The Minnesota Twins and Chicago White Sox have split the first two of their three-game set and will play the series finale at Rate Field on Wednesday, May 27.
My top Twins vs. White Sox predictions and MLB picks are calling for Chicago to win a high-scoring Game 3 tonight.
Who will win Twins vs White Sox today: White Sox moneyline (-111)
The Chicago White Sox rank fifth in wOBA against left-handed starters this season and second in overall xwOBA while averaging 4.9 runs per game in May.
Chicago righty Davis Martin is also dealing and sports an elite 2.04 ERA and 1.02 WHIP backed by a high-end 2.85 xFIP and 22.4 K-BB%.
As a result, I give the edge to the White Sox on the mound and at the dish.
The Minnesota Twins are countering with lefty Connor Prielipp, and in addition to him coming off his worst start of the season, the rookie’s 4.03 ERA and 4.34 xFIP are run-of-the-mill marks.
I’d back Pale Hose to -125.
COVERS INTEL: My support for the Chicago moneyline is strengthened by starter Davis Martin holding opposing hitters to a miniscule .569 OPS and .261 wOBA while posting a 2.76 xFIP at Rate Field this season.
Twins vs White Sox Over/Under pick: Over 7.5 (-115)
Both the Twins and White Sox have trended to the Over, and in addition to the highlighted strength of the Chicago lineup against lefties, Minnesota is also rolling.
The Twins have won seven of their past nine games with a solid .325 wOBA and an average of 4.4 runs per game, so I’m anticipating them chipping in enough to send this total Over the number.
Additionally, the Chicago bullpen ranks 25th in xFIP while allowing the second-highest squared-up contact rate in baseball, and the White Sox have tasked their relievers with 21 innings across the past five games.
This Over is in play until -125, and I’d also bet the Over 8.0 at +100.
- ML/RL bets: 22-12, +11.68 units
- Over/Under bets: 12-9, +2.37 units
Twins vs White Sox odds
- Moneyline: Twins +100 | White Sox -120
- Run line: Twins -1.5 (+155) | White Sox +1.5 (-210)
- Over/Under: Over 8.0 (+100) | Under 8.0 (-120)
Twins vs White Sox trend
The Minnesota Twins have hit the Over in 23 of their last 40 games (+7.55 Units / 17% ROI), and the Chicago White Sox have played to the Over in 11 of their last 14 games (+8.95 Units / 59% ROI). Find more MLB betting trends for Twins vs. White Sox.
How to watch Twins vs White Sox and game info
| Location | Rate Field, Chicago, IL |
| Date | Wednesday, May 27, 2026 |
| First pitch | 7:40 p.m. ET |
| TV | Twins.TV, CHSN |
| Twins starting pitcher | Connor Prielipp (1-2, 4.03 ERA) |
| White Sox starting pitcher | Davis Martin (7-1, 2.04 ERA) |
Twins vs White Sox latest injuries
Twins vs White Sox weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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