NFL Week 4 is a benchmark in the schedule and also the point at which bettors can start to make solid assumptions about the success — or lack of — of NFL teams.
Today’s slate gets an early 9:30 a.m. ET wake-up call with the Minnesota Vikings and Pittsburgh Steelers playing in Ireland. From there, we have an anticipated meeting of the Baltimore Ravens and Kansas City Chiefs, as well as a Sunday Night Football fight between the Green Bay Packers and Dallas Cowboys.
Week 4 comes to a close with a double-header on Monday Night Football, with the New York Jets visiting the Miami Dolphins and the Denver Broncos hosting the Cincinnati Bengals.
Here’s a look at the opening odds for NFL Week 4 and early adjustments in the first 12 hours of action.
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NFL odds for Week 4
| Matchup | Spread | Moneyline | Over/Under |
|---|---|---|---|
 Seahawksvs  Cardinals |
Cardinals -1.5 | Seahawks -108 Cardinals -108 |
43.5 |
 Vikingsvs  Steelers |
Steelers +2.5 | Vikings -146 Steelers +124 |
40.5 |
 Titansvs  Texans |
Texans -7.5 | Titans +310 Texans -390 |
38.5 |
 Panthersvs  Patriots |
Patriots -5.5 | Panthers +210 Patriots -255 |
43.5 |
 Chargersvs  Giants |
Giants +6.5 | Chargers -290 Giants +235 |
43.5 |
 Saintsvs  Bills |
Bills -14.5 | Saints +870 Bills -1500 |
48.5 |
 Eaglesvs  Buccaneers |
Buccaneers +3.5 | Eagles -198 Buccaneers +166 |
44.5 |
 Commandersvs  Falcons |
Falcons -2.5 | Commanders +112 Falcons -132 |
43.5 |
 Brownsvs  Lions |
Lions -9.5 | Browns +430 Lions -590 |
44.5 |
 Coltsvs  Rams |
Rams -3.5 | Colts +156 Rams -186 |
49.5 |
 Jaguarsvs  49ers |
49ers -3.5 | Jaguars +146 49ers -174 |
46.5 |
 Bearsvs  Raiders |
Raiders -1.5 | Bears +108 Raiders -126 |
47.5 |
 Ravensvs  Chiefs |
Chiefs +2.5 | Ravens -146 Chiefs +126 |
48.5 |
 Packersvs  Cowboys |
Cowboys +6.5 | Packers -330 Cowboys +265 |
46.5 |
 Jetsvs  Dolphins |
Dolphins -2.5 | Jets +132 Dolphins -156 |
44.5 |
 Bengalsvs  Broncos |
Broncos -7.5 | Bengals +360 Broncos -460 |
43.5 |
Lines as of 9-28
Seahawks vs Cardinals odds (Thursday, 8:15 p.m. ET, PRIME)
Opening line
- Cardinals -1.5
- Over/Under 43.5
- View full Seahawks vs. Cardinals odds and matchup
The Cardinals are slight 1.5-point home favorites, but a short week doesn’t leave Arizona much time to get over the loss of RB James Conner, who suffered a severe ankle injury in Week 3. This total is at 43.5 points.
Also see: full Thursday Night Football odds
Vikings vs Steelers odds (Sunday, 9:30 a.m. ET, NFL Network)
Opening line
- Steelers -1.5
- Over/Under 40.5
- View full Vikings vs. Steelers odds and matchup
The first international game of the 2025 season sends the Steelers and Vikings to Dublin, Ireland. Minnesota could have J.J. McCarthy back under center after he missed Week 3 with a high ankle sprain. Bookies installed the Vikings as 1.5-point underdogs in this neutral-site contest, but that has since jumped the fence to Minnesota -1.5. The total is at 40.5 points.
Titans vs Texans odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Texans -7.5
- Over/Under 38.5
- View full Titans vs. Texans odds and matchup
Houston opened as a 7.5-point home favorite, but early movement has been away from the winless Texans, dropping this spread to a touchdown. The Over/Under opened at 38.5 points — the lowest total on the Week 4 board.
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Panthers vs Patriots odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Patriots -4.5
- Over/Under 43.5
- View full Panthers vs. Patriots odds and matchup
New England hit the board as a 4.5-point home favorite for this non-conference contest, with Carolina coming off a rare victory. The total opened at 43.5 points.
Chargers vs Giants odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Giants +5.5
- Over/Under 45.5
- View full Chargers vs. Giants odds and matchup
The Chargers cross the country for a 1 p.m. ET start (10 a.m. PT) in East Rutherford, opening as 5.5-point road favorites. Los Angeles lost RB Najee Harris to an Achilles injury in Week 3. The total opened at 45.5 points after the Giants’ low-scoring loss to Kansas City on Sunday night.
