Despite a 4-1 record to open their season, the Philadelphia Eagles aren’t exactly giving off Super Bowl vibes so far. But that could change quickly as they head to MetLife Stadium to take on the embarrassment that is the New York Giants in the Week 6 edition of Thursday Night Football.
After playing a string of playoff contenders, this will be Philadelphia’s easiest test to date, as they’re favored by 7.5 points. The game also features one of the lowest totals of the week at 40.5.
My Eagles vs. Giants predictions think this matchup sets up particularly well for Saquon Barkley to have his first breakout game of the season. Check out my free NFL picks for October 9.
Eagles vs Giants prediction
Eagles vs Giants Best bet: Saquon Barkley Over 84.5 rushing yards (-114)
Much has been made of a slow start in 2025 for Saquon Barkley and that’s very much justified as he’s only averaging 53.4 rushing yards per game.
However, he’s yet to face a rushing defense as poor as the New York Giants', which ranks 29th in yards per rush attempt allowed. That ranking for the Giants is even worse when you consider they still haven’t faced an elite running back this season.
New York could be in a lot of trouble against their former teammate as Barkley absolutely went off against them in their lone head-to-head last season, rushing for an insane 176 yards on just 17 attempts.
Some might scoff at the motivation factor for Barkley, but I think those 176 yards are good evidence that he was eager to face his former team. There’s no reason not to expect a similar mindset, especially after coming off a loss in Week 5.
Don’t be surprised to see Barkley break a big one or two as the Giants have already allowed five runs of 20+ yards, which is the fourth-most in the NFL entering Week 6.
It is a short week, but Barkley’s coming off a game where he only had six rush attempts. He had 18 or more in his previous four games this season, so he should be relatively fresh.
Barkley has been limited in practice this week due to general soreness, but it’s been reported that he fully expects to play.
Eagles vs Giants TNF same-game parlay
Can you tell I like Saquon and the Philadelphia Eagles to bounce back?
Yes, the Eagles have shown some cracks early on, but they’re still 4-1, and this sets up to be their lightest opponent up to this point in the season after playing a string of playoff contenders.
This is a similar spot to last season when the Eagles got off to a shaky 3-2 start then smashed the Giants 28-3 in a Week 7 game which put a dominant run in motion.
Let's round things out with a logical addition of Barkley breaking the plane to put the cherry on top of a big rushing day.
Eagles vs Giants SGP
- Saquon Barkley Over 84.5 rushing yards
- Eagles -7
- Saquon Barkley anytime touchdown
Our big-ticket SGP: Barkley breaks free
This young Giants defense has been beat for five runs of 20+ yards so far this season. Last season, Barkley topped this mark in 13 regular season games, including a 55-yard run in that Giants game.
Eagles vs Giants SGP
- Eagles -7
- Saquon Barkley Over 84.5 rushing yards
- Saquon Barkley anytime touchdown
- Saquon Barkley longest rush Over 16.5 yards
Eagles vs Giants odds
- Spread: Philadelphia -7.5 | New York +7.5
- Moneyline: Philadelphia -390 | New York +310
- Over/Under: Over 40.5 | Under 40.5
Eagles vs Giants betting trend to know
The Giants have only covered the first-half spread in five of their last 19 games (-8.45 units / -39% ROI). Find more NFL betting trends for Eagles vs. Giants.
How to watch Eagles vs Giants
| Location | MetLife Stadium, East Rutherford, NJ |
| Date | Thursday, October 9, 2025 |
| Kickoff | 8:15 p.m. ET |
| TV | Amazon Prime |
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