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Best NFL Picks Today

Find the best NFL bets today - Sept. 16, 2026. Free expert and computer picks for every NFL game.

New Computer Picks powered by Odds Shark

Predicted Score

DET logo
DET
DET

25.66 @ 27.69

BUF
BUF logo
BUF

Lions vs Bills · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

DET logo
DET
DET

25.66

+5.5 -110

o54.5 -107

+195

BUF logo
BUF
BUF

27.69

-5.5 -105

u55.0 -115

-225

Philadelphia @ Tennessee
Matchup Stats

Predicted Score

PHI logo
PHI
PHI

24.02 @ 15.46

TEN
TEN logo
TEN

Eagles vs Titans · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

PHI logo
PHI
PHI

24.02

-7.0 -110

o39.5 -109

-325

TEN logo
TEN
TEN

15.46

+7.0 -110

u40.0 -115

+290

Top Projection Tony Pollard o43.5 Rushing Yards (-109)
o43.5-109
Pittsburgh @ New England
Matchup Stats

Predicted Score

PIT logo
PIT
PIT

19.02 @ 24.77

NE
NE logo
NE

Steelers vs Patriots · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

PIT logo
PIT
PIT

19.02

+5.5 -109

o41.5 -108

+210

NE logo
NE
NE

24.77

-5.5 -105

u41.5 -107

-225

Top Projection Aaron Rodgers o205.5 Passing Yards (-115)
o199.5-175
Minnesota @ Chicago
Matchup Stats

Predicted Score

MIN logo
MIN
MIN

18.31 @ 24.71

CHI
CHI logo
CHI

Vikings vs Bears · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

MIN logo
MIN
MIN

18.31

+5.5 -114

o48.0 -110

+188

CHI logo
CHI
CHI

24.71

-5.5 -106

u48.5 -112

-210

Carolina @ Atlanta
Matchup Stats

Predicted Score

CAR logo
CAR
CAR

22.24 @ 23.21

ATL
ATL logo
ATL

Panthers vs Falcons · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

CAR logo
CAR
CAR

22.24

-2.5 -105

o43.5 -110

-132

ATL logo
ATL
ATL

23.21

+2.5 -105

u44.5 -120

+121

Green Bay @ N.Y. Jets
Matchup Stats

Predicted Score

GB logo
GB
GB

24.68 @ 18.91

NYJ
NYJ logo
NYJ

Packers vs Jets · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

GB logo
GB
GB

24.68

-3.5 -105

o44.5 -110

-180

NYJ logo
NYJ
NYJ

18.91

+3.5 -108

u45.5 -115

+165

Top Projection Geno Smith Score a Touchdown (Yes: +900)
+1000
New Orleans @ Baltimore
Matchup Stats

Predicted Score

NO logo
NO
NO

20.49 @ 26.38

BAL
BAL logo
BAL

Saints vs Ravens · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

NO logo
NO
NO

20.49

+8.5 -109

o46.5 -108

+330

BAL logo
BAL
BAL

26.38

-8.5 -105

u47.5 -127

-395

Top Projection Lamar Jackson u40.5 Rushing Yards (-115)
u40.5-114
Cincinnati @ Houston
Matchup Stats

Predicted Score

CIN logo
CIN
CIN

24.26 @ 25.68

HOU
HOU logo
HOU

Bengals vs Texans · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

CIN logo
CIN
CIN

24.26

+2.5 +100

o45.5 -115

+132

HOU logo
HOU
HOU

25.68

-2.5 -118

u46.5 -109

-145

Cleveland @ Tampa Bay
Matchup Stats

Predicted Score

CLE logo
CLE
CLE

15.11 @ 22.80

TB
TB logo
TB

Browns vs Buccaneers · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

CLE logo
CLE
CLE

15.11

+8.5 -109

o41.0 -114

+350

TB logo
TB
TB

22.80

-8.5 -105

u41.5 -110

-395

Top Projection Deshaun Watson o20.5 Rushing Yards (-140)
o20.5-140
Jacksonville @ Denver
Matchup Stats

