MLB Spring Training Picks and Predictions for February 21: Rocking Red Sox

Look for the Red Sox to keep up their strong Spring Training track record against the Twins, along with a few underdog picks worth keeping an eye on.

Aisha Quiñones - Betting Analyst at Covers
Aisha Quiñones • Betting Analyst
Feb 21, 2026 • 09:51 ET • 4 min read
Payton Tolle Boston Red Sox MLB
Photo By - Reuters Connect. Boston Red Sox starting pitcher Payton Tolle (70) pitches during the eighth inning.

Spring Training is back! As the frost of a baseball-less winter finally melts away, we’re here to heat things up with picks while every team gets into full swing today.

Take a look at why I’m focusing on a couple of plus-money teams in my MLB picks for Saturday, February 21.

Spring Training predictions for February 21

Picks DraftKings
Phillies Phillies moneyline +120
Red Sox Red Sox moneyline -112
Giants Giants moneyline +120
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Pick #1: Phillies moneyline

+120 at DraftKings

Spring Training games often hinge on bullpen depth and timely hitting which is two areas where the Philadelphia Phillies have been pretty steady this time of year.

With the Toronto Blue Jays slightly favored (around -142) and Philly sitting at +120, the Phillies bring some nice value if their early arms give them solid innings and the offense can scratch across runs.

I’m expecting a tight, competitive game, but Philadelphia’s underdog price and recent edge in the matchup make them a strong moneyline lean against Eric Lauer.

Pick #2: Red Sox moneyline

-112 at DraftKings

Lately, when the Boston Red Sox and Minnesota Twins have met in Spring Training, things have usually leaned Boston’s way, including last year’s 6–5 Grapefruit League win in a pretty similar spot.

Boston’s deeper lineup and balanced position group could give them an edge, especially in key at-bats and late-game situations.

Minnesota is expected to hand the ball to Joe Ryan to start, and they may mix in different bullpen looks early, which can lead to some uneven innings.

Boston, on the other hand, tends to use these spring games to get its regular hitters into a steady rhythm at the plate.

Pick #3: Giants moneyline

+120 at DraftKings

With plenty of young hitters and players competing for roster spots, the San Francisco Giants tend to take a scrappy, opportunistic approach early in the year and that style can really pay off in close spring games when pitching is all over the place.

This one could be a low- to moderate-scoring affair as both Hayden Birdsong and Emerson Hancock, along with the spring bullpen arms, work on finding their best grips and rhythms.

Still, San Francisco’s offense has shown it can put runs on the board against the Seattle Mariners in spring matchups, and at +120, the Giants look like a smart moneyline play here.

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Aisha Quiñones - Covers
Betting Analyst

Hailing from Harlem, New York, Aisha Quiñones joined Covers in 2024 after an illustrious career with several other major media outlets. A proud Johnnie, after graduating from the Big East basketball powerhouse St. John's University, Quiñones earned her bachelor's degree in sport management and journalism, then obtained her master's degree in media studies from The New School.

Over a span of 12+ years, Quiñones has built her portfolio as a writer, dipped her toe into on-camera work, and also been behind the scenes in producing sports content.

Despite being a New Yorker, Quiñones has always been a lifelong Los Angeles Lakers fan thanks to her mom's joy of watching Kobe Bryant play — so much of a fan to the point that Quiñones named her toy poodle after the late-great legend.

Her hometown roots stay true to her MLB and WNBA choice in teams, as a Yankees and Liberty fan, due to her uncle and grandmother's love for the sports throughout her childhood.

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