The Philadelphia Eagles and Buffalo Bills make up two of the Top 3 betting favorites on our Super Bowl odds board, and we'll get a chance to see them go head-to-head in the later stages of the regular season.
The matchup is going down in Philly and as such, the opening NFL odds are giving the Birds a slight edge as 1.5-point home favorites.
Check out the full slate in our Week 12 odds below.
NFL Week 12 odds, lines, and spreads
Here are the NFL odds for Week 12, headlined by an interconference affair between the Buffalo Bills and Philadelphia Eagles in the City of Brotherly Love.
| Matchup | Time | Spread | Over/Under |
|---|---|---|---|
| Packers at Lions | Thurs, 1:30 p.m. ET | Lions -4 | OTB |
| Commanders at Cowboys | Thurs, 5:30 p.m. ET | Cowboys -5.5 | OTB |
| 49ers at Seahawks | Thurs, 9:20 p.m. ET | Seahawks +1.5 | OTB |
| Dolphins at Jets | Fri, 4 p.m. ET | Jets -2.5 | OTB |
| Saints at Falcons | Sun, 1 p.m. ET | Falcons +1 | OTB |
| Steelers at Bengals | Sun, 1 p.m. ET | Bengals -4.5 | OTB |
| Jaguars at Texans | Sun, 1 p.m. ET | Texans +4.5 | OTB |
| Buccaneers at Colts | Sun, 1 p.m. ET | Colts -1 | OTB |
| Patriots at Giants | Sun, 1 p.m. ET | Giants -1.5 | OTB |
| Panthers at Titans | Sun, 1 p.m. ET | Titans -1 | OTB |
| Rams at Cardinals | Sun, 4:05 p.m. ET | Cardinals +2 | OTB |
| Browns at Broncos | Sun, 4:05 p.m. ET | Broncos -1 | OTB |
| Chiefs at Raiders | Sun, 4:25 p.m. ET | Raiders +5 | OTB |
| Bills at Eagles | Sun, 4:25 p.m. ET | Eagles -1.5 | OTB |
| Ravens at Chargers | Sun, 8:20 p.m. ET | Chargers -2 | OTB |
| Bears at Vikings | Mon, 8:15 p.m. ET | Vikings -3.5 | OTB |
Odds courtesy of DraftKings as of May 13, 2023.
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More weekly NFL odds content
- Week 1 odds
- Week 2 odds
- Week 3 odds
- Week 4 odds
- Week 5 odds
- Week 6 odds
- Week 7 odds
- Week 8 odds
- Week 9 odds
- Week 10 odds
- Week 11 odds
- Week 13 odds
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- Week 15 odds
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- Week 17 odds
- Week 18 odds
