Oklahoma State hosts Colorado on Saturday, Oct. 24, at 7 p.m. ET at Boone Pickens Stadium.
Oklahoma State is favored by 13.5 points, with the total set at 56.5. Colorado makes its first trip to Stillwater since 2009, and my Colorado vs. Oklahoma State prediction targets the spread, total, and first-quarter market.
For more Week 8 analysis and betting angles, check out our latest college football picks.
TOP PICK
Who will win Colorado vs Oklahoma State: Colorado +13.5
I'm backing the Colorado Buffaloes +13.5 and would play them down to +12.5. Colorado has one of the most underrated defenses in the country and just delivered its best offensive performance of the season against a better defense than the Oklahoma State Cowboys have.
Colorado averaged a season-high 7.2 yards per play in last week's 27-24 loss to Utah as a 15.5-point underdog. The Utes rank 21st nationally in yards per play allowed, while Oklahoma State sits 68th.
The matchup looks even better through the air. The Cowboys' pass defense has been torched over the last two weeks, allowing opponents to complete 72% of their passes for 608 yards and nine touchdowns.
Oklahoma State will also be without starting safety Mose Phillips III.
COVERS INTEL: According to GameOnPaper.com, Colorado ranks fourth nationally in EPA per play, adjusted for opponent strength and home-field advantage, with garbage time excluded.
Colorado vs Oklahoma State Over/Under pick: Under 56.5
I'd play Under 56.5 down to 55.5, especially with 55 being a key number for college football totals.
The Buffaloes are also dealing with significant offensive injuries. They'll be without second-leading rusher Micah Welch, who leads the team with two rushing touchdowns, along with offensive lineman Jayven Richardson.
Last week's Over against Utah was misleading, too. The teams combined for just 13 first-half points before Colorado scored a meaningless touchdown with 1:24 remaining.
Outside of that result, the Buffaloes are 1-2 to the Under in Big 12 games this season, and their injuries give me another reason to expect a lower-scoring game.
Colorado vs Oklahoma State combo
I don't need Colorado to win this game. I just need the Buffaloes to make Oklahoma State earn everything.
A slow first quarter would keep Colorado from falling into an early hole and allow this to become the kind of ugly game I'm expecting. If the Buffaloes are still hanging around in the second half, there's no reason for either team to start playing with its hair on fire.
That's the script: start slowly, keep Colorado within striking distance, and force Oklahoma State to grind through four quarters instead of running away with it.
Colorado vs Oklahoma State combo
- Colorado +13.5
- Under 56.5
- First-quarter Under 13.5
- Top picks: 13-17, -5.20 units
- Combos: 3-27, -17.84 units
Colorado vs Oklahoma State odds
For help understanding probabilities, see our odds calculator.
- Spread: Colorado +13.5 | Oklahoma State -13.5
- Over/Under: Over 56.5 (51%) | Under 56.5 (54%)
- Moneyline: Colorado 19% | Oklahoma State 84%
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Colorado vs Oklahoma State weather
Temperatures are expected to be in the mid-70s, with winds around 9 mph and no rain in the forecast.
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Colorado vs Oklahoma State trend to know
The Buffaloes are 10-6 to the Under as road underdogs since Deion Sanders took over as head coach in 2023. Find more college football betting trends for Colorado vs. Oklahoma State.
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How to watch Colorado vs Oklahoma State
| Location | Boone Pickens Stadium, Stillwater, OK |
| Date | Saturday, Oct. 24, 2026 |
| Kickoff | 7:00 p.m. ET |
| TV | FS1 |
Colorado vs Oklahoma State latest injuries
Check out our college football injuries page for updates on every team.
Odds are correct at the time of publishing and are subject to change.
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