NFL Week 7 Odds and Betting Lines: Injuries Cloud Over Monday Night Affair

After a week replete with upsets and injuries, sportsbooks have their work cut out for them when it comes to setting the NFL Week 7 odds.

Sunday featured a marquee non-conference clash on Sunday Night Football, with the Philadelphia Eagles walking away with a 31-17 victory that contained many head-scratching calls from the referees.

Week 7 come to a close on Monday night with the San Francisco 49ers taking on the Minnesota Vikings in a tilt that could be heavily influenced by — ALL TOGETHER NOW — injuries.

Here's a look at the opening NFL Week 7 odds and early line moves.

NFL Week 7 odds, lines, and spreads

These are the live NFL odds for Week 7, highlighting the best odds available from regulated sportsbooks within your area.

Jaguars vs. Saints odds

Opening line

• Saints PK
• Over/Under 42
• View full Jaguars vs. Saints line movement
• Read our Jaguars vs. Saints picks and predictions 

With Trevor Lawrence's bruised knee the center of attention, oddsmakers opened this game as tight as pick'em with some books leaning toward Jacksonville -1. The total opened 42 and slipped to 41 points quickly on Sunday night.

Also see: full Thursday Night Football odds

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Lions vs. Ravens odds

Opening line

• Ravens -2.5
• Over/Under 44
• View full Lions vs. Ravens line movement
• Read our Lions vs. Ravens picks and predictions 

This non-conference game could be the most fun matchup of Week 7. Baltimore opened as a 2.5-point home favorite, coming back from playing in London last weekend. Some books are down to Ravens -2. This total opened between 44.5 and 44 points and is down to as low as 43.5 on Sunday night.

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Raiders vs. Bears odds

Opening line

• Raiders -3
• Over/Under 40
• View full Raiders vs. Bears line movement
• Read our Raiders vs. Bears picks and predictions 

The look-ahead line had the Raiders laying one point on the road, but with Justin Fields suffering a dislocated thumb, his status for Week 7 is up in the air. Las Vegas will likely be starting backup Brian Hoyer with QB1 Jimmy Garoppolo leaving Week 6 and heading to the hospital with a back injury. Those QB injuries have taken this total from a look-ahead mark of 46.5 to an official Week 7 opener of 40 points.

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Browns vs. Colts odds

Opening line

• Colts +2
• Over/Under 41.5
• View full Browns vs. Colts line movement
• Read our Browns vs. Colts picks and predictions 

Browns QB Deshaun Watson is still day-to-day with a shoulder injury while Colts backup QB Gardiner Minshew will remain under center for the foreseeable future. The total hit the board as high as 41.5 points but early play on the Under has dropped this number as low as 39 points on Sunday night.

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Bills vs. Patriots odds

Opening line

• Patriots +8.5
• Over/Under 41
• View full Bills vs. Patriots line movement
• Read our Bills vs. Patriots picks and predictions 

The Bills knocked off the visiting Giants, 14-9, on Sunday Night Football and roll into Foxborough as 8.5-point road favorites over the struggling Patriots. The total had a lookahead number of 43.5, but officially opened the week at a much lower 41.

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Commanders vs. Giants odds

Opening line

• Giants +2
• Over/Under 40
• View full Commanders vs. Giants line movement
• Read our Commanders vs. Giants picks and predictions 

The Giants lost 14-9 on the road in Buffalo in Week 6, and return home to MetLife Stadium in Week 7 as 2-point home underdogs with their NFL East rivals from D.C. coming to town. The total had a lookahead number of 42, but opened the week at a much lower 40.

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Falcons vs. Buccaneers odds

Opening line

• Buccaneers -2.5
• Over/Under 40
• View full Falcons vs. Buccaneers line movement
• Read our Falcons vs. Buccaneers picks and predictions 

Tampa Bay opened as a 2.5-point home favorite to division rival Atlanta. The Falcons fell to Washington in Week 6, suffering their third loss in the past four games. This total opened at 40 points and is down to 39 at some shops on Sunday night.

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Steelers vs. Rams odds

Opening line

• Rams -3
• Over/Under 42
• View full Steelers vs. Rams line movement
• Read our Steelers vs. Rams picks and predictions 

The Rams opened as low as field goal favorites for Week 7 and quickly jumped to -3.5 in the opening hour of action Sunday night. Pittsburgh is coming off a bye after an ugly Week 5 win over Baltimore. This total opened at 42 points and is sitting at 42.5.

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Cardinals vs. Seahawks odds

Opening line

• Seahawks -7
• Over/Under 46.5
• View full Cardinals vs. Seahawks line movement
• Read our Cardinals vs. Seahawks picks and predictions 

Seattle opened as a touchdown favorite at home in this NFC West rivalry and early play has come in on the Seahawks, pushing the spread to -9 at some books on Sunday night. This total is bouncing between 45.5 and 46.5 points.

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Packers vs. Broncos odds

Opening line

• Broncos +2
• Over/Under 44.5
• View full Packers vs. Broncos line movement
• Read our Packers vs. Broncos picks and predictions 

The Broncos get a mini-bye after losing to Kansas City last Thursday while the Packers have had two weeks to heal up and prep for Week 7. Oddsmakers opened Green Bay as big as 2-point road chalk and that number is down to -1 at some shops on Sunday night. The total opened 44.5 and is sitting at 45 points.

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Chargers vs. Chiefs odds

Opening line

• Chiefs -5.5
• Over/Under 49
• View full Chargers vs. Chiefs line movement
• Read our Chargers vs. Chiefs picks and predictions 

The Chargers lost a hard-fought, 20-17, decision to the Dallas Cowboys at home on Monday Night Football. The Chiefs are coming off a mini-bye after dumping the Broncos, 19-8, on Thursday Night Football in Week 6. Books opened the Chiefs as 5.5-point home favorites for this Sunday afternoon clash with a total of 49.

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Dolphins vs. Eagles odds

Opening line

• Eagles -2.5
• Over/Under 51.5
• View full Dolphins vs. Eagles line movement
• Read our Dolphins vs. Eagles picks and predictions 

The Sunday Night Football game is a great one, with the Eagles opening between -2 and -2.5 for this huge non-conference clash. The total hit the board as low as 51.5 and has climbed to 53 points on Sunday night.

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49ers vs. Vikings odds

Opening line

• Vikings +7
• Over/Under 45.5
• View full 49ers vs. Vikings line movement
• Read our 49ers vs. Vikings picks and predictions

The 49ers are coming off a stunning loss at Cleveland and play their second straight road game with a number of big-name injuries, including RB Christian McCaffrey and WR Deebo Samuel. The books that did open this game have San Francisco as 7-point road chalk with a total at 44.5 points.

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