Predicted Score

JAC logo
JAC
JAC

20.86 @ 24.35

DEN
DEN logo
DEN

Jaguars vs Broncos · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

JAC logo
JAC
JAC

20.86

+3.5 -135

o44.5 -118

+130

DEN logo
DEN
DEN

24.35

-3.5 -115

u45.5 -110

-148

Las Vegas @ L.A. Chargers
Matchup Stats

Predicted Score

LV logo
LV
LV

18.70 @ 25.57

LAC
LAC logo
LAC

Raiders vs Chargers · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

LV logo
LV
LV

18.70

+6.5 -102

o43.5 -105

+250

LAC logo
LAC
LAC

25.57

-6.5 -110

u43.5 -107

-290

Seattle @ Arizona
Matchup Stats

Predicted Score

SEA logo
SEA
SEA

21.49 @ 21.13

ARI
ARI logo
ARI

Seahawks vs Cardinals · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

SEA logo
SEA
SEA

21.49

-3.5 -110

o40.5 -120

-198

ARI logo
ARI
ARI

21.13

+3.5 -105

u41.0 -108

+175

Top Projection Jacoby Brissett u5.5 Rushing Yards (-115)
u5.5-115
Miami @ San Francisco
Matchup Stats

Predicted Score

MIA logo
MIA
MIA

18.96 @ 27.14

SF
SF logo
SF

Dolphins vs 49ers · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

MIA logo
MIA
MIA

18.96

+13.5 -105

o45.0 -110

+750

SF logo
SF
SF

27.14

-13.5 -105

u45.5 -110

-900

Washington @ Dallas
Matchup Stats

Predicted Score

WAS logo
WAS
WAS

24.41 @ 28.75

DAL
DAL logo
DAL

Commanders vs Cowboys · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

WAS logo
WAS
WAS

24.41

+4.5 -113

o50.5 -108

+185

DAL logo
DAL
DAL

28.75

-4.5 -105

u50.5 -106

-200

Indianapolis @ Kansas City
Matchup Stats

Predicted Score

IND logo
IND
IND

20.17 @ 24.13

KC
KC logo
KC

Colts vs Chiefs · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

IND logo
IND
IND

20.17

+6.5 +100

o46.0 -110

+265

KC logo
KC
KC

24.13

-6.5 -115

u47.0 -114

-285

Top Projection Patrick Mahomes o15.5 Rushing Yards (-135)
o15.5-117
N.Y. Giants @ L.A. Rams
Matchup Stats

Predicted Score

NYG logo
NYG
NYG

19.94 @ 29.02

LA
LA logo
LA

Giants vs Rams · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

NYG logo
NYG
NYG

19.94

+7.5 -115

o47.5 -110

+295

LA logo
LA
LA

29.02

-7.5 +102

u48.5 -110

-345

Top Projection Matthew Stafford Score a Touchdown (Yes: +3000)
+2400
Detroit Lions image thumbnail DET @ Buffalo Bills image thumbnail BUF Thu, Sep 17 • 8:15 PM ET
Rushing Yards
Josh Allen logo Josh Allen o30.5 Rushing Yards (-114)
Best Odds
Pick made: 2 hours ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

Josh Allen will do everything he can to make sure the Bills win this first game at new Highmark Stadium. That includes tearing up the turf with his legs. If you’ve followed Allen’s stellar career, you know he does his most damage on the ground in high-stakes showdowns and playoff pressure. He had 30+ in both playoff outings as well as high-profile pairings with Baltimore, New England (twice), Cincinnati, Tampa Bay, and Pittsburgh. On top of calling his own number for designed runs, Allen will get flushed out of the pocket and put on the run by an aggressive Detroit defense that blitzed at the third highest rate in Week 1, collecting five sacks. Projections range from 27.5 to 35 rushing yards for the Bills QB, with my number at 33 but recognizing the higher ceiling based on Allen’s “Big Game” tendencies.

Passing Yards
Jared Goff logo Jared Goff o263.5 Passing Yards (-115)
Best Odds
Pick made: 3 hours ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

Expect Goff to air it out in what should be an absolute shootout between these two offenses on Thursday Night Football. Detroit's secondary gave up 410 yards through the air in Week 1, while the Bills' unit coughed up 274, paving the way for points - and strong quarterback play. When it comes to Goff, he went over this number 11 times last season, averaging roughly 39 pass attempts per game. If we get anywhere near that type of volume in a matchup projected for 54+ points, Goff will fly over this number.

