The 9-3 Los Angeles Rams are coming off a bad road loss and can ill afford another when they travel within their division to face the injury-riddled 3-9 Arizona Cardinals as State Farm Stadium.
The Rams defense struggled last week, but I expect them to get back on track this week with heavy pressure on the quarterback.
Find out who I like in my Rams vs. Cardinals predictions and NFL picks for Sunday, December 7
Rams vs Cardinals prediction
Rams vs Cardinals Best bet: Jared Verse to record a sack (+120)
It is important to recognize that this market at FanDuel means Jared Verse will only need to get a half sack for this bet to hit and does not necessarily need a full sack.
The reason I love this bet is because of the matchup and the fact that Verse has been getting sacks at a strong rate in the second half of the season.
After forcing a lot of pressure early in the season, but struggling to actually finish off the sack, Verse now has six sacks on the season. The Arizona Cardinals have struggled this season to avoid heavy pass rushes despite which quarterback was at the helm.
Kyler Murray was sacked 16 times on 194 dropbacks and Jacoby Brissett has been sacked on 26 times on 344 dropbacks. That is a total of 42 sacks on 538 dropbacks, which is a 7.8% sack rate. Only Cam Ward and Geno Smith have been sacked more than the combination of these two quarterbacks.
Meanwhile, the Los Angeles Rams rank 10th in the NFL in team sacks and 13th in sack rate. They also rank 10th in quarterback pressures and 12th in pressure rate despite only ranking 28th in blitz percentage.
That is because they have a stud like Jared Verse that can get to the quarterback without needing extra blitzers to open it up.
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Rams vs Cardinals same-game parlay
To add to my best bet, I am going to add Davante Adams to score a touchdown because it has almost become a lock with him scoring in each of the last six games.
Finally, I am taking Bam Knight to stay Under his rushing total against a solid rushing defense and in a trailing game script.
Rams vs Cardinals SGP
- Jared Verse to record a sack
- Davante Adams anytime touchdown
- Bam Knight Under 38.5 rushing yards
Our big-ticket SGP: On the run
For the same reason I love my best bet, I will add Brissett to hit his rushing total on all the times he will be pressured and forcing him to take off enough times to hit this low total.
Rams vs Cardinals SGP
- Jared Verse to record a sack
- Davante Adams anytime touchdown
- Bam Knight Under 38.5 rushing yards
- Jacoby Brissett Over 11.5 rushing yards
Rams vs Cardinals odds
- Spread: Los Angeles -9.5 (-110) | Arizona +9.5 (-110)
- Moneyline: Los Angeles -550 | Arizona +410
- Over/Under: Over 47.5 (-115) | Under 47.5 (-105)
More NFL picks and odds from Covers
Rams vs Cardinals trend to know
The Los Angeles Rams have hit the Team Total Over in 15 of their last 22 games. Find more NFL betting trends for Rams vs. Cardinals.
How to watch Rams vs Cardinals
| Location | State Farm Stadium, Glendale, AZ |
| Date | Sunday, December 7, 2025 |
| Kickoff | 4:25 p.m. ET |
| TV | FOX |
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