Derrick Henry is already a lock for the Hall of Fame, and the 31-year-old is showing no signs of slowing down following Week 1.
The Baltimore Ravens superstar is coming off a 169-yard, two-touchdown rushing performance against Buffalo, and he looks primed for another rushing title.
Spearheading the 2025-26 NFL Offensive Player of the Year odds, Henry is set for another monster season at FanDuel, with Saquon Barkley and Puka Nacua also headlining the NFL odds.
NFL Offensive Player of the Year odds
| Player | Team | Position |  |
|---|---|---|---|
| Derrick Henry |  Baltimore Ravens |
RB | +600 |
| Saquon Barkley |  Philadelphia Eagles |
RB | +750 |
| Puka Nacua |  Los Angeles Rams |
WR | +1200 |
| Christian McCaffrey |  San Francisco 49ers |
RB | +1300 |
| CeeDee Lamb |  Dallas Cowboys |
WR | +1400 |
| Bijan Robinson |  Atlanta Falcons |
RB | +1400 |
| Ja'Marr Chase |  Cincinnati Bengals |
WR | +1400 |
| Justin Jefferson |  Minnesota Vikings |
WR | +1500 |
| Jahmyr Gibbs |  Detroit Lions |
RB | +1500 |
| Malik Nabers |  Houston Texans |
WR | +2200 |
Odds as of 9-9-2025.
NFL Offensive Player of the Year betting splits
Highest ticket percentage:
• Ja'Marr Chase 13.2%
Highest handle percentage:
• Ja'Marr Chase 13.7%
Biggest liabilities:
• Ja'Marr Chase
All data courtesy of BetMGM.
Popular NFL futures markets
NFL Offensive Player of the Year betting trends
• Since this award was first given out in 1972, seven offensive players have claimed this award more than once. However, Jerry Rice is the only receiver to win it multiple times.
• Only four receivers have won OPOY since '72, but three of the four (Michael Thomas, Cooper Kupp, and Justin Jefferson) have won it in the last five years.
• Among the 51 Offensive Player of the Year winners, 28 were named Most Valuable Player in the same season.
• Running backs have won OPOY the most, with 29, and quarterbacks are second with 20.
NFL Offensive Player of the Year history
A quick look at the NFL OPOY winners since 2000 and the position they played.
| Year | NFL OPOY Award Winner | Position |
|---|---|---|
| 2024 | Saquon Barkley | RB |
| 2023 | Christian McCaffrey | RB |
| 2022 | Justin Jefferson | WR |
| 2021 | Cooper Kupp | WR |
| 2020 | Derrick Henry | RB |
| 2019 | Michael Thomas | WR |
| 2018 | Patrick Mahomes | QB |
| 2017 | Todd Gurley | RB |
| 2016 | Matt Ryan | QB |
| 2015 | Cam Newton | QB |
| 2014 | DeMarco Murray | RB |
| 2013 | Peyton Manning | QB |
| 2012 | Adrian Peterson | RB |
| 2011 | Drew Brees | QB |
| 2010 | Tom Brady | QB |
| 2009 | Chris Johnson | RB |
| 2008 | Drew Brees | QB |
| 2007 | Tom Brady | QB |
| 2006 | LaDainian Tomlinson | RB |
| 2005 | Shaun Alexander | RB |
| 2004 | Peyton Manning | QB |
| 2003 | Jamal Lewis | RB |
| 2002 | Priest Holmes | RB |
| 2001 | Marshall Faulk | RB |
| 2000 | Marshall Faulk | RB |
NFL OPOY Odds FAQs
Baltimore Ravens running back Derrick Henry is the current OPOY odds leader at +600.
Philadelphia Eagles RB Saquon Barkley won the 2024 OPOY award.
