. 24: There has been no change to the pointspread since the initial move from Cowboys -6 to -4.5 in the wake of the official Jalen Hurts news. DraftKings is reporting 75% of the bets and 68% of the money wagered on the Eagles, and there are similar reports from other keys books across the industry on Saturday morning. The total is up from 46.5 to 47.5/48 depending on the book.

Raiders at Steelers odds

Opening line

Steelers -2, 40.5 O/U

Why the line moved

11:30 A.M. ET, SATURDAY, DEC. 24: The pointspread for tonight's Christmas Eve primetime game has slimmed from Steelers -2/-2.5 to -1.5/-2. DraftKings is reporting "Pros-vs-Joes" betting action with 62% of the bets on the Raiders, but 54% of the money wagered on the home favorite Steelers. The total is up a tick from 38 to 38.5. Cool and breezy contitions are still in the forecast for Pittsburgh on Saturday evening. Keep your eyes on all potential weather issues on our NFL Weather page.

Packers at Dolphins odds

Opening line

Miami -5.5, 46.5 O/U

Why the line moved

11:45 A.M. ET, SATURDAY, DEC. 24: The pointspread for this Christmas Day game is at Dolphins -3.5 across the board as of Saturday morning. BetMGM is reporting 60% of the bets and 64% of the money wagered on the road underdog Packers. The total is at 49.5/50.

Broncos at Rams odds

Opening line

Rams +1, 35.5 O/U

Why the line moved

11:53 A.M. ET, SATURDAY, DEC. 24: The pointspread for this Christmas Day afternoon game has lengthened from Broncos -2.5 up to the key number of -3 as of Saturday morning. The Rams are a mess and BetMGM is reporting 78% of the bets and 88% of the money wagered on the road favorite Broncos. The total is holding at 36.5.

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Buccaneers at Cardinals odds

Opening line

Cardinals +3, 41.5 O/U

Why the line moved

11:58 A.M. ET, SATURDAY, DEC. 24: The pointspread for this Christmas Day primetime game between Tom Brady and the Buccaneers and Trace McSorley and the Cardinals is at Bucs -7.5 as of Saturday morning. BetMGM is reporting 69% of the bets and 79% of the money wagered on the road favorites. The total is holding at 40.5.

Chargers at Colts odds

Opening line

Colts +3, 48.5 O/U

Why the line moved

12:04 P.M. ET, SATURDAY, DEC. 24: Chargers -4 is the consensus number across the industry as of Saturday morning. BetMGM is reporting "Pros-vs-Joes" betting action with 66% of the bets on the Chargers and 54% of the money wagered on Nick Foles and the Colts. The total is at 45.5.

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