View 19 Picks
Philadelphia Eagles image thumbnail PHI @ Tennessee Titans image thumbnail TEN Sun, Sep 20 • 1:00 PM ET
Receiving Yards
Wan'Dale Robinson logo
Wan'Dale Robinson o35.5 Receiving Yards (-125)
Projection 44.74 (Over)
Best Odds
Pick made: 18 minutes ago
EV Model Rating
Star rating: 5 out of 5
An extreme throwing game script is implied by the Titans being a giant -7-point underdog in this game.. The predictive model expects the Tennessee Titans as the 10th-most pass-oriented offense among all teams this week with a 59.5% pass rate, accounting for their underlying propensities and matchup dynamics.. At the moment, the 3rd-fastest paced team in the NFL (adjusted for context) according to the predictive model is the Tennessee Titans.. In this contest, Wan'Dale Robinson is projected by our trusted projection set to position himself in the 89th percentile among WRs with 7.5 targets.. With an excellent 53.0 adjusted yards per game on passes (89th percentile) since the start of last season, Wan'Dale Robinson places as one of the top wide receivers in the game in football.
Receptions Made
Carnell Tate logo
Carnell Tate o3.5 Receptions Made (-135)
Projection 4.2 (Over)
Best Odds
Pick made: 26 minutes ago
EV Model Rating
Star rating: 4 out of 5
An extreme throwing game script is implied by the Titans being a giant -7-point underdog in this game.. The predictive model expects the Tennessee Titans as the 6th-most pass-oriented offense among all teams this week with a 59.4% pass rate, accounting for their underlying propensities and matchup dynamics.. Based on the game dynamics and the underlying tendencies of each team, this game is expected by the projections to see 130.1 offensive plays run: the 4th-most out of all the games this week.. When it comes to cornerbacks in defending pass-catchers, Philadelphia's CB corps has been easily exploitable last year, profiling as the 7th-worst in the NFL.
View 10 Picks
Pittsburgh Steelers image thumbnail PIT @ New England Patriots image thumbnail NE Sun, Sep 20 • 1:00 PM ET
Spread
Pittsburgh Steelers image thumbnail PIT +5.5 (-110)
Best Odds
Pick made: an hour ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

Pittsburgh is shipping out to Boston to battle the Patriots, who have had extra time to stew over their dud at Seattle on opening night. New England’s offense looked bad and it’s running thin on weapons, with WR1 A.J. Brown out and RB TreVeyon Henderson questionable. The Patriots averaged 4.1 yards per play in Week 1 and now face a retooled Steelers defense that tops all those sexy advanced metrics. Yes, Pittsburgh did beat up on Atlanta and a third-stringer last Sunday but those analytics that account for all that still love the Steelers, who are tops in defensive DVOA and No. 2 in EPA allowed per play. Laying almost six points seems like a steel climb for a Pats offense this Sunday.

Total
Pittsburgh Steelers image thumbnail New England Patriots image thumbnail u42.5 (-110)
Best Odds
Pick made: 2 days ago
Neil Parker logo
Neil Parker
Betting Analyst

The Steelers are built for Unders, and the Patriots lack game-breaking talent on offense with wide receiver A.J. Brown (ankle) out and running back TreVeyon Henderson (ankle) still nursing an injury. Pittsburgh quarterback Aaron Rodgers completed just 60% of his passes for a pedestrian 5.6 yards per attempt in Week 1, and New England QB Drake Maye’s 5.4 YPA and 6.5 aDoT in the season opener don’t jump off the page, either. The Steelers also allowed the fourth-lowest EPA per play, with the Pats surrendering the seventh lowest ahead of Monday Night Football, so we’re landing a fair number on this Under given the lack of offensive explosiveness going against this pair of stout stop units.

View 12 Picks
Minnesota Vikings image thumbnail MIN @ Chicago Bears image thumbnail CHI Sun, Sep 20 • 1:00 PM ET
Spread
Chicago Bears image thumbnail CHI -5.5 (-110)
Best Odds
Pick made: 2 days ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

While Wentz was serviceable, I see more than two points separating him and Murry in terms of value to the spread. That’s especially true if the Bears can break away on the scoreboard and force Wentz to carry the load. Minnesota’s defense is dangerous but gave up a ton of yards to the Packers. If we take the Cheeseheads’ fourth-quarter collapse out of the equation, the Vikes stop unit was 21st in EPA allowed per play in the first three quarters. Murray’s chances of clearing concussion protocols seems slim when you look at his reaction to the hit. Once he’s officially ruled out, this spread jumps to Bears -6 or higher. Give me Chicago below the key number now.

