Week 5 of the NFL season is the first shortened slate of the year, with Atlanta, Chicago, Green Bay and Pittsburgh all on a bye week.
That doesn't mean we don't have intriguing games to focus on, including a Thursday Night Football clash between division rivals, the San Francisco 49ers and Los Angeles Rams.
On Sunday, the festivities get underway early with Minnesota and Cleveland hooking up in London as part of the NFL's International Series.
And to wrap things up, the Kansas City Chiefs visit the Jacksonville Jaguars on Monday Night Football.
Here’s a look at the opening NFL odds for Week 5 and early adjustments in the first 12 hours of action.
NFL odds Week 5
| Matchup | Spread | Moneyline | Over/Under |
|---|---|---|---|
 49ersvs  Rams |
Rams -3.5 | 49ers +142 Rams -168 |
46.5 |
 Vikingsvs  Browns |
Browns +4.5 | Vikings -220 Browns +184 |
37.5 |
 Dolphinsvs  Panthers |
Panthers +1.5 | Dolphins -130 Panthers +110 |
43.5 |
 Giantsvs  Saints |
Saints +1.5 | Giants -132 Saints +112 |
41.5 |
 Broncosvs  Eagles |
Eagles -4.5 | Broncos +198 Eagles -240 |
43.5 |
 Raidersvs  Colts |
Colts -6.5 | Raiders +235 Colts -290 |
48.5 |
 Cowboysvs  Jets |
Jets +1.5 | Cowboys -122 Jets +104 |
45.5 |
 Texansvs  Ravens |
Ravens -9.5 | Texans +350 Ravens -460 |
45.5 |
 Titansvs  Cardinals |
Cardinals -9.5 | Titans +400 Cardinals -520 |
40.5 |
 Buccaneersvs  Seahawks |
Seahawks -2.5 | Buccaneers +120 Seahawks -142 |
44.5 |
 Commandersvs  Chargers |
Chargers -3 | Commanders +130 Chargers -154 |
49.5 |
 Lionsvs  Bengals |
Bengals +8.5 | Lions -430 Bengals +340 |
49.5 |
 Patriotsvs  Bills |
Bills -10.5 | Patriots +440 Bills -590 |
49.5 |
 Chiefsvs  Jaguars |
Jaguars +2.5 | Chiefs -152 Jaguars +128 |
44.5 |
Lines as of 9-28
49ers vs Rams odds (Thursday, 8:15 p.m. ET, Prime)
Opening line
- Rams -3
- Over/Under 47.5
- View full 49ers vs. Rams odds and matchup
- Read our 49ers vs. Rams picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Thursday Night Football odds
Vikings vs Browns odds (Sunday, 9:30 a.m. ET, NFL Network)
Opening line
- Browns +4.5
- Over/Under 37.5
- View full Vikings vs. Browns odds and matchup
- Read our Vikings vs. Browns picks and predictions (coming soon)
Opening line analysis coming soon!
Dolphins vs Panthers odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Panthers +1.5
- Over/Under 44.5
- View full Dolphins vs. Panthers odds and matchup
- Read our Dolphins vs. Panthers picks and predictions (coming soon)
Opening line analysis coming soon!
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Giants vs Saints odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Saints +1.5
- Over/Under 41.5
- View full Giants vs. Saints odds and matchup
- Read our Giants vs. Saints picks and predictions (coming soon)
Opening line analysis coming soon!
Broncos vs Eagles odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Eagles -4.5
- Over/Under 42.5
- View full Broncos vs. Eagles odds and matchup
- Read our Broncos vs. Eagles picks and predictions (coming soon)
Opening line analysis coming soon!
Raiders vs Colts odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Colts -6.5
- Over/Under 47.5
- View full Raiders vs. Colts odds and matchup
- Read our Raiders vs. Colts picks and predictions (coming soon)
Opening line analysis coming soon!
Covers NFL awards analysis
Cowboys vs Jets odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Jets +2.5
- Over/Under 45.5
- View full Cowboys vs. Jets odds and matchup
- Read our Cowboys vs. Jets picks and predictions (coming soon)
Opening line analysis coming soon!
Texans vs Ravens odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Ravens -9.5
- Over/Under 45.5
- View full Texans vs. Ravens odds and matchup
- Read our Texans vs. Ravens picks and predictions (coming soon)
Opening line analysis coming soon!
Titans vs Cardinals odds (Sunday, 4:05 p.m. ET, CBS)
Opening line
- Cardinals -8.5
- Over/Under 41.5
- View full Titans vs. Cardinals odds and matchup
- Read our Titans vs. Cardinals picks and predictions (coming soon)
Opening line analysis coming soon!
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Buccaneers vs Seahawks odds (Sunday, 4:05 p.m. ET, CBS)
Opening line
- Seahawks -1.5
- Over/Under 44.5
- View full Buccaneers vs. Seahawks odds and matchup
- Read our Buccaneers vs. Seahawks picks and predictions (coming soon)
Opening line analysis coming soon!
Commanders vs Chargers odds (Sunday, 4:25 p.m. ET, FOX)
Opening line
- Chargers -3
- Over/Under 49.5
- View full Commanders vs. Chargers odds and matchup
- Read our Commanders vs. Chargers picks and predictions (coming soon)
Opening line analysis coming soon!
Lions vs Bengals odds (Sunday, 4:25 p.m. ET, FOX)
Opening line
- Bengals +7.5
- Over/Under 48.5
- View full Lions vs. Bengals odds and matchup
- Read our Lions vs. Bengals picks and predictions (coming soon)
Opening line analysis coming soon!
Patriots vs Bills odds (Sunday, 8:20 p.m. ET, NBC)
Opening line
- Bills -10.5
- Over/Under 49.5
- View full Patriots vs. Bills odds and matchup
- Read our Patriots vs. Bills picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Sunday Night Football odds
Chiefs vs Jaguars odds (Monday, 8:15 p.m. ET, ABC/ESPN)
Opening line
- Jaguars +3
- Over/Under 43.5
- View full Chiefs vs. Jaguars odds and matchup
- Read our Chiefs vs. Jaguars picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Monday Night Football odds
Best NFL bets this week
Looking for our favorite spread, total, and NFL prop bets for this week's action? Check out our best free NFL picks from the Covers staff!
Odds are correct at the time of publishing and are subject to change.
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