Our Favorite College Football Combos: Week 4

Week 4 brings a loaded college football slate, and we're combining our favorite betting angles from the biggest games into our best college football combos of the weekend.

Our latest college football picks include combos for Texas vs. Tennessee, Iowa vs. Michigan, Oklahoma vs. Georgia, Oregon vs. USC, and more.

Best Week 4 college football combos

For help understanding probabilities, please see our odds calculator.

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Saturday, Sept. 26

Best Wake Forest vs Louisville combo

The strength of the Wake Forest roster is its defense, as supporters saw last week against Miami. If looking for a combo to sweat this weekend, Wake Forest to cover in a low-scoring game is a correlated outcome that could be worth considering. 

Check out Nick Galaida's full Wake Forest vs. Louisville predictions.

Best Texas vs Tennessee combo

If Manning gets off to an iffy start, as he did against Ohio State, or his struggles from the UTSA game bleed into this one, Tennessee can keep this game close, especially in the first half.

Manning is an enigma. His inaccuracies and indecisiveness could allow Jim Knowles' defense to capitalize on missed throws and apply pressure when he holds the ball too long. He has the eighth-highest time to throw in the country (3.19 seconds).

And with the Volunteers' offensive consistency under Heupel, they're bound to hit a big play or two through the air while their physical run game wears down Texas' defense.

Check out Rob Paul's full Texas vs. Tennessee predictions.

Best Illinois vs Ohio State combo

Katin Houser has thrown the ball well to start the season, tossing eight touchdowns against just two interceptions. He will lead Illinois to points against an Ohio State defense that has yet to prove itself against a Power Four opponent in 2026. 

In a game script that should feature plenty of second-half passing from the Illini, taking the underdog with the points pairs well with the Over.

Check out Nick Galaida's full Illinois vs. Ohio State predictions.

Best Notre Dame vs Purdue combo

Combining those three plays gets you 5.69x, which is a great price if you believe the Fighting Irish will waltz into West Lafayette and completely dominate the Boilermakers.

Check out Colby Marchio's full Notre Dame vs. Purdue predictions.

Best Ole Miss vs Florida combo

The Over fits how both offenses have been scoring lately. As we've covered throughout this article, both defenses have clear weaknesses, and I expect those to show up early and often.

That's why we paired it with Florida to cover the first half and Ole Miss to cover the full game. The letdown spot gives the Gators a real chance to come out fast and grab an early edge.

Over four quarters, though, Chambliss should keep Ole Miss in it and give the Rebels enough offense to pull ahead late. 

Check out Chris Hatfield's full Ole Miss vs. Florida predictions.

Best Iowa vs Michigan combo

Iowa’s path to this 5.97x combo starts with controlling the trenches and shortening the game. The Hawkeyes’ defense should keep Michigan from creating separation, while their early scoring edge supports my first-half moneyline leg. 

If Iowa hangs around early and both teams lean on the run, possessions should stay limited and points scarce. That script ties all three legs together: Iowa stays inside the number, leads early, and helps keep the total Under 38.5.

Check out Geoff Clark's full Iowa vs. Michigan predictions.

Best Oklahoma vs Georgia combo

The payout for this combo is 12.34x, while the more straightforward "Bulldogs full-game and first-half spreads, and Under" combo pays at roughly 5-to-1.

Here is my game script: The Sooners keep things competitive early before UGA takes control. While its defense should make Georgia work for points, Oklahoma's offensive-line issues could become a bigger problem as the game wears on. That sets up the Bulldogs to pull away late and hold the Sooners' offense down.

Check out Geoff Clark's full Oklahoma vs. Georgia predictions.

Best South Carolina vs Alabama combo

If you are looking to end the evening with a sweat, take the Crimson Tide to cover the 11.5 points, pair it with the over and add the Gamecocks to keep it close in the first half for a little reverse correlation. That gets you 17.36x odds.

Check out Colby Marchio's full South Carolina vs. Alabama predictions.

Best Texas A&M vs LSU combo

I'm handicapping a slower, tighter game than the market expects. The Aggies have enough talent to stay within one score, while both offenses have struggled to generate explosive plays and face pass rushes capable of disrupting their shaky quarterback play. 

If LSU and Texas A&M don't get out to a fast start, the first-half Under should hit, while a lower-scoring script naturally helps the Aggies stay inside +9.5.

Check out Geoff Clark's full Texas A&M vs. LSU predictions.

Best Oregon vs USC combo

Oregon should win this game outright because it's more well-rounded and has more proven playmakers (USC is also expected to be without freshman phenom receiver Trent Mosley).

But Oregon's defense has underwhelmed, too, and sits 14th in the Big Ten in havoc rate (15.1%). With one of the country's top QBs in Maiava, the Trojans rank second nationally in available yards percentage (75.8%). USC should be able to score at least 31 points against the Ducks.

I have Oregon winning 41-37.

Check out Rob Paul's full Oregon vs. USC predictions.

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