NBA Opening Night wraps up with a Western Conference Finals rematch, and my Thunder vs. Spurs prediction backs San Antonio as a 2.5-point home favorite.
Tipoff is at 9:30 p.m. ET at Frost Bank Center, with a total of 231.5.
For more opening-night analysis and angles, check out our latest NBA picks.
TOP PICK
Thunder vs Spurs prediction: Spurs -2.5
Ultimately, I'd invest in the San Antonio Spurs up to -3.5 at home over any team in the NBA.
San Antonio is my preseason pick in the NBA championship odds, led by the best basketball player I've ever seen, Victor Wembanyama, plus two All-NBA-caliber young guards in Dylan Harper and Stephon Castle.
The Spurs were 8-4 straight up (SU) and against the spread (ATS) vs. the Oklahoma City Thunder with a +7.6 spread differential last regular season and in the playoffs.
San Antonio also went 4-1 SU and ATS against OKC in the regular season and NBA Cup despite Wembanyama starting only twice and averaging 25.1 minutes across those five games. Now Wemby should be fully unleashed.
COVERS INTEL: The Spurs beat the Thunder in 3-pointers, free-throw attempts, and rebounds per game in their 12 meetings last season.
Thunder vs Spurs combo
San Antonio’s moneyline gives me a little more margin for error while keeping the combo centered on how I think this game plays out.
Oklahoma City should still generate quality half-court offense through Isaiah Hartenstein, whose passing can punish San Antonio when it sends extra attention toward the Thunder’s primary scorers.
On the other end, Spurs PG De’Aaron Fox doesn’t need to dominate the ball to make an impact. With San Antonio's young playmakers creating advantages, Fox can slide into space and capitalize from outside.
If both offenses lean into those roles, Hartenstein and Fox can deliver their pieces without preventing San Antonio from finishing the night with a win.
Thunder vs Spurs combo
- San Antonio's moneyline
- Isaiah Hartenstein 3+ assists
- De'Aaron Fox 2+ threes
Thunder vs Spurs odds
For help understanding probabilities, see our odds calculator.
- Spread: Thunder +2.5 | Spurs -2.5
- Over/Under: Over 231.5 | Under 231.5
- Moneyline: Thunder 45% | Spurs 56%
For the full slate of NBA matchups, check out our NBA odds board!
Thunder vs Spurs trend
San Antonio was 18-12 ATS vs. teams with a 60% winning rate or higher last regular season. Find more NBA betting trends.
How to watch Thunder vs Spurs
| Location | Frost Bank Center, San Antonio, Texas |
| Date | Tuesday, Oct. 20, 2026 |
| Tip off | 9:30 p.m. ET |
| TV | NBC |
Thunder vs Spurs latest injuries
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Odds are correct at the time of publishing and are subject to change.
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