Receiving Yards
Luther Burden III logo
Luther Burden III o50.5 Receiving Yards (-115)
Projection 51.88 (Over)
Best Odds
Pick made: 6 minutes ago
EV Model Rating
Star rating: 4 out of 5
The predictive model expects the Bears to run the 4th-most offensive plays among all teams this week with 66.2 plays, based on their underlying traits and game dynamics.. The Bears have run the 2nd-most plays in the NFL since the start of last season, averaging a staggering 60.7 plays per game.. When it comes to protecting the passer (and the strong impact it has on all passing offense metrics), the O-line of the Chicago Bears profiles as the 7th-best in the NFL since the start of last season.. The Vikings pass defense has been vulnerable when opposing wide receivers have gotten into space, yielding an average of 0.68 yards-after-the-catch since the start of last season: the most in football.. As it relates to safeties in defending receivers, Minnesota's group of safeties has been awful since the start of last season, projecting as the worst in football.
View 8 Picks
Carolina Panthers image thumbnail CAR @ Atlanta Falcons image thumbnail ATL Sun, Sep 20 • 1:00 PM ET
Total
Carolina Panthers image thumbnail Atlanta Falcons image thumbnail o43.5 (-111)
Best Odds
Pick made: 2 days ago
Shawn Krest logo
Shawn Krest
Betting Analyst

Stay Over up to 45.5. The Panthers answered all questions about their offense in the opener, and the Carolina defense didn't show it was capable of stopping anyone. The Panthers have set scoring records for the preseason Hall of Fame Game and the NFL Week One opener. 

Spread
Atlanta Falcons image thumbnail ATL +1.5 (-111)
Best Odds
Pick made: 2 days ago
Shawn Krest logo
Shawn Krest
Betting Analyst

Stick with Atlanta up until -1.5. Falcons running back Bijan Robinson carrying the ball against a Panthers' defense that gave up a half dozen rushing touchdowns in the opener is a bad matchup for Carolina. Atlanta's offense could also get a boost if Tua Tagovailoa can return from injury.

View 8 Picks
Green Bay Packers image thumbnail GB @ New York Jets image thumbnail NYJ Sun, Sep 20 • 1:00 PM ET
Total
Green Bay Packers image thumbnail New York Jets image thumbnail u44.5 (-111)
Best Odds
Pick made: yesterday
Ed Scimia logo
Ed Scimia
Betting Analyst

The New York Jets averaged just 17.6 ppg last year and while Geno Smith is an upgrade at quarterback, I'm unconvinced that he's going to improve the situation all that much at age 35. Meanwhile, the Jets defense will get pressure on a one-dimensional Green Bay Packers offense that totaled just 66 yards on the ground against the Vikings. I'm backing the Under down to 42.5 points.

Spread
New York Jets image thumbnail NYJ +3.5 (-111)
Best Odds
Pick made: yesterday
Ed Scimia logo
Ed Scimia
Betting Analyst

There's no denying it: the New York Jets looked downright competent in Week 1. Breece Hall ran for 102 yards, Geno Smith was efficient in the passing game, and the defense held the Tennessee Titans to -0.28 EPA per pass. At home, I like New York to cover against the Green Bay Packers as long as the spread stays above a field goal.

View 10 Picks
New Orleans Saints image thumbnail NO @ Baltimore Ravens image thumbnail BAL Sun, Sep 20 • 1:00 PM ET
Spread
New Orleans Saints image thumbnail NO +8.5 (-110)
Best Odds
Pick made: an hour ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

The Saints showed tremendous fight against the Lions. New Orleans was down 21-0 in the third quarter before scoring 24 second half points and pushing Detroit to the brink in overtime.  That had the Saints covering as 6.5-point road dogs. Much like Washington, NOLA found its footing in the final 30 minutes and rated Top 10 in EPA among 2H offenses in Week 1. The Saints were also Top 10 in third down success and red-zone scoring (4 for 5). This spread was New Orleans +7.5 in the summer and has jumped to +8.5 (and as high as +9 at some shops), despite those ailments to the Ravens receiving corps. Baltimore wins but not by this many.

Total
New Orleans Saints image thumbnail Baltimore Ravens image thumbnail u47.5 (-110)
Best Odds
Pick made: 2 days ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

The New Orleans Saints looked dead in the water for the first 30 minutes of the 2026 season. They were 27th in EPA per play in the first half versus Detroit on Sunday before the Lions took their foot off the gas and found themselves in an overtime squeaker. New Orleans’ output looks better than it was, scoring six points in the extra frame (before missing the 2-point convert). The Baltimore Ravens hung 41 points on Indianapolis in Week 1 but took a hit in the receiving corps, losing Zay Flowers and Ja'Kobi Lane to injury. This group was already thin and could have Baltimore’s offense short and simple in Week 2. The Ravens ran at the second highest rate in the opener (58%), mainly due to protecting a big lead in the second half. But they could be forced into similar handoffs with the passing game missing pieces.

