Football will be back before you know it.
The 2026 NFL season opens on Wednesday, September 9, with the defending champion Seattle Seahawks hosting a Super Bowl LX rematch against the New England Patriots, marking the first season opener to feature such stakes.
Australia will also dip its toe into the pigskin as an NFC West battle between the San Francisco 49ers and Los Angeles Rams takes place at the Melbourne Cricket Ground on Friday, September 11.
Now that the full schedule has been released, here are the latest NFL Week 1 odds, betting lines, spreads, and totals for every game of the opening weekend.
NFL Week 1 Odds
| Matchup | Spread | Moneyline | Over/Under |
|---|---|---|---|
 Patriotsvs  Seahawks |
+3.5 -110 -3.5 -110 |
+160 -192 |
o44.5 -110 u44.5 -110 |
|
|
+2.5 +100 -2.5 -120 |
+124 -148 |
o48.5 -110 u48.5 -110 |
|
|
-2.5 -110 +2.5 -110 |
-135 +114 |
o44.5 -110 u44.5 -110 |
|
|
+3.5 -110 -3.5 -110 |
+164 -198 |
o50.5 -115 u50.5 -105 |
|
|
-3.5 -110 +3.5 -110 |
-185 +154 |
o49.5 -110 u49.5 -110 |
 Billsvs  Texans |
-1.5 +102 +1.5 -122 |
-112 -108 |
o45.5 -105 u45.5 -115 |
|
|
+7 -110 -7 -110 |
+260 -325 |
o48.5 -110 u48.5 -110 |
|
|
+3 -105 -3 -115 |
+142 -170 |
o39.5 -110 u39.5 -110 |
|
|
+7 -110 -7 -110 |
+235 -290 |
o40.5 -110 u40.5 -110 |
|
|
+3 +100 -3 -120 |
+145 -175 |
o42.5 -110 u42.5 -110 |
|
|
+5.5 -110 -5.5 -110 |
+195 -238 |
o46.5 -110 u46.5 -110 |
|
|
-1.5 -110 +1.5 -110 |
-125 +105 |
o44.5 -110 u44.5 -110 |
 Cardinalsvs  Chargers |
+11.5 -110 -11.5 -110 |
+455 -625 |
o45.5 -110 u45.5 -110 |
|
|
+3 +100 -3 -120 |
+145 -175 |
o41.5 -110 u41.5 -110 |
|
|
-2.5 -105 +2.5 -115 |
-130 +110 |
o47.5 -115 u47.5 -105 |
|
|
+2.5 +100 -2.5 -120 |
+130 -155 |
o42.5 -110 u42.5 -110 |
49ers
Rams
Bears
Panthers
Buccaneers
Bengals
Ravens
Colts
Saints
Lions
Jets
Titans
Browns
Jaguars
Steelers
Commanders
Eagles
Packers
Vikings
Dolphins
Raiders
Cowboys
Giants
Broncos
ChiefsOdds as of 5-14-2026. Odds from DraftKings, one of our best betting apps. Sign up with our DraftKings promo code, or get one of our other sportsbook promos.
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Buccaneers vs. Bengals odds: Former No. 1 Picks Collide
In a battle of two Heisman winners, Baker Mayfield and the Tampa Bay Buccaneers will head to Paycor Stadium to face Joe Burrow and the Cincinnati Bengals as part of Sunday’s afternoon schedule.
Believe it or not, Mayfield has had the leg up in this showdown so far, boasting a 3-1 record in head-to-head matchups against Burrow dating back to 2020.
Ravens vs. Colts odds: Indy's Week 1 Blues
Before defeating the Miami Dolphins in Week 1 last year, the Indianapolis Colts had gone 2-12-1 in their last 15 season openers.
Set to face a Baltimore Ravens team that should be rejuvenated by the hire of new head coach Jesse Minter — as well as a healthy Lamar Jackson — Colts nation could be in for another rough start.
Cardinals vs. Chargers odds: Lopsided Line
Justin Herbert may be a fraud come playoff time, but a soft opener has the Los Angeles Chargers favored by 11.5 points ahead of their clash with the rebuilding Miami Dolphins — the only double-digit spread offered in Week 1.
Malik Willis will make his debut under center for the Dolphins, looking to prove the doubters wrong after signing a 3-year, $67.5 million contract over the offseason.
Primetime Prowess
The John Harbaugh era in Gotham begins on Sunday Night Football when the New York Giants host the Dallas Cowboys.
Meanwhile, the Kansas City Chiefs are set to play host to the Denver Broncos on Monday, September 14, potentially marking the return of Patrick Mahomes.
Covers NFL betting tools
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