The Week 8 college football slate is built around a historic USC-Notre Dame rivalry and a flurry of fascinating SEC showdowns.
I pick a side in each of those matchups and more in our Week 8 ATS college football picks below.
College football picks against the spread for Week 8
| Matchup | Pick |
|---|---|
 Louisville vs  Miami |
(-13.5) |
 LSU vs  Vanderbilt |
(-2.5) |
 Oklahoma vs  South Carolina |
(+5.5) |
 Texas A&M vs  Arkansas |
(-7.5) |
 Mississippi vs  Georgia |
(+7.5) |
 Ohio State vs  Wisconsin |
(-25.5) |
 Texas Tech vs  Arizona State |
(-11.5) |
 Texas vs  Kentucky |
(+12.5) |
 USC vs  Notre Dame |
(+9.5) |
 Tennessee vs  Alabama |
(+9.5) |
 Utah vs  BYU |
(+3.5) |
Lines courtesy of FanDuel.
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Expert Week 8 college football ATS picks
Louisville vs Miami (-13.5): Miami -13.5
Both squads are coming off a bye, but at home, that's an advantage for Miami. The gap between the Canes and everyone else in the ACC will be felt in a dominant win.
Read our full Louisville vs. Miami predictions.
LSU vs Vanderbilt (-2.5): Vanderbilt -2.5
LSU produced just 19 points the last time it played away from home and has been a mess offensively all season long. Take Vanderbilt to score a win coming off a bye.
Read our full LSU vs. Vanderbilt predictions.
Oklahoma (-5.5) vs South Carolina: South Carolina +5.5
Oklahoma is back on the road after mustering just six points in the Red River Rivalry last week. I'll take the points with what should be a desperate South Carolina squad at home.
Read our full Oklahoma vs. South Carolina predictions.
Texas A&M (-7.5) vs Arkansas: Texas A&M -7.5
The Aggies have passed every test thus far, including games that would've caused issues for Texas A&M teams of old. Lay the points as the Aggies stay undefeated.
Read our full Texas A&M vs. Arkansas predictions.
Mississippi vs Georgia (-7.5): Mississippi +7.5
Did Mississippi struggle with Wazzu? Yes. Was Georgia a goal-line fumble away from probably losing to Auburn? Also, yes. I'll take the points.
Read our full Mississippi vs. Georgia predictions.
Ohio State (-25.5) vs Wisconsin: Ohio State -25.5
The Wisconsin team that just gave up 37 points to Iowa in a shutout loss at home? That Wisconsin team? Don't overthink this.
Read our full Ohio State vs. Wisconsin predictions.
Texas Tech (-11.5) vs Arizona State: Texas Tech -11.5
These teams both played Utah at Rice–Eccles Stadium; Texas Tech won by 24 as a 3.5-point dog, and Arizona State lost by 32 as a 9-point dog. That's only scratching the surface of TTU's domination thus far.
Read our full Texas Tech vs. Arizona State predictions.
Texas (-12.5) vs Kentucky: Kentucky +12.5
I'm not here to say Arch Manning didn't look improved last week, but the 23-6 scoreline masks the fact that Texas scored just one offensive touchdown at home. Back on the road, a double-digit SEC spread could prove a tall task.
Read our full Texas vs. Kentucky predictions.
USC vs Notre Dame (-9.5): USC +9.5
Rivalry game aside, this is essentially Notre Dame's last chance to notch a meaningful win. I expect the Irish to win, but USC is playing well enough to avoid a huge margin.
Read our full North Carolina vs. California predictions.
Tennessee vs Alabama (-9.5): Tennessee +9.5
Alabama's offense is rolling right now, but the same can be said for Tennessee. I expect the Vols to score just enough to stay inside the number.
Read our full Tennessee vs. Alabama predictions.
Utah (-3.5) vs BYU: BYU +3.5
BYU has won the last two Holy War matchups, is an undefeated 6-0 after an overtime win over Arizona, and gets this one at home. Take the points if the line remains above a field goal.
Read our full Utah vs. BYU predictions.
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My college football ATS/ML record is 23-29 this season for -7.45 units.
Odds are correct at the time of publishing and are subject to change.
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