Marking their first visit to Stillwater since 2009, Colorado takes on Oklahoma State tonight at 7 p.m. ET on FS1.
Kalshi lists the Cowboys as 13.5-point home favorites with an over/under of 56.5, and my Colorado vs. Oklahoma State prediction locks in on the spread, full-game total, and first quarter.
For more Week 8 analysis and betting angles, see our latest college football picks, along with our Week 8 college football top picks and Brad Powers' Week 8 predictions.
TOP PICK
Who will win Colorado vs Oklahoma State today? Pick: Colorado +13.5
I'm backing the Colorado Buffaloes +13.5 and would play them down to +12.5. Colorado has one of the most underrated defenses in the country and just delivered its best offensive performance of the season against a better defense than the Oklahoma State Cowboys have.
Colorado averaged a season-high 7.2 yards per play in last week's 27-24 loss to Utah as a 15.5-point underdog. The Utes rank 21st nationally in yards per play allowed, while Oklahoma State sits 68th.
The matchup looks even better through the air. The Cowboys' pass defense has been torched over the last two weeks, allowing opponents to complete 72% of their passes for 608 yards and nine touchdowns.
Oklahoma State will also be without starting safety Mose Phillips III. Check the college football injury report for the latest on both teams. For more spread plays, see our college football Week 8 picks against the spread.
COVERS INTEL: According to GameOnPaper.com, Colorado ranks fourth nationally in EPA per play, adjusted for opponent strength and home-field advantage, with garbage time excluded.
Colorado vs Oklahoma State Over/Under pick: Under 56.5
I'd play Under 56.5 down to 55.5, especially with 55 being a key number for college football totals.
The Buffaloes are also dealing with significant offensive injuries. They'll be without second-leading rusher Micah Welch, who leads the team with two rushing touchdowns, along with offensive lineman Jayven Richardson.
Last week's Over against Utah was misleading, too. The teams combined for just 13 first-half points before Colorado scored a meaningless touchdown with 1:24 remaining.
Outside of that result, the Buffaloes are 1-2 to the Under in Big 12 games this season, and their injuries give me another reason to expect a lower-scoring game. For more totals, see our college football Week 8 Over/Under picks.
Colorado vs Oklahoma State prop: First-quarter Under 13.5
I'd play the first-quarter Under 13.5 down to 10.5.
The Cowboys are prone to slow starts, averaging just 5.0 first-quarter points per game, which ranks 91st nationally. Four of Oklahoma State's five games against FBS opponents have produced 10 or fewer combined first-quarter points.
Colorado allows just 3.4 first-quarter points per game against FBS opponents, ranking 29th nationally. Each of the Buffaloes' five games against FBS programs has also featured 10 or fewer combined first-quarter points.
Colorado vs Oklahoma State combo
I don't need Colorado to win this game. I just need the Buffaloes to make Oklahoma State earn everything.
A slow first quarter would keep Colorado from falling into an early hole and allow this to become the kind of ugly game I'm expecting. If the Buffaloes are still hanging around in the second half, there's no reason for either team to start playing with its hair on fire.
That's the script: start slowly, keep Colorado within striking distance, and force Oklahoma State to grind through four quarters instead of running away with it. For player-level angles, see our Week 8 college football player props and anytime touchdown picks.
Colorado vs Oklahoma State combo
- Colorado +13.5
- Under 56.5
- First-quarter Under 13.5
More multi-leg plays are in our Week 8 college football parlays and combos.
- Top picks: 13-17, -5.20 units
- Combos: 3-27, -17.84 units
More Week 8 college football picks
These Covers pages cover multiple games on today's Week 8 slate.
- Week 8 college football top picks for today
- Brad Powers' Week 8 college football predictions and best bets
- Week 8 college football AI predictions
- Week 8 Top 25 college football predictions with watchability ratings
- Week 8 Group of 6 college football predictions
- Week 8 college football picks against the spread
- Week 8 college football moneyline picks
- Week 8 college football Over/Under picks
- Week 8 college football parlays and combos
- Week 8 college football anytime touchdown picks
- Week 8 college football player props
Colorado vs Oklahoma State odds today
For help understanding probabilities, see our odds calculator.
- Spread: Colorado +13.5 | Oklahoma State -13.5
- Over/Under: Over 56.5 (51%) | Under 56.5 (54%)
- Moneyline: Colorado 19% | Oklahoma State 84%
For straight-up plays across the slate, see our college football Week 8 moneyline picks. If you prefer to trade the game, college football markets are available on Kalshi.
For the full slate of today's college football matchups, see our college football odds board.
More Covers college football betting tools
Colorado vs Oklahoma State weather
Temperatures are expected to be in the mid-70s, with winds around 9 mph and no rain in the forecast.
Our college football weather page has up-to-date information on every matchup.
Colorado vs Oklahoma State trend to know
The Buffaloes are 10-6 to the Under as road underdogs since Deion Sanders took over as head coach in 2023. Find more college football betting trends for Colorado vs. Oklahoma State, or see our Week 8 college football AI predictions for a model-based read on the slate.
or our BET99 promo code COVERS99 if you're in Canada.
How to watch Colorado vs Oklahoma State
| Location | Boone Pickens Stadium, Stillwater, Okla. |
| Date | Today, Saturday, Oct. 24, 2026 |
| Kickoff | 7 p.m. ET |
| TV | FS1 |
Colorado vs Oklahoma State latest injuries
Our college football injuries page has updates on every team.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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