The Minnesota Twins have caught fire of late, winning six of their past eight games.
With Joe Ryan set to take the mound, my Twins vs. White Sox predictions expect the road team to pick up an important divisional win.
Let's break it all down with my MLB picks for Tuesday, May 26.
Who will win Twins vs White Sox today: Twins moneyline (-115)
Sean Burke allowed 12 earned runs over his last three starts and posted a 5.40 xFIP during that stretch.
It'll be difficult for him to get on track tonight. He's pitched much worse at home, posting a 4.15 FIP in Chicago compared to a 2.85 on the road.
He'll be tasked with slowing down a Minnesota Twins lineup that sits fifth in ISO and sixth in wOBA against right-handed pitching away from Target Field.
The Twins should do damage at the plate, and ace Joe Ryan doesn't need much run support. Back the Twins to -130.
COVERS INTEL: The White Sox rank 24th in home batting average (.224) against right-handed pitching.
Twins vs White Sox Over/Under pick: Over 7.5 (-115)
Isolating home games against Top-20 teams in OBP, Burke owns a 6.22 ERA, 6.41 xERA, and conceded multiple runs in four of five starts. Minnesota ranks ninth in OBP, so they fit the profile.
The Chicago White Sox don't have as strong of a matchup against Ryan, but they should still chip in their share of runs.
Ryan's indicators (FIP, xFIP, barrel rate, etc.) are worse on the road than at the pitcher-friendly Target Field, and the White Sox have scored 3+ runs against eight of the last 11 right-handed starters.
Play the Over to -125.
- ML/RL bets: 18-16, -3.08
- Over/Under bets: 16-17-1, -3.51 units
Twins vs White Sox odds
- Moneyline: Twins -115 | White Sox -105
- Run line: Twins -1.5 (+150) | White Sox +1.5 (-175)
- Over/Under: Over 7.5 (-115) | Under 7.5 (-105)
Twins vs White Sox trend
Minnesota has hit the game total Over in 24 of the last 40 games (+9.55 units, 22% ROI). Find more MLB betting trends for Twins vs. White Sox.
How to watch Twins vs White Sox and game info
| Location | Rate Field, Chicago, IL |
| Date | Tuesday, May 26, 2026 |
| First pitch | 7:40 p.m. ET |
| TV | Twins.TV, CHSN |
| Twins starting pitcher | Joe Ryan (3-3, 3.02 ERA) |
| White Sox starting pitcher | Sean Burke (2-3, 4.08 ERA) |
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Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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