With most of the slate wrapped, the NFL Week 1 odds are now focused on Monday Night Football.
The Kansas City Chiefs (-2.5) will have Patrick Mahomes under center against the visiting Denver Broncos tonight.
Let's look at today's NFL odds, spreads, outrights, and totals for every game on the opening week slate.
NFL Week 1 odds
| Matchup | Spread | Win Probability | Over/Under |
|---|---|---|---|
 Bearsvs  Panthers |
-2.5 55% +2.5 46% |
60% 40% |
o46.5 52% u46.5 48% |
 Buccaneersvs  Bengals |
+3.5 50% -3.5 51% |
36% 64% |
o49.5 51% u49.5 49% |
 Ravensvs  Colts |
-3.5 46% +3.5 55% |
60% 40% |
o47.5 51% u47.5 49% |
 Billsvs  Texans |
-1.5 48% +1.5 52% |
52% 48% |
o44.5 49% u44.5 52% |
 Saintsvs  Lions |
+7.5 55% -7.5 46% |
26% 74% |
o49.5 51% u49.5 49% |
 Jetsvs  Titans |
+1.5 52% -1.5 49% |
49% 51% |
o38.5 52% u38.5 49% |
 Brownsvs  Jaguars |
+9.5 52% -9.5 48% |
21% 79% |
o40.5 48% u40.5 52% |
 Falconsvs  Steelers |
+6.5 52% -6.5 50% |
29% 71% |
o40.5 50% u40.5 50% |
 Commandersvs  Eagles |
+5.5 49% -5.5 52% |
32% 68% |
o44.5 46% u44.5 54% |
 Packersvs  Vikings |
+1.5 49% -1.5 51% |
46% 54% |
o45.5 51% u45.5 49% |
 Cardinalsvs  Chargers |
+9.5 52% -9.5 49% |
19% 81% |
o47.5 48% u47.5 52% |
 Dolphinsvs  Raiders |
+3.5 54% -3.5 47% |
40% 60% |
o40.5 48% u40.5 52% |
 Cowboysvs  Giants |
-2.5 56% +2.5 45% |
60% 40% |
o47.5 51% u47.5 50% |
 Broncosvs  Chiefs |
+2.5 51% -2.5 50% |
45% 55% |
o43.5 49% u43.5 52% |
Percentages courtesy of Kalshi, one of the best prediction market apps.
Start trading with Kalshi today!
Sign up now using our exclusive Kalshi promo code 'COVERS60' and trade $25 on any event contracts to get $60 — including the NFL!
*Eligible U.S. locations only
Buccaneers vs Bengals odds: Former No. 1 picks collide
In a battle of former No. 1 overall picks and Heisman winners, Baker Mayfield and the Tampa Bay Buccaneers will head to Paycor Stadium to face Joe Burrow and the Cincinnati Bengals on Sunday's afternoon schedule.
Mayfield has had the upper hand in this matchup, boasting a 3-1 record in four head-to-head meetings with Burrow. However, Kalshi gives Cincinnati a 65% win probability as the Bengals look to make it four straight wins over Tampa Bay as a franchise.
Ravens vs Colts odds: Indy's Week 1 blues
Before defeating the Miami Dolphins in Week 1 last year, the Indianapolis Colts had gone 2-12-1 in their previous 15 season openers.
Now they'll face a Baltimore Ravens team beginning a new era under head coach Jesse Minter. Lamar Jackson says he's "absolutely" ready for Week 1 after spending the offseason learning a new offense, and Kalshi gives Baltimore a 64% win probability in Indianapolis.
Cardinals vs Chargers odds: Lopsided line
The Los Angeles Chargers enter Week 1 as one of the biggest favorites on the board, with Kalshi giving Justin Herbert & Co. an 81% win probability against the rebuilding Arizona Cardinals.
Herbert offered a glimpse of what the Chargers' new offense could look like in the preseason finale, connecting with Quentin Johnston for a 65-yard touchdown in Mike McDaniel's system. Now they'll look to carry that explosiveness into a favorable Week 1 matchup.
Prime-time prowess
The John Harbaugh era in Gotham begins on Sunday Night Football when the New York Giants host the Dallas Cowboys. Jaxson Dart will make his first Week 1 start, while Malik Nabers is trending toward being available after missing time during the preseason.
Meanwhile, the Kansas City Chiefs are set to host the Denver Broncos on Monday, Sept. 14, with all eyes on the potential return of Patrick Mahomes as Kansas City opens the season against its AFC West rival.
Covers NFL betting tools
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
