Opening NFL Week 12 Odds and Betting Lines: Colts +3.5 at Chiefs

NFL Week 12 is a little short on marquee matchups, but there is still plenty of betting intrigue.

Of all the games on the slate, the Indianapolis Colts vs. Kansas City Chiefs clash is the most interesting. Kansas City was -4.5 on the look-ahead line, but reopened at -3.5 after losing in Denver on Sunday.

The Los Angeles Rams host the Tampa Bay Buccaneers as 6.5-point favorites. Both teams are coming off tough games, with the Rams narrowly beating the Seahawks (despite Sam Darnold's four interceptions) and the Bucs just couldn't overcome the Buffalo Bills. This is still a bout between contenders worth keeping an eye on.

Here's a full look at the NFL Week 12 opening odds and early line moves, starting with Buffalo vs. Houston on Thursday Night Football.

NFL odds Week 12

Matchup	Spread	Moneyline	Over/Under
Bills vs Texans	Texans +5.5	Bills -270 Texans +220	43.5
Vikings vs Packers	Packers -6.5	Vikings +245 Packers  -300	41.5
Colts vs Chiefs	Chiefs -3.5	Colts +154 Chiefs -184	49.5
Patriots vs Bengals	Bengals +7.5	Patriots -460 Bengals +360	48.5
Steelers vs Bears	Bears -3	Steelers +138 Bears -164	44.5
Jets vs Ravens	Ravens -13.5	Jets +640 Ravens -950	44.5
Giants vs Lions	Lions -10.5	Giants +500 Lions -700	49.5
Seahawks vs Titans	Titans +13.5	Seahawks -900 Titans +610	40.5
Jaguars vs Cardinals	Cardinals +2.5	Jaguars -146 Cardinals +124	47.5
Browns vs Raiders	Raiders -3	Browns +134 Raiders -158	36.5
Eagles vs Cowboys	Cowboys +3.5	Eagles -205 Cowboys +172	49.5
Falcons vs Saints	Saints -1.5	Falcons +110 Saints -130	38.5
Buccaneers vs Rams	Rams -6.5	Buccaneers +265 Rams -330	49.5
Panthers vs 49ers	49ers -6.5	Panthers +285 49ers -355	47.5

Lines as of 11-18

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Bills vs Texans odds (Thursday, 8:15 p.m. ET, Prime Video)

Opening line

• Texans +4.5
• Over/Under 43.5
• View full Bills vs. Texans odds and matchup
• Read our Bills vs. Texans picks and predictions (coming soon)

The Bills opened as 4.5-point road chalk on the short week with that spread dipping to -3.5 before coming back up in the first 12 hours of action. Texans QB C.J. Stroud remains in concussion protocol and has a small window to get clear before TNF. This total opened at 43.5 points.

Also see: full Thursday Night Football odds

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Vikings vs Packers odds (Sunday, 1:00 p.m. ET, FOX)

Opening line

• Packers -6.5
• Over/Under 43.5
• View full Vikings vs. Packers odds and matchup
• Read our Vikings vs. Packers picks and predictions (coming soon)

The Packers opened as 6.5-point home favorites for this NFC North rivalry, just shy of the key number of a touchdown. The total opened at 43.5 and has slimmed to 42.5 O/U with initial action on the Under. Eyes are on the status of Green Bay RB Josh Jacobs, who left Week 11 with a knee injury.

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Colts vs Chiefs odds (Sunday, 1:00 p.m. ET, CBS)

Opening line

• Chiefs -3.5
• Over/Under 50.5
• View full Colts vs. Chiefs odds and matchup
• Read our Colts vs. Chiefs picks and predictions (coming soon)

The Chiefs are in “must win mode” after suffering their second straight loss. Kansas City comes home as 3.5-point chalk and juice on the favorite is climbing, indicating a potential move to KC -4. This total opened as high as 50.5 and dropped to 49.5 with early action on the Under.

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Patriots vs Bengals odds (Sunday, 1:00 p.m. ET, CBS)

Opening line

• Bengals +5.5
• Over/Under 50.5
• View full Patriots vs. Bengals odds and matchup
• Read our Patriots vs. Bengals picks and predictions (coming soon)

The Patriots enjoyed a mini-bye after winning last Thursday and now travel to Ohio as big chalk. New England opened as short as -5.5 and quickly jumped to -6.5 and then a touchdown in the opening hours of action Sunday night. The total hit the board at 50.5 and moved past the key number to 51.5 before coming back to the original opener.

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Steelers vs Bears odds (Sunday, 1:00 p.m. ET, CBS)

Opening line

• Bears -2.5
• Over/Under 45.5
• View full Steelers vs. Bears odds and matchup
• Read our Steelers vs. Bears picks and predictions (coming soon)

Two surprise squads clash in a non-conference contest, with Chicago opening as a 2.5-point home favorite and moving to -3 with the status of Pittsburgh QB Aaron Rodgers up in the air. He left Week 11 with an injury to his non-throwing hand. Steelers RB Jaylen Warren and WR Ke'Shawn Williams also suffered injuries that forced them out. This total opened at 44.5 O/U.