View 12 Picks
Cincinnati Bengals image thumbnail CIN @ Houston Texans image thumbnail HOU Sun, Sep 20 • 1:00 PM ET
Spread
Houston Texans image thumbnail HOU -2.5 (-110)
Best Odds
Pick made: 2 days ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

The Bengals got four takeaways and still had to sweat out the Bucs in Week 1. Houston's defense bounces back and that offense is improved and always strong at home. The Texans were 9 for 18 on 3rd/4th down conversions and went 4/5 for TDs in the red zone. Cincy finished 2/5 in RZ and needed a defensive score and four FGM (two 50+ yarders) to get to 33 points, despite those extra possesions.

Receiving Yards
Dalton Schultz logo
Dalton Schultz o35.5 Receiving Yards (-115)
Projection 43.42 (Over)
Best Odds
Pick made: 4 minutes ago
EV Model Rating
Star rating: 5 out of 5
The predictive model expects the Texans to be the 7th-most pass-focused team in football (adjusted for context) at the moment with a 61.9% pass rate.. With regard to a defense's influence on tempo, at 28.05 seconds per snap, the predictive model expects the Houston Texans to be the 8th-quickest in the league (context-neutralized) at the present time.. The pass attacks of both teams (in terms of both volume and effectiveness) figure to benefit from the still "weather" conditions (i.e. zero wind) inside this dome, while run volume may drop.. This week, Dalton Schultz is expected by the projections to slot into the 94th percentile among tight ends with 6.3 targets.. The Cincinnati Bengals defense has surrendered the most adjusted receiving yards per game in the NFL (81.0) to tight ends since the start of last season.
View 9 Picks
Cleveland Browns image thumbnail CLE @ Tampa Bay Buccaneers image thumbnail TB Sun, Sep 20 • 1:00 PM ET
Anytime Touchdown
Bucky Irving logo
Bucky Irving Score a Touchdown (Yes: -110)
Projection 0.72 (Yes)
Best Odds
Pick made: an hour ago
EV Model Rating
Star rating: 4 out of 5
The Buccaneers rank as the 5th-most pass-focused team in football near the end zone (in a neutral context) this year with a 77.8% red zone pass rate.
Receiving Yards
Harold Fannin Jr. logo
Harold Fannin Jr. o35.5 Receiving Yards (-115)
Projection 41.24 (Over)
Best Odds
Pick made: an hour ago
EV Model Rating
Star rating: 4 out of 5
At a -8.5-point disadvantage, the Browns are big underdogs in this game, implying much more of a focus on throwing than their typical game plan.. The Tampa Bay Buccaneers defense has conceded the 8th-most adjusted receiving yards per game in the NFL (56.0) to TEs last year.. The Buccaneers pass defense has been vulnerable when opposing tight ends have gotten into space, conceding an average of 0.00 yards-after-the-catch last year: the most in football.. The Tampa Bay Buccaneers safeties profile as the 3rd-worst collection of safeties in the league last year in covering receivers.
View 9 Picks
Jacksonville Jaguars image thumbnail JAC @ Denver Broncos image thumbnail DEN Sun, Sep 20 • 4:05 PM ET
Rushing Attempts
Bhayshul Tuten logo
Bhayshul Tuten u12.5 Rushing Attempts (-116)
Projection 10.81 (Under)
Best Odds
Pick made: 15 minutes ago
EV Model Rating
Star rating: 4 out of 5
Based on their underlying propensities and matchup dynamics, the projections expect the Jacksonville Jaguars to run on 40.3% of their downs: the 8th-lowest rate on the slate this week.
Rushing Yards
J.K. Dobbins logo
J.K. Dobbins o50.5 Rushing Yards (-120)
Projection 58.6 (Over)
Best Odds
Pick made: 28 minutes ago
EV Model Rating
Star rating: 5 out of 5
The leading projections forecast this game to have the most plays run out of all the games this week at 131.9 plays, given the play styles of each team and game dynamics.. The Broncos have run the 8th-most plays in football since the start of last season, totaling a staggering 58.7 plays per game.. The leading projections forecast J.K. Dobbins to accrue 13.8 rush attempts in this week's contest, on average, ranking him in the 80th percentile when it comes to running backs.. Out of all RBs, J.K. Dobbins grades out in the 92nd percentile for rush attempts last year, taking on 61.1% of the workload in his team's rushing attack.. J.K. Dobbins has picked up 67.0 adjusted rushing yards per game last year, one of the largest marks in football among RBs (94th percentile).
View 10 Picks
Las Vegas Raiders image thumbnail LV @ Los Angeles Chargers image thumbnail LAC Sun, Sep 20 • 4:05 PM ET
Receiving Yards
Ashton Jeanty logo
Ashton Jeanty u30.5 Receiving Yards (-135)
Projection 25.1 (Under)
Best Odds
Pick made: 11 minutes ago
EV Model Rating
Star rating: 4 out of 5
Based on their underlying traits and game dynamics, the Raiders are forecasted by the predictive model to run just 62.3 total plays in this game: the 8th-lowest number on the slate this week.. The Las Vegas Raiders have run the 4th-fewest plays in the league since the start of last season, totaling just 52.8 plays per game.. Opposing offenses teams have been afraid to rely on the passing game too much against the Los Angeles Chargers, totaling the 6th-fewest attempts in the NFL (a lowly 29.7 per game) since the start of last season.. When talking about pass protection (and the importance it has on all passing offense metrics), the O-line of the Raiders grades out as the 7th-worst in the NFL since the start of last season.. Since the start of last season, the stout Los Angeles Chargers defense has allowed a feeble 24.0 adjusted receiving yards per game versus opposing RBs: the 4th-fewest in the NFL.
