A Week 9 matchup between the Arizona Cardinals and Dallas Cowboys might not scream excitement in prime time, but with a 53.5-point total and that Dallas defense, anything is possible on Monday night, even with some uncertainty under center for the visitors.
My Cardinals vs. Cowboys predictions expect points and a heavy dose of both starting running backs in this one.
Find out why in my free NFL picks for Monday, November 3.
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Cardinals vs Cowboys prediction
Cardinals vs Cowboys Best bet: Bam Knight Over 57.5 rushing yards (-110)
Last week, Denver’s running backs gashed this awful Dallas Cowboys defense for over 150 rushing yards on 7.13 yards per carry. The Cowboys are giving up the fourth-most rushing yards per game (146), and now Bam Knight steps into a great spot with almost no competition for touches. Trey Benson is still out, Emari Demercado is banged up, and Michael Carter was released before landing back on the practice squad.
With a game total north of 50 and Knight’s rushing line set at 57.5 yards, I’m all in on him this week. I’ve already grabbed his anytime touchdown at +145, and I’m adding his rushing overs. Whether it’s Kyler Murray or Jacoby Brissett under center, I’m comfortable — Brissett actually ran the offense more efficiently in Weeks 6 and 7.
In the Arizona Cardinals' last game, Knight handled 64% of the running back opportunities, even with Carter getting seven carries for just 11 yards. Knight finished with 57 yards on 14 carries against an elite Green Bay run defense. Over his two starts, he’s faced tough run units (Packers, Colts) but still logged 25 carries for 91 yards and a score.
With that kind of volume against this soft Dallas defense, 15 carries for 60 yards would only require 4.0 yards per carry—a modest ask versus a defense allowing 4.9 per rush on the season.
The matchup is perfect, and the opportunities could be more than expected.
Cardinals vs Cowboys MNF same-game parlay
The man with two names will have plenty of room to run as the Dallas defense tries to cover its warts in the secondary and mask the extensive injuries. He could be facing some light boxes. Javonte Williams might be an auto-bet to score in a game with a total of 53.5. Only Josh Jacobs and Jonathan Taylor have more red-zone TDs than Williams at seven.
Cardinals vs Cowboys SGP
- Bam Knight TD
- Javonte Williams TD
- Bam Knight Over 56.5 rushing yards
Our big-ticket SGP: Knight and Jay
It might only be two legs, but with the indoor setting and a 53.5-point total, these are the two backs who get to finish off every drive.
Cardinals vs Cowboys SGP
- Knight 2+ TDs
- Williams 2+ TDs
Cardinals vs Cowboys odds
- Spread: Cardinals +3 | Cowboys -3
- Moneyline: Cardinals +130 | Cowboys -155
- Over/Under: Over 53.5 | Under 53.5
Cardinals vs Cowboys betting trend to know
Dating back to last season, Dak Prescott is a perfect 6-0 O/U at home on the closing total. Find more NFL betting trends for Cardinals vs. Cowboys.
How to watch Cardinals vs Cowboys
| Location | AT&T Stadium, Arlington, TX |
| Date | Monday, November 3, 2025 |
| Kickoff | 8:15 p.m. ET |
| TV | ESPN or ABC |
Cardinals vs Cowboys latest injuries
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