NFL Week 2 Odds and Betting Lines: Pair of Monday Night Football Clashes Wrap Up Hectic Week

NFL Week 2 puts football bettors to the test, with plenty of overreactions to the opening week results. We wrap up the week with a pair of Monday Night Football clashes, including a Vikings-Eagles battle that bettors are banking on to go Over the total.

Last Updated: Sep 19, 2022 5:33 PM ET Read Time: 8 min
Justin Jefferson Minnesota Vikings NFL
Photo By - USA TODAY Sports

The second Sunday of the 2022 NFL season is just about done, but the week is hardly over.

The NFL Week 2 odds are known to be a bit reactive, at least after the betting public gets their say. We looked at the openers and action throughout the week, tracking the biggest line moves and adjustments right up until kickoff.

Now, we get a double-dose of the pigskin on Monday Night Football to put a pin in Week 2. The Buffalo Bills look to build off their impressive Week 1 victory over the reigning Super Bowl champs by knocking off the Tennessee Titans as 10-point home favorites. Later in the evening, we'll see the Minnesota Vikings travel to the City of Brotherly Love to face the Philadelphia Eagles, who are favored by nearly a field goal.

Here are the latest NFL odds for Week 2.

These are the latest NFL odds for Week 2, with the Bills and Eagles favored in their respective Monday Night Football clashes.

Matchup Time Spread Over/Under
Chargers at Chiefs Thurs, 8:20 p.m. ET Chiefs -4 54
Panthers at Giants Sun, 1 p.m. ET Giants +1 43.5
Dolphins at Ravens Sun, 1 p.m. ET Ravens -3.5 44
Patriots at Steelers Sun, 1 p.m. ET Steelers +3 40.5
Jets at Browns Sun, 1 p.m. ET Browns -6.5 39
Commanders at Lions Sun, 1 p.m. ET Lions -1 48
Colts at Jaguars Sun, 1 p.m. ET Jaguars +3 43.5
Buccaneers at Saints Sun, 1 p.m. ET Saints +2.5 44
Falcons at Rams Sun, 4:05 p.m. ET Rams -10 46
Seahawks at 49ers Sun, 4:05 p.m. ET 49ers -8.5 39.5
Cardinals at Raiders Sun, 4:25 p.m. ET Raiders -5.5 51.5
Texans at Broncos Sun 4:25 p.m. ET Broncos -10 45.5
Bengals at Cowboys Sun, 4:25 p.m. ET Cowboys +7.5 42
Bears at Packers Sun, 8:20 p.m. ET Packers -10 41.5
Titans at Bills Mon, 8:15 p.m. ET Bills -10 47.5
Vikings at Eagles Mon, 9:30 p.m. ET Eagles -2.5 50

Odds courtesy of DraftKings as of September 18, 2022

Best NFL sign-up bonuses

If you're signing up for a new sportsbook for the new NFL season, here are two of the best bonuses* available:

A) New users at FanDuel can bet $5 and get $150 in free bets! Sign Up Now

B) New users can get two risk-free bets up to $2,000 at PointsBet! Sign Up Now

*Eligible USA locations only

Opening line

Giants -2.5, 42.5 O/U

Why the line moved

11:30 A.M. ET, SUNDAY, SEPT. 18: Sunday morning money on Carolina has bumped the Panthers all the way from 2.5-point underdogs to 1-point road favorites at many sportsbooks, while other shops sit on the fence at a PK. Most books were reporting heavier ticket count on New York but relatively split money on this game.

BACK TO TOP

Opening line

Ravens -4.5, 45.5 O/U

Why the line moved

8:00 A.M. ET, SUNDAY, SEPT. 18: After the quick move from Baltimore  -4.5 to -3.5 in the first two days of action, the majority of books have held steady at that spread heading into Sunday. There is one sharper offshore operator down to Ravens -3 (-124) as of Sunday morning. Heading into the weekend, books were reporting two-way ticket count but more money riding on the Dolphins from that early-week movement. The total is at 44.5 points.

Opening line

Steelers +1, 41 O/U

Why the line moved

8:00 A.M. ET, SUNDAY, SEPT. 18: After a short move to Patriots -2 in the middle of the week, this spread is back to New England -2.5 at most shops with the vig up to -115, indicating a potential move to a field goal line if morning money taking the road team. The total is sitting as low as 40 points with a market consensus of 40.5/ Covers Consensus shows 65% of picks on Pittsburgh and 65% of total picks on the Under.

Opening line

Browns -6, 43 O/U

Why the line moved

8:00 A.M. ET, SUNDAY, SEPT. 18: The Browns are 6.5-point chalk at most operators with a few dealing Cleveland -6 as of Sunday morning. This total moved dramatically this week, sinking from 43 points to 39 and has now settled at 39.5 across the industry. Heading into the week books like DraftKings were reporting split ticket count on the total but 67% of handle taking the Under.

Opening line

Lions -1, 46.5 O/U

Why the line moved

8:00 A.M. ET, SUNDAY, SEPT. 18: As of Sunday morning, this matchup is all over the board. The Lions are as big as -2.5 favorite at Circa Colorado and the line is as low as pick’em at a number of sportsbooks. Detroit star RB D’Andre Swift is playing through an ankle injury and could be limited in the offense in Week 2. Covers Consensus shows 62% of picks on the Lions. This total opened at 46.5 and took sharp action on the Over all the way to 49.5. However, with the Swift news the number has slimmed as low as 48 points.

