The NFL schedule turns the calendar to October in Week 5.
The NFL Week 5 odds begin with another NFC West war on Thursday night, this time between the San Francisco 49ers and Los Angeles Rams.
We get another early wake-up call when the Minnesota Vikings take on the Cleveland Browns in London on Sunday morning, followed by a marquee non-conference matchup between the Denver Broncos and Philadelphia Eagles.
Prime time pits the New England Patriots against the rival Buffalo Bills on Sunday night, and the Kansas City Chiefs come to Duval County to clash with the Jacksonville Jaguars in Monday’s finale.
Here’s a look at the opening odds for NFL Week 5 and where those lines have moved in the first 12 hours of betting action.
NFL odds Week 5
| Matchup | Spread | Moneyline | Over/Under |
|---|---|---|---|
 49ersvs  Rams |
Rams -5.5 | 49ers +205 Rams -250 |
46.5 |
 Vikingsvs  Browns |
Browns +3.5 | Vikings -194 Browns +162 |
36.5 |
 Dolphinsvs  Panthers |
Panthers -1.5 | Dolphins +100 Panthers -118 |
44.5 |
 Giantsvs  Saints |
Saints -1.5 | Giants -104 Saints -112 |
41.5 |
 Broncosvs  Eagles |
Eagles -4.5 | Broncos +180 Eagles -215 |
44.5 |
 Raidersvs  Colts |
Colts -6.5 | Raiders +245 Colts -300 |
47.5 |
 Cowboysvs  Jets |
Jets +2.5 | Cowboys -142 Jets +118 |
46.5 |
 Texansvs  Ravens |
Ravens -3.5 | Texans +138 Ravens -164 |
43.5 |
 Titansvs  Cardinals |
Cardinals -8.5 | Titans +385 Cardinals -500 |
41.5 |
 Buccaneersvs  Seahawks |
Seahawks -3 | Buccaneers +140 Seahawks -166 |
44.5 |
 Commandersvs  Chargers |
Chargers -2.5 | Commanders +134 Chargers -158 |
47.5 |
 Lionsvs  Bengals |
Bengals +9.5 | Lions -460 Bengals +360 |
49.5 |
 Patriotsvs  Bills |
Bills -8.5 | Patriots +350 Bills -450 |
50.5 |
 Chiefsvs  Jaguars |
Jaguars +3 | Chiefs -176 Jaguars +148 |
45.5 |
Lines as of 9-30
49ers vs Rams odds (Thursday, 8:15 p.m. ET, Prime)
Opening line
- Rams -3.5
- Over/Under 46.5
- View full 49ers vs. Rams odds and matchup
- Read our 49ers vs. Rams picks and predictions (coming soon)
The Rams slayed the dragon that was the Colts in Week 4, while the Niners struggled in a loss to the Jaguars. That bumped this opener to L.A. -3.5 from the look-ahead line of a field goal. The total also took a dip, opening at 46.5 O/U (look-ahead total was 47.5).
Also see: full Thursday Night Football odds
Vikings vs Browns odds (Sunday, 9:30 a.m. ET, NFL Network)
Opening line
- Browns +4.5
- Over/Under 37.5
- View full Vikings vs. Browns odds and matchup
- Read our Vikings vs. Browns picks and predictions (coming soon)
The Vikings stay on the other side of the pond after losing to the Steelers in Dublin on Sunday morning. Minnesota opened -4.5 but sank to -3.5 with questions still surrounding the QB position and injuries mounting on both sides of the ball. The total opened at 47.5 and slimmed to 46.5 O/U.
Dolphins vs Panthers odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Panthers -1.5
- Over/Under 44.5
- View full Dolphins vs. Panthers odds and matchup
- Read our Dolphins vs. Panthers picks and predictions (coming soon)
Miami picked up its first win of the season on Monday and now has a short week before facing Carolin. The Dolphins are down WR Tyreek Hill for the season after a gruesome knee injury in Week 4. The Fins were -1.5 look-ahead favorites but officially opened as +1.5 dogs. The total hit the board at 44.5 O/U.
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Giants vs Saints odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Saints +2.5
- Over/Under 41.5
- View full Giants vs. Saints odds and matchup
- Read our Giants vs. Saints picks and predictions (coming soon)
The Giants scored one of the bigger upsets of the young season... but lost star WR Malik Nabers in the process. New York opened as big as a 2.5-point favorite in New Orleans and immediately dropped to -1.5. The total opened at 41.5 points.
Broncos vs Eagles odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Eagles -4.5
- Over/Under 44.5
- View full Broncos vs. Eagles odds and matchup
- Read our Broncos vs. Eagles picks and predictions (coming soon)
Denver dominated Cincinnati on Monday and officially opened as a 4.5-point road underdog in Philadelphia for this non-conference contest. The Over/Under opened at 44.5 points.
