49ers 3rd NFC West12-5

Cardinals 4th NFC West3-14

4:05PM ET Nov 16, 2025

49ers @ Cardinals Odds

Game Odds

Game Odds San Francisco 49ers vs. Arizona Cardinals
	Spread	Total	Moneyline
Sports.OddsComparison.BettingLines.Models.BettingSide.SpreadBettingSideVm San Francisco	-3.5 +100	o48.0 -118	-185
Sports.OddsComparison.BettingLines.Models.BettingSide.SpreadBettingSideVm Arizona	+3.5 -105	u48.5 -106	+166

Spread

Game Odds San Francisco 49ers vs. Arizona Cardinals
	SF	ARI
	-3.5 +100	+3.5 -105

Odds Comparison

ALL BOOKS	SF	ARI
DraftKings logo	-3.5 +100	+3.5 -120
bet365 logo	-3.5 -105	+3.5 -115
FanDuel logo	-3.5 -110	+3.5 -110
BetMGM logo	-3.5 -105	+3.5 -105
Caesars logo	-3.5 -106	+3.5 -114

Total

Game Odds vs.
	OVER	UNDER
	o48.0 -118	u48.5 -106

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o48.5 -108	u48.5 -112
bet365 logo	o48.5 -110	u48.5 -110
FanDuel logo	o48.5 -114	u48.5 -106
BetMGM logo	o48.0 -118	u48.0 -110
Caesars logo	o48.5 -112	u48.5 -108

Moneyline

Game Odds San Francisco 49ers vs. Arizona Cardinals
	SF	ARI
	-185	+166

Odds Comparison

ALL BOOKS	SF	ARI
DraftKings logo	-185	+154
bet365 logo	-190	+160
FanDuel logo	-198	+166
BetMGM logo	-190	+155
Caesars logo	-190	+156

Passing Yards

Brock Purdy Projection 282.92

Game Odds vs.
OVER	UNDER
o252.5 -115	u254.5 -112

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o253.5 -112	u253.5 -112
bet365 logo	-	-
FanDuel logo	o254.5 -112	u254.5 -112
BetMGM logo	o252.5 -115	u252.5 -115
Caesars logo	o254.5 -114	u254.5 -115

Mac Jones Projection 274.79

Game Odds vs.
OVER	UNDER
o0.5 +240	u0.5 -350

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	-	-
bet365 logo	-	-
FanDuel logo	-	-
BetMGM logo	o0.5 +240	u0.5 -350
Caesars logo	-	-

Jacoby Brissett Projection 274.65

Game Odds vs.
OVER	UNDER
o227.5 -112	u230.5 -115

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o228.5 -112	u228.5 -112
bet365 logo	-	-
FanDuel logo	o227.5 -112	u227.5 -112
BetMGM logo	o230.5 -115	u230.5 -115
Caesars logo	o227.5 -118	u227.5 -113

Rushing Yards

Christian McCaffrey Projection 66.3

Game Odds vs.
OVER	UNDER
o69.5 -112	u72.5 -113

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o72.5 -111	u72.5 -113
bet365 logo	-	-
FanDuel logo	o69.5 -112	u69.5 -112
BetMGM logo	o71.5 -115	u71.5 -115
Caesars logo	o70.5 -117	u70.5 -114

Bam Knight Projection 47.02

Game Odds vs.
OVER	UNDER
o39.5 -112	u39.5 -112

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	-	-
bet365 logo	-	-
FanDuel logo	o39.5 -112	u39.5 -112
BetMGM logo	-	-
Caesars logo	-	-

Brock Purdy Projection 19.76

Game Odds vs.
OVER	UNDER
o7.5 -119	u8.5 -111

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o7.5 -119	u7.5 -106
bet365 logo	-	-
FanDuel logo	o8.5 -112	u8.5 -112
BetMGM logo	o8.5 -105	u8.5 -125
Caesars logo	o8.5 -121	u8.5 -111

Jacoby Brissett Projection 17.47

Game Odds vs.
OVER	UNDER
o17.5 -112	u18.5 -110

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o17.5 -116	u17.5 -108
bet365 logo	-	-
FanDuel logo	o17.5 -112	u17.5 -112
BetMGM logo	o18.5 -118	u18.5 -110
Caesars logo	o17.5 -120	u17.5 -110

Mac Jones Projection 13.59

Game Odds vs.
OVER	UNDER
o0.5 +1400	u5.5 -125

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	-	-
bet365 logo	-	-
FanDuel logo	-	-
BetMGM logo	o0.5 +1400	u5.5 -125
Caesars logo	-	-

Brian Robinson Jr.

Game Odds vs.
OVER	UNDER
o19.5 -120	u23.5 -116

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o23.5 -108	u23.5 -116
bet365 logo	-	-
FanDuel logo	o21.5 -118	u21.5 -108
BetMGM logo	o19.5 -120	u19.5 -110
Caesars logo	o21.5 -122	u21.5 -110

Emari Demercado

Game Odds vs.
OVER	UNDER
o22.5 -115	u23.5 -112

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	-	-
bet365 logo	-	-
FanDuel logo	o23.5 -112	u23.5 -112
BetMGM logo	o22.5 -115	u22.5 -115
Caesars logo	o22.5 -120	u22.5 -110

Receiving Yards

Receptions Made

Rushing Attempts

Passing Attempts

Passing Completions

Interceptions Thrown

Rush and Rec Yards

Passing and Rushing Yards

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