NFL Week 3 Odds: Texans Major Underdogs at Home on Thursday Night Football

The hard-luck Houston Texans will play in primetime at home on Thursday, welcoming the upstart Carolina Panthers. They'll be heavy underdogs with rookie QB Davis Mills under center, getting more than a TD. That and more in the full Week 3 NFL betting odds.

Posted: May 17, 2021 12:27 PM ET Updated: Sep 22, 2021 7:55 PM ET Est Time: 8 min

Week 3 of the NFL season is headlined by a powerhouse showdown between a pair of the NFC's best.

The Tampa Bay Buccaneers, who escaped a slight scare from the Atlanta Falcons en route to a blowout win (and double-digit cover) in Week 2, head to Los Angeles as favorites against the Rams, who are off to a 2-0 start behind new QB Matthew Stafford.

The week kicks off with a clash between the undefeated Carolina Panthers and the Houston Texans on Thursday and wraps up with the NFC East rival Dallas Cowboys and Philadelphia Eagles colliding in Arlington on Monday Night Football.

Here's the list of all the NFL Week 3 matchups and odds.

NFL odds for Week 3 are headlined by the undefeated Buccaneers visiting the 2-0 Rams as 1-point road underdogs, while the Cowboys are 4-point chalk in an NFC East showdown with the Eagles on Monday Night Football.

Matchup Time Spread Over/Under
Panthers at Texans Thurs, 8:20 p.m. ET Texans +8 43
Colts at Titans Sun, 1 p.m. ET Titans -5.5 48
Falcons at Giants Sun, 1 p.m. ET Giants -3 47.5
Chargers at Chiefs Sun, 1 p.m. ET Chiefs -6.5 55
Bengals at Steelers Sun, 1 p.m. ET Steelers -3 43.5
Bears at Browns Sun, 1 p.m. ET Browns -7 45.5
Ravens at Lions Sun, 1 p.m. ET Lions +9 49.5
Saints at Patriots Sun, 1 p.m. ET Patriots -3 42.5
Cardinals at Jaguars Sun, 1 p.m. ET Jaguars +7 51.5
Washington at Bills Sun, 1 p.m. ET Bills -7.5 45.5
Jets at Broncos Sun, 4:05 p.m. ET Broncos -10 42
Dolphins at Raiders Sun, 4:05 p.m. ET Raiders -4 45
Seahawks at Vikings Sun, 4:25 p.m. ET Vikings +1.5 55.5
Buccaneers at Rams Sun, 4:25 p.m. ET Rams +1.5 55
Packers at 49ers Sun, 8:20 p.m. ET 49ers -3 50.5
Eagles at Cowboys Mon, 8:15 p.m. ET Cowboys -3.5 51.5

Odds courtesy of DraftKings Sportsbook as of September 22, 2021

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Opening line

Texans +7, Over/Under 43.5

Why the line moved

UPDATE 8:10 A.M. ET, MONDAY SEPT. 20: Carolina opened as a touchdown favorite on the road in Houston and was quickly bet up to -7.5, due to the Texans’ QB situation. 

Starter Tyrod Taylor will miss Week 3 with a hamstring injury, leaving rookie Davis Mills under center on a short week of preparation. Of course, Houston still has Deshaun Watson on the roster and his status for Week 3 is foggy after a falling out with the franchise and multiple sexual assault accusations this offseason.  

The total for this game opened at 43.5 points.

Opening line

Titans -5, Over/Under 50

Why the line moved

UPDATE 8:20 A.M. ET, MONDAY SEPT. 20: With the status of Colts QB Carson Wentz (ankle) up in the air as of Sunday night, oddsmakers opened Indianapolis as 5-point road underdog at Tennessee — a dead number that would allow them more line flexibility to move off injury news. 

Most books are staying at Titans -5, however, FanDuel sportsbooks dropped to -4.5 shortly after posting the Week 3 spread. The Colts would turn to Jacob Eason as QB in Week 3 if Wentz is unable to go. The total for this AFC South rivalry opened at 50 points.

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Opening line

Giants -3.5, Over/Under 48.5

Why the line moved

UPDATE 8:30 A.M. ET, MONDAY SEPT. 20: This spread opened with the Giants as 3-point home chalk, enjoying a mini-bye after a close loss to Washington last Thursday, which is the first time New York has been a point spread favorite since Week 12 of last season. The total opened at 48.5 points and could climb considering Atlanta has hemorrhaged 80 total points in the first two games of 2021.

Opening line

Chiefs -6.5, Over/Under 55.5

Why the line moved

UPDATE 6:30 P.M. ET, TUESDAY SEPT. 21: A vital AFC West war will be waged in Arrowhead Stadium in Week 3. The lookahead line for this divisional game was as big as Chiefs -7 and after their loss at Baltimore on Sunday night, they opened as 6.5-point favorites. 

Opening line

Steelers -4.5, Over/Under 45

Why the line moved

UPDATE 7:55 P.M. ET, WEDNESDAY SEPT. 22: Despite the uncertainty still surrounding Ben Roethlisberger (among other key Steelers starters), this game is back on the board after coming down on Tuesday. After coming down at Steelers -4.5 with a total of 45, it came back at Pittsburgh -3 with a total of 43.5.

