We flip the calendar to October in NFL Week 4 and also welcome the first international game of the season as well as a thrilling Thursday Night Football contest.
The NFL Week 4 odds include a mid-week war between the Dolphins and Bengals, the Vikings taking on the Saints in the UK on Sunday morning, and a game between GOATS pitting Patrick Mahomes against Tom Brady on Sunday Night Football.
Here's a look at the opening NFL Week 4 odds and the notable line moves to point spreads and Over/Under totals.
NFL Week 4 Odds
These are the look-ahead NFL odds for Week 4, headlined by Brady and the Bucs sitting as 1-point home dogs against Kansas City on Sunday Night Football.
| Matchup | Time | Spread | Over/Under |
|---|---|---|---|
| Dolphins at Bengals | Thurs, 8:15 p.m. ET | Bengals -3 | 47.5 |
| Vikings at Saints* | Sun, 9:30 a.m. ET | Saints +2.5 | 44 |
| Browns at Falcons | Sun, 1 p.m. ET | Falcons +2.5 | 48 |
| Bills at Ravens | Sun, 1 p.m. ET | Ravens +3.5 | 51.5 |
| Commanders at Cowboys | Sun, 1 p.m. ET | Cowboys -3 | 42.5 |
| Seahawks at Lions | Sun, 1 p.m. ET | Lions -6 | 50 |
| Chargers at Texans | Sun, 1 p.m. ET | Texans +5.5 | 46 |
| Titans at Colts | Sun, 1 p.m. ET | Colts -3.5 | 42.5 |
| Bears at Giants | Sun, 1 p.m. ET | Giants -2.5 | 39.5 |
| Jaguars at Eagles | Sun, 1 p.m. ET | Eagles -6.5 | 48.5 |
| Jets at Steelers | Sun, 1 p.m. ET | Steelers -3.5 | 41.5 |
| Cardinals at Panthers | Sun, 4:05 p.m. ET | Panthers -1.5 | 44 |
| Patriots at Packers | Sun, 4:25 p.m. ET | Packers -11 | 39 |
| Broncos at Raiders | Sun, 4:25 p.m. ET | Raiders -1.5 | 44.5 |
| Chiefs at Buccaneers | Sun, 8:20 p.m. ET | Buccaneers +2.5 | 44.5 |
| Rams at 49ers | Mon, 8:15 p.m. ET | 49ers -2.5 | 43 |
Odds courtesy of DraftKings as of September 26, 2022
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Dolphins at Bengals odds
Opening line
Bengals -3, 48 O/U
Why the line moved
10:00 P.M. ET, SUNDAY, SEPT. 25: This could be a fun Thursday nighter with two explosive offenses taking the field. Miami is coming off a huge win over Buffalo, which could leave the Fins open to a letdown spot on a short week. Books opened the Bengals as field goal faves, which has dropped to -2.5 at some shops. This total opened at 48 points and has slimmed a bit to 47.5.
Previous Dolphins at Bengals action
Coming soon!
Vikings at Saints odds
Opening line
Saints +2.5, 43.5 O/U
Why the line moved
10:00 P.M. ET, SUNDAY, SEPT. 25: The neutral-site London game has Minnesota opening between -2.5 and -3 across the industry. The Vikings could be without RB Dalvin Cook, who left the Week 3 win over Detroit with a shoulder injury and is day-to-day, according to Minnesota head coach Kevin O’Connell. This total hit the board at 43.5 points and is as high as 44.5 Sunday night.
Previous Vikings at Saints action
Coming soon!
Browns at Falcons odds
Opening line
Falcons +3, 46 O/U
Why the line moved
1:48 P.M. ET, MONDAY, SEPT. 26: On Monday morning the Browns slimmed from 3-point favorites down to -2.5. The total continued the upward trend that began Sunday, jumping from 47 to 48 at most books.
Previous Browns at Falcons action
10:00 P.M. ET, SUNDAY, SEPT. 25: The Browns have enjoyed a mini bye since winning last Thursday and opened as field-goal favorites in Atlanta. The Falcons picked up a road win in Seattle on Sunday and are a perfect 3-0 ATS heading into Week 4. This Over/Under opened at 46 points and is now up to 47 points at some sharper online books.
Bills at Ravens odds
Opening line
Ravens +3, 54.5 O/U
Why the line moved
1:44 P.M. ET, MONDAY, SEPT. 26: Monday saw huge downward movement in the total as some high-profile betting groups entered bets on the Under. After opening at 54.5 the Over/Under dropped to 53.5 on Sunday night, and dropped further to 51.5 on Monday morning.
Previous Bills at Ravens action
10:00 P.M. ET, SUNDAY, SEPT. 25: The Bills opened as field-goal favorites in Baltimore for this battle between top-tier QBs. Early money showed up on Buffalo and bumped this spread to Ravens +3.5 at some shops on Sunday night. This total opened at 54.5 points and has slimmed to 53.5 points.
Commanders at Cowboys odds
Opening line
TBD, Over/Under TBD
Why the line moved
Check back later for an update from Jason!
Previous Commanders at Cowboys action
Coming soon!
Seahawks at Lions odds
Opening line
Lions -6, 48 O/U
Why the line moved
10:30 P.M. ET, SUNDAY, SEPT. 25: The Lions opened as 6-point home favorites hosting Seattle in Week 4 — rare air for Detroit. The Lions haven’t closed as a favorite since November 22, 2020. Some books are already up to Lions -6.5 with early interest in Detroit, which is a perfect 3-0 ATS in 2022 and 14-6 ATS going back to last season. The total opened at 48 and is up to 49 points with early money on the Over.
