We're officially into the second half of the NFL season, as Week 10 kicks off with the Las Vegas Raiders battling the Denver Broncos at Mile High on Thursday Night Football as nearly double-digit dogs.
The Atlanta Falcons and Indianapolis Colts play in Germany on Sunday morning, as both squads lick their wounds.
As far as this week's marquee matchups, Lamar Jackson will look to make it a winning streak as his Baltimore Ravens travel North to face the Minnesota Vikings as 3.5-point visiting faves. Meanwhile, the New England Patriots and Tampa Bay Buccaneers (-2.5) meet at Raymond James Stadium.
Wrapping up the week, will the Green Bay Packers (-2.5) put up a better effort against the Philadelphia Eagles on Monday Night Football than they did in a surprise loss to the Carolina Panthers in Week 9?
Jason Logan breaks down the opening NFL Week 10 odds and the early line movement across the industry.
NFL odds Week 10
| Matchup | Spread | Moneyline | Over/Under |
|---|---|---|---|
 Raidersvs  Broncos |
Broncos -9.5 | Raiders +385 Broncos -500 |
41.5 |
 Falconsvs  Colts |
Colts -5.5 | Falcons +220 Colts -270 |
48.5 |
 Ravensvs  Vikings |
Vikings +4.5 | Ravens -220 Vikings +184 |
47.5 |
 Patriotsvs  Buccaneers |
Buccaneers -2.5 | Patriots +120 Buccaneers -142 |
48.5 |
 Jaguarsvs  Texans |
Texans -1.5 | Jaguars +106 Texans -124 |
36.5 |
 Brownsvs  Jets |
Jets -1.5 | Browns +106 Jets -124 |
36.5 |
 Saintsvs  Panthers |
Panthers -5.5 | Saints +198 Panthers -240 |
39.5 |
 Giantsvs  Bears |
Bears -3.5 | Giants +162 Bears -194 |
48.5 |
 Billsvs  Dolphins |
Dolphins +9.5 | Bills -510 Dolphins +390 |
49.5 |
 Cardinalsvs  Seahawks |
Seahawks -6.5 | Cardinals +260 Seahawks -320 |
44.5 |
 Ramsvs  49ers |
49ers +3.5 | Rams -194 49ers +162 |
49.5 |
 Lionsvs  Commanders |
Commanders +8.5 | Lions -480 Commanders +370 |
49.5 |
 Steelersvs  Chargers |
Chargers -3 | Steelers +126 Chargers -148 |
44.5 |
 Eaglesvs  Packers |
Packers -2.5 | Eagles +116 Packers -136 |
44.5 |
Lines as of 11-04
Raiders vs Broncos odds (Thursday, 8:15 p.m. ET, Prime Video)
Opening line
- Broncos -9.5
- Over/Under 42.5
- View full Raiders vs. Broncos odds and matchup
- Read our Raiders vs. Broncos picks and predictions (coming soon)
The Broncos opened as 9.5-point home favorites for Thursday Night Football. Las Vegas is coming off an overtime loss to Jacksonville and now has to deal with the thin air of Mile High on a short turnaround in Week 10. This total opened at 42.5 points and dipped to 41.5 O/U.
Also see: full Thursday Night Football odds
Falcons vs Colts odds (Sunday, 9:30 a.m. ET, NFL Network)
Opening line
- Colts -6.5
- Over/Under 48.5
- View full Falcons vs. Colts odds and matchup
- Read our Falcons vs. Colts picks and predictions (coming soon)
Berlin plays host to the NFL in Week 10, with the Falcons and Colts playing in Germany on Sunday morning. Indianapolis opened as a 6.5-point neutral-site chalk, with both teams traveling on back-to-back weeks and the third time in four games. This total opened at 48.5 points.
Ravens vs Vikings odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Vikings +3.5
- Over/Under 46.5
- View full Ravens vs. Vikings odds and matchup
- Read our Ravens vs. Vikings picks and predictions (coming soon)
The Vikings made noise in the NFC with a win over the Lions in Week 10. Minnesota returned QB1 J.J. McCarthy, and the defense looked very strong in that big divisional win. Baltimore opened as a 3.5-point road underdog, coming off a mini-bye after dropping the Dolphins last Thursday. This Over/Under hit the board at 46.5 O/U.
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Patriots vs Buccaneers odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Buccaneers -2.5
- Over/Under 48.5
- View full Patriots vs. Buccaneers odds and matchup
- Read our Patriots vs. Buccaneers picks and predictions (coming soon)
This is a great non-conference contest with the Bucs opening as 2.5-point home chalk coming off the bye. Tampa Bay is hoping to return key players on both sides of the ball in Week 10, and this line will see significant movement as injury updates roll out. The Over/Under number opened at 48.5 points.
Jaguars vs Texans odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Texans -1.5
- Over/Under 39.5
- View full Jaguars vs. Texans odds and matchup
- Read our Jaguars vs. Texans picks and predictions (coming soon)
Houston QB C.J. Stroud's status will shift these odds later in the week. He left the Week 9 loss with a concussion and could be replaced by QB2 Davis Mills in Week 10. The Texans hit the board as 1.5-point home favorites (look-ahead line was -2.5) versus Jacksonville, which watched several starters go down with injuries this past week. The total opened at 38.5 after the look-ahead number was 41.5 O/U.
