Iowa State vs Iowa Combo Picks for College Football Week 2: TD Picks & Props

Rob Paul - Betting Analyst at Covers.com
Rob Paul • Betting Analyst 5+ years betting experience
Updated: Sep 12, 2026 , 03:00 PM ET • 4 min read

With Iowa State facing significant roster turnover, expect the Cy-Hawk Trophy to stay in Iowa City following a dominant Hawkeyes performance.

Iowa wide receiver Tony Diaz (14) reacts after scoring a touchdown.
Photo By - Reuters Connect. Iowa wide receiver Tony Diaz (14) reacts after scoring a touchdown.

Iowa will look to hoist the Cy-Hawk Trophy for the first time since 2023 when the Hawkeyes host archrival Iowa State this evening at 7:30 p.m. ET (NBC).

While the Cyclones have won the last two Cy-Hawk games, my Iowa State vs. Iowa combos and college football picks project this Saturday, Sept. 12, matchup to be dominated by the Hawkeyes at Kinnick Stadium, especially with Matt Campbell no longer in Ames.

Best Iowa State vs Iowa combos for Week 2

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Iowa State vs Iowa combo

The recent Iowa State vs. Iowa rivalry history has featured low-scoring games, with six of the last seven contests hitting the Under. The trend should continue this year, even with Iowa set to dominate both sides of the ball.

Iowa State will struggle to score even 13 points against an Iowa defense ranked 11th by SP+. Eight of the Cyclones' 11 offensive starters are Group of Six or FCS transfers, and they managed just 303 total yards last week against a Southeast Missouri State team coming off a 4-8 season.

In four starts against P4 defenses while at Arkansas State, Cyclones quarterback Jaylen Raynor threw just one touchdown and had 11 turnover-worthy plays.

This rivalry also hasn't been kind to first-year head coaches on the Cyclones' sideline. During Hayden Fry's and Kirk Ferentz's tenures, Iowa is 6-1 straight-up against Iowa State head coaches in their first Cy-Hawk game, beating them by an average score of 35.1 to 9.1.

Iowa State vs Iowa player prop combo

The biggest reason my Iowa State vs. Iowa prediction projects a 27-10 home win for Iowa is due to the Hawkeyes' offensive advantage.

Iowa State's defense is starting seven players who were playing at the G6/FCS/JUCO level last season, while Iowa has its best set of playmakers in years.

Not only do the Hawkeyes boast a top offensive line led by preseason All-Americans Trevor Lauck and Kade Pieper, but the offensive trio of Kamari Moulton, Tony Diaz, and DJ Vonnahme are All-Big Ten talents.

Moulton led the country in 15+-yard runs in Week 1 (4), thriving in Tim Lester's Shanahan zone scheme behind this O-line. That only made things easier on Diaz and Vonnahme, who combined for 11 receptions for 126 yards last week, despite Iowa running a two-QB system.

Diaz's big-play ability and Vonnahme's versatility should create mismatches against an Iowa State back seven featuring six new starters.

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Rob Paul - Contributor at Covers.com
Betting Analyst

Rob Paul has worked in the sports betting industry for several years, primarily covering collegiate sports with a sprinkle of NFL, NBA, WNBA, and CFL. He uses a combination of advanced stats and film to find betting value, and aims to exploit specific matchups with plus-money player props.

A college sports junky, Rob's betting process tends to revolve around which games he plans on watching on a given day/week. He begins the process by looking at the college football/basketball schedule and making a list of what he plans on watching before diving into advanced numbers to help inform how to bet each matchup.

Typically, Rob bets at FanDuel and bet365, as they tend to offer a wider array of collegiate player props. Rob loves the way sports betting can act as a catalyst for telling stories and growing interest in certain sports, particularly Group of Six and FCS football, WNBA, and mid-major college basketball.

Before joining Covers, he contributed to various sports outlets, including FanSided and Pro Football Network, building his college football and NFL experience and expertise while working as a full-time local community journalist.

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