Clemson and Florida State will meet under the lights at Doak Campbell Stadium for an ACC showdown on Saturday, Oct. 31, at 7 p.m. ET.
Florida State is a 6.5-point favorite ahead of kickoff, with the total at 50.5 points. My Clemson vs. Florida State predictions and college football picks have Florida State on upset alert in front of its home fans.
TOP PICK
Who will win Clemson vs Florida State: Clemson +6.5
Playable to 54%.
Clemson hasn't looked great the last two times we saw it face an FBS opponent — losing 20-16 at home to Virginia Tech and getting run off the field in a 41-13 blowout against Miami. That said, it wasn't that long ago that we saw it dominate Cal and North Carolina.
The process metrics suggest Clemson is still a competitive football team, and this is a program that has proven it always gets up for this rivalry game.
COVERS INTEL: The final score didn't look great against Virginia Tech, but Clemson was +54 in net yards in that matchup. Even against Miami, Clemson was only outgained by 69 yards. If not for losing the turnover battle 2-0 in that game, the final score would have looked much more respectable.
Clemson vs Florida State Over/Under pick: Over 50.5
Playable to 52%.
Trend bettors might find it difficult to bet an Over in a game involving Clemson, but its offense is talented enough to take advantage of an underwhelming Florida State defense.
Florida State allowed 583 yards of total offense and 26 first downs to Miami in its last game. Louisville had 537 yards of total offense and 21 first downs against Florida State the week before that.
Pro Football Focus has Florida State's defense graded 133rd in the nation, out of 138 FBS schools. When the total went Under in their head-to-head meeting last year, it was the first time since 2014-15 that Clemson and Florida State saw the game total go Under in consecutive matchups.
Expect both of these offenses to have success moving the ball on Saturday.
Clemson vs Florida State combo
Playable to 29%.
Florida State has played six games against FBS opponents this fall — all of those contests have featured at least 51 points, except for a 38-7 final against Virginia. Three of its last four games against FBS opponents have seen at least 64 points scored, including an 86-point final against Alabama and a 78-point final against Miami.
Points are going to be scored between Clemson and Florida State this weekend. The Tigers have enough talent on both sides of the ball to keep this game competitive, making these two plays correlated for bettors seeking a combo play.
Clemson vs Florida State combo
- Clemson +6.5
- Over 50.5
- Top picks: 8-5, +2.44 units
- Combos: 6-8, +4.02 units
Clemson vs Florida State odds
For help understanding probabilities, see our odds calculator.
- Spread: Clemson +6.5 | Florida State -6.5
- Over/Under: Over 50.5 (50%) | Under 50.5 (51%)
- Moneyline: Clemson 33% | Florida State 67%
For the full slate of college football matchups, check out our college football odds board!
More Covers college football betting tools
- College football picks
- College football odds
- College football prop projections
- National championship odds
- Heisman Trophy odds
Clemson vs Florida State weather
The weather shouldn't play a big role in this weekend's game between Clemson and Florida State. The forecast at kickoff has the temperature in the mid-70s, with no rain expected.
Check out our college football weather page for up-to-date info on every matchup.
Clemson vs Florida State trend to know
Clemson has hit the first-quarter game total Over in only 4 of its last 12 games (-5.40 units / 39% ROI). Find more college football betting trends for Clemson vs. Florida State.
or our BET99 promo code COVERS99 if you're in Canada.
How to watch Clemson vs Florida State
| Location | Doak Campbell Stadium, Tallahassee, Fla. |
| Date | Saturday, Oct. 31, 2026 |
| Kickoff | 7 p.m. ET |
| TV | ACC Network |
Clemson vs Florida State latest injuries
Check out our college football injuries page for updates on every team.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
