NFL Week 11 Odds and Betting Lines: Niners -10 vs Wounded Cardinals

A clash between NFC West rivals in Mexico City wraps up Week 11 of the NFL season on Monday Night Football. The San Francisco 49ers are favored by 10 points as the Arizona Cardinals will be without starting QB Kyler Murray.

Last Updated: Nov 21, 2022 6:48 PM ET Read Time: 8 min
George Kittle San Francisco 49ers NFL
Photo By - USA TODAY Sports

NFL Week 11 has been a wild week, with a game being moved due to a snowstorm, winter weather and winds impacting odds, and it all wraps up with a south-of-the-border clash in Mexico City.

The San Francisco 49ers are the betting favorites at -10 over the Arizona Cardinals in the latest edition of the international series. The Cardinals are dealing with a variety of injuries, which could play into the Niners' favor. 

Here are the NFL Week 11 betting odds and action reports for today's games.

NFL Week 11 odds, lines, and spreads

These are the live NFL odds for Week 11, highlighting the best odds available from regulated sportsbooks within your area.

Teams on bye this week: Jaguars, Buccaneers, Seahawks, Dolphins

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Opening line

Falcons -3.5, 50 O/U

Why the line moved

10:00 A.M. SUNDAY, NOV. 20: As of Sunday morning, the Falcons are down to -2.5 at many books while there are a few -3 lines still available. BetMGM books are reporting 81% of tickets and 85% of money backing the visiting Bears. The total is sitting at 48.5 points after opening as high as 49.5.

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Opening line

Ravens -12.5, 45 O/U

Why the line moved

10:00 A.M. SUNDAY, NOV. 20: The Ravens can be had between -12.5 and -13 on Sunday morning. Baltimore is expected to have TE Mark Andrews back and RB Gus Edwards is up in the air, pending a pregame workout. This total has moved from as far as 45 points to as low as 41 on Sunday morning. The forecast for Baltimore is calling for wind gusts up to 32 mph and game-time temperatures feeling like 25 degrees. According to BetMGM, 66% of the money and 74% of bets are riding on the Panthers and the points while the Under has drawn 84% of the money and 74% of bets wagered on the total.

Opening line

Bills -8.5, 47 O/U

Why the line moved

10:00 A.M. SUNDAY, NOV. 20: After the game was moved to Detroit due to a massive snowstorm in Buffalo, the Bills weren’t sure if they would be able to travel to Motown. However, the team arrived in Detroit last night and Buffalo is currently sitting as a 7.5-point favorite for this neutral-site matchup with Cleveland after being as high as -9.5 at home for the original spread. According to BetMGM books, 79% of bets and 87% of the handle is backing the Bills. This total also changed dramatically, after falling to 41 points for what was supposed to be a wild winter day in Orchard Park. The new O/U – inside the domed confines of Ford Field – opened at 49.5 and has jumped to 50.5 points with 69% of the handle on the Over. 

Opening line

Texans +3.5, 40 O/U

Why the line moved

10:00 A.M. SUNDAY, NOV. 20: The Commanders are sitting as an expensive 3-point favorite at most books on Sunday morning, after slimming from an opener of -3.5. There are some shops back to the half-point hook on the spread. BetMGM books are reporting 77% of bets and 78% of money riding on Washington. This total is climbing to 41.5 after sitting as low as 40.5 points entering the weekend.

Opening line

Colts +7.5, 44 O/U

Why the line moved

3:24 P.M. ET, FRIDAY, NOV. 18: It's been a pretty quiet week for the betting numbers in this matchup. The pointspread has been at Eagles -6.5 for most of the week, although we're starting to see a few books flirt with -7 on Friday afternoon. The total is up slightly from 45 to 45.5.

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Opening line

Patriots -4, 39 O/U

Why the line moved

10:30 A.M. SUNDAY, NOV. 20: After falling from as much as -5, the Patriots are cheap -3.5 favorites hosting the Jets in Week 11. If more Jets action comes in this morning, this spread could fall to a field goal. DraftKings books are reporting 64% of bets and 63% of handle on New York while WynnBET shops shows 53% of tickets on the Patriots along with 62% of the money. This total is sitting as low as 38 points with the forecast in Foxborough calling for steady winds over 20 mph with gusts reaching 40 mph, cooling the “Feels Like” temperatures into the low 20s.

