Opening NFL Week 15 Odds and Betting Lines: Buffalo -1.5 at New England

The NFL Week 15 odds are loaded with marque matchups carrying plenty of postseason weight.

The Buffalo Bills at New England Patriots (+1.5), Detroit Lions at Los Angeles Rams (-4.5), and Green Bay Packers at Denver Broncos (+2.5) are the big games for this go-around, and they'll all be in the books before Sunday Night Football.

Here's a look at the opening NFL Week 15 odds and early adjustments.

NFL odds Week 15

Matchup	Spread	Moneyline	Over/Under
Falcons vs Buccaneers	Buccaneers -4.5	Falcons +194 Buccaneers -235	44.5
Raiders vs Eagles	Eagles -11.5	Raiders +560 Eagles -770	38.5
Commanders vs Giants	Giants -2.5	Commanders +116 Giants -136	46.5
Chargers vs Chiefs	Chiefs -4.5	Chargers +180 Chiefs -215	42.5
Browns vs Bears	Bears -7.5	Browns +330 Bears -420	40.5
Cardinals vs Texans	Texans -9.5	Cardinals +420 Texans -560	42.5
Jets vs Jaguars	Jaguars -11.5	Jets +560 Jaguars -800	41.5
Ravens vs Bengals	Bengals +2.5	Ravens -142 Bengals +120	51.5
Bills vs Patriots	Patriots +1.5	Bills -118 Patriots +100	49.5
Panthers vs Saints	Saints +2.5	Panthers -144 Saints +122	40.5
Colts vs Seahawks	Seahawks -13.5	Colts +730 Seahawks -1150	42.5
Lions vs Rams	Rams -5.5	Lions +205 Rams -250	54.5
Titans vs 49ers	49ers -12.5	Titans +730 49ers -1150	44.5
Packers vs Broncos	Broncos +2.5	Packers -136 Broncos +116	42.5
Vikings vs Cowboys	Cowboys -6.5	Vikings +240 Cowboys -295	47.5
Dolphins vs Steelers	Steelers -3.5	Dolphins +164 Steelers -196	42.5

Lines as of 12-9

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Falcons vs Buccaneers odds (Thursday, 8:15 p.m. ET, Prime)

Opening line

• Buccaneers -5.5
• Over/Under 43.5
• View full Falcons vs. Buccaneers odds and matchup
• Read our Falcons vs. Buccaneers picks and predictions (coming soon)

The Buccaneers opened as 5.5-point home favorites, but the vig is swinging toward Atlanta, and this spread could shorten later in the week. There are some injuries on both sides of the ball for Tampa Bay on the short week, and WR Mike Evans' status is up in the air. This total hit the board at 43.5 and climbed to 44.5, through the key stop of 44 points.

Also see: full Thursday Night Football odds

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Raiders vs Eagles odds (Sunday, 1:00 p.m. ET, FOX)

Opening line

• Eagles -11.5
• Over/Under 38.5
• View full Raiders vs. Eagles odds and matchup
• Read our Raiders vs. Eagles picks and predictions (coming soon)

The Eagles stumble back home after an ugly loss on MNF to the Chargers. Philadelphia is a 11.5-point home chalk hosting the Raiders in what is forecasted to be a chilly day at Lincoln Financial Field. The total is at 38.5 points.

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Commanders vs Giants odds (Sunday, 1:00 p.m. ET, FOX)

Opening line

• Giants -1.5
• Over/Under 46.5
• View full Commanders vs. Giants odds and matchup
• Read our Commanders vs. Giants picks and predictions (coming soon)

The Commanders are likely without QB Jayden Daniels again after he made a brief return in Week 14 before suffering a wrist injury. New York is coming off the bye week and opened as a 1.5-point favorite before jumping to -2.5. This total opened at 46.5 and climbed to 47.5 points through the key O/U number of 47 points.

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Chargers vs Chiefs odds (Sunday, 1:00 p.m. ET, CBS)

Opening line

• Chiefs -4.5
• Over/Under 43.5
• View full Chargers vs. Chiefs odds and matchup
• Read our Chargers vs. Chiefs picks and predictions (coming soon)

The Chargers got past Philadelphia in OT on MNF and now visit the rival Chiefs in Week 15. Kansas City opened as a 4.5-point home favorite and all eyes are on the non-throwing hand of L.A. quarterback Justin Herbert, who had to alter his snaps in Week 14. This total opened at 43.5 and dropped to 42.5 with the Chargers going run heavy with Herbert hurting.

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Browns vs Bears odds (Sunday, 1:00 p.m. ET, FOX)

Opening line

• Bears -7.5
• Over/Under 40.5
• View full Browns vs. Bears odds and matchup
• Read our Browns vs. Bears picks and predictions (coming soon)

The Bears dropped from the No. 1 seed in the NFC to the No. 7 spot after a tough loss at Lambeau Field on Sunday. Chicago returns home as 7.5-point home chalk to Cleveland, though many books are already down to a touchdown. The Over/Under opened at 40.5 and slipped to 39.5 points. The Browns have some notable injuries on both sides of the ball, including DB Denzel Ward and TE David Njoku.

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Cardinals vs Texans odds (Sunday, 1:00 p.m. ET, FOX)

Opening line

• Texans -8.5
• Over/Under 42.5
• View full Cardinals vs. Texans odds and matchup
• Read our Cardinals vs. Texans picks and predictions (coming soon)

The Texans looked locked in during their win over Kansas City on Sunday night. Houston was a touchdown favorite on the look-ahead line, but the official opener hit the board at Texans -8.5 and instantly leaped to -9.5. The total opened at 42.5 points.

