NFL Week 4 Odds and Betting Lines: Bengals Battle Red-Hot Dolphins in Primetime

NFL Week 4 odds are on the board with a bunch of interesting contests to handicap, including a Thursday night shootout between the Dolphins and Bengals and a trip to London for the Vikings and Saints.

Last Updated: Sep 26, 2022 2:17 PM ET Read Time: 4 min
Joe Burrow Cincinnati Bengals NFL
Photo By - USA TODAY Sports

We flip the calendar to October in NFL Week 4 and also welcome the first international game of the season as well as a thrilling Thursday Night Football contest.

The NFL Week 4 odds include a mid-week war between the Dolphins and Bengals, the Vikings taking on the Saints in the UK on Sunday morning, and a game between GOATS pitting Patrick Mahomes against Tom Brady on Sunday Night Football. 

Here's a look at the opening NFL Week 4 odds and the notable line moves to point spreads and Over/Under totals.

These are the look-ahead NFL odds for Week 4, headlined by Brady and the Bucs sitting as 1-point home dogs against Kansas City on Sunday Night Football.

Matchup Time Spread Over/Under
Dolphins at Bengals Thurs, 8:15 p.m. ET Bengals -3 47.5
Vikings at Saints* Sun, 9:30 a.m. ET Saints +2.5 44
Browns at Falcons Sun, 1 p.m. ET Falcons +2.5 48
Bills at Ravens Sun, 1 p.m. ET Ravens +3.5 51.5
Commanders at Cowboys Sun, 1 p.m. ET Cowboys -3 42.5
Seahawks at Lions Sun, 1 p.m. ET Lions -6 50
Chargers at Texans Sun, 1 p.m. ET Texans +5.5 46
Titans at Colts Sun, 1 p.m. ET Colts -3.5 42.5
Bears at Giants Sun, 1 p.m. ET Giants -2.5 39.5
Jaguars at Eagles Sun, 1 p.m. ET Eagles -6.5 48.5
Jets at Steelers Sun, 1 p.m. ET Steelers -3.5 41.5
Cardinals at Panthers Sun, 4:05 p.m. ET Panthers -1.5 44
Patriots at Packers Sun, 4:25 p.m. ET Packers -11 39
Broncos at Raiders Sun, 4:25 p.m. ET Raiders -1.5 44.5
Chiefs at Buccaneers Sun, 8:20 p.m. ET Buccaneers +2.5 44.5
Rams at 49ers Mon, 8:15 p.m. ET 49ers -2.5 43

Odds courtesy of DraftKings as of September 26, 2022
*This game will be played on a neutral field.

Best NFL sign-up bonuses

If you're signing up for a new sportsbook for the new NFL season, here are two of the best bonuses* available:

A) New users at FanDuel can get a no-sweat first bet up to $1,000! Sign Up Now

B) New users at DraftKings can get a deposit bonus up to $1,000! Sign Up Now

*Eligible USA locations only. Also, check out our full list of NFL promo codes for 2022.

Opening line

Bengals -3, 48 O/U

Why the line moved

10:00 P.M. ET, SUNDAY, SEPT. 25: This could be a fun Thursday nighter with two explosive offenses taking the field. Miami is coming off a huge win over Buffalo, which could leave the Fins open to a letdown spot on a short week. Books opened the Bengals as field goal faves, which has dropped to -2.5 at some shops. This total opened at 48 points and has slimmed a bit to 47.5.  

Opening line

Saints +2.5, 43.5 O/U

Why the line moved

10:00 P.M. ET, SUNDAY, SEPT. 25: The neutral-site London game has Minnesota opening between -2.5 and -3 across the industry. The Vikings could be without RB Dalvin Cook, who left the Week 3 win over Detroit with a shoulder injury and is day-to-day, according to Minnesota head coach Kevin O’Connell. This total hit the board at 43.5 points and is as high as 44.5 Sunday night.

BACK TO TOP

Opening line

Falcons +3, 46 O/U

Why the line moved

1:48 P.M. ET, MONDAY, SEPT. 26: On Monday morning the Browns slimmed from 3-point favorites down to -2.5. The total continued the upward trend that began Sunday, jumping from 47 to 48 at most books.

Opening line

Ravens +3, 54.5 O/U

Why the line moved

1:44 P.M. ET, MONDAY, SEPT. 26: Monday saw huge downward movement in the total as some high-profile betting groups entered bets on the Under. After opening at 54.5 the Over/Under dropped to 53.5 on Sunday night, and dropped further to 51.5 on Monday morning.

Opening line

TBD, Over/Under TBD

Why the line moved

Check back later for an update from Jason!