Opening line

Browns -7.5, Over/Under 47

Why the line moved

UPDATE 8:45 A.M. ET, MONDAY SEPT. 20: Injuries plagued the Browns’ win over Houston in Week 2, with QB Baker Mayfield, WR Jarvis Landry, and a slew of other Cleveland starters listed as questionable for Week 3. The spread opened with Cleveland as high as -7.5 and those injury concerns have swayed the vig on the Browns from -110 to -105. Chicago will likely be starting rookie QB Justin Fields on the road with Andy Dalton suffering a knee injury in Week 2.

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Opening line

Detroit +9, Over/Under 49.5

Why the line moved

UPDATE 6:30 P.M. ET, TUESDAY SEPT. 21: The early line on his matchup had Detroit getting 7.5 points from the visiting Ravens. After the Ravens played and won in a massive Sunday Night Football matchup, then the Lions put up a dud on MNF, it went back on the board with the 0-2 Lions getting 9.0 points.

Opening line

Patriots -3, Over/Under 42.5

Why the line moved

UPDATE 9:05 A.M. ET, MONDAY SEPT. 20: New England opened as a field-goal favorite at home, taking on a Saints squad technically playing in its third straight travel game due to being displaced by Hurricane Ida before Week 1. New Orleans looked terrible in a loss at Carolina in Week 2, with a good chunk of the coaching staff out due to COVID-19 exposure, while the Patriots beat up on the Jets and rookie QB Zach Wilson. The total for this game is set at 43 points — one of the lowest Over/Under numbers in Week 3.

Opening line

Jaguars +7, Over/Under 52

Why the line moved

UPDATE 9:05 A.M. ET, MONDAY SEPT. 20: Arizona opened as a touchdown favorite on the road in Florida and that line quickly jumped to -7.5 at some books Monday morning, with others dealing Arizona -7 (-115). The Cardinals offense has produced 72 points in two games while the Jaguars have allowed 60 points against in that span. The total for this non-conference clash opened as low as 51 points and has climbed to 52.

Opening line

Bills -9.5, Over/Under 46.5

Why the line moved

UPDATE 9:10 A.M. ET, MONDAY SEPT. 20: The Washington Football Team has enjoyed a mini bye, thanks to a close win last Thursday, and now hits the road for the first time in 2021. Bookies opened Buffalo between -8.5 and -9.5, with some shops splitting the difference at Bills -9 (-110). The total for this non-conference game opened 47.5 and has dipped to 46.5 as of Monday morning.

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Opening line

Broncos -11, Over/Under 41.5

Why the line moved

UPDATE 9:15 A.M. ET, MONDAY SEPT. 20: What a difference two games can make. The lookahead line for this game was sitting at Denver -5.5 heading into the season, however, with the Broncos going 2-0 and the Jets falling to 0-2, books installed the home side as an 11-point favorite in Week 3. This spread has climbed to -11.5 at some books while others are dealing -10.5.

Denver hasn’t been a double-digit favorite since Week 6 of the 2017 season but is a tough team to beat in home openers, going 18-3 SU and 13-4-4 ATS in its first homestand of the schedule since 2000. The total for Week 3’s tilt is sitting at 41 points after moving down from 41.5 — the lowest O/U number on the board.

Opening line

Raiders -5.5, Over/Under 45.5

Why the line moved

UPDATE 6:40 P.M. ET, TUESDAY SEPT. 21: After somewhat positive news surrounding the status of Tua Tagovailoa, the spread shifted from Dolphins +5.5 to +3.5, though more movement is sure to come as Miami's picture under center clears up ahead of Sunday. 

The spread's shift did little to impact the total, which moved from 45.5 to 45.

Opening line

Vikings +1, Over/Under 55

Why the line moved

UPDATE 9:25 A.M. ET, MONDAY SEPT. 20: The 0-2 Vikings opened as 1-point home underdogs for Week 3, hosting the Seahawks, who are coming off a collapse (and overtime loss) to Tennessee in their homer opener in Week 2. This spread is sitting as high as Minnesota +1.5 at some books, with our Covers Consensus showing 69 percent of early picks on Seattle. The total for this game is opened at 56 points and has come down to 55.5.

Opening line

Rams +1.5, Over/Under 54.5

Why the line moved

UPDATE 6:40 P.M. ET, TUESDAY SEPT. 21: Well, that was short-lived. After Tampa Bay opened the week getting points in a rare spot as underdogs, action on the Bucs has shifted the line to TB -1. The total continues to climb, from 53.5 at opening to 55.5 as of Tuesday evening. 

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Opening line

49ers -4, Over/Under 48.5

Why the line moved

UPDATE 9:35 A.M. ET, MONDAY SEPT. 20: With the Packers still to play the Lions on Monday Night Football in Week 2, the early spread on this one has San Francisco as 4-point home favorites. Some books are down to 49ers -3.5 with injuries mounting for the home side. This line will come down before the Monday game and repost with reaction to those results. A strong showing from the Packers (-11.5 vs. Detroit) could slim this to a field goal spread.

Opening line

Cowboys -4, Over/Under 48.5

Why the line moved

UPDATE 9:50 A.M. ET, MONDAY SEPT. 20: A classic NFC East rivalry gets the Monday spotlight in Week 3 with the Eagles visiting the Cowboys, set between +3.5 and +4. Bettors have been bullish on Philadelphia the past two weeks but with the Eagles losing at home to San Francisco — and the Cowboys putting in two impressive performances to start the season (close loss to Tampa, win at Chargers) — this spread could grow as the public pounds “America’s Team” closer to the weekend. 

The total for this finale opened as low as 48 points and is on the board at 47.5 and 48.5, depending on where you bet.

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