The banged-up Arizona Cardinals will try to break a four-game losing streak as they host the Green Bay Packers at State Farm Stadium today. Kickoff comes your way at 4:25 p.m. ET on FOX, with the Packers holding as a 7-point favorite with a total of 44.5.
My Packers vs. Cardinals predictions believe Green Bay is in great position to pick up its first road win of the season.
Read more in my free NFL picks for Sunday, October 19.
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Packers vs Cardinals prediction
Packers vs Cardinals Best bet: Packers -6.5 (-120)
The Arizona Cardinals haven't won a game since a 27-22 win over the Carolina Panthers back on September 14, and though its four consecutive losses have all been close games, things aren’t looking up heading into Sunday’s game against the Packers.
The Cardinals don’t know who their quarterback will be this week, as Kyler Murray is still questionable with a foot injury, while Jacoby Brissett is coming off a solid performance in relief last week.
While the Green Bay Packers are 3-1-1 on the year, that might undersell how good they’ve looked overall. Green Bay had a few bad minutes against the Cleveland Browns which led to their only loss, and suffered a bizarre 40-40 tie on the road against the Dallas Cowboys.
But this is the same team that has a two-touchdown victory over the Detroit Lions. Along with continued improvement by Jordan Love at quarterback, the Packers have held every opponent except for Dallas to 18 points or less, while Arizona is only averaging 21.7 ppg.
The Cardinals have been keeping games close, but the Packers should be able to outgun them by enough to win by at least a touchdown.
I’m taking Green Bay to cover.
Packers vs Cardinals same-game parlay
The Packers are the clear favorite, as their defense should be able to shut down a Cardinals offense that’s averaging just 21.7 ppg and is dealing with a series of injuries.
Romeo Doubs is an excellent option as a TD scorer for our SGP, as opponents are throwing for 246 yards per game against Arizona.
Packers vs Cardinals 3-leg SGP
- Packers -6.5
- Under 44.5
- Romeo Doubs anytime TD
Our big-ticket SGP: Doubs to have a day
Doubs has gone for 55+ yards in each of his last two games, and is getting more looks than ever in the Green Bay offense over that span.
Packers vs Cardinals 4-leg SGP
- Packers -6.5
- Under 44.5
- Romeo Doubs anytime TD
- Romeo Doubs Over 49.5 receiving yards
Packers vs Cardinals odds
- Spread: Packers -7 (-105) | Cardinals +7 (-115)
- Moneyline: Packers -350 | Cardinals +280
- Over/Under: Over 44.5 (-108) | Under 44.5 (-112)
Packers vs Cardinals game predictions
Packers vs Cardinals moneyline prediction
The Cardinals have lost four straight and are dealing with a series of injuries. The Packers should have little trouble picking up a road win.
Packers vs Cardinals spread prediction
The Packers are the far better team, and with the spread hanging below a full touchdown, I’m backing Green Bay to cover.
Packers vs Cardinals Over/Under prediction
Between a Green Bay defense that has held four of its five opponents to 18 points or less and a mediocre Arizona offense, the Under is the better play in this game.
More NFL picks and odds from Covers
Packers vs Cardinals trend to know
The Cardinals are 0-3 ATS at home this season. Find more NFL betting trends for Packers vs. Cardinals.
How to watch Packers vs Cardinals
| Location | State Farm Stadium, Glendale, AZ |
| Date | Sunday, October 19, 2025 |
| Kickoff | 4:25 p.m. ET |
| TV | FOX |
Packers vs Cardinals latest injuries
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