NFL Week 4 Odds and Betting Lines: Money Likes Rams on the Road on Monday Night Football

11:08 A.M. ET, FRIDAY, SEPT. 30: Friday's injury update brought bad news for Saints backers. Starting quarterback Jameis Winston (back) is now doubtful for Sunday, and wide receiver Micheal Thomas is officially out. Books have adjusted the point spread for this London contest from Vikings -2.5 to -3.5, and the total has dropped from 43.5 to 41.5.

9:45 A.M. ET, THURSDAY, SEPT. 29: This spread climbed from Vikings -2.5 to -3 after Saints QB Jameis Winston was absent from practice on Wednesday, leaving backup QB Andy Dalton to run first-team reps. However, NOLA coach Dennis Allen told the media he expects Winston to play on Sunday despite a bad back. That trimmed the spread back under the field goal. This total is sitting at 43.5 points.

10:00 P.M. ET, SUNDAY, SEPT. 25: The neutral-site London game has Minnesota opening between -2.5 and -3 across the industry. The Vikings could be without RB Dalvin Cook, who left the Week 3 win over Detroit with a shoulder injury and is day-to-day, according to Minnesota head coach Kevin O’Connell. This total hit the board at 43.5 points and is as high as 44.5 Sunday night.

12:19 P.M. ET, SATURDAY, OCT. 1: The Browns announced Saturday morning that DE Myles Garrett will miss Sunday's game in Atlanta. This was expected, and already reflected in the betting numbers, so the news didn't cause any initial movement. The pointspread stayed at Browns -1 and the total held at 47.5. We'll see over the next 24 hours if the public pushes this number over the fence.

12:54 P.M. ET, TUESDAY, SEPT. 27: After shortening from Browns -3 to -2.5 on Monday, the pointspread for this game dropped even further to -1.5 on Tuesday. The total also continued its upward trend early in the week, bumping up to 49.5.

1:48 P.M. ET, MONDAY, SEPT. 26: On Monday morning the Browns slimmed from 3-point favorites down to -2.5. The total continued the upward trend that began Sunday, jumping from 47 to 48 at most books.

10:00 P.M. ET, SUNDAY, SEPT. 25: The Browns have enjoyed a mini bye since winning last Thursday and opened as field-goal favorites in Atlanta. The Falcons picked up a road win in Seattle on Sunday and are a perfect 3-0 ATS heading into Week 4. This Over/Under opened at 46 points and is now up to 47 points at some sharper online books.

9:45 A.M. ET, THURSDAY, SEPT. 29: The total has slimmed from 55 to 51 points after respected betting groups grabbed the Under earlier in the week. As for the point spread, Buffalo has dropped from -4 to -3 across the industry. The Bills have a number of starters on both sides of the ball listed as questionable entering Week 4.

1:44 P.M. ET, MONDAY, SEPT. 26: Monday saw huge downward movement in the total as some high-profile betting groups entered bets on the Under. After opening at 54.5 the Over/Under dropped to 53.5 on Sunday night, and dropped further to 51.5 on Monday morning.

10:00 P.M. ET, SUNDAY, SEPT. 25: The Bills opened as field-goal favorites in Baltimore for this battle between top-tier QBs. Early money showed up on Buffalo and bumped this spread to Ravens +3.5 at some shops on Sunday night. This total opened at 54.5 points and has slimmed to 53.5 points.

9:45 A.M. ET, THURSDAY, SEPT. 29: After opening with a hook on the field goal, Dallas has dropped from -3.5 to -3 for this NFC East encounter with a pro betting group siding with the Commanders on Wednesday. The Over/Under has come down a bit, from 42 to 41.5 points. PointsBet books are reporting 62% of bets on Dallas but bigger bets have shown up on Washington, which has drawn 68% of the money.

11:02 P.M. ET, FRIDAY, SEPT. 30: The Lions will be without their top two offensive playmakers Sunday against the Seattle Seahawks with RB D'Andre Swift and WR Amon-Ra St. Brown both expected to sit out. Sportsbooks have adjusted the pointspread from Lions -4 to -3.5 and the total has come down slightly from 48 to 47.5.

10:00 A.M. ET, THURSDAY, SEPT. 29: Detroit has dropped from -6 to -4 with RB D’Andre Swift expected to sit out and WR Amon-Ra St. Brown dealing with an ankle injury that held him out of practice Wednesday. PointsBet books are still reporting 68% of ticket count and 62% of money on the Lions, who have been very popular with public players the past two years. This total has dropped from as high as 50.5 to 48 points as of Thursday.

12:45 P.M. ET, TUESDAY, SEPT. 27: Nobody appears to trust the Detroit Lions as a big favorite. After opening at -6 for Sunday's matchup against the Seattle Seahawks, both sharp and public bettors have forced the number down to -4.5 at most books by Tuesday afternoon.

10:30 P.M. ET, SUNDAY, SEPT. 25: The Lions opened as 6-point home favorites hosting Seattle in Week 4 — rare air for Detroit. The Lions haven’t closed as a favorite since November 22, 2020. Some books are already up to Lions -6.5 with early interest in Detroit, which is a perfect 3-0 ATS in 2022 and 14-6 ATS going back to last season. The total opened at 48 and is up to 49 points with early money on the Over.

