NFL Week 2 odds wrap up with a coast-to-coast showdown on Monday Night Football, as the New York Giants (+6.5) visit SoFi Stadium to take on the Los Angeles Rams. Can the G-Men open the campaign with back-to-back upset wins?
With Week 2 rolling, we're tracking the latest NFL odds, spreads, outrights, and totals for the full slate, including tonight's main event in Inglewood.
NFL odds Week 2
| Matchup | Spread | Moneyline | Over/Under |
|---|---|---|---|
 Panthersvs  Falcons |
-2.5 53% +2.5 48% |
57% 43% |
o43.5 50% u43.5 51% |
 Vikingsvs  Bears |
+4.5 51% -4.5 50% |
34% 66% |
o47.5 51% u47.5 50% |
 Eaglesvs  Titans |
-7.5 47% +7.5 54% |
75% 25% |
o39.5 50% u39.5 50% |
 Steelersvs  Patriots |
+5.5 52% -5.5 48% |
31% 69% |
o41.5 49% u41.5 51% |
 Packersvs  Jets |
-3.5 46% +3.5 54% |
61% 39% |
o44.5 49% u44.5 52% |
 Brownsvs  Buccaneers |
+7.5 50% -7.5 51% |
22% 78% |
o41.5 49% u41.5 51% |
 Saintsvs  Ravens |
+8.5 52% -8.5 48% |
22% 78% |
o45.5 51% u45.5 50% |
 Bengalsvs  Texans |
+2.5 48% -2.5 53% |
41% 59% |
o45.5 49% u45.5 51% |
 Jaguarsvs  Broncos |
+2.5 48% -2.5 53% |
42% 58% |
o45.5 50% u45.5 50% |
 Raidersvs  Chargers |
+6.5 50% -6.5 50% |
28% 72% |
o43.5 49% u43.5 51% |
 Commandersvs  Cowboys |
+4.5 53% -4.5 48% |
35% 65% |
o50.5 52% u50.5 49% |
 Seahawksvs  Cardinals |
-3.5 51% +3.5 50% |
65% 35% |
o41.5 49% u41.5 51% |
 Dolphinsvs  49ers |
+13.5 52% -13.5 49% |
11% 89% |
o44.5 52% u44.5 49% |
 Coltsvs  Chiefs |
+5.5 50% -5.5 51% |
29% 71% |
o46.5 48% u46.5 52% |
 Giantsvs  Rams |
+6.5 48% -6.5 52% |
28% 72% |
o47.5 51% u47.5 50% |
Lines as of 9-21.
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Bengals vs Texans odds (Sunday, Sept. 20 at 1 p.m. ET, CBS)
Opening line
- Texans -2.5 (Kalshi probability: 70%)
- Over/Under 45.5
- View full Bengals vs. Texans odds and matchup
- Read our Bengals vs. Texans picks and predictions
We get a great AFC showdown on Sunday afternoon as Joe Burrow and the Cincinnati Bengals test the Houston Texans.
Houston lost a shootout to Buffalo and needs to tighten the bolts on this top-rated defense. Markets are moving toward the host, with the spread climbing to a field goal at most places.
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Jaguars vs Broncos odds (Sunday, Sept. 20 at 4:05 p.m. ET, CBS)
Opening line
- Broncos -2.5 (Kalshi probability: 87%)
- Over/Under 43.5
- View full Jaguars vs. Broncos odds and matchup
- Read our Jaguars vs. Broncos picks and predictions
Denver had a rough Monday in Kansas City but comes back home for this key AFC fight with Jacksonville. The Broncos are always tough in home openers and hit the board just short of field goal favorites. The Under opened just shy of the key number of 44 points.
Colts vs Chiefs odds (Sunday, Sept. 20 at 8:20 p.m. ET, NBC)
Opening line
- Kansas City -6.5 (Kalshi probability: 74%)
- Over/Under 47.5
- View full Colts vs. Chiefs odds and matchup
- Read our Colts vs. Chiefs picks and predictions
OK, Patrick Mahomes is fine. He led the Chiefs to a big win over Denver on Monday and that's powering this spread to -6.5 and boosting the total to 47.5 points. The Colts gave up 41 points to Baltimore in Week 1 and play their second straight road game in Week 2.
Also see: full Sunday Night Football odds
Giants vs Rams odds (Sunday, Sept. 21 at 8:15 p.m. ET, ESPN)
Opening line
- Rams -7.5 (Kalshi probability: N/A)
- Over/Under 48.5
- View full Giants vs. Rams odds and matchup
- Read our Giants vs. Rams picks and predictions
Public perception is contrasting for these teams. New York is coming off a huge home win on opening Sunday, kicking off the Harbaugh Era with a victory over Dallas.
The Rams return home from a trip Down Under and a bad loss to San Francisco in Week 1. On top of that, prized offseason add Myles Garrett is on the IR after just one game. Los Angeles opened -7.5 and has dropped as low as -6.5, despite a rest edge in Week 2.
Also see: full Monday Night Football odds
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Looking for our favorite spread, total, and NFL prop picks for this week's action? Check out our best free NFL picks from the Covers staff!
Odds are correct at the time of publishing and are subject to change.
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