Opening line

Lions -6, 48 O/U

Why the line moved

10:30 P.M. ET, SUNDAY, SEPT. 25: The Lions opened as 6-point home favorites hosting Seattle in Week 4 — rare air for Detroit. The Lions haven’t closed as a favorite since November 22, 2020. Some books are already up to Lions -6.5 with early interest in Detroit, which is a perfect 3-0 ATS in 2022 and 14-6 ATS going back to last season. The total opened at 48 and is up to 49 points with early money on the Over.

BACK TO TOP

Opening line

Texans +6.5, 45 O/U

Why the line moved

1:52 P.M. ET, MONDAY, SEPT. 26: As mentioned in the previous update, injuries are really becoming an issue for the Chargers and bettors have responded by taking the home underdog Texans early in the week. Books have adjusted the pointspread from the opener of Bolts -6.5 down to -5.5 as of Monday morning.

Opening line

Colts +3, 44 O/U

Why the line moved

10:30 P.M. ET, SUNDAY, SEPT. 25: Indianapolis opened as big as -4 and that spread has slimmed as much as a point at some shops. The Colts won an ugly home opener against Kansas City while Tennessee avoided a 0-3 start with a home win over Las Vegas. This total opened at 44 points and early Under action had taken it down to 43 points.

Opening line

TBD, Over/Under TBD

Why the line moved

Check back later for an update from Jason!

Opening line

Eagles +7, 47.5 O/U

Why the line moved

10:30 P.M. ET, SUNDAY, SEPT. 25: The Eagles opened between -7 and -7.5 and early play has taken this spread down as low as -6.5 with interest in the Jaguars. Jacksonville shut out Indianapolis at home in Week 2 and stomped the L.A. Chargers in Week 3, with impressive efforts on both sides of the ball. This total hit the board at 47.5 and has jumped to 48 points at some respected online books.

BACK TO TOP

Opening line

Steelers -4, 41 O/U

Why the line moved

10:30 P.M. ET, SUNDAY, SEPT. 25: The Steelers opened as big as -4 coming off a mini bye after losing on Thursday in Week 3. Early play has jumped on the Jets with No. 1 QB Zach Wilson expected to return under center. New York’s offense has been better than expected with backup Joe Flacco but came undone against Cincinnati on Sunday. This total opened at 41 points and is up to 41.5. 

Opening line

Panthers -1, 44 O/U

Why the line moved

10:30 P.M. ET, SUNDAY, SEPT. 25: Carolina is coming off its first win of the season and opened as a 1-point favorite hosting Arizona in Week 4. The Cardinals are 1-2 SU and dealing with injuries on both sides of the ball. This spread has climbed as high as Panthers -2 as of Sunday night. The total opened at 44 points and is up to 44.5.

Opening line

Packers -8.5, 42.5 O/U

Why the line moved

1:56 P.M. ET, MONDAY, SEPT. 26: A high-ankle sprain is an incredibly painful injury, and it's very unlikely Mac Jones will be able to play Sunday in Green Bay. Brian Hoyer will likely get the start for the Patriots and the betting numbers are on the move early in the week. On Monday morning the spread moved from -10 to -11 and the total dropped from 41/41.5 down to 39.

Opening line

Raiders -1.5, 44.5 O/U

Why the line moved

The Raiders took a tough 24-22 loss in Tennessee in Week 3, and the Broncos didn't look great but squeaked out an 11-10 win over the 49ers on Sunday Night Football. For this Week 4 matchup in Las Vegas, the Raiders opened as slim 1-point home favorites, which edged up slightly to -1.5 on Monday afternoon. The total hit betting boards at 44.5.

BACK TO TOP

Opening line

Buccaneers +3, 47 O/U

Why the line moved

10:45 P.M. ET, SUNDAY, SEPT. 25: The Chiefs opened between -2 and -3 for this Sunday Night Football showdown and the early market consensus has settled at Kansas City -2.5. This total had a look-ahead number of 53 points in the summer but opened officially at 47 points and has slimmed to 46.5 with early play on the Under.

Opening line

Rams -2.5, 47 O/U

Why the line moved

2:06 P.M. ET, MONDAY, SEPT. 26: The San Francisco 49ers did not look good on offense in their 11-10 loss to the Broncos on Sunday Night Football. The Rams took down the rival Cardinals 20-12 and opened as 2.5-point road favorites for this Monday Night Football matchup with the Niners. The total dropped from the opener of 47 all the way down to 43 on Monday morning.

More weekly NFL odds content

Pages related to this topic

Popular Content

Legal Canadian sports betting

Best Canadian betting sites Ontario sports betting
Covers 25 Years Logo Established in 1995,
Covers is the world
leader in sports
betting information.
Covers is verified safe by: Evalon Logo GPWA Logo GDPR Logo GeoTrust Logo Evalon Logo