Before you know it, football will be back on our screens, so there’s no better time to dive into the latest NFL odds!
The Week 1 schedule kicks off with the defending champion Philadelphia Eagles hosting the Dallas Cowboys on Thursday Night Football.
Meanwhile, Sunday’s primetime spotlight features a rematch between the Baltimore Ravens and Buffalo Bills, with Lamar Jackson & Co. looking for revenge following last year's devastating playoff loss.
Here’s a look at the opening NFL Week 1 odds you need to know as the betting season gets underway.
2025 NFL Week 1 Odds
Cowboys vs Eagles opening odds
- Spread: Cowboys +7 | Eagles -7
- Moneyline: Cowboys +260 | Eagles -325
- Total: Over/Under 46.5
With Dallas failing to make any notable moves in free agency, Philadelphia has jumped to hefty -325 favorites ahead of this Week 1 opener.
Chiefs vs Chargers opening odds
- Spread: Chiefs -3 | Chargers +3
- Moneyline: Chiefs -148 | Chargers +124
- Total: Over/Under 45.5
The O/U has climbed a full point since opening. Keep a close watch on the expected field conditions in Sao Paulo, especially after last year’s turf turned into a slip-and-slide for the Packers and Eagles.
Steelers vs Jets opening odds
- Spread: Steelers -3 | Jets +3
- Moneyline: Steelers -155 | Jets +130
- Total: Over/Under 39.5
Pittsburgh has moved from -2.5 to -3 following the signing of Aaron Rodgers.
Meanwhile, the O/U has crashed down to 39.5 after being initially listed at 46.5.
Giants vs Commanders opening odds
- Spread: Giants +7 | Commanders -7
- Moneyline: Giants +235 | Commanders -290
- Total: Over/Under 45.5
The Giants have moved from +7.5 to a key number of +7, while the O/U of 45.5 hasn't budged.
Buccaneers vs Falcons opening odds
- Spread: Buccaneers -2.5 | Falcons +2.5
- Moneyline: Buccaneers -142 | Falcons +120
- Total: Over/Under 48.5
The total has ticked up to 48.5, which isn’t surprising considering both head-to-head matchups cleared 50 points last season.
Panthers vs Jaguars opening odds
- Spread: Panthers +3 | Jaguars -3
- Moneyline: Panthers +130 | Jaguars -155
- Total: Over/Under 45.5
Bettors are fading Liam Coen in his Jags head coaching debut, moving Jacksonville from +3.5 to +3.
Dolphins vs Colts opening odds
- Spread: Dolphins +1.5 | Colts -1.5
- Moneyline: Dolphins +100 | Colts -120
- Total: Over/Under 45.5
The Dolphins currently traded away Pro Bowl tight end Jonnu Smith and corner Jalen Ramsey, but the line remains unchanged.
Indianapolis hasn't won a home opener since 2014, so bettors remain hesitant to back the Shoe in Week 1.
Raiders vs Patriots opening odds
- Spread: Raiders +3 | Patriots -3
- Moneyline: Raiders +130 | Patriots -155
- Total: Over/Under 42.5
With both Pete Carroll and Mike Vrabel kicking off new eras in Vegas and New England, the market is putting more trust in Carroll, as the Raiders have moved from +3.5 to +3.
Bengals vs Browns opening odds
- Spread: Bengals -5.5 | Browns +5.5
- Moneyline: Bengals -230 | Browns +190
- Total: Over/Under 44.5
With the Browns expected to start Joe Flacco under center, the Battle of Ohio now has the Bengals listed as 5.5-point road favorites.
Cardinals vs Saints opening odds
- Spread: Cardinals -5.5 | Saints +5.5
- Moneyline: Cardinals -230 | Saints +190
- Total: Over/Under 42.5
The Cardinals have swung from -3.5 to -5.5 favorites following the retirement of Saints QB Derek Carr.
With Spencer Rattler and Tyler Shough competing for QB1 in New Orleans, betting confidence is shifting heavily toward Arizona.
49ers vs Seahawks opening odds
- Spread: 49ers -1.5 | Seahawks +1.5
- Moneyline: 49ers -122 | Seahawks +102
- Total: Over/Under 45.5
San Francisco holds steady as slight favorites in this NFC West rivalry, which hasn’t shifted since the opening line.
Titans vs Broncos opening odds
- Spread: Titans +7.5 | Broncos -7.5
- Moneyline: Titans +285 | Broncos -360
- Total: Over/Under 41.5
The total has dipped a few points, with Tennessee and Denver each flexing impressive defenses last season.
Lions vs Packers opening odds
- Spread: Lions +1.5 | Packers -1.5
- Moneyline: Lions +102 | Packers -122
- Total: Over/Under 48.5
Despite Detroit going 2-0 SU against Green Bay last season, the Lions remain short road dogs ahead of this matchup at Lambeau.
Texans vs Rams opening odds
- Spread: Texans +3 | Rams -3
- Moneyline: Texans +130 | Rams -155
- Total: Over/Under 45.5
Los Angeles has been bet down to a key number of -3, while the total has ticked up a point since open.
Ravens vs Bills opening odds
- Spread: Ravens +1.5 | Bills -1.5
- Moneyline: Ravens +100 | Bills -120
- Total: Over/Under 51.5
Sunday night's showcase hasn't budged, with Josh Allen and the Bills getting the benefit of the doubt until the Ravens prove they can win at Highmark Stadium.
Vikings vs Bears opening odds
- Spread: Vikings +1.5 | Bears -1.5
- Moneyline: Vikings -105 | Bears -1115
- Total: Over/Under 45.5
Questions about J.J. McCarthy’s readiness under center have pushed this total down by three points.
Minnesota’s defense was elite under Brian Flores last year, so Caleb Williams and Ben Johnson also have their work cut out for them on Monday night.
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