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Jets vs Jaguars odds (Sunday, 1:00 p.m. ET, CBS)

Opening line

• Jaguars -10.5
• Over/Under 42.5
• View full Jets vs. Jaguars odds and matchup
• Read our Jets vs. Jaguars picks and predictions (coming soon)

Jacksonville scored a huge win over Indianapolis in Week 14 and now hosts the Jets, who will likely be without QB1 Tyrod Taylor. The Jaguars opened as 10.5-point chalk and climbed to -11.5. This Over/Under opened as high as 42.5 points at some shops, but is down to 41.5 O/U on Monday morning.

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Ravens vs Bengals odds (Sunday, 1:00 p.m. ET, CBS)

Opening line

• Bengals +2.5
• Over/Under 51.5
• View full Ravens vs. Bengals odds and matchup
• Read our Ravens vs. Bengals picks and predictions (coming soon)

The Bengals are making life interesting in the AFC North and face the Ravens for the second time in three weeks. Baltimore opened as a 2.5-point road favorite, but the vig on the Bengals +2.5 is rising, and we could see this spread shorten up. This total is a tall one, opening at 51.5 and bouncing between that number and 52.5. Cincinnati beat Baltimore 32-14 on Thanksgiving Thursday in Week 13.

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Bills vs Patriots odds (Sunday, 1:00 p.m. ET, CBS)

Opening line

• Patriots +1.5
• Over/Under 48.5
• View full Bills vs. Patriots odds and matchup
• Read our Bills vs. Patriots picks and predictions (coming soon)

A massive game in the AFC East saw the Patriots open as 1.5-point home underdogs to the Bills in Week 15. However, we’re watching this spread shrink across the industry on Monday morning, with some sportsbooks at New England -1. The total opened at 48.5 and jumped to 49.5 points. 

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Panthers vs Saints odds (Sunday, 4:25 p.m. ET, FOX)

Opening line

• Saints +2.5
• Over/Under 39.5
• View full Panthers vs. Saints odds and matchup
• Read our Panthers vs. Saints picks and predictions (coming soon)

The Saints stunned the Bucs in Week 14 and now host the Panthers, who are fresh off a bye week. New Orleans hit the board as a 2.5-point underdog, and the vig is rising on the favorite, which means a move to a field goal could be coming. This total opened at 39.5 points. 

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Colts vs Seahawks odds (Sunday, 4:25 p.m. ET, CBS)

Opening line

• Seahawks -9.5
• Over/Under 43.5
• View full Colts vs. Seahawks odds and matchup
• Read our Colts vs. Seahawks picks and predictions (coming soon)

Colts QB Daniel Jones suffered a torn Achilles in Week 14, and that leaves Indianapolis in the hands of third-string rookie Riley Leonard. The look-ahead line was Seattle -3.5, but the official opener – with Jones out – hit the board at Seahawks -9.5 and instantly jumped through the key number to -10.5. The look-ahead total was at 46.5 points, but the official O/U opened at 43.5 points.  

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Lions vs Rams odds (Sunday, 4:25 p.m. ET, FOX)

Opening line

• Rams -4.5
• Over/Under 52.5
• View full Lions vs. Rams odds and matchup
• Read our Lions vs. Rams picks and predictions (coming soon)

The Lions and Rams have a nice non-divisional rivalry going, thanks to their quarterbacks. Matthew Stafford and L.A. opened as 4.5-point favorites in Detroit, and that spread swelled to -5.5. The Lions beat up on Dallas on Thursday and have had extra time to heal and prep for this monster NFC matchup. The total opened at 52.5 and is up to 53.5 O/U.  

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Titans vs 49ers odds (Sunday, 4:25 p.m. ET, FOX)

Opening line

• 49ers -13.5
• Over/Under 44.5
• View full Titans vs. 49ers odds and matchup
• Read our Titans vs. 49ers picks and predictions (coming soon)

The Titans stole a win in Cleveland and now head to Santa Clara to face the 49ers in Week 15. San Francisco is coming off a much-needed bye and opened as a 13.5-point home favorite. That number dropped to -12.5 with early opinions on the underdog. This Over/Under opened at 44.5 and has bounced between that number and 43.5 points.

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Packers vs Broncos odds (Sunday, 4:25 p.m. ET, FOX)

Opening line

• Broncos +2.5
• Over/Under 41.5
• View full Packers vs. Broncos odds and matchup
• Read our Packers vs. Broncos picks and predictions (coming soon)

The Broncos opened as 2.5-point home underdogs to the Packers on Sunday afternoon. Vig on the home pup is up to -115, which could see this spread shrink later in the week. The Over/Under hit the board at 41.5 points and is up to 42.5 with play on the Over.

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Vikings vs Cowboys odds (Sunday, 8:20 p.m. ET, NBC)

Opening line

• Cowboys -7.5
• Over/Under 47.5
• View full Vikings vs. Cowboys odds and matchup
• Read our Vikings vs. Cowboys picks and predictions (coming soon)

The Cowboys have had a mini-bye to shake off last Thursday’s loss to the Lions. Dallas opened as a 6.5-point home chalk to the Vikings on Sunday Night Football, and the vig on the dog could see this spread get knocked down to Minnesota +6 later in the week. This Over/Under number opened at 47.5 points.

Also see: full Sunday Night Football odds

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Dolphins vs Steelers odds (Monday, 8:15 p.m. ET, ESPN)

Opening line

• Steelers -3.5
• Over/Under 42.5
• View full Dolphins vs. Steelers odds and matchup
• Read our Dolphins vs. Steelers picks and predictions (coming soon)

The Dolphins have won four in a row but opened as 3.5-point road underdogs at Pittsburgh on Monday Night Football. This total opened at 42.5 points and has bounced between that number and 43.5 O/U. Miami RB De’Von Achane left Sunday’s game with a rib injury but isn’t expected to miss MNF.

Also see: full Monday Night Football odds

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