NFL Week 2 Odds: Chiefs Slim Faves Over Visiting Chargers

We're inching closer to the 2022 NFL season, with the full season's schedule released on Thursday night. Things will look to get spicy in the second week, as we bring you all the odds for the Week 2 matchups.

Last Updated: May 12, 2022 8:10 PM ET Read Time: 8 min
Patrick Mahomes Kansas City Chiefs NFL
Photo By - USA TODAY Sports

The NFL season will be here before we know it, and we now have access to all of Week 2's matchups.

With the release of the schedule, we see Week 2 will bring plenty of drama, with all 32 teams in action. This week's marquee matchup will take place when the Los Angeles Chargers visit the Kansas City Chiefs on Thursday Night Football.

Here are all of the NFL Week 2 odds and line moves to know.

These are the opening NFL odds for Week 2, headlined by the Chiefs as 3-point home favorites over the Chargers.

Matchup Time Spread Over/Under
Chargers at Chiefs Thurs, 8:20 p.m. ET Chiefs -3 52.5
Panthers at Giants Sun, 1 p.m. ET Giants -2.5 OTB
Dolphins at Ravens Sun, 1 p.m. ET Ravens -4 OTB
Patriots at Steelers Sun, 1 p.m. ET Steelers +1 OTB
Jets at Browns Sun, 1 p.m. ET OTB OTB
Commanders at Lions Sun, 1 p.m. ET Lions +3 OTB
Colts at Jaguars Sun, 1 p.m. ET Jaguars +6.5 OTB
Buccaneers at Saints Sun, 1 p.m. ET Saints +4 OTB
Falcons at Rams Sun, 4:05 p.m. ET Rams -13.5 OTB
Seahawks at 49ers Sun, 4:05 p.m. ET 49ers -8 OTB
Cardinals at Raiders Sun, 4:25 p.m. ET Raiders -4.5 OTB
Texans at Broncos Sun 4:25 p.m. ET Broncos -10 OTB
Bengals at Cowboys Sun, 4:25 p.m. ET PK OTB
Bears at Packers Sun, 8:20 p.m. ET Packers -7.5 OTB
Titans at Bills Mon, 8:15 p.m. ET Bills -7 OTB
Vikings at Eagles Mon, 9:30 p.m. ET Eagles -2.5 OTB

Odds courtesy of DraftKings as of May 12, 2022

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