Saints vs Bills odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Bills -15.5
- Over/Under 48.5
- View full Saints vs. Bills odds and matchup
The Bills opened as massive 15.5-point home chalk hosting the Saints in Week 4, and that jumped to -16.5 as New Orleans was getting crushed by Seattle on Sunday. This is the biggest spread of the 2025 season so far and just the 11th spread of -16.5 or higher since 2021. The total opened at 48.5 points.
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Eagles vs Buccaneers odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Buccaneers +3
- Over/Under 46.5
- View full Eagles vs. Buccaneers odds and matchup
The Eagles opened as field goal favorites in Tampa Bay with the total hitting the board at 46.5 points and dropping to 45.5 O/U with initial play on the Under. The Bucs could be missing top WR Mike Evans, who left with a hamstring injury in Week 3.
Commanders vs Falcons odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Falcons +3
- Over/Under 45.5
- View full Commanders vs. Falcons odds and matchup
Atlanta was shut out 30-0 by Carolina in Week 3 and now opens as a 3-point home underdog to Washington. But with the status of Commanders QB Jayden Daniels (knee) up in the air and WR Terry McClaurin leaving Week 3 with a quad injury, this spread has dipped to Falcons +2.5. The total is at 45.5 points.
Browns vs Lions odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Lions -8.5
- Over/Under 45.5
- View full Browns vs. Lions odds and matchup
After a big win over Baltimore on Monday, bookies opened the Lions as 8.5-point home favorites hosting the Browns on a short week. The total hit the board at 45.5 points.
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Colts vs Rams odds (Sunday, 4:05 p.m. ET, FOX)
Opening line
- Rams -3.5
- Over/Under 47.5
- View full Colts vs. Rams odds and matchup
The Rams come back home after a crushing collapse in Philadelphia, opening as 3.5-point favorites hosting the undefeated Colts in Week 4. This total hit the board at 47.5 points and has jumped to 48.5 with initial play on the Over.
Jaguars vs 49ers odds (Sunday, 4:05 p.m. ET, FOX)
Opening line
- 49ers -4.5
- Over/Under 46.5
- View full Jaguars vs. 49ers odds and matchup
The 49ers opened as 4.5-point home chalk to Jacksonville, but with injuries still an issue, this spread is down to San Francisco -3.5. Star defensive lineman Nick Bosa is suspected to have an ACL tear that would end his season. The health of QBs Brock Purdy and Mac Jones will be something to keep an eye on this week. This total opened at 46.5 and is down to 45.5 O/U.
Bears vs Raiders odds (Sunday, 4:25 p.m. ET, CBS)
Opening line
- Raiders -1.5
- Over/Under 47.5
- View full Bears vs. Raiders odds and matchup
Books varied on the opening number for this non-conference clash, but the market consensus boiled down to Las Vegas as a slim home favorite, with FanDuel opening -1.5. The total hit the board at 47.5 with both teams putting up points but not providing much push back on defense.
Ravens vs Chiefs odds (Sunday, 4:25 p.m. ET, CBS)
Opening line
- Chiefs +2.5
- Over/Under 48.5
- View full Ravens vs. Chiefs odds and matchup
Following the Ravens’ loss to the Lions on Monday, oddsmakers opened Baltimore as a 2.5-point road favorite at Arrowhead Stadium in Week 4. The total officially opened at 48.5 points.
Packers vs Cowboys odds (Sunday, 8:20 p.m. ET, NBC)
Opening line
- Cowboys +5.5
- Over/Under 48.5
- View full Packers vs. Cowboys odds and matchup
Micah Parsons returns to AT&T Stadium for the first time since being traded to the Packers. Green Bay opened as a 5.5-point road favorite for Sunday Night Football, and some books have already jumped to as high as -6.5. Dallas could be without top WR CeeDee Lamb after he left with an ankle injury in Week 3. The Packers could have cluster injuries on the offensive line. This total hit the board at 48.5 O/U.
Also see: full Sunday Night Football odds
Jets vs Dolphins odds (Monday, 7:15 p.m. ET, ESPN)
Opening line
- Dolphins -2.5
- Over/Under 43.5
- View full Jets vs. Dolphins odds and matchup
Miami has enjoyed a mini bye since losing on Thursday in Week 3, giving the Dolphins a rest edge in this AFC East encounter on Monday Night Football. The Fins opened as 2.5-point home favorites with the status of Jets QB Justin Fields still up in the air after he missed Week 3 due to a concussion. This Over/Under opened at 44.5 points and dipped briefly to 43.5 before coming back to its original post.
Also see: full Monday Night Football odds
Bengals vs Broncos odds (Monday, 7:15 p.m. ET, ABC)
Opening line
- Broncos -6.5
- Over/Under 44.5
- View full Bengals vs. Broncos odds and matchup
The Bengals aren’t loving life without Joe Burrow and face another stiff defensive test in Denver on Monday Night Football. The Broncos opened as 8.5-point favorites but have come down to -7.5 for Week 4. The total opened at 43.5 and has risen to 44.5 O/U.
Also see: full Monday Night Football odds
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Odds are correct at the time of publishing and are subject to change.
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