With Shane Steichen on the hot seat following a rough 2-4 start, the Indianapolis Colts are teetering on the brink of a lost season as 6.5-point road underdogs for Sunday's matchup against the unbeaten Minnesota Vikings.
Fresh off a bye week and sitting atop an ultra-competitive NFC North with a 71% win probability in lines on Kalshi, my top Colts vs. Vikings predictions and NFL picks anticipate Minnesota's aggressive defense setting the tone for another comfortable home victory at U.S. Bank Stadium ahead of the 1 p.m. ET kickoff on CBS on Sunday, Oct. 25.
TOP Pick
Colts vs Vikings prediction today: Vikings -6.5
This ruthless Minnesota Vikings start is no fluke, as they've won 10 straight games dating back to last season, with an 8-2 ATS mark in that span, and their blitzing defense has Daniel Jones in its sights on Sunday.
Brian Flores' aggressive unit ranks among the stingiest in the league against both the pass and the run (just 259.8 YPG allowed overall), and that spells trouble for an Indianapolis Colts team that's lost 11 of its past 13 contests and had three costly turnovers last weekend.
Minnesota's bye week has also cleaned up the injury report, with T.J. Hockenson, Jordan Addison and Jordan Mason returning to diversify an offense that racked up 364 yards in Week 5 and capitalized on the defense's forced field position.
Meanwhile, Indy is unlikely to have Sauce Gardner to throw at the Justin Jefferson assignment and could also be without key target Tyler Warren. Jones has already turned the ball over nine times through the first six games, and I'd bet this to 53%.
For a spread pick on every game, see our NFL picks against the spread for Week 7.
COVERS INTEL: The Vikings are sending extra pressure on 70.4% of snaps this season, and Jones' completion rate drops to 61% against the blitz, with an average of just 5.49 YPA against that look.
Colts vs Vikings combo
I expect a Minnesota win to come with a sharper offensive outing, with an extra week of preparation and more weapons for Kyler Murray to call on. The Vikings scored 39 points in their home opener against Green Bay, while the Colts gave up at least 30 points in road losses to Pittsburgh and Kansas City.
The Over has been a winning ticket in Indy's last two contests, and this line feels too low for a matchup featuring Jefferson and (possible trade candidate) Jonathan Taylor on an indoor track.
Jones' brief spell with the Vikings in 2024 at least means he knows what to expect here. Expect the Indy offense to lean heavily on Taylor and quick checkdowns. That's where Keenan Allen can thrive on Sunday, and he's been busy in his last three appearances, catching 19 of 29 targets for 190 yards.
The Minnesota blitz will limit Jones' deep shots, but Allen's ability to win on short routes is highly valuable in this matchup.
Colts vs Vikings combo
- Vikings moneyline
- Over 41.5
- Keenan Allen Over 39.5 receiving yards
Colts vs Vikings player prop: Kyler Murray Over 199.5 passing yards
Murray’s start with the Vikings has been bumpy, but he’s found a rhythm with 225+ passing yards in back-to-back games.
The ceiling is even higher here, with a healthier supporting cast for this Week 7 battle, and chunk plays are on offer against a banged-up Indy defense, especially with Addison’s ability to stretch the field (average depth of target: 14.2 yards).
Indoor conditions play to Murray’s strengths, and he’s gone past this number in his last eight home outings in Arizona and Minnesota (excluding the brief start in this year’s season opener).
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For more same-game parlays, see our NFL parlay and SGP picks.
Colts vs Vikings touchdown scorer: Justin Jefferson
This is a great price on a Jefferson touchdown, especially with Gardner expected to be sidelined and the Colts' secondary overmatched.
The Vikings' No. 1 receiver already has three scores this season, and he shouldn't be tied down by as many double teams with Addison and Hockenson back this weekend.
Jefferson had two TDs in the season opener at U.S. Bank Stadium, and this is a favorable matchup against an Indy defense that gave up six passing touchdowns in road losses to Patrick Mahomes and Aaron Rodgers.
For more touchdown props, see our NFL anytime touchdown picks for Week 7.
- Top picks: 2-3, -1.31 units
- Combos: 1-4, -1.0 units
More Week 7 NFL picks and predictions
- NFL AI predictions for Week 7
- NFL picks against the spread for Week 7
- NFL moneyline picks for Week 7
- NFL anytime touchdown picks for Week 7
- NFL touchdown parlay for Week 7
- NFL picks and computer predictions
- Steelers vs. Saints prediction and picks
- Browns vs. Titans prediction and picks
- Giants vs. Texans prediction and picks
- Rams vs. Raiders prediction and picks
- Packers vs. Lions prediction and picks
Colts vs Vikings odds today
For help understanding probabilities, see our odds calculator.
- Spread: Colts +6.5 | Vikings -6.5
- Over/Under: Over 41.5 (51%) | Under 41.5 (51%)
- Moneyline: Colts 29% | Vikings 71%
See our NFL moneyline picks for every Week 7 game.
Follow the Colts vs. Vikings market prices on Kalshi up to kickoff.
For the full slate of NFL matchups, see our NFL odds board.
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Colts vs Vikings weather
U.S. Bank Stadium is a dome, protecting against any weather challenges and serving up a clean indoor track.
See our NFL weather page for up-to-date info on every matchup.
Colts vs Vikings trend to know
The Colts have lost seven straight on the road (non-Europe games). Find more NFL betting trends for Colts vs. Vikings, and see our NFL AI predictions for score projections on every Week 7 game.
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How to watch Colts vs Vikings
| Location | U.S. Bank Stadium, Minneapolis |
| Date | Sunday, Oct. 25, 2026 |
| Kickoff | 1 p.m. ET |
| TV | CBS |
Colts vs Vikings latest injuries
See our NFL injuries page for updates on every team.
Odds are correct at the time of publishing and are subject to change.
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