NFL Week 12 Odds and Betting Lines: Birds Favored Against Bills in City of Brotherly Love

Two of the NFL's elite teams will go head-to-head when Josh Allen and the Bills head to the City of Brotherly Love to take on the Eagles as slim 1.5-point road underdogs. Check out the full Week 12 odds below.

Last Updated: May 13, 2023 5:13 PM ET Read Time: 8 min
Jalen Hurts Philadelphia Eagles NFL
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The Philadelphia Eagles and Buffalo Bills make up two of the Top 3 betting favorites on our Super Bowl odds board, and we'll get a chance to see them go head-to-head in the later stages of the regular season. 

The matchup is going down in Philly and as such, the opening NFL odds are giving the Birds a slight edge as 1.5-point home favorites.

Check out the full slate in our Week 12 odds below. 

NFL Week 12 odds, lines, and spreads

Here are the NFL odds for Week 12, headlined by an interconference affair between the Buffalo Bills and Philadelphia Eagles in the City of Brotherly Love.  

Matchup Time Spread Over/Under
Packers at Lions Thurs, 1:30 p.m. ET Lions -4 OTB
Commanders at Cowboys Thurs, 5:30 p.m. ET Cowboys -5.5 OTB
49ers at Seahawks Thurs, 9:20 p.m. ET Seahawks +1.5 OTB
Dolphins at Jets Fri, 4 p.m. ET Jets -2.5 OTB
Saints at Falcons Sun, 1 p.m. ET Falcons +1 OTB
Steelers at Bengals Sun, 1 p.m. ET Bengals -4.5 OTB
Jaguars at Texans Sun, 1 p.m. ET Texans +4.5 OTB
Buccaneers at Colts Sun, 1 p.m. ET Colts -1 OTB
Patriots at Giants Sun, 1 p.m. ET Giants -1.5 OTB
Panthers at Titans Sun, 1 p.m. ET Titans -1 OTB
Rams at Cardinals Sun, 4:05 p.m. ET Cardinals +2 OTB
Browns at Broncos Sun, 4:05 p.m. ET Broncos -1 OTB
Chiefs at Raiders Sun, 4:25 p.m. ET Raiders +5 OTB
Bills at Eagles Sun, 4:25 p.m. ET Eagles -1.5 OTB
Ravens at Chargers Sun, 8:20 p.m. ET Chargers -2 OTB
Bears at Vikings Mon, 8:15 p.m. ET Vikings -3.5 OTB

Odds courtesy of DraftKings as of May 13, 2023.

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