Week 16 wraps up with a Monday Night Football matchup between two teams fighting for playoff position in the San Francisco 49ers and the Indianapolis Colts.
Our 49ers vs. Colts same-game parlay picks believe both Brock Purdy and Philip Rivers will be slinging it with success on December 22.
Our best 49ers vs Colts SGP for Week 16
Philip Rivers gets another week to settle into this offense, and he’s no longer dealing with the chaos of Lumen Field as the venue shifts indoors to his old stomping grounds of Lucas Oil Stadium.
On the other side, the San Francisco 49ers are finally healthy on offense and could be one of the strongest units down the stretch.
THE BLITZ projects this total at 52.1 points, well above the listed cutoff. There’s nothing about the Indianapolis Colts’ pace of play with Rivers under center that suggests they’re slowing games down compared to their season averages so far.
San Francisco’s defense just allowed 24 points and 6.2 yards per play at home to the dreadful Titans, and Brock Purdy looked sharp coming out of the bye. This team is also 6-3-1 to the Over at home or indoors, where offensive efficiency jumps.
The Colts will have more confidence passing the ball and might be forced to after an easy week vs. Seattle, where they played in a neutral game script from start to finish. Rivers threw a lot of balls at or behind the line of scrimmage, as RB targets accounted for nine throws.
Those might move downfield on Monday, and it was Ty Warren who led all Colts pass catchers in targets last week with six. More aggressive passing means more yards for the grandpa, and even Cam Ward moved the ball vs. this 49ers defense last week.
Odds are correct at the time of publishing and are subject to change.
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