The NFL Week 5 odds open with a prime-time clash on TNF, as the Tampa Bay Buccaneers head to Dallas to take on the Cowboys, and the slate caps off Sunday night with another high-stakes matchup as the Ravens visit the Falcons on SNF.
Heading into Monday Night Football, all eyes will be on Los Angeles as the Rams host the Buffalo Bills. Will we see a prime-time underdog pull off an upset, or will the favorites prevail on the road?
We're tracking the latest NFL odds, spreads, outrights, and totals for every game on the Week 5 slate ahead of Monday Night Football.
NFL odds Week 5
| Matchup | Spread | Moneyline | Over/Under |
|---|---|---|---|
 Buccaneersvs  Cowboys |
+9.5 30% -9.5 70% |
20% 83% |
o46.5 55% u46.5 52% |
 Eaglesvs  Jaguars |
+2.5 40% -2.5 80% |
44% 60% |
o45.5 52% u45.5 55% |
 Bearsvs  Packers |
+2.5 56% -2.5 44% |
47% 58% |
o45.5 53% u45.5 53% |
 Texansvs  Titans |
-6.5 69% +6.5 31% |
75% 28% |
o38.5 55% u38.5 52% |
 Bengalsvs  Dolphins |
-8.5 76% +8.5 24% |
85% 19% |
o46.5 53% u46.5 53% |
 Raidersvs  Patriots |
+3.5 58% -3.5 42% |
38% 64% |
o43.5 53% u43.5 53% |
 Vikingsvs  Saints |
-2.5 53% +2.5 47% |
56% 49% |
o46.5 52% u46.5 55% |
 Brownsvs  Jets |
+2.5 35% -2.5 65% |
45% 59% |
o39.5 53% u39.5 53% |
 Coltsvs  Steelers |
+2.5 35% -2.5 65% |
44% 57% |
o44.5 56% u44.5 57% |
 Giantsvs  Commanders |
+2.5 55% -2.5 45% |
44% 57% |
o43.5 52% u43.5 55% |
 Broncosvs  Chargers |
-2.5 62% +2.5 38% |
56% 47% |
o43.5 53% u43.5 53% |
 Lionsvs  Cardinals |
-5.5 35% +5.5 65% |
69% 34% |
o51.5 53% u51.5 57% |
 49ersvs  Seahawks |
+3.5 61% -3.5 39% |
39% 63% |
o47.5 53% u47.5 53% |
 Ravensvs  Falcons |
-6.5 67% +6.5 33% |
77% 28% |
o49.5 53% u49.5 53% |
 Billsvs  Rams |
+2.5 66% -2.5 34% |
49% 56% |
o52.5 57% u52.5 43% |
Lines as of 9-30.
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Thursday Night Football: Buccaneers vs Cowboys odds (8:15 p.m., Prime)
Opening line
- Cowboys -9.5
- Over/Under 46.5
- View full Buccaneers vs. Cowboys odds and matchup
- Read our Buccaneers vs. Cowboys picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Thursday Night Football odds
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Sunday Night Football: Ravens vs Falcons odds (8:20 p.m. ET, NBC)
Opening line
- Ravens -6.5
- Over/Under 49.5
- View full Bills vs. Rams odds and matchup
- Read our Bills vs. Rams picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Sunday Night Football odds
Monday Night Football: Bills vs Rams odds (8:15 p.m., ESPN)
Opening line
- Rams -2.5
- Over/Under 52.5
- View full Bills vs. Rams odds and matchup
- Read our Bills vs. Rams picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Monday Night Football odds
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Best NFL bets this week
Looking for our favorite spread, total, and NFL prop bets for this week's action? Check out our best free NFL picks from the Covers staff!
Odds are correct at the time of publishing and are subject to change.
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