NFL Week 4 Odds and Betting Lines: Lions Favored at Home Over Seahawks

Another week, another double dip of Monday Night Football action. The Dolphins are slight favorites over the Titans in South Florida while the Lions look to defend the Motor City as 4.5-point chalk from the Seahawks.

Jason Logan: Senior Betting Analyst at Covers
Jason Logan • Senior Betting Analyst
Sep 29, 2024 • 20:39 ET • 4 min read
Aidan Hutchinson Detroit Lions NFL
Photo By - USA TODAY Sports

Green Day asked that we "wake them up when September ends," but then they'd miss out on the NFL Week 4 odds.

The first month of the schedule closes with an exciting slate of betting matchups. With Sunday's slate done or in progress, the NFL odds for Week 4 are headlined by a Monday Night Football double-feature: Titans at Dolphins and Seahawks at Lions.

I break down the NFL Week 4 odds and all the early line movement below.

NFL Week 4 Odds

These are the NFL odds for Week 4, highlighted by the two more games on Monday Night Football. 

Matchup Time (E.T.) Odds
Cowboys Cowboys
vs
Giants Giants
Thursday
8:15 p.m.
Prime
Giants +6
O/U 45.5
Steelers Steelers
vs
Colts Colts
Sunday
1:00 p.m.
CBS
Colts +2
O/U 40
Vikings Vikings
vs
Packers Packers

Sunday
1:00 p.m.
CBS
Packers -2.5
O/U 43.5
Jaguars Jaguars
vs
Texans Texans
Sunday
1:00 p.m.
CBS
Texans -6
O/U 44.5
Saints Saints
vs
Falcons Falcons
Sunday
1:00 p.m.
FOX
Falcons -3
O/U 41
Rams Rams
vs
Bears Bears
Sunday
1:00 p.m.
FOX
Bears -3
O/U 40.5
Eagles Eagles
vs
Buccaneers Buccaneers
Sunday
1:00 p.m.
FOX
Buccaneers +1
O/U 42.5
Bengals Bengals
vs
Panthers Panthers
Sunday
1:00 p.m.
FOX
Panthers +4.5
O/U 47.5
Broncos Broncos
vs
Jets Jets
Sunday
1:00 p.m.
CBS
Jets -8
O/U 39.5
CommandersCommanders
vs
Cardinals Cardinals
Sunday
4:05 p.m.
FOX
Cardinals -3.5
O/U 49
Patriots Patriots
vs
49ers 49ers
Sunday
4:05 p.m.
FOX
49ers -10.5
O/U 40.5
Browns Browns
vs
Raiders Raiders
Sunday
4:25 p.m.
CBS
Raiders +2
O/U 36.5
Chiefs Chiefs
vs
Chargers Chargers
Sunday
4:25 p.m.
CBS
Chargers +7
O/U 39.5
Bills Bills
vs
Ravens Ravens
Sunday
8:20 p.m.
NBC
Ravens -2.5
O/U 46.5
Titans Titans
vs
Dolphins Dolphins
Monday
7:30 p.m.
ESPN
Dolphins -1.5
O/U 37
Seahawks Seahawks
vs
Lions Lions
Monday
8:15 p.m.
ABC
Lions -3.5
O/U 46.5

Lines courtesy of BetMGM as of 9-28.

Steelers vs. Colts odds

Justin Fields

Opening line

The look-ahead line has the Colts as 1.5-point home chalk but the official Week 4 opener jumps the fence, with Pittsburgh hitting the board at -1.5. This spread is now up to -2.5 on Sunday morning. The total opened as high as 40 points and quickly drew Under money, dropping the number to as short as 38.5. That has since rebounded to as high as 40.5 O/U.

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Vikings vs. Packers odds

Sam Darnold

Opening line

Green Bay opened as a 2-point favorite, leaning toward Jordan Love being under center. As of Sunday morning, the Packers are now favored by -3 at most books. However, Minnesota is looking very good at 3-0, especially on defense. This total opened at 43.5 O/U and is up to 44 points.

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Jaguars vs. Texans odds

Stefon Diggs

Opening line

Jacksonville is on a short week and back on the road after getting blasted in Buffalo on Monday. The look-ahead line was as low as Texans -4.5 but the official Week 4 opener was up to -6 with Houston -6.5 widely available on Thursday. However, that spread has dropped below the key number and sits as low as Texans -5 on Sunday morning. Jacksonville's offensive woes trimmed the total to as low as 44.5 O/U.

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Saints vs. Falcons odds

Bijan Robinson

Opening line

The Saints' explosive offense came back to earth in Week 3 and now New Orleans is a 3-point road underdog at Atlanta in Week 4. The Falcons gave Kansas City a fight on Sunday night, with some controversial calls keeping them from pulling off the upset. This total opened at 45.5 O/U and has cratered to as low as 40.5, but there are some 42-point totals on the board Sunday morning.

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Rams vs. Bears odds

Kyren Williams

Opening line

Chicago was a 3-point favorite on the look-ahead lines but with the offense struggling, this spread was hacked in half with the Bears laying -1.5 at home to Los Angeles at open. That number is back up to Bears -3 on Sunday morning. The Rams are ravaged by injuries but snuck out an upset win over the rival 49ers in Week 3. The total opened at 40.5 O/U and remains as such.

