The Chicago Cubs host the Chicago White Sox in the second matchup of this three-game series at Wrigley Field. MLB odds list Chicago as a -270 favorite, while the total sits at 10.5.
My White Sox vs. Cubs prediction targets a side in this intrastate matchup.
Read on for my MLB picks for Saturday, May 17.
White Sox vs Cubs prediction
My White Sox vs Cubs best bet: Cubs -1.5 (-128 at FanDuel)
While the Chicago Cubs are a chalky pick in this game, they are the stronger team in every category. First, their lineup is superior.
The Cubs are more powerful than the Chicago White Sox, outranking them in slugging percentage, OPS and home runs. They are also better at reaching base, outpacing the White Sox in hits per game, batting average and on-base percentage.
Subsequently, there is a substantial gap of 2.1 runs scored per game between these two teams.
The Cubs also possess the pitching advantage as left-hander Matthew Boyd takes the mound. Through eight starts this season, Boyd is 3-2 with a 2.78 ERA and 1.30 WHIP.
His underlying metrics are equally impressive, as he ranks in the top half of the league in expected ERA (xERA), average exit velocity, barrel rate and hard-hit rate. Boyd also possesses solid command, ranking in the top half of the league in both strikeout rate and walk rate.
On the other hand, the White Sox send right-hander Sean Burke to the mound. Analytically, Burke is one of the worst pitchers in baseball, ranking in the bottom fifth of the league in xERA, expected batting average (xBA) and barrel rate.
White Sox vs Cubs same-game parlay (SGP)
Cubs -1.5
Pete Crow-Armstrong to record a hit
Kyle Tucker to record a hit
If we’re backing the Cubs to win this game, then they’ll need contributions from key hitters. There are perhaps no two better candidates than Pete Crow-Armstrong and Kyle Tucker.
Crow-Armstrong is making a push for NL MVP, recording 16 hits over his past 13 games. He boasts a .320 batting average over that stretch.
Meanwhile, Tucker has tallied 13 hits over his past 14 games, proving nearly as dominant.
Learn how to bet a same-game parlay with these helpful tips and strategies.
White Sox vs Cubs odds
White Sox vs Cubs live odds
White Sox vs Cubs opening odds
- Moneyline: Chicago (AL) +220 | Chicago (NL) -270
- Run line: Chicago (AL) +1.5 (+106) | Chicago (NL) -1.5 (-128)
- Over/Under: Over 10.5 (+100) | Under 10.5 (-122)
White Sox vs Cubs trend
The Cubs have won each of the past six meetings between these two teams. Find more MLB betting trends for White Sox vs. Cubs.
How to watch White Sox vs Cubs and game info
| Location | Wrigley Field, Chicago, Illinois |
| Date | Saturday, 5-17-2025 |
| First pitch | 2:20 p.m. ET |
| TV | CHSN, MARQ |
| White Sox starting pitcher | Sean Burke (2-4, 4.15 ERA) |
| Cubs starting pitcher | Matthew Boyd (3-2, 2.78 ERA) |
White Sox vs Cubs latest injuries
White Sox vs Cubs weather
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