1:55 P.M. ET, WEDNESDAY, SEPT. 28: After shortening to Chargers -4.5 on Tuesday, the pointspread for this Sunday afternoon matchup bumped back up to -5.5 during the day Wednesday. The total is now down to 44 after opening between 45 and 46.5.

12:50 P.M. ET, TUESDAY, SEPT. 27: Respected betting groups and sharps continue to push this number down. After opening at Chargers -6.5 and moving to -5.5 on Monday, this pointspread shortened again Tuesday to -4.5. The total sits at 44.5.

1:52 P.M. ET, MONDAY, SEPT. 26: As mentioned in the previous update, injuries are really becoming an issue for the Chargers and bettors have responded by taking the home underdog Texans early in the week. Books have adjusted the pointspread from the opener of Bolts -6.5 down to -5.5 as of Monday morning.

10:30 P.M. ET, SUNDAY, SEPT. 25: Houston opened as a 6.5-point home underdog and has dipped to +6 with injuries stacking up for the L.A. Chargers following their Week 3 loss to Jacksonville. Quarterback Justin Herbert is battling a rib injury and his offensive line could be down Rashawn Slater while the defense could miss top pass rusher Joey Bosa. The total opened at 45 points and is out there between 45 and 46.5 points as of Sunday night.

10:00 A.M. ET, THURSDAY, SEPT. 29: Money on Tennessee had trimmed this spread from Colts -3 to -2.5 at some books but play on Indianapolis on Wednesday pumped this spread back to a field goal and beyond, now sitting Colts -3.5. The total for this AFC South showdown has been trimmed from 44.5 to 42.5 points.

10:30 P.M. ET, SUNDAY, SEPT. 25: Indianapolis opened as big as -4 and that spread has slimmed as much as a point at some shops. The Colts won an ugly home opener against Kansas City while Tennessee avoided a 0-3 start with a home win over Las Vegas. This total opened at 44 points and early Under action had taken it down to 43 points.

10:45 A.M. ET, THURSDAY, SEPT. 29: Early money fading the Bears showed up and moved this spread from Giants -3 to -3.5. However, with injuries to the New York offense and playing on a short week, some action bumped this back to a field goal. The total has moved from 39 to 39.5 points.

10:45 A.M. ET, THURSDAY, SEPT. 29: Action on Jacksonville has taken this spread through the touchdown and down to Eagles -6.5. It sat there most of the week, with PointsBet books reporting 61% of bets and 66% of action on the home side.  Both teams have drawn money from pro bettors in the first two weeks, so this will be a fun line to watch closer to the weekend. This total has plummeted from 48.5 to as low as 46.5 as of Thursday. There is 62% of bets on the Over but 63% of money on the Under at PointsBet. 10:30 P.M. ET, SUNDAY, SEPT. 25: The Eagles opened between -7 and -7.5 and early play has taken this spread down as low as -6.5 with interest in the Jaguars. Jacksonville shut out Indianapolis at home in Week 2 and stomped the L.A. Chargers in Week 3, with impressive efforts on both sides of the ball. This total hit the board at 47.5 and has jumped to 48 points at some respected online books.

1:57 P.M. ET, WEDNESDAY, SEPT. 28: Jets quarterback Zach Wilson was officially cleared to return under center for Sunday's game in Pittsburgh. It was assumed Wilson would return for this game, but the betting numbers did adjust slightly Wednesday. The Steelers shortened from -3.5 down to the key number of -3 and books bumped the total from 40.5 up to 42.

10:30 P.M. ET, SUNDAY, SEPT. 25: The Steelers opened as big as -4 coming off a mini bye after losing on Thursday in Week 3. Early play has jumped on the Jets with No. 1 QB Zach Wilson expected to return under center. New York’s offense has been better than expected with backup Joe Flacco but came undone against Cincinnati on Sunday. This total opened at 41 points and is up to 41.5.

12:27 P.M. ET, SATURDAY, OCT. 1: The pointspread for this Sunday matchup jumped back over the fence on Saturday morning to Panthers -1. News of RB Christian McCaffrey returning to the practice field Friday may have promted this move, but he was very limited at practice and he is still very much Questionable for Sunday's game. The total stayed put at 43.5.

11:18 A.M. ET, FRIDAY, SEPT. 30: With running back Christian McCaffrey missing practice all week for Carolina, the pointspread for this matchup jumped the fence Friday morning from Panthers -1/-1.5 to Cardinals -1. McCaffrey is officially listed as Questionable for Sunday's game, but he did return to practice in a "limited" role Friday. The total is sitting at 43.5.

10:29 A.M. ET, WEDNESDAY, SEPT. 28: As of Wednesday morning, the pointspread for this Sunday afternoon matchup is sitting at Panthers -1.5 at most books. There are a couple of books out there hanging on at -2, so if you're looking to bet the Cardinals do some shopping. The total has been bet down from the opener of 44/44.5 to 42.5/43.

