NFL Week 5 odds open with a prime-time clash, as the Tampa Bay Buccaneers take on the Dallas Cowboys on Thursday Night Football in Arlington.
Sunday's schedule kicks off with an early UK showdown between the Philadelphia Eagles and Jacksonville Jaguars. Meanwhile, the main slate wraps with another high-stakes matchup as the Baltimore Ravens visit the Atlanta Falcons on Sunday Night Football.
Heading into Monday Night Football, all eyes will be on La-La Land as the Los Angeles Rams host the Buffalo Bills in what could be a Super Bowl preview.
We're tracking the latest NFL odds, spreads, outrights, and totals for every game on the Week 5 slate.
NFL odds Week 5
For help understanding probabilities, see our odds converter.
| Matchup | Spread | Moneyline | Over/Under |
|---|---|---|---|
 Buccaneersvs  Cowboys |
+7.5 49% -7.5 51% |
21% 79% |
o47.5 51% u47.5 50% |
 Eaglesvs  Jaguars |
+7.5 52% -7.5 49% |
24% 76% |
o42.5 49% u42.5 52% |
 Bearsvs  Packers |
OTB | 59% 41% |
OTB |
 Texansvs  Titans |
-7.5 48% +7.5 53% |
75% 25% |
o37.5 50% u37.5 50% |
 Bengalsvs  Dolphins |
-7.5 46% +7.5 54% |
75% 25% |
o42.5 51% u42.5 49% |
 Raidersvs  Patriots |
+3.5 50% -3.5 50% |
37% 63% |
o44.5 53% u44.5 48% |
 Vikingsvs  Saints |
-2.5 49% +2.5 52% |
54% 46% |
o41.5 50% u41.5 49% |
 Brownsvs  Jets |
+2.5 52% -2.5 53% |
46% 54% |
o39.5 53% u39.5 48% |
 Coltsvs  Steelers |
+2.5 49% -2.5 52% |
43% 57% |
o44.5 51% u44.5 50% |
 Giantsvs  Commanders |
+3.5 52% -3.5 48% |
38% 62% |
o43.5 50% u43.5 51% |
 Broncosvs  Chargers |
-3.5 48% +3.5 53% |
62% 38% |
o42.5 49% u42.5 51% |
 Lionsvs  Cardinals |
-5.5 51% +5.5 50% |
69% 31% |
o54.5 51% u54.5 50% |
 49ersvs  Seahawks |
+2.5 47% -2.5 53% |
42% 58% |
o46.5 50% u46.5 51% |
 Ravensvs  Falcons |
+3.5 52% -3.5 48% |
39% 61% |
o43.5 53% u43.5 48% |
 Billsvs  Rams |
+2.5 46% -2.5 55% |
41% 59% |
o54.5 50% u54.5 51% |
Lines as of 10-7.
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Thursday Night Football: Buccaneers vs Cowboys odds (8:15 p.m., Prime)
Opening line
- Cowboys -9.5
- Over/Under 47.5
- View full Buccaneers vs. Cowboys odds and matchup
- Read our Buccaneers vs. Cowboys picks and predictions (coming soon)
The Dallas Cowboys opened as 9.5-point home chalk on Thursday night. The Tampa Bay Buccaneers are winless and running a backup quarterback under center in Week 5.
This spread could climb after early market movement toward the host Cowboys, who boast one of the most powerful offenses of the past 26 years. That's led to the total being at 47.5 O/U for TNF.
Also see: full Thursday Night Football odds
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Sunday Night Football: Ravens vs Falcons odds (8:20 p.m. ET, NBC)
Opening line
- Ravens -2.5
- Over/Under 45.5
- View full Ravens vs Falcons odds and matchup
- Read our Ravens vs. Falcons picks and predictions (coming soon)
The Baltimore Ravens opened as 2.5-point road favorites for Sunday Night Football with Lamar Jackson questionable with an ankle injury. A report on Tuesday morning was positive for the Baltimore dual-threat passer. That update, coupled with Atlanta’s strong win on Monday, has flipped this spread to Falcons -2.5. The total opened 45.5 and quickly dropped to as low as 43.5 O/U.
Also see: full Sunday Night Football odds
Monday Night Football: Bills vs Rams odds (8:15 p.m., ESPN)
Opening line
- Rams -2.5
- Over/Under 54
- View full Bills vs. Rams odds and matchup
- Read our Bills vs. Rams picks and predictions (coming soon)
The Los Angeles Rams are short home favorites on Monday Night Football after a thrilling comeback win at Philadelphia in Week 4. With that victory and the Buffalo Bills losing to New England, the Rams opened at -2.5, and that could creep to a field goal with early adjustments toward L.A.
This total is a tall one, opening at 54 points and slipping a bit to 53.5 O/U.
Also see: full Monday Night Football odds
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Looking for our favorite spread, total, and NFL prop bets for this week's action? Check out our best free NFL picks from the Covers staff!
Odds are correct at the time of publishing and are subject to change.
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