Ole Miss will look to keep their slim playoff hopes alive in Week 11 when it visits Oklahoma at Memorial Stadium on Saturday, Nov. 14.
Kickoff is scheduled for 4:15 p.m. ET on SEC Network, with the Sooners favored by 1.5 points and the total set at 49.5.
My Ole Miss vs. Oklahoma prediction and college football picks have the Sooners taking care of business in front of their home fans.
TOP PICK
Who will win Ole Miss vs Oklahoma: Oklahoma -1.5
Playable to 54%.
Following a promising start to the 2026 campaign, Ole Miss has done potentially irreversible damage to their playoff hopes with two losses in the last three weeks.
Last weekend, Georgia dominated Ole Miss from the opening kickoff (91.9% win probability at the end of the 1st quarter), to the point that head coach Pete Golding told his team at the half that he wasn't worried about the score — he only wanted his players to focus on putting good effort on tape in the final two quarters.
Ole Miss's defense has been nowhere to be found against quality opponents, most recently getting outgained 481-252 at home by Georgia last weekend.
Oklahoma's strength is its stop unit, but John Mateer & Co. are also coming off a 10-for-18 showing on third down against Florida, dominating time of possession in the process. They should have a field day against the Rebels in Norman.
COVERS INTEL: Trinidad Chambliss, who has struggled to a 4-to-5 TD-to-INT ratio across his last three games. He's been increasingly unproductive when under duress — completing only 37.5% of his pass attempts when pressured this season.
Ole Miss vs Oklahoma Over/Under pick: Under 49.5
Playable to 54%.
The Sooners dominated Florida last weekend, holding them to 203 yards of total offense and only 11 first downs. They had a similarly dominant showing against No. 15 Kentucky earlier this year, too, limiting them to 230 yards of offense.
Oklahoma generated a 46.2% pressure rate last weekend against Florida. If the Sooners can get anywhere close to that number again in Week 11, Chambliss' struggles will continue, making it difficult for Ole Miss to move the ball consistently.
Ole Miss vs Oklahoma combo
Playable to 28%.
Oklahoma is coming off a 23-7 win over Florida and has been competitive in lower-scoring matchups against No. 1 Texas (27-24 win), No. 15 Kentucky (21-13 loss), and Michigan (17-10).
However, the Sooners have struggled to keep pace in games where the combined score approaches 60 points.
Taking OU on the side and the Under is a correlated combo in this SEC showdown.
Ole Miss vs Oklahoma combo
- Oklahoma moneyline
- Under 49.5
- Top picks: 10-8 +1.40 units
- Combos: 8-12, +6.57 units
Ole Miss vs Oklahoma odds
For help understanding probabilities, see our odds calculator.
- Spread: Ole Miss -1.5 | Oklahoma +1.5
- Over/Under: Over 49.5 (49%) | Under 49.5 (52%)
- Moneyline: Ole Miss 50% | Oklahoma 51%
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Ole Miss vs Oklahoma weather
The forecast for this weekend's game between Ole Miss and Oklahoma looks uneventful.
Cooler temperatures and wind gusts could have a minimal impact on downfield passing, but there is no precipitation expected, which should result in a relatively clean game.
Check out our college football weather page for up-to-date info on every matchup.
Ole Miss vs Oklahoma trend to know
Oklahoma has hit the moneyline in seven of its last 12 games (+1.65 Units / 4% ROI). Find more college football betting trends for Ole Miss vs. Oklahoma.
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How to watch Ole Miss vs Oklahoma
| Location | Memorial Stadium, Norman, Okla. |
| Date | Saturday, Nov. 14, 2026 |
| Kickoff | 4:15 p.m. ET |
| TV | SEC Network |
Ole Miss vs Oklahoma latest injuries
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