10:30 P.M. ET, SUNDAY, SEPT. 25: Carolina is coming off its first win of the season and opened as a 1-point favorite hosting Arizona in Week 4. The Cardinals are 1-2 SU and dealing with injuries on both sides of the ball. This spread has climbed as high as Panthers -2 as of Sunday night. The total opened at 44 points and is up to 44.5.

12:32 P.M. ET, SATURDAY, OCT. 1: The pointspread for this late Sunday afternoon matchup between the Patriots and Packers continues to shorten heading into game day. The initial reaction to the Mac Jones injury news jumped the spread to as high as Packers -11, but that number has continued to drop all week and currently sits at -9. The realization of bettors that perhaps Brian Hoyer isn't as much of a step down from Jones as inititially thought has this number heading close the the opening number of -8.5.

10:39 A.M. ET, WEDNESDAY, SEPT. 28: Opinions from sharp and public bettors are starting to surface that perhaps having Brian Hoyer at quarterback instead of Mac Jones isn't as much of a step-down as first anticipated. After initially getting as high as Packers -11 early in the week, the pointspread for Sunday's game has shortened through the key number of -10 and now stands at Packers -9.5 at most respected books. The total sits at 40.5.

1:56 P.M. ET, MONDAY, SEPT. 26: A high-ankle sprain is an incredibly painful injury, and it's very unlikely Mac Jones will be able to play Sunday in Green Bay. Brian Hoyer will likely get the start for the Patriots and the betting numbers are on the move early in the week. On Monday morning the spread moved from -10 to -11 and the total dropped from 41/41.5 down to 39.

10:30 P.M. ET, SUNDAY, SEPT. 25: The status of Mac Jones’ ankle has this spread trending toward double digits. The Patriots QB suffered a bad ankle injury at the end of Week 3’s loss to Baltimore and is likely doubtful for Week 4. Green Bay ground out a win over Tampa Bay and opened at -8.5 before action steamed this spread all the way to -10 on Sunday night. The total opened at 42.5 and is as low as 41.5 points.

The Raiders took a tough 24-22 loss in Tennessee in Week 3, and the Broncos didn't look great but squeaked out an 11-10 win over the 49ers on Sunday Night Football. For this Week 4 matchup in Las Vegas, the Raiders opened as slim 1-point home favorites, which edged up slightly to -1.5 on Monday afternoon. The total hit betting boards at 44.5.

11:27 A.M. ET, FRIDAY, SEPT. 30: With news late Thursday that this game will, in fact, be played in Tampa Bay, books continued to move the pointspread in the direction of the home side - jumping the fence from Chiefs -1 to Buccaneers -1 on Friday morning. The total bumped slightly from 45 to 46.

11:00 A.M. ET, THURSDAY, SEPT. 29: Following Hurricane Ian ravaging Florida on Wednesday, this game could be moved to Minnesota — which could have the game pulled and voided before a new set of neutral-site odds come out. As it stands, the Bucs appear to be getting healthy for this Week 4 marquee matchup with Kansas City, notably Tom Brady’s passing targets. Tampa Bay has gone from +2.5 to as low as +1 as of Thursday. This total has moved from an opener of 47 to as low as 45 points.

10:45 P.M. ET, SUNDAY, SEPT. 25: The Chiefs opened between -2 and -3 for this Sunday Night Football showdown and the early market consensus has settled at Kansas City -2.5. This total had a look-ahead number of 53 points in the summer but opened officially at 47 points and has slimmed to 46.5 with early play on the Under.

1:00 P.M. ET MONDAY, OCT. 3: After the Niners shrunk to as low as -1 yesterday morning, the line started moving in favor of San Francisco and can now be found between -1.5 and -2.5. Pinnacle is offering 49ers -1 but at a steper price of -120. The total still sits at 42.5 across the board as of Monday afternoon. Currently, DraftKings is reporting 74% of bets and 62% of handle on Rams -2, as well as 64% of bets on the Over with 61% of handle.

9:00 A.M. ET SUNDAY, OCT. 2: The NFC West war on Monday Night Football has seen San Francisco shrink from a 2.5-point home chalk to as low as -1 on Sunday morning. BetMGM shops are reporting 72% of bet count and 70% of money riding with the Rams on the road in the Week 4 finale. This total opened at 47 points and plummeted to as low as 42.5 points on the weekend.

1:00 P.M. ET, TUESDAY, SEPT. 27: Early in the week, bettors are really not putting a lot of trust behind Jimmy G and the 49ers as 2.5-point favorites over the visiting Rams. Some books have started to make the move down to Niners -2. The total continues to tumble after opening at 47 and dropping to 43 on Monday, down to 41.4/42 on Tuesday.

2:06 P.M. ET, MONDAY, SEPT. 26: The San Francisco 49ers did not look good on offense in their 11-10 loss to the Broncos on Sunday Night Football. The Rams took down the rival Cardinals 20-12 and opened as 2.5-point road underdogs for this Monday Night Football matchup with the Niners. The total dropped from the opener of 47 all the way down to 43 on Monday morning.