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Eagles vs. Buccaneers odds

Saquon Barkley

Opening line

Philadelphia pulled out of its tailspin with a comeback win in New Orleans in Week 3. The Eagles are 1-point favorites in Tampa Bay, with the Bucs coming off an upset loss to Denver. The Over/Under opened between 45 and 46 points and is down to 42 O/U on Sunday morning. The Eagles have injuries piling up on the offensive line and will be down WRs DeVonta Smith and A.J. Brown.

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Bengals vs. Panthers odds

Andy Dalton

Opening line

The Bengals burned bettors again, losing outright as 7.5-point home chalk to Washington on Monday. That has knocked the look-ahead line down a point from Cincinnati -5.5 to -4.5. The total was up to 48.5 with Andy Dalton giving new life to Carolina's offense and the Bengals' defense coming off a short week, but it has since dipped to 47.5 on Sunday.

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Broncos vs. Jets odds

Aaron Rodgers

Opening line

New York had a mini-bye to build on its win last Thursday. Oddsmakers opened the Jets as 7.5-point favorites hosting the Broncos, who could be ripe for a letdown after an upset at Tampa Bay in Week 3. This spread is a consensus -8 on Sunday morning. The total opened at 38.5 points and as gained a full point across the board at 39.5 O/U.

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Commanders vs. Cardinals odds

Jayden Daniels

Opening line

What looked like a dud of a Week 4 game when the schedule was released could be the most exciting matchup on the board. The tall total thinks so, with this Over/Under opening at 50.5 (now 49) following Washington's explosive upset over Cincinnati on Monday. Arizona was -4.5 on the look-ahead spread but the official Week 4 opener is Cardinals -3.5.

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Patriots vs. 49ers odds

Jauan Jennings

Opening line

Even with New England holding the rest edge and the injury-plagued 49ers coming off a loss, books went big on San Francisco. The Niners opened as 10.5-point favorites and that is as high as -11 on Sunday morning. Receiver Deebo Samuel and OT Trent Williams are leaning toward playing in Week 4. The Over/Under opened at 40 points, ticked down to 39-39.5 and has jumped back to 40.5 on Sunday. 

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Browns vs. Raiders odds

Maxx Crosby

Opening line

This spread was bouncing around a pick'em at some books with others opening Cleveland as a 1-point road favorite. Las Vegas quickly took money and ran to a short favorite before ruling WR Davonte Adams out for Week 4, pushing the spread to Browns -2.5 on Sunday morning. The total is one of the lowest on the board, at 36.5 O/U.

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Chiefs vs. Chargers odds

Rashee Rice

Opening line

With a long list of injuries stacking for the Chargers, oddsmakers opened Kansas City as an 8.5-point favorite on the road in Week 4. The spread was all over the place, ranging from a low of -7.5 to a high of -9.5 before books settled on KC -7. Chargers QB Justin Herbert is expected to play in Week 4. That's bumped this total from a low of 39.5 to as many as 42 points on Sunday morning.

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Bills vs. Ravens odds

Josh Allen

Opening line

Even a one-sided win over Jacksonville on Monday night can't budge the spread for this huge AFC outing. Baltimore is a 2.5-point home chalk for Sunday Night Football, with the total staying between 45.5 and 46.5.

Also see: full Sunday Night Football odds

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Titans vs. Dolphins odds

Tyreek Hill

Opening line

Tennessee opened between -1 and +1.5 for this Monday matchup with Miami. The market has come back on the Dolphins, with recently signed QB Tyler Huntley getting the start in Week 4. That has the spread at Miami -2.5 on Sunday morning. This total is down to between 36.5 and 37.5 points.

Also see: full Monday Night Football odds

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Seahawks vs. Lions odds

Amon-Ra St. Brown

Opening line

Both teams were victorious in Week 3, with Detroit opening as a 4.5-point home favorite. Most operators were down to -3.5 with injuries to the Lions slimming that spread, but it's since rebounded to the opening number at several books on Sunday evening. This total opened at 48.5 points and is down as low as 46.5 points on Sunday.  

Also see: full Monday Night Football odds

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Best NFL bets this week

Looking for our favorite spread, total, and NFL prop bets for this week's action? Check out our best free NFL picks from the Covers staff!

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Jason Logan Senior Industry Analyst Covers.com
Senior Betting Analyst

In his 20 years with Covers, lead NFL betting analyst “JLo” has seen it all and bet it all. Through the wild west of early Internet gambling to lobbying for legalized sports betting to our brave new wagering world, Jason has been a consistent source of actionable info and entertainment for squares and sharps alike.

Since joining the Covers team back in 2005, he’s honed his handicapping skills to provide audiences with the most thorough insights, blending traditional capping methods with advanced modelling and predictive analysis. Jason has studied the ins and outs of the sports betting business, learning from some of the most successful gamblers in the industry and the biggest sportsbook operators on the planet.

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His best advice for bettors new and old is “Handicapping isn’t a ‘one size fits all’ process. The impact and importance of information varies from bet to bet. Treat each wager different than the last.”

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