BACK TO TOP

Opening line

Jaguars +4, 45.5 O/U

Why the line moved

8:00 A.M. ET, SUNDAY, SEPT. 18: With Colts WR Michael Pittman out for Week 2 due to a quad injury, this spread has slimmed from Indianapolis -4 to -3. Some shops are dealing a soft Colts -3 with some down to EVEN money on the field-goal favorite, indicating a potential moved to -2.5. Covers Consensus shows 61% of picks on the Colts. The total has also moved, down from 45.5 to 45 points with a few spots down to 44.5 points.

Opening line

Saints +3, 47 O/U

Why the line moved

8:00 A.M. ET, SUNDAY, SEPT. 18: Saints RB Alvin Kamara could sit out Week 2 with a rib injury and will be a game-time decision for this NFC South showdown. The Bucs also have skill positions banged up, with WR Julio Jones questionable and Chris Godwin out. Those injuries are somewhat offsetting adjustments, with this spread still at Tampa Bay -2.5 with a handful of books down to -2. This total opened as high as 46 points last Monday and is down to 44 points as of Sunday morning. BetMGM books are reporting 66% of bets and 72% of handle on the Buccaneers while 56% of the money is siding with the Over.

Opening line

Rams -11, 48 O/U

Why the line moved

8:30 A.M. ET, SUNDAY, SEPT. 18:  The Rams are -10 across the industry as of Sunday morning, with BetMGM books reporting 73% of money riding on Los Angeles. This lookahead line was -13.5 before the start of the season and dropped to -12 after L.A.’s loss to Buffalo in the 2022 season opener. After the Falcons close loss to NOLA in Week 1, it re-opened -10 and bounced between that and Rams -10.5 this week. The total is down as low as 46.5 after opening at 48 points.

Opening line

49ers -10, 43 O/U

Why the line moved

8:30 A.M. ET, SUNDAY, SEPT. 18:  The 49ers range from -8.5 to -9.5 across the market as of Sunday morning. Covers Consensus is showing only 33% of picks on the host Niners while sportsbooks like BetMGM – which is dealing San Francisco -9 – is reporting 69% of picks on Seattle but split handle on this NFC West matchup. The total is down as low as 39.5 points with the forecast calling for rain and winds gusting up to 22 mph.

BACK TO TOP

Opening line

Raiders -3, 52.5 O/U

Why the line moved

8:30 A.M. ET, SUNDAY, SEPT. 18:  Early money moved this spread from as low as Raiders -3 to as high as -6 but that has slimmed to -5.5 with some books dealing Las Vegas as low as -5 as of Sunday morning. Covers Consensus shows 52% of picks on the home side while BetMGM books are reporting a similar split in ticket but 60% of the money on the Silver and Black. This total moved from 52 to 51.5 when it opened and has stayed steady at the number, despite more than 70% of total bets and handle on the Over.

Opening line

Broncos -10.5, 43.5 O/U

Why the line moved

8:30 A.M. ET, SUNDAY, SEPT. 18: Denver is -10 across the industry with some places upping the vig on the Broncos to -120, indicating a potential move to -10.5 — which is where the lookahead line was for this game before Week 1. BetMGM is taking 64% of bets and 72% of money on the home side. The total has seen significant movement this week, jumping from 43.5 to 46 points with play on the Over. Buyback on that has settled the total at 45.5 as of Sunday morning but there are some books as high as 46 and some as low as 45.

Opening line

Cowboys +6, 44.5 O/U

Why the line moved

8:30 A.M. ET, SUNDAY, SEPT. 18: Early money jumped on Cincinnati after the Dak Prescott injury news for the Cowboys QB. The lookahead line was Dallas -2.5 before his injury in Week 1, and books re-opened with the Cowboys as 6-point underdogs — which got pushed up as high as +8.5 before buyback trimmed the spread as low as a touchdown on Sunday morning. The total dropped from 44.5 points to 41.5. BetMGM books are reporting 81% of tickets on the Bengals and 83% of the handle on the visitor in Week 2.

Opening line

Packers -8.5, 44 O/U

Why the line moved

8:30 A.M. ET, SUNDAY, SEPT. 18: After opening at Green Bay -9, this spread has bounced on and off the key number of -10 all week. As of Sunday morning, the industry consensus is Packers -10 with Covers Consensus showing just 43% of picks on the Cheeseheads following their opening loss to Minnesota and Chicago’s upset of San Francisco in Week 1. The total opened at 44.5 points and sunk to as low as 41.5 points. BetMGM is reporting 67% of ticket count and 70% of the money on the Under for Sunday Night Football.

BACK TO TOP

Opening line

Bills -9, 50 /U

Why the line moved

5:30 P.M. ET, MONDAY, SEPT. 19: The Bills opened today between -9.5 and -10 depending on the book, and that has stayed steady throughout the day. DraftKings is reporting 67% of the bets on the Bills, along with 73% of the handle. On the total side, the line currently sits at 47.5 with most books. DK is also reporting 62% on the Over, but just 29% of the handle.

Opening line

Eagles -3, 50 O/U

Why the line moved

5:30 P.M. ET, MONDAY, SEPT. 19: The line can be found at -3 or -2.5 depending on the book, but the public still seems to be backing the Vikings, with DraftKings reporting 60% of bets on the Vikes. With that said, 70% of the handle is on Philadelphia. There is still heavy money on the 49.5 line as well, with DK having 65% backing the Over, and 75% of the handle.

More weekly NFL odds content

Pages related to this topic

Popular Content

Legal Canadian sports betting

Best Canadian betting sites Ontario sports betting
Covers 25 Years Logo Established in 1995,
Covers is the world
leader in sports
betting information.
Covers is verified safe by: Evalon Logo GPWA Logo GDPR Logo GeoTrust Logo Evalon Logo