Anytime Touchdown
Omarion Hampton logo
Omarion Hampton Score a Touchdown (Yes: -130)
Projection 0.76 (Yes)
Best Odds
Pick made: an hour ago
EV Model Rating
Star rating: 4 out of 5
Our trusted projections expect the Chargers to be the 8th-most pass-centric team in the NFL near the goal line (in a neutral context) at the present time with a 58.2% red zone pass rate.. The 7th-most plays in the NFL have been run by the Los Angeles Chargers since the start of last season (a colossal 59.5 per game on average).. The weatherman calls for 1-mph wind in this game. Low wind usually means increased pass volume, and reduced rush volume, increased touchdown potential, and better passing effectiveness.
View 5 Picks
Seattle Seahawks image thumbnail SEA @ Arizona Cardinals image thumbnail ARI Sun, Sep 20 • 4:25 PM ET
Receiving Yards
Jaxon Smith-Njigba logo
Jaxon Smith-Njigba o80.5 Receiving Yards (-115)
Projection 89.18 (Over)
Best Odds
Pick made: 24 minutes ago
EV Model Rating
Star rating: 5 out of 5
The Seahawks will be starting backup QB Drew Lock this week, which typically means fewer pass attempts and more rushing.. The pass games of both teams (in terms of both volume and effectiveness) figure to benefit from the calm "weather" conditions (as in zero wind) inside this dome, while run volume may decline.. In this week's contest, Jaxon Smith-Njigba is predicted by the predictive model to slot into the 99th percentile when it comes to wide receivers with 10.9 targets.. With a high 36.5% Target% (100th percentile) since the start of last season, Jaxon Smith-Njigba rates as one of the wideouts with the biggest workloads in the NFL.. With an exceptional 86.0 adjusted receiving yards per game (99th percentile) since the start of last season, Jaxon Smith-Njigba ranks among the leading wide receivers in the league in the NFL.
Receiving Yards
Jeremiyah Love logo
Jeremiyah Love o13.5 Receiving Yards (-115)
Projection 15.01 (Over)
Best Odds
Pick made: 24 minutes ago
EV Model Rating
Star rating: 4 out of 5
A passing game script is indicated by the Cardinals being a -4-point underdog in this week's game.. The predictive model expects the Arizona Cardinals as the 3rd-most pass-focused team among all teams this week with a 62.6% pass rate, based on their underlying strategic approach and matchup dynamics.. The 4th-largest volume of plays in the league have been run by the Arizona Cardinals since the start of last season (a staggering 60.0 per game on average).. This game will be played in a dome—which means no wind, increased pass volume, increased TD potential, and better passing effectiveness.. The Seattle Seahawks defense has been a prominent pass funnel since the start of last season, leading opposing quarterbacks to attempt the 3rd-most passes in football (36.1 per game) since the start of last season.
View 10 Picks
Miami Dolphins image thumbnail MIA @ San Francisco 49ers image thumbnail SF Sun, Sep 20 • 4:25 PM ET
Passing Yards
Malik Willis logo
Malik Willis o173.5 Passing Yards (-115)
Projection 197.57 (Over)
Best Odds
Pick made: 14 minutes ago
EV Model Rating
Star rating: 5 out of 5
An extreme throwing game script is suggested by the Dolphins being a giant -13.5-point underdog in this game.. The 49ers defense has been a bit of pass funnel since the start of last season, allowing opposing QBs to attempt the 8th-most passes in the NFL (33.9 per game) since the start of last season.. Malik Willis has been one of the most on-target quarterbacks in football since the start of last season with a fantastic 72.1% Adjusted Completion%, checking in at the 91st percentile.. Malik Willis has been one of the best per-play quarterbacks in the league since the start of last season, averaging a fantastic 10.36 adjusted yards-per-target while grading out in the 99th percentile.
Passing Yards
Brock Purdy logo
Brock Purdy o229.5 Passing Yards (-115)
Projection 237.59 (Over)
Best Odds
Pick made: 14 minutes ago
EV Model Rating
Star rating: 4 out of 5
The 10th-largest volume of plays in the NFL have been called by the San Francisco 49ers since the start of last season (a colossal 58.3 per game on average).. Brock Purdy profiles as one of the most accurate QBs in the league since the start of last season with an outstanding 70.7% Adjusted Completion%, ranking in the 94th percentile.. With an outstanding 7.92 adjusted yards-per-target (84th percentile) since the start of last season, Brock Purdy stands among the best per-play passers in the league.. Opposing teams have completed passes at the 4th-highest clip in the league vs. the Miami Dolphins defense since the start of last season (74.3% Adjusted Completion%).
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Washington Commanders image thumbnail WAS @ Dallas Cowboys image thumbnail DAL Sun, Sep 20 • 4:25 PM ET
Spread
Washington Commanders image thumbnail WAS +4.5 (-109)
Best Odds
Pick made: an hour ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

