NFL Week 1 Odds and Betting Lines: Wilson Returns to Seattle as Favorite

As the Sunday slate winds down on Week 1 of the NFL schedule, we set our sights on one of the premier matchups to open the season as the Denver Broncos are nearly a touchdown favorite over the Seattle Seahawks in the first edition of Monday Night Football.

Last Updated: Sep 12, 2022 7:20 PM ET Read Time: 4 min
Russell Wilson Denver Broncos NFL Week 1 odds
Photo By - USA TODAY Sports

The first Sunday of the NFL 2022 season was unsurprisingly packed with betting action. 

NFL odds for Week 1 were in the slow cooker since the schedule was released in the spring, taking action over the course of the summer and adjusting to any player movement, injuries, and team news. Now, NFL Week 1 is nearly in the books.

The Buffalo Bills and Los Angeles Rams gave us a potential Super Bowl preview on Thursday while Sunday's slate was headlined by the Tampa Bay Buccaneers taking on the Dallas Cowboys on Sunday Night Football.

Monday Night Football brings us the Week 1 finale as Russell Wilson debuts with the Denver Broncos as 6.5-point favorites vs. his former team, the Seattle Seahawks.

Here is the full slate of games for opening weekend and the latest NFL Week 1 odds. 

These are the NFL odds for Week 1, which have some really interesting angles: Russell Wilson's return to Seattle, Mayfield's revenge game vs. Cleveland, and the L.A. Chargers looking for payback against the rival Raiders.

Matchup Time Spread Over/Under
Bills at Rams Thurs, 8:20 p.m. ET Rams +2.5 52
Saints at Falcons Sun, 1 p.m. ET Falcons +5.5 43.5
Browns at Panthers Sun, 1 p.m. ET Panthers -1.5 42
49ers at Bears Sun, 1 p.m. ET Bears +6 38
Steelers at Bengals Sun, 1 p.m. ET Bengals -7 44
Eagles at Lions Sun, 1 p.m. ET Lions +6 48.5
Colts at Texans Sun, 1 p.m. ET Texans +7 45.5
Patriots at Dolphins Sun, 1 p.m. ET Dolphins -3 46
Ravens at Jets Sun, 1 p.m. ET Jets +6.5 44
Jaguars at Commanders Sun, 1 p.m. ET Commanders -3 43
Chiefs at Cardinals Sun, 4:25 p.m. ET Cardinals +6.5 54
Raiders at Chargers Sun, 4:25 p.m. ET Chargers -3.5 52.5
Packers at Vikings Sun, 4:25 p.m. ET Vikings -2.5 46
Giants at Titans Sun, 4:25 p.m. ET Titans -5 44
Buccaneers at Cowboys Sun, 8:20 p.m. ET Cowboys +2 50
Broncos at Seahawks Mon, 8:15 p.m. ET Seahawks +6.5 44.5

Odds courtesy of DraftKings Sportsbook as of September 11, 2022.

Best NFL sign-up bonuses

If you're signing up for a new sportsbook for the new NFL season, here are two of the best bonuses* available:

New users can bet $20 and get $200 in free bets with Caesars! Sign Up Now

New users can get two risk-free bets up to $2,000 at PointsBet! Sign Up Now

*Eligible USA locations only

Opening line

Rams +1, Over/Under 52

Why the line moved

4:10 P.M. ET, THURSDAY, SEPT. 8: With kickoff looming, the market consensus is Bills -2.5 with most shops dealing the total at 52 points. DraftKings sportsbooks are reporting 68% of bets on Buffalo, which also has attracted 74% of the handle. Our Covers Consensus numbers show 57% of picks on the visitor while 56% of total picks are siding with the Over.

Opening line

Falcons +3.5, Over/Under 42

Why the line moved

12:15 P.M. ET, SUNDAY, SEPT. 11: Money on New Orleans has this spread jumping to Saints -6 at some online books while others are dealing -5.5. Books reporting one-sided play on the road team, with spots like PointsBet taking 74% of bets and 70% of handle on NOLA.

BACK TO TOP

Opening line

Panthers +3.5, Over/Under 42.5

Why the line moved

8:00 A.M. ET, SUNDAY, SEPT. 11: The most interesting line of Week 1 continues to move, with Carolina now back as a 1-point home favorite to Cleveland. The Panthers had jumped the fence (again) to +1 earlier this week with sharp money buying back the Browns but operators are reporting heavy bet count and money on Carolina, which has this contest between -1 and PK as of Sunday morning. The total is sitting between 42 and 42.5 points.

Opening line

Bears +6.5, Over/Under 42.5

Why the line moved

12:15 P.M. ET, SUNDAY, SEPT. 11: Total for this game has sunk two points since Sunday morning with rains flooding Solider Field – which was just redone in Bermuda grass last weekend. Wind gusts expected to get up to 25 mph in the second half. That has this number down to as low as 37.5 points across the industry and operators like WynnBET reporting more than 97% of money on the Under.

Opening line

Bengals -6, Over/Under 45

Why the line moved

12:20 P.M. ET, SUNDAY, SEPT. 11: After a few spots showed a touchdown spread on Pittsburgh at Cincinnati this morning, the market has moved to a consensus Bengals -7 with gameday action on Cincy. Books like BetMGM were reporting relatively split action on this game over the course of the summer, with some sharper wagers riding on Pittsburgh.