Browns vs Jets odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Jets -1.5
- Over/Under 37.5
- View full Browns vs. Jets odds and matchup
- Read our Browns vs. Jets picks and predictions (coming soon)
We call matchups like Browns vs. Jets a “friends and family” game, because the only ones bothering to watch this mess will be friends and family of the teams involved. Both sides are coming off byes, with New York opening as a 1.5-point favorite and some books moving to -2. The Over/Under is 36.5 after initially starting at 37.5 points.
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Saints vs Panthers odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Panthers -4.5
- Over/Under 38.5
- View full Saints vs. Panthers odds and matchup
- Read our Saints vs. Panthers picks and predictions (coming soon)
The Panthers are coming off a massive upset over Green Bay and host the rival Saints in Week 10. Carolina opened as a 4.5-point favorite, and some shops have run this spread as high as Panthers -5.5 on Monday morning. This is just the fourth time Carolina has laid more than a field goal since 2020. The Over/Under opened at 38.5 and is up to 39.5 O/U with early play on the Over.
Giants vs Bears odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Bears -3.5
- Over/Under 48.5
- View full Giants vs. Bears odds and matchup
- Read our Giants vs. Bears picks and predictions (coming soon)
The Bears won a wild one against the Bengals in Week 9 and opened as 3.5-point home chalk hosting the Giants. With two porous defenses, the Week 10 total opened at 48.5 points in Chicago. Extended forecasts do call for a chance of rain and some classic “Windy City” gusts at Soldier Field on Sunday.
Bills vs Dolphins odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Dolphins +9.5
- Over/Under 50.5
- View full Bills vs. Dolphins odds and matchup
- Read our Bills vs. Dolphins picks and predictions (coming soon)
Buffalo hits the road after exacting some revenge on Kansas City in Week 9. The Dolphins opened as 9.5-point home underdogs. With rumors rumbling about South Beach before Tuesday’s trade deadline, this roster could look a little different come mid-week. The total opened at 50.5 and dipped to 49.5 at some books. The extended forecast is calling for hot, muggy conditions at Hard Rock Stadium, with temperatures feeling like 100 degrees.
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Cardinals vs Seahawks odds (Sunday, 4:05 p.m. ET, CBS)
Opening line
- Seahawks -6.5
- Over/Under 44.5
- View full Cardinals vs. Seahawks odds and matchup
- Read our Cardinals vs. Seahawks picks and predictions (coming soon)
Look-ahead lines has Seattle as a touchdown favorite after a strong win on Sunday night. But after the Cardinals crashed the Cowboys on Monday, this spread officially opened at Seahawks -6.5. Arizona could return QB1 Kyler Murray in Week 10, which may not be an upgrade considering how well backup Jacoby Brissett has played the past few weeks. This total opened at 44.5 points.
Rams vs 49ers odds (Sunday, 4:25 p.m. ET, FOX)
Opening line
- 49ers +3
- Over/Under 48.5
- View full Rams vs. 49ers odds and matchup
- Read our Rams vs. 49ers picks and predictions (coming soon)
This is a massive matchup in the NFC West, with the division becoming a three-horse race. The Rams opened as 3-point road favorites and have been bet up to -3.5. Injury updates around San Francisco QB Brock Purdy will shift this spread and total later in the week. The Over/Under opened at 48.5 and has climbed to 49.5, with some books showing 50 O/U on Monday morning.
Lions vs Commanders odds (Sunday, 4:25 p.m. ET, FOX)
Opening line
- Commanders +8.5
- Over/Under 49.5
- View full Lions vs. Commanders odds and matchup
- Read our Lions vs. Commanders picks and predictions (coming soon)
Washington won’t have QB Jayden Daniels for Week 10 and probably not for the remainder of the season after he suffered a dislocated left arm in Sunday night’s loss to Seattle. That leaves QB2 Marcus Mariota under center, shifting the look-ahead line from Lions -3.5 to -8.5 on Monday morning. The look-ahead total was at 51.5 points, but officially opened at 49.5 following Daniels’ injury.
Steelers vs Chargers odds (Sunday, 8:20 p.m. ET, NBC)
Opening line
- Chargers -3.5
- Over/Under 45.5
- View full Steelers vs. Chargers odds and matchup
- Read our Steelers vs. Chargers picks and predictions (coming soon)
Sunday Night Football sends the Steelers West to clash with the Chargers in Week 10. Los Angeles opened as a 3.5-point home favorite, but with injuries mounting on the offensive line again, this spread dropped to a field goal. The total hit the board at 45.5 points and slimmed to 44.5 O/U.
Also see: full Sunday Night Football odds
Eagles vs Packers odds (Monday, 8:15 p.m. ET, ABC/ESPN)
Opening line
- Packers -2.5
- Over/Under 44.5
- View full Eagles vs. Packers odds and matchup
- Read our Eagles vs. Packers picks and predictions (coming soon)
A rematch of the NFC wild-card round has the Eagles traveling to Lambeau Field on Monday night. The Packers opened as 2.5-point home favorites, and the vig is climbing on Philly +2.5, indicating a move down. Green Bay is looking to bounce back from a poor showing versus Carolina in Week 9 (and a bad injury to star TE Tucker Kraft) while Philadelphia is coming off a bye. This total opened at 44.5 points, dropped briefly to 43.5, then returned to the original number.
Also see: full Monday Night Football odds
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