The Commanders overcame a no-show first half in Philadelphia and looked very strong offensively in the final 30 minutes, amassing almost 200 yards and 13 points against the Eagles’ elite stop unit. Washington was No. 6 in EPA per play in 2H offense last week. Defensively, the Commies dialed up the chaos. New defensive coordinator Daronte Jones blitzed at the fifth highest rate among all Week 1 stop units, boiling up the ninth best pressure rate and three sacks. That was against Philly’s protection, which rates out as a Top 5 o-line. The Cowboys offensive line is nowhere close to that and losing LG Tyler Smith showed up against New York last Sunday night.

Anytime Touchdown
CeeDee Lamb logo CeeDee Lamb Score a Touchdown (Yes: +120)
Best Odds
Pick made: 5 hours ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

The reason I gravitate to Lamb over Pickens in Week 2 is Washington’s new defensive coordinator Daronte Jones and his blitz-happy approach. He blitzed at the fifth highest rate in Week 1 (37.5% up from 23.5% in 2025). Dak Prescott is exceptional at recognizing and exposing the blitz, most often finding Lamb on quick reads for yards after the catch. He has six touchdowns in 11 career games versus Washington and multiple projections have Lambs’s TD probability as high as 60% on Sunday.

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Indianapolis Colts image thumbnail IND @ Kansas City Chiefs image thumbnail KC Sun, Sep 20 • 8:20 PM ET
Passing Yards
Patrick Mahomes logo
Patrick Mahomes u222.5 Passing Yards (-115)
Projection 204.66 (Under)
Best Odds
Pick made: 14 minutes ago
EV Model Rating
Star rating: 5 out of 5
This week's spread implies a rushing game script for the Chiefs, who are favored by 6.5 points.. Based on their underlying strategic approach and matchup dynamics, the projections expect the Kansas City Chiefs to pass on 52.7% of their chances: the 7th-lowest rate on the slate this week.. In this week's contest, Patrick Mahomes is projected by the projections to wind up with the 8th-fewest pass attempts among all quarterbacks with 31.6.
Receiving Yards
Josh Downs logo
Josh Downs o36.5 Receiving Yards (-115)
Projection 51.75 (Over)
Best Odds
Pick made: 26 minutes ago
EV Model Rating
Star rating: 5 out of 5
The Colts are a 6.5-point underdog in this week's game, likely creating a passing game script.. Based on their underlying propensities and matchup dynamics, the predictive model expects the Indianapolis Colts to pass on 0.0% of their opportunities: the lowest frequency among all teams this week.. In this week's contest, Josh Downs is anticipated by the projection model to position himself in the 88th percentile among wideouts with 7.3 targets.. The Colts offensive line grades out as the best in football since the start of last season in protecting the QB, which has a positive effect on all passing attack metrics across the board.. Josh Downs ranks as one of the worst wide receivers in the NFL at picking up extra yardage, averaging a lowly 0.00 yards-after-the-catch (YAC) last year while grading out in the 1st percentile.
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New York Giants image thumbnail NYG @ Los Angeles Rams image thumbnail LA Mon, Sep 21 • 8:15 PM ET
Game Prop
Los Angeles Rams image thumbnail o27.5 Team Total (-120)
Best Odds
Pick made: yesterday
Jason Logan logo
Jason Logan
Senior Betting Analyst

