Opening NFL Week 10 Odds and Betting Lines: Maye & Pats Are Slight Underdogs in Tampa Bay

One of Week 10's marquee matchups features Drake Maye and the Patriots traveling to Raymond James Stadium as 2.5-point underdogs against the Buccaneers, who are fresh off a bye.

Jason Logan: Senior Betting Analyst at Covers
Jason Logan • Senior Betting Analyst
Nov 2, 2025 • 21:22 ET • 4 min read
Opening NFL Week 10 odds Drake Maye New England Patriots NFL
Photo By - Imagn Images. Patriots QB Drake Maye smiles during their Week 9 win over the Falcons.

We're officially into the second half of the NFL season, as Week 10 kicks off with the Las Vegas Raiders battling the Denver Broncos at Mile High on Thursday Night Football as nearly double-digit dogs.

The Atlanta Falcons and Indianapolis Colts play in Germany on Sunday morning, as both squads lick their wounds.

As far as this week's marquee matchups, Lamar Jackson will look to make it a winning streak as his Baltimore Ravens travel North to face the Minnesota Vikings as 3.5-point visiting faves. Meanwhile, the New England Patriots and Tampa Bay Buccaneers (-2.5) meet at Raymond James Stadium.

Wrapping up the week, will the Green Bay Packers (-2.5) put up a better effort against the Philadelphia Eagles on Monday Night Football than they did in a surprise loss to the Carolina Panthers in Week 9?

Jason Logan will break down all the odds early in the week, but for now, here's a look at where we currently stand.

NFL odds Week 10

Matchup Spread Moneyline Over/Under
Raiders Raiders
vs
Broncos Broncos
Broncos -9.5 Raiders +420
Broncos -560
42.5
Falcons Falcons
vs
Colts Colts
Colts -6.5 Falcons +245
Colts  -300
48.5
Ravens Ravens
vs
Vikings Vikings

Vikings +3.5 Ravens -194
Vikings +162
46.5
Patriots Patriots
vs
Buccaneers Buccaneers
Buccaneers -2.5 Patriots +122
Buccaneers -144
48.5
Jaguars Jaguars
vs
Texans Texans
Texans -1.5 Jaguars +102
Texans -120
38.5
Browns Browns
vs
Jets Jets
Jets -1.5 Browns +108
Jets -126
36.5
Saints Saints
vs
Panthers Panthers
Panthers -4.5 Saints +200
Panthers -245
39.5
Giants Giants
vs
Bears Bears
Bears -3.5 Giants +160
Bears -190
48.5
Bills Bills
vs
Dolphins Dolphins
Dolphins +9.5 Bills -490
Dolphins +380
50.5
Cardinals Cardinals
vs
Seahawks Seahawks
Seahawks -6.5 Cardinals +225
Seahawks -275
43.5
Rams Rams
vs
49ers 49ers
49ers +3 Rams -174
49ers +146
48.5
Lions Lions
vs
CommandersCommanders
Commanders +3.5 Lions -196
Commanders +164
51.5
Steelers Steelers
vs
Chargers Chargers
Chargers -3 Steelers +142
Chargers -168
45.5
Eagles Eagles
vs
Packers Packers
Packers -2.5 Eagles +124
Packers -146
44.5

Lines as of 11-02

Raiders vs Broncos odds (Thursday, 8:15 p.m. ET, Prime Video)

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Falcons vs Colts odds (Sunday, 9:30 a.m. ET, NFL Network)

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Ravens vs Vikings odds (Sunday, 1:00 p.m. ET, FOX)

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Covers NFL betting tools


Patriots vs Buccaneers odds (Sunday, 1:00 p.m. ET, CBS)

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Jaguars vs Texans odds (Sunday, 1:00 p.m. ET, CBS)

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Browns vs Jets odds (Sunday, 1:00 p.m. ET, CBS)

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Covers NFL awards analysis


Saints vs Panthers odds (Sunday, 1:00 p.m. ET, FOX)

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Giants vs Bears odds (Sunday, 1:00 p.m. ET, FOX)

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Bills vs Dolphins odds (Sunday, 1:00 p.m. ET, CBS)

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More NFL betting analysis


Cardinals vs Seahawks odds (Sunday, 4:05 p.m. ET, CBS)

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Rams vs 49ers odds (Sunday, 4:25 p.m. ET, FOX)

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Lions vs Commanders odds (Sunday, 4:25 p.m. ET, FOX)

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Steelers vs Chargers odds (Sunday, 8:20 p.m. ET, NBC)

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Also see: full Sunday Night Football odds

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Eagles vs Packers odds (Monday, 8:15 p.m. ET, ABC/ESPN)

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Also see: full Monday Night Football odds

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Best NFL bets this week

Looking for our favorite spread, total, and NFL prop bets for this week's action? Check out our best free NFL picks from the Covers staff!

Odds are correct at the time of publishing and are subject to change.
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Jason Logan Senior Industry Analyst Covers.com
Senior Betting Analyst

In his 20 years with Covers, lead NFL betting analyst; has seen it all and bet it all. Through the wild west of early Internet gambling to lobbying for legalized sports betting to our brave new wagering world, Jason has been a consistent source of actionable info and entertainment for squares and sharps alike. Since joining the Covers team back in 2005, he honed his handicapping skills to provide audiences with the most thorough insights, blending traditional capping methods with advanced modelling and predictive analysis. Jason has studied the ins and outs of the sports betting business, learning from some of the most successful gamblers in the industry and the biggest sportsbook operators on the planet. He is under center for Covers during NFL season as our top NFL expert, taking the points in his infamous NFL Underdogs column and representing the Covers Community at the Super Bowl. While he lives for football season, Jasons first love is basketball and that shows in his in-depth NBA, NCAA, and WNBA betting breakdowns. On top of being a mainstay in media from coast to coast; WPIX, PHL17, Fox 5 San Diego, WGNO, TSN, SportsNet, ESPN Radio; he had his analysis featured in USA Today, MSNBC, ESPN, the Wall Street Journal, CBS, Bloomberg, the L.A. Times, the New York Times and other major publications. You can also find JLo stuffing all the top picks and predictions he can into 10 minutes as the host of Covers; flagship podcast, The Sharp 600.

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