NFL Week 12 is a little short on marquee matchups, but there is still plenty of betting intrigue.
Of all the games on the slate, the Indianapolis Colts vs. Kansas City Chiefs clash is the most interesting. KC was -4.5 on the look-ahead line, but reopened at -3.5 after losing in Denver on Sunday.
The Los Angeles Rams host the Tampa Bay Buccaneers as 6.5-point favorites. Both teams are coming off tough games, with the Rams narrowly beating the Seahawks (despite Sam Darnold's four interceptions) and the Bucs just couldn't overcome the Buffalo Bills. This is still a bout between contenders worth keeping an eye on.
Here's a full look at the NFL Week 12 slate and all the early odds, starting with Buffalo vs. Houston on Thursday Night Football.
NFL odds Week 12
| Matchup | Spread | Moneyline | Over/Under |
|---|---|---|---|
 Billsvs  Texans |
Texans +4.5 | Bills -200 Texans +168 |
43.5 |
 Vikingsvs  Packers |
Packers -6.5 | Vikings +235 Packers -290 |
42.5 |
 Coltsvs  Chiefs |
Chiefs -3.5 | Colts +172 Chiefs -205 |
49.5 |
 Patriotsvs  Bengals |
Bengals +7 | Patriots -355 Bengals +285 |
50.5 |
 Steelersvs  Bears |
Bears -3 | Steelers +136 Bears -162 |
44.5 |
 Jetsvs  Ravens |
Ravens -14.5 | Jets +750 Ravens -1200 |
44.5 |
 Giantsvs  Lions |
Lions -11.5 | Giants +540 Lions -770 |
48.5 |
 Seahawksvs  Titans |
Titans +12.5 | Seahawks -820 Titans +570 |
42.5 |
 Jaguarsvs  Cardinals |
Cardinals +2.5 | Jaguars -138 Cardinals +118 |
46.5 |
 Brownsvs  Raiders |
Raiders -3 | Browns +132 Raiders -156 |
37.5 |
 Eaglesvs  Cowboys |
Cowboys +3.5 | Eagles -205 Cowboys +172 |
51.5 |
 Falconsvs  Saints |
Saints +2.5 | Falcons -132 Saints +112 |
40.5 |
 Buccaneersvs  Rams |
Rams -6.5 | Buccaneers +260 Rams -320 |
49.5 |
 Panthersvs  49ers |
49ers -7 | Panthers +270 49ers -335 |
47.5 |
Lines as of 11-16
Bills vs Texans odds (Thursday, 8:15 p.m. ET, Prime Video)
Opening line
- Texans +2.5
- Over/Under 45.5
- View full Bills vs. Texans odds and matchup
- Read our Bills vs. Texans picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Thursday Night Football odds
Vikings vs Packers odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Packers -6.5
- Over/Under 43.5
- View full Vikings vs. Packers odds and matchup
- Read our Vikings vs. Packers picks and predictions (coming soon)
Opening line analysis coming soon!
Colts vs Chiefs odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Chiefs -4.5
- Over/Under 50.5
- View full Colts vs. Chiefs odds and matchup
- Read our Colts vs. Chiefs picks and predictions (coming soon)
Opening line analysis coming soon!
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Patriots vs Bengals odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Bengals +5.5
- Over/Under 50.5
- View full Patriots vs. Bengals odds and matchup
- Read our Patriots vs. Bengals picks and predictions (coming soon)
Opening line analysis coming soon!
Steelers vs Bears odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Bears -1.5
- Over/Under 45.5
- View full Steelers vs. Bears odds and matchup
- Read our Steelers vs. Bears picks and predictions (coming soon)
Opening line analysis coming soon!
Jets vs Ravens odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Ravens -14.5
- Over/Under 44.5
- View full Jets vs. Ravens odds and matchup
- Read our Jets vs. Ravens picks and predictions (coming soon)
Opening line analysis coming soon!
Covers NFL awards analysis
Giants vs Lions odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Lions -9.5
- Over/Under 49.5
- View full Giants vs. Lions odds and matchup
- Read our Giants vs. Lions picks and predictions (coming soon)
Opening line analysis coming soon!
Seahawks vs Titans odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Titans +12.5
- Over/Under 43.5
- View full Seahawks vs. Titans odds and matchup
- Read our Seahawks vs. Titans picks and predictions (coming soon)
Opening line analysis coming soon!
Jaguars vs Cardinals odds (Sunday, 4:05 p.m. ET, CBS)
Opening line
- Cardinals -1.5
- Over/Under 44.5
- View full Jaguars vs. Cardinals odds and matchup
- Read our Jaguars vs. Cardinals picks and predictions (coming soon)
Opening line analysis coming soon!
More NFL betting analysis
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- Lamar Jackson’s record vs. every NFL team
Browns vs Raiders odds (Sunday, 4:05 p.m. ET, CBS)
Opening line
- Raiders -2.5
- Over/Under 37.5
- View full Browns vs. Raiders odds and matchup
- Read our Browns vs. Raiders picks and predictions (coming soon)
Opening line analysis coming soon!
Eagles vs Cowboys odds (Sunday, 4:25 p.m. ET, FOX)
Opening line
- Cowboys +3.5
- Over/Under 51.5
- View full Eagles vs. Cowboys odds and matchup
- Read our Eagles vs. Cowboys picks and predictions (coming soon)
Opening line analysis coming soon!
Falcons vs Saints odds (Sunday, 4:25 p.m. ET, FOX)
Opening line
- Saints +3.5
- Over/Under 41.5
- View full Falcons vs. Saints odds and matchup
- Read our Falcons vs. Saints picks and predictions (coming soon)
Opening line analysis coming soon!
Buccaneers vs Rams odds (Sunday, 8:20 p.m. ET, NBC)
Opening line
- Rams -6.5
- Over/Under 48.5
- View full Buccaneers vs. Rams odds and matchup
- Read our Buccaneers vs. Rams picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Sunday Night Football odds
Panthers vs 49ers odds (Monday, 8:15 p.m. ET, ESPN)
Opening line
- 49ers -6.5
- Over/Under 46.5
- View full Panthers vs. 49ers odds and matchup
- Read our Panthers vs. 49ers picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Monday Night Football odds
Best NFL bets this week
Looking for our favorite spread, total, and NFL prop bets for this week's action? Check out our best free NFL picks from the Covers staff!
Odds are correct at the time of publishing and are subject to change.
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