The 9-3 Los Angeles Rams will be playing with conviction today after coming off a tough loss against the Panthers, and the Arizona Cardinals will feel the wrath.
My Rams vs. Cardinals predictions expect Jared Verse to get to the quarterback at least once this afternoon.
Find out more in my free NFL picks for Sunday, December 7, ahead of kickoff at 4:25 p.m. ET on FOX.
Rams vs Cardinals prediction
Rams vs Cardinals Best bet: Jared Verse to record a sack (+120)
It's important to recognize this market at FanDuel means Jared Verse will only need to get a half sack for this bet to hit and does not necessarily need a full sack.
The reason I love this bet is because of the matchup and the fact that Verse has been getting sacks at a strong rate in the second half of the season.
After forcing a lot of pressure early in the season, but struggling to actually finish off the sack, Verse now has six sacks on the season. The Arizona Cardinals have struggled this season to avoid heavy pass rushes despite which quarterback was at the helm.
Kyler Murray was sacked 16 times on 194 dropbacks and Jacoby Brissett has been sacked on 26 times on 344 dropbacks. That is a total of 42 sacks on 538 dropbacks, which is a 7.8% sack rate. Only Cam Ward and Geno Smith have been sacked more than the combination of these two quarterbacks.
Meanwhile, the Los Angeles Rams rank 10th in the NFL in team sacks and 13th in sack rate. They also rank 10th in quarterback pressures and 12th in pressure rate despite only ranking 28th in blitz percentage.
That is because they have a stud like Jared Verse that can get to the quarterback without needing extra blitzers to open it up.
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Rams vs Cardinals same-game parlay
To add to my best bet, I am going to add Davante Adams to score a touchdown because it has almost become a lock with him scoring in each of the last six games.
Finally, I am taking Bam Knight to stay Under his rushing total against a solid rushing defense and in a trailing game script.
Rams vs Cardinals SGP
- Jared Verse to record a sack
- Davante Adams anytime touchdown
- Bam Knight Under 38.5 rushing yards
Our big-ticket SGP: On the run
For the same reason I love my best bet, I will add Brissett to hit his rushing total on all the times he will be pressured and forcing him to take off enough times to hit this low total.
Rams vs Cardinals SGP
- Jared Verse to record a sack
- Davante Adams anytime touchdown
- Bam Knight Under 38.5 rushing yards
- Jacoby Brissett Over 11.5 rushing yards
Rams vs Cardinals game predictions
Rams vs Cardinals moneyline prediction
Rams moneyline (-549): The Rams cannot afford a loss here if they want to keep a stranglehold on the NFC West and they will not squander it after losing last week.
Rams vs Cardinals spread prediction
Cardinals +9.5 (-113): It is hard to bet against a divisional home team at this high of a spread. The Cardinals have still been competitive in recent weeks against good teams.
Rams vs Cardinals Over/Under prediction
Over 47.5 (-115): Most of the sharp money has come in on the Over here and the Cardinals should still be able to score enough to hit this total.
Rams vs Cardinals odds
- Spread: Los Angeles -9.5 (-112) | Arizona +9.5 (-108)
- Moneyline: Los Angeles -590 | Arizona +430
- Over/Under: Over 47.5 (-115) | Under 47.5 (-105)
More NFL picks and odds from Covers
Rams vs Cardinals trend to know
The Los Angeles Rams have hit the team total Over in 15 of their last 22 games. Find more NFL betting trends for Rams vs. Cardinals.
How to watch Rams vs Cardinals
| Location | State Farm Stadium, Glendale, AZ |
| Date | Sunday, December 7, 2025 |
| Kickoff | 4:25 p.m. ET |
| TV | FOX |
Rams vs Cardinals latest injuries
Kyler Murray was announced out for the season, meaning Jacoby Brissett will remain as Arizona's QB1.
Rams vs Cardinals weather
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