Sean McVay is an excellent game planner with added time he'll work out the kinks on this offense. Matthew Stafford couldn’t get going against the 49ers but faces a softer stop unit from the Giants. New York’s defense looked much better than it truly was in Week 1, due to the offense grinding out gains and chewing up TOP. The Cowboys offense only had two second half possessions and while it was limited in action, Dallas ranked out well in terms of advanced metrics like EPA per play DVOA. This is a fast track indoor at SoFi Stadium and it doesn’t seem likely that L.A.’s offense gets bottled up for a second straight game. 

Rushing Yards
Cam Skattebo logo
Cam Skattebo o50.5 Rushing Yards (-115)
Projection 57.11 (Over)
Best Odds
Pick made: 30 seconds ago
EV Model Rating
Star rating: 5 out of 5
At the moment, the 7th-most run-oriented team in the league (41.0% context-neutralized) according to our trusted projection set is the New York Giants.. The 6th-highest number of plays in the league have been called by the Giants since the start of last season (a staggering 59.7 per game on average).
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For every matchup in an NFL season, our NFL computer produces selections for a variety of different betting angles. Our computer picks are based on a proprietary algorithm that values each team in the current week to produce moneyline, spread, and point total selections.

The table above, below the game picks, tracks our NFL computer's results over the last 100 games, outlining the record and profit for selections, based on $100 unit size. We track the profit based on both opening and closing lines for every matchup.

How to Use NFL Computer Picks

The easiest way to utilize our computer picks is to simply follow our selections for every matchup, what you'd call ailing the computer." But there are other ways to utilize our NFL computer picks, as well.

You can use our NFL computer as a jumping-off point to do more research into specific lines, cross-referencing with expert picks, which can be found above the selections for some matchups, recent NFL betting trends, and more.

As well, you can gauge the confidence of the matchup. The larger the projected score, the more confident the computer is in a specific pick.

Or, if you want to implement a system, betting only on underdogs, for example, you can look for matchups in which our computer likes the underdog to inform which picks you're going to hone in on for a given week.

We have these computer picks for every sport you're looking to wager on, as well:

Free Computer Picks by Odds Shark

Moneyline

NFL moneyline picks are the simplest way to get in on the NFL action. All you have to do is simply bet on which team you think will win the game.

For moneyline picks, the favorite is represented with a minus sign (-) in front of the odds, while the underdog has a plus (+). However, you don't get the same profit for picking an underdog compared to a favorite. If the favored team is -120, a $100 bet on them would pay out $80 in profit and $180 total, if they win the game. The underdog winning at +150 would pay out a $150 profit, $250 total.

We have a complete breakdown of how to read NFL moneyline odds for these NFL computer picks.

Spread

While moneyline picks are the simplest, picking NFL games against the spread is probably the most common wager for regular NFL bettors.

To bet an NFL spread, you wager on whether a team will win by a certain number of points or more or if they'll lose by fewer points than the spread. For example, if the spread is -6.5 for the New England Patriots, you would win the bet if they win the game by 7 points or more. Or if a team is +6.5, you're betting on if they'll win outright or lose by fewer than 6.5 points.

There is a correlation between moneyline odds and the spread, as books set these lines based on the same information.

You can read more about NFL spreads here.

Totals (Over/Under)

If you aren’t entirely sold on which NFL team will win or cover in an NFL game, you can still use our NFL computer picks to bet on the point total.

As opposed to taking a side, in total or Over/Under betting, you wager on whether both NFL teams will combine for a final score of more than (Over) or less than (Under) the total number of points set by oddsmakers.

The computer picks, and your handicapping of totals is more about how you think both teams will score points, not which team has the edge to win.

More NFL Picks & Betting Tools

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NFL Free Picks FAQs

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Covers NFL picks are released two to three days before each game on the NFL schedule.

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Covers provides free NFL picks covering many markets, including point spreads, totals, moneylines, player props, and more.