Raiders vs Colts odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Colts -6.5
- Over/Under 48.5
- View full Raiders vs. Colts odds and matchup
- Read our Raiders vs. Colts picks and predictions (coming soon)
Indianapolis comes back home after its first loss of the season, opening as 6.5-point chalk hosting Las Vegas in Week 5. The juice on Colts -6.5 is climbing, indicating a potential move to a touchdown spread. This Over/Under opened at 48.5 points.
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Cowboys vs Jets odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Jets +2.5
- Over/Under 46.5
- View full Cowboys vs. Jets odds and matchup
- Read our Cowboys vs. Jets picks and predictions (coming soon)
The Jets lost to Miami on Monday night and have a short turnaround to prep for Dallas in Week 5. Bookies opened the Jets as 2.5-point home underdogs while the total for this non-conference clash hit the board at 46.5 points.
Texans vs Ravens odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Ravens -9.5
- Over/Under 45.5
- View full Texans vs. Ravens odds and matchup
- Read our Texans vs. Ravens picks and predictions (coming soon)
The Ravens are coming off a one-sided loss at Kansas City, and the health of QB Lamar Jackson (hamstring) is dragging this spread down. Look-ahead lines had Baltimore as big as a 9.5-point favorite, but that is as short as Ravens -7 on Monday morning. The total has also come off the look-ahead line of 45.5 points, sinking to 43.5 before buyback up to 44.5 O/U.
Titans vs Cardinals odds (Sunday, 4:05 p.m. ET, CBS)
Opening line
- Cardinals -9.5
- Over/Under 40.5
- View full Titans vs. Cardinals odds and matchup
- Read our Titans vs. Cardinals picks and predictions (coming soon)
The Cardinals have a mini bye after losing to Seattle on Thursday and take on the Titans in Week 5. Arizona was a 7.5-point look-ahead favorite but officially opened as a 9.5-point home chalk with Tennessee getting blanked 26-0 by Houston on Sunday. This total opened at 40.5 points.
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Buccaneers vs Seahawks odds (Sunday, 4:05 p.m. ET, CBS)
Opening line
- Seahawks -2.5
- Over/Under 44.5
- View full Buccaneers vs. Seahawks odds and matchup
- Read our Buccaneers vs. Seahawks picks and predictions (coming soon)
Seattle has extra rest after winning last Thursday, and opened as a 2.5-point home favorite before moving up to a field goal on Sunday night. The Bucs could be missing a slew of defensive starters for Week 5. This total opened 44.5 O/U.
Commanders vs Chargers odds (Sunday, 4:25 p.m. ET, FOX)
Opening line
- Chargers -3
- Over/Under 48.5
- View full Commanders vs. Chargers odds and matchup
- Read our Commanders vs. Chargers picks and predictions (coming soon)
Washington hopes QB Jayden Daniels can return in Week 5 after losing at Atlanta on Sunday. The Commanders opened as field goal underdogs in L.A., taking on a Chargers team coming off an embarrassing loss at New York. The vig on Washington +3 is rising, which could see a drop off the key number to +2.5. This total opened at 48.5 and slimmed to 47.5 O/U.
Lions vs Bengals odds (Sunday, 4:25 p.m. ET, FOX)
Opening line
- Bengals +9.5
- Over/Under 49.5
- View full Lions vs. Bengals odds and matchup
- Read our Lions vs. Bengals picks and predictions (coming soon)
Cincinnati looked horrible in a Monday night loss to Denver and now takes on the Lions in Week 5. Detroit was a 8.5-point look-ahead favorite before that finish and officially opened as a 9.5-point chalk. The total is at 49.5 O/U.
Patriots vs Bills odds (Sunday, 8:20 p.m. ET, NBC)
Opening line
- Bills -10.5
- Over/Under 49.5
- View full Patriots vs. Bills odds and matchup
- Read our Patriots vs. Bills picks and predictions (coming soon)
Buffalo hosts division rival New England on Sunday Night Football, with bookies opening the Bills as big as -10.5 and seeing that spread hacked down to -8.5 as of Monday morning. The Patriots pounded the Panthers in Week 4, while the Bills had trouble pulling away from the Saints as massive faves. This total opened at 49.5 and has climbed to as high as 50.5 at some shops.
Also see: full Sunday Night Football odds
Chiefs vs Jaguars odds (Monday, 8:15 p.m. ET, ABC/ESPN)
Opening line
- Jaguars +2.5
- Over/Under 44.5
- View full Chiefs vs. Jaguars odds and matchup
- Read our Chiefs vs. Jaguars picks and predictions (coming soon)
The Jaguars are 3-1 and hosting the Chiefs on Monday Night Football. Look-ahead lines were Kansas City -2.5 before its one-sided win over Baltimore in Week 4. Books officially opened KC as a field goal favorite on the road. This total hit the board at 44.5 points and climbed to 45.5 O/U.
Also see: full Monday Night Football odds
Best NFL bets this week
Looking for our favorite spread, total, and NFL prop bets for this week's action? Check out our best free NFL picks from the Covers staff!
Odds are correct at the time of publishing and are subject to change.
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