Opening line

Saints -1, 41 O/U

Why the line moved

10:30 A.M. SUNDAY, NOV. 20: With Rams QB Matthew Stafford in, but his favorite target WR Cooper Kupp out, Los Angeles is sitting as a 2.5-point underdog in the Big Easy. WynnBET books are reporting 55% of bets on New Orleans but 84% of the money backing the Rams as road underdogs. This total is sitting at 39.5 points.

Opening line

Giants -4, 46 O/U

Why the line moved

10:30 A.M. SUNDAY, NOV. 20: After falling from as high as -4 with sharp play taking the points with the Lions early in the week, the Giants are 3-point home favorites. However, public players have come back on New York and the G-Men are an expensive -3 at many mainstream books, indicating a potential move back to -3.5. WynnBET books are showing 75% of ticket count on the home team but 52% of the handle taking the points with Detroit. This total is down to 44.5 points as the forecast for East Rutherford is calling for winds over 20 mph with gusts up to 41 mph and temperatures feeling like 20 degrees. 

Opening line

Broncos -2.5, 42.5 O/U

Why the line moved

10:30 A.M. SUNDAY, NOV. 20: After sitting as 2.5-point home favorites most of the week, the Broncos are starting to climb to -3 for this AFC West matchup with Las Vegas but there has been buyback on the Silver and Black at those brief stops at Raiders +3. The Raiders are missing multiple skill players again and WR Davante Adams is expected to play through an abdominal injury. According to DraftKings, however, 60% of bets and 58% of the money is on Las Vegas. The total for this game is at 41.5 points.

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Opening line

Steelers +4.5, 43.5 O/U

Why the line moved

10:30 A.M. SUNDAY, NOV. 20: Pittsburgh has been a popular bet with sharp players as a home underdog, which has moved this spread from Steelers +5 to as low as +3.5 on Sunday morning. WynnBET books are reporting 53% of ticket count and 83% of money on Pittsburgh and the points. The total for this AFC North rivalry has dropped from 42.5 to 39.5 points with the forecast for Pittsburgh calling for wind gusts up to 25 mpg and game-time temperatures feeling like 17 degrees.

Opening line

Vikings +2, 48 O/U

Why the line moved

10:30 A.M. SUNDAY, NOV. 20: The Vikings opened as big as +2.5 at home for this run-in with the Cowboys and quickly got bet down to +1 early in the week. There has been some buyback on Dallas, which sits as big as -2 at some shops Sunday morning. According to DraftKings, 60% of bets are on the Vikings while 56% of handle is backing Dallas. WynnBET is reporting a much heavier handle on the home side, with 59% of tickets taking the home dog and 67% of the money on Minnesota. This total is sitting at 48.5 points with 65% of bets and 67% of money riding on the Over.

Chiefs at Chargers odds

Opening line

Chargers +6, 50 O/U

Why the line moved

10:30 A.M. SUNDAY, NOV. 20: The Sunday Night Football showdown between these AFC West foes dipped as low as Kansas City -4.5 with injuries to their receiving corps. However, this spread is back up to as high as Chiefs -5.5. The Chargers are hoping to have Keenan Allen back at WR and are expecting Mike Williams to return as well. That’s pumped this total up to 52.5 points after sitting as low as 50.5 earlier in the week. According to DraftKings, 70% of bets and 65% of money is on Kansas City as a road chalk while the Over has drawn 63% of tickets and 69% of handle on the total.

49ers at Cardinals odds

Opening line

Cardinals +5.5, 44 O/U

Why the line moved

6:45 P.M. MONDAY, NOV. 21: After the news of Kyler Murray missing tonight's game was announced this morning, the line shifted in the Niners' favor and now sits at -9.5 or -10 depending on the book. After the total dropped to 42.5 it has since been bet back up to 43 or 43.5. DraftKings is reporting 59% of bets and 71% of money on Arizona +10. For the total of 43, 68% of bets are on the Over, along with 63% of handle.

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