The Miami Dolphins notched their first win of the season last week and now travel north looking to make it two straight when they face the 1-3 Carolina Panthers on Sunday.
My Dolphins vs. Panthers predictions and NFL picks expect Miami to cover the number on the heels of a busy afternoon from running back De'Von Achane.
Dolphins vs Panthers prediction
Dolphins vs Panthers Best bet: De'Von Achane Over 63.5 rushing yards (-114)
There’s nothing scary about a Carolina Panthers rush defense that’s surrendered the fourth-highest yards per carry to opposing running backs (5.4), while also allowing the ninth-highest EPA per run.
Of course, Miami Dolphins running back De'Von Achane has also run well in consecutive games, averaging a rock-solid 161 yards at 5.0 per tote.
With No. 1 wide receiver Tyreek Hill (knee) out for the season, the Miami offense has all the more reason to turn to Achane early and often on Sunday.
The third-year rusher has impressed with strong underlying metrics, ranking top 10 in yards after contact per attempt and forced missed tackles, while leading all running backs with at least 40 carries in PFF’s elusive rating.
It all adds up to a big day on the ground for Achane.
Dolphins vs Panthers same-game parlay
Miami has played well in consecutive weeks, hanging tight with the Bills on Thursday Night Football in Week 3 and following it up with a Week 4 win over the Jets.
I also give the Dolphins the advantage behind center, with Panthers QB Bryce Young ranking 32nd in adjusted EPA per play and 33rd in air yards among the 36 qualified signal callers.
Meanwhile, the Panthers have been shredded by opposing tight ends for the sixth-highest catch percentage and second-highest yards per target. I’m eyeing Miami tight end Darren Waller to have another impact week after catching three of four targets for 27 yards and two touchdowns on MNF.
Dolphins vs Panthers 3-leg SGP
- Dolphins -1.5
- De'Von Achane Over 63.5 rushing yards
- Darren Waller Over 29.5 receiving yards
Our big-ticket SGP: Achane Express
Achane has found the end zone 26 times across 32 career games, and he’s already piled up five multi-touchdown showings, including scoring four times in Week 3 as a rookie.
Dolphins vs Panthers 4-leg SGP
- Dolphins -1.5
- De'Von Achane Over 63.5 rushing yards
- De'Von Achane 2+ touchdowns
- Darren Waller Over 29.5 receiving yards
Dolphins vs Panthers game predictions
Dolphins vs Panthers moneyline prediction
I give Miami an advantage at quarterback and on defense, which should be enough for the Dolphins to improve to 3-2 in Week 5. Plus, Young is just 7-25 across his 32 career starts.
Dolphins vs Panthers spread prediction
While there’s potential for Carolina to be a popular addition to six-point teasers because the line can be moved through multiple key numbers, it’s not a leg I’d be racing to the window to add.
We should also see more from Miami QB Tua Tagovailoa, considering his 6.6 yards per attempt is well below his 7.8 mark over the prior two years, and this is the perfect matchup to pad his stat line.
Dolphins vs Panthers Over/Under prediction
Considering these are two of the worst statistical defenses in the league, there’s a strong case for the Over. I’m leaning the opposite way, though.
Expect Carolina to lean on its running game and insulate Young’s lackluster QB play, while Miami builds a lead and then relies on its own rushing attack to run the clock.
Dolphins vs Panthers odds
- Spread: Dolphins -1.5 | Panthers +1.5
- Moneyline: Dolphins -125 | Panthers +105
- Over/Under: Over 45.5 | Under 45.5
More NFL picks and odds from Covers
Dolphins vs Panthers trend to know
The Dolphins have cashed the Over in 12 of their last 20 games for +3.20 units and a 15% ROI. Find more NFL betting trends for Dolphins vs. Panthers.
How to watch Dolphins vs Panthers
| Location | Bank of America Stadium, Charlotte, NC |
| Date | Sunday, October 5, 2025 |
| Kickoff | 1:00 p.m. ET |
| TV | DAZN |
Dolphins vs Panthers latest injuries
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