NL Central rivals collide this afternoon as the St. Louis Cardinals and Milwaukee Brewers begin a three-game set at American Family Field. First pitch is scheduled for 2:05 p.m. ET.
With Jacob Misiorowski on the hill, my Cardinals vs. Brewers predictions are targeting Milwaukee to take the series opener.
Read more in my MLB picks for Monday, May 25.
Who will win Cardinals vs Brewers today: Brewers moneyline (-210)
The Milwaukee Brewers send their ace to the hill this afternoon in Jacob Misiorowski, who sports an impressive 1.89 ERA and a 4-2 record. He has been absolutely lights out this month, throwing four straight scoreless outings.
Misiorowski's ERA is 2.04 at home, and he's historically had success against the St. Louis Cardinals, though the sample size is small. Across 33 at-bats, they're hitting just .212 off the right-hander.
On the other side, the Brew Crew will face left-hander Matthew Liberatore, who has given up four earned runs in back-to-back starts.
Overall, he has a 4.70 ERA, and Liberatore's ERA is above four on the road. Milwaukee has a 16-11 record at American Family Field, and it's won three of its last four meetings with St. Louis at home.
COVERS INTEL: Misiorowski has posted a career-best 2.12 FIP this season through 10 appearances. 
Cardinals vs Brewers Over/Under pick: Under 7.5 (-105)
While Liberatore has had his struggles lately, there have been a few solid starts for him over the last month as well.
Before surrendering four earned on the road to the Athletics, he only allowed two earned in each of his previous two starts away from St. Louis, and the Brewers aren't exactly coming in hot, scoring four runs against the Dodgers across Saturday and Sunday.
Misiorowski's case here is clear. He rarely gives up runs, and the Cardinals offense is inconsistent. They're losers of three of four, and St. Louis scored only eight runs combined in those defeats.
Two of the last four meetings have also cashed the Over.
- ML/RL bets: 16-11, +5.54 units
- Over/Under bets: 15-11, +1.09 units
Cardinals vs Brewers odds
- Moneyline: Cardinals +122 | Brewers -163
- Run line: Cardinals +1.5 (-120) | Brewers -1.5 (+120)
- Over/Under: Over 7.5 (-118) | Under 7.5 (-104)
Cardinals vs Brewers trend
Six of Milwaukee's last 10 games have cashed the Under in total runs. Find more MLB betting trends for Cardinals vs. Brewers.
How to watch Cardinals vs Brewers and game info
| Location | American Family Field, Milwaukee, WI |
| Date | Monday, May 25, 2026 |
| First pitch | 2:10 p.m. ET |
| TV | Cardinals.TV, Brewers.TV |
| Cardinals starting pitcher | Matthew Liberatore (2-2, 4.70 ERA) |
| Brewers starting pitcher | Jacob Misiorowski (4-2, 1.89 ERA) |
Cardinals vs Brewers latest injuries
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Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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