Previous Seahawks at Lions action
Coming soon!
Chargers at Texans odds
Opening line
Texans +6.5, 45 O/U
Why the line moved
1:52 P.M. ET, MONDAY, SEPT. 26: As mentioned in the previous update, injuries are really becoming an issue for the Chargers and bettors have responded by taking the home underdog Texans early in the week. Books have adjusted the pointspread from the opener of Bolts -6.5 down to -5.5 as of Monday morning.
Previous Chargers at Texans action
10:30 P.M. ET, SUNDAY, SEPT. 25: Houston opened as a 6.5-point home underdog and has dipped to +6 with injuries stacking up for the L.A. Chargers following their Week 3 loss to Jacksonville. Quarterback Justin Herbert is battling a rib injury and his offensive line could be down Rashawn Slater while the defense could miss top pass rusher Joey Bosa. The total opened at 45 points and is out there between 45 and 46.5 points as of Sunday night.
Titans at Colts odds
Opening line
Colts +3, 44 O/U
Why the line moved
10:30 P.M. ET, SUNDAY, SEPT. 25: Indianapolis opened as big as -4 and that spread has slimmed as much as a point at some shops. The Colts won an ugly home opener against Kansas City while Tennessee avoided a 0-3 start with a home win over Las Vegas. This total opened at 44 points and early Under action had taken it down to 43 points.
Previous Titans at Colts action
Coming soon!
Bears at Giants odds
Opening line
TBD, Over/Under TBD
Why the line moved
Check back later for an update from Jason!
Previous Bears at Giants action
Coming soon!
Jaguars at Eagles odds
Opening line
Eagles +7, 47.5 O/U
Why the line moved
10:30 P.M. ET, SUNDAY, SEPT. 25: The Eagles opened between -7 and -7.5 and early play has taken this spread down as low as -6.5 with interest in the Jaguars. Jacksonville shut out Indianapolis at home in Week 2 and stomped the L.A. Chargers in Week 3, with impressive efforts on both sides of the ball. This total hit the board at 47.5 and has jumped to 48 points at some respected online books.
Previous Jaguars at Eagles action
Coming soon!
Jets at Steelers odds
Opening line
Steelers -4, 41 O/U
Why the line moved
10:30 P.M. ET, SUNDAY, SEPT. 25: The Steelers opened as big as -4 coming off a mini bye after losing on Thursday in Week 3. Early play has jumped on the Jets with No. 1 QB Zach Wilson expected to return under center. New York’s offense has been better than expected with backup Joe Flacco but came undone against Cincinnati on Sunday. This total opened at 41 points and is up to 41.5.
Previous Jets at Steelers action
Coming soon!
Cardinals at Panthers odds
Opening line
Panthers -1, 44 O/U
Why the line moved
10:30 P.M. ET, SUNDAY, SEPT. 25: Carolina is coming off its first win of the season and opened as a 1-point favorite hosting Arizona in Week 4. The Cardinals are 1-2 SU and dealing with injuries on both sides of the ball. This spread has climbed as high as Panthers -2 as of Sunday night. The total opened at 44 points and is up to 44.5.
Previous Cardinals at Panthers action
Coming soon!
Patriots at Packers odds
Opening line
Packers -8.5, 42.5 O/U
Why the line moved
1:56 P.M. ET, MONDAY, SEPT. 26: A high-ankle sprain is an incredibly painful injury, and it's very unlikely Mac Jones will be able to play Sunday in Green Bay. Brian Hoyer will likely get the start for the Patriots and the betting numbers are on the move early in the week. On Monday morning the spread moved from -10 to -11 and the total dropped from 41/41.5 down to 39.
Previous Patriots at Packers action
10:30 P.M. ET, SUNDAY, SEPT. 25: The status of Mac Jones’ ankle has this spread trending toward double digits. The Patriots QB suffered a bad ankle injury at the end of Week 3’s loss to Baltimore and is likely doubtful for Week 4. Green Bay ground out a win over Tampa Bay and opened at -8.5 before action steamed this spread all the way to -10 on Sunday night. The total opened at 42.5 and is as low as 41.5 points.
Broncos at Raiders odds
Opening line
Raiders -1.5, 44.5 O/U
Why the line moved
The Raiders took a tough 24-22 loss in Tennessee in Week 3, and the Broncos didn't look great but squeaked out an 11-10 win over the 49ers on Sunday Night Football. For this Week 4 matchup in Las Vegas, the Raiders opened as slim 1-point home favorites, which edged up slightly to -1.5 on Monday afternoon. The total hit betting boards at 44.5.
Previous Broncos at Raiders action
Coming soon!
Chiefs at Buccaneers odds
Opening line
Buccaneers +3, 47 O/U
Why the line moved
10:45 P.M. ET, SUNDAY, SEPT. 25: The Chiefs opened between -2 and -3 for this Sunday Night Football showdown and the early market consensus has settled at Kansas City -2.5. This total had a look-ahead number of 53 points in the summer but opened officially at 47 points and has slimmed to 46.5 with early play on the Under.
Previous Chiefs at Buccaneers action
Coming soon!
Rams at 49ers odds
Opening line
Rams -2.5, 47 O/U
Why the line moved
2:06 P.M. ET, MONDAY, SEPT. 26: The San Francisco 49ers did not look good on offense in their 11-10 loss to the Broncos on Sunday Night Football. The Rams took down the rival Cardinals 20-12 and opened as 2.5-point road favorites for this Monday Night Football matchup with the Niners. The total dropped from the opener of 47 all the way down to 43 on Monday morning.
Previous Rams at 49ers action
Coming soon!
More weekly NFL odds content
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