My early Panthers vs. Packers prediction leans on a familiar bounce-back trend and fewer fireworks as both teams limp into Thursday Night Football off a loss.
The Panthers were embarrassed 43-13 by the Buccaneers, while the Packers fell 20-17 to the Lions. I'm backing the Panthers to cover +3.5 and the Under 47.5 in my latest NFL picks for Thursday, Oct. 29, with kickoff set for 8:15 p.m. ET on Prime Video.
Panthers vs Packers predictions
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Early Panthers vs Packers spread pick: Panthers +3.5
My favorite active betting trend is on the line: the Carolina Panthers are an incredible 13-0 ATS in their last 13 games following an outright loss. I'll happily back them again in this spot.
Trusting a team that just got obliterated 43-13 by the Buccaneers takes some courage, but rebounding is clearly this team's thing.
Conveniently enough, the Green Bay Packers are a brutal 1-9-1 ATS in their last 11 games following an outright loss and 4-11-1 ATS in their last 16 as a favorite. Remember their last Thursday night as a home favorite? The Packers completely no-showed, getting manhandled 35-14 by the Falcons.
Statistically, it's close, with the Packers holding a slight edge in net yards per play, but we've seen them struggle to put lesser competition away, edging a Buccaneers squad led by rookie quarterback Jalon Daniels and the Jets by just three points each.
And I don't think the Panthers qualify as lesser competition than the Packers in 2026. The Panthers also pulled off a 16-13 upset at Lambeau Field last season. Give me the points... and that beautiful hook!
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Early Panthers vs Packers total pick: Under 47.5
Packers games have generally been light on scoring. Four of their last five stayed below this number, with four not even reaching 40 combined points. We're getting a decent cushion if that pattern continues.
The Packers' offense is doing its part to keep scoring down, ranking 28th in third-down conversion percentage and 30th in red-zone TD conversion percentage. Moving the ball is one thing. Finishing drives has been a much bigger ask, so don't be shocked if the Packers' kicker gets plenty of screen time.
Going back to last season, the Panthers have gone Under in six straight road games, with all six staying below 40 combined points.
Looking at a more recent sample size, I must give credit to this Packers defense, which has held four straight opponents to 20 points or fewer, notably limiting the Cowboys and Bears to just 20 combined points in their last two games at Lambeau.
Panthers vs Packers odds
For help understanding market probabilities, see our odds calculator.
- Panthers vs Packers spread: Packers -3.5
- Panthers vs Packers moneyline: Panthers 35%, Packers 65%
- Panthers vs Packers Over/Under: 47.5
How to watch Panthers vs Packers
- Date: Thursday, Oct. 29, 2026, 8:15 p.m. ET
- City: Green Bay, Wisconsin
- Venue: Lambeau Field
- TV: Prime Video
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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