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Jets vs Ravens odds (Sunday, 1:00 p.m. ET, CBS)

Opening line

• Ravens -13.5
• Over/Under 44.5
• View full Jets vs. Ravens odds and matchup
• Read our Jets vs. Ravens picks and predictions (coming soon)

The Jets come into Week 12 on a mini-bye after losing last Thursday. Bookies opened Baltimore as a 13.5-point fave, and that pushed through the two-touchdown barrier to -14.5 in opening 12 hours of action. This total opened at 44.5 points.

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Giants vs Lions odds (Sunday, 1:00 p.m. ET, FOX)

Opening line

• Lions -10.5.5
• Over/Under 48.5
• View full Giants vs. Lions odds and matchup
• Read our Giants vs. Lions picks and predictions (coming soon)

The Lions limp back home after a bad showing in Philly on Sunday night, opening as 10.5-point chalk hosting the Giants in Week 12. Many sportsbooks have gone to Detroit -11.5 for this game. This total hit the board at 48.5 and jumped to 49.5 points with early play on the Over.

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Seahawks vs Titans odds (Sunday, 1:00 p.m. ET, FOX)

Opening line

• Titans +12.5
• Over/Under 42.5
• View full Seahawks vs. Titans odds and matchup
• Read our Seahawks vs. Titans picks and predictions (coming soon)

The Seahawks opened as 12.5-point road favorites in Nashville coming off a tough loss to Los Angeles on Sunday. Most books are trending upward, with Seattle as high as -13 for Week 12. This total opened at 42.5 and slimmed to 41.5 O/U.

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Jaguars vs Cardinals odds (Sunday, 4:05 p.m. ET, CBS)

Opening line

• Cardinals -2.5
• Over/Under 46.5
• View full Jaguars vs. Cardinals odds and matchup
• Read our Jaguars vs. Cardinals picks and predictions (coming soon)

The Jaguars are fresh from a one-sided win over the Chargers, but now hit the road as 2.5-point favorites at Arizona. This Over/Under hit the board at 46.5 and is now up to 47.5 points.

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Browns vs Raiders odds (Sunday, 4:05 p.m. ET, CBS)

Opening line

• Raiders -3
• Over/Under 36.5
• View full Browns vs. Raiders odds and matchup
• Read our Browns vs. Raiders picks and predictions (coming soon)

The Raiders were rolled on MNF and now face Cleveland on a short week. The Browns have QB questions with Dillion Gabriel in concussion protocol, leaving Cleveland to potentially start Shedeur Sanders in Week 12. Las Vegas opened as a 3-point home favorite with the total at 36.5 O/U. 

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Eagles vs Cowboys odds (Sunday, 4:25 p.m. ET, FOX)

Opening line

• Cowboys +3.5
• Over/Under 49.5
• View full Eagles vs. Cowboys odds and matchup
• Read our Eagles vs. Cowboys picks and predictions (coming soon)

The Cowboys blasted the Raiders on the road but have a short week to ready themselves for the Eagles. Dallas was +4.5 on the look-ahead line before MNF and officially opened +3.5 for this NFC East encounter. The total opened at 49.5 O/U.  

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Falcons vs Saints odds (Sunday, 4:25 p.m. ET, FOX)

Opening line

• Saints +2.5
• Over/Under 40.5
• View full Falcons vs. Saints odds and matchup
• Read our Falcons vs. Saints picks and predictions (coming soon)

Atlanta is mired in a five-game losing skid and travels to the Big Easy for an NFC South showdown with the Saints, who enjoyed a bye in Week 11. Oddsmakers opened the Falcons as 2.5-point road favorites, but we’re seeing many books drop that spread to as low as -1.5 with injuries to QB Michael Penix Jr. and WR Drake London. This total opened at 40.5 and dipped to 39.5 points in the opening hours of action.

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Buccaneers vs Rams odds (Sunday, 8:20 p.m. ET, NBC)

Opening line

• Rams -6.5
• Over/Under 49.5
• View full Buccaneers vs. Rams odds and matchup
• Read our Buccaneers vs. Rams picks and predictions (coming soon)

This Sunday Night Football pairing could be one of the more entertaining games of Week 12, especially when you consider the opening total hit the board at 49.5 points. Any positive injury updates to Tampa Bay RB Bucky Irving or WR Chris Godwin will push this number to 50 or higher. The Rams opened as 6.5-point home favorites, and that spread will move according to the Bucs’ injury reports.

Also see: full Sunday Night Football odds

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Panthers vs 49ers odds (Monday, 8:15 p.m. ET, ESPN)

Opening line

• 49ers -6.5
• Over/Under 46.5
• View full Panthers vs. 49ers odds and matchup
• Read our Panthers vs. 49ers picks and predictions (coming soon)

The 49ers are picking up steam and getting healthy at the right time. The Niners welcomed QB1 Brock Purdy back on the weekend and opened as a 6.5-point home chalk hosting Carolina on Monday Night Football. That spread has jumped to the key number of a touchdown with early play on the home side. This total opened at 46.5 points and is now up to 47.5 O/U.

Also see: full Monday Night Football odds

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