Opening line

Lions +4, Over/Under 46.5

Why the line moved

12:15 P.M. ET, SUNDAY, SEPT. 11: With injuries on the Lions offensive line, money pushed Philadelphia from -3.5 to -5.5 over the weekend. Now books are dealing Eagles -6 and money continues to come in on the road team. WynnBET books heavy on Eagles ticket count (71%) and handle (80%) on Sunday.

BACK TO TOP

Opening line

Texans +7.5, Over/Under 44.5

Why the line moved

8:15 A.M. ET, SUNDAY, SEPT. 11: This spread has dance on and around a touchdown all week. As of Sunday morning, operators are mainly dealing Colts -7 with a few -7.5 hooks out there for those leaning toward the home underdog. Ticket count is high on Indianapolis – as much as 70% on the Colts at BetMGM – but there is slightly more money on the Texans with bigger bets grabbing the points with Houston.

Opening line

Dolphins -2.5, Over/Under 45

Why the line moved

12:15 P.M. ET, SUNDAY, SEPT. 11: Interest in the Patriots has slimmed the Dolphins from -3.5 to -3 at some shops an hour out from kickoff. The total has also seen a spike from 45.5 to 46.5 with pro groups jumping into the Over for the first half total on Sunday morning.

Opening line

Jets +4, Over/Under 45.5

Why the line moved

12:30 P.M. ET, SUNDAY, SEPT. 11: Baltimore will be missing bodies on the offensive line as well as RB JK Dobbins, who is ruled out. That has most shops dealing Ravens -6.5 with a solo -6 showing at Circa (Colorado). Money had been on Baltimore in the wake of the Zach Wilson injury from the preseason but it looks like gameday play is buying back Gang Green with the Ravens dealing with injuries in Week 1.

Opening line

Commanders -4, Over/Under 44.5

Why the line moved

8:15 A.M. ET, SUNDAY, SEPT. 11: The Jaguars were a popular underdog pick, moving from +4.5 to +3 before professional groups jumped on the Jags and bumped this spread through the key number of a field goal to +2.5 early last week. Over the weekend, Washington has seen buyback and this point spread is on the board at Commanders -3 at most places – with some still holding on to -2.5. Our Covers Consensus currently shows 61% of picks on Washington. The total sits between 43.5 and 44 points.

BACK TO TOP

Opening line

Cardinals +3, Over/Under 53

Why the line moved

8:30 A.M. ET, SUNDAY, SEPT. 11: The Chiefs are one of the biggest liabilities for sportsbooks in Week 1, moving from -3 to as high as -6.5 at some places. There are some Kansas City -6 lines out there with heavier juice for those still looking to get on KC Sunday morning. This total remains one of the heights in Week 1, currently sitting between 53.5 and 54 points. Heading into the weekend, books like BetMGM had 73% of bets and 75% of the handle riding on the Over. 

Opening line

Chargers -4, Over/Under 52

Why the line moved

8:30 A.M. ET, SUNDAY, SEPT. 11: While a few books dropped to Los Angeles -3 early last week, the industry consensus is now L.A. -3.5 as of Sunday morning. Books were reporting solid two-way play on this game and books based in Las Vegas will see regional bias to the Raiders while national spots are drawing more on the Chargers. This total is on the board between 52 and 52.5 points. Covers Consensus is showing 71% of picks on the Over.

Opening line

Vikings +1, Over/Under 49

Why the line moved

8:45 A.M. ET, SUNDAY, SEPT. 11: The Vikings have been home underdogs to the Packers in Week 1 since this line came out in the spring. That number slimmed to +1 over the week and dropped to -1 on the weekend at some books. Those still at +1 moved to PK and then as high as Minnesota -2 on Sunday morning with a flood of bets on the home side.

Opening line

Titans -7, Over/Under 44

Why the line moved

12:30 P.M. ET, SUNDAY, SEPT. 11: Spreads range from Titans -6 to -5 for Tennessee’s home opener versus the Giants. This game originally opened -6.5 back in the spring. According to DraftKings, 67% of handle is on the Titans but there is more Giants money showing up today. Tennessee has drawn 77% of the total ticket count.

BACK TO TOP

Opening line

Cowboys +3, Over/Under 51

Why the line moved

7:15 P.M. ET, SUNDAY, SEPT. 11: With the first Sunday Night Football of the season kicking off, the Buccaneers are 2.5-point road favorites across the industry. Sportsbooks are heavier on Tampa Bay action, with WynnBet reporting 62% of bets and 70% of the handle on the visitor. This game will be a huge decider for operators as any existing parlays and teasers are tied into the SNF result.

The total for this game is down as low as 49.5 after opening at 52 points back in May. With injuries to offensive lines and receivers for both teams, money started showing up on the Under in August. WynnBet is reporting 58% of bets on the Under but a whopping 91% of the money banking on a low-scoring finish in Dallas.

Opening line

Seahawks +4, Over/Under 41

Why the line moved

7:00 P.M. ET, MONDAY, SEPT. 12: After sitting at -6.5 throughout the day, the line has been bet down to as low as 5.5, and 6.0 at other major books. You'll have to give up a few cents to get the half point, but some may see it worth the price. According to Covers Consensus, 69% of picks are on the Broncos, and books were reporting heavy one-sided play on Denver (84% of bets, but just 53% of handle at PointsBet) as of this evening.

More weekly NFL odds content

Pages related to this topic

Popular Content

Legal Canadian sports betting

Best Canadian betting sites Ontario sports betting
Covers 25 Years Logo Established in 1995,
Covers is the world
leader in sports
betting information.
Covers is verified safe by: Evalon Logo GPWA Logo GDPR Logo GeoTrust Logo Evalon Logo