Our Week 4 NFL picks for Sunday are here: one top pick from each of Sunday’s 14 games, listed in kickoff order (all times ET) with the analyst behind every play.
A “top pick” is the analyst’s best angle in that preview, which isn’t always the point spread. Lines move, so confirm the number on the NFL oddsboard before locking in your picks.
Week 4 top picks at a glance (Sunday, Oct. 4)
| Matchup & kickoff | Top pick & analyst |
|---|---|
| Cardinals vs. Giants 1 p.m. |
Cardinals moneyline Neil Parker |
| Cowboys vs. Texans 1 p.m. |
Jake Ferguson 25+ receiving yards Jason Logan |
| Jaguars vs. Bengals 1 p.m. |
Over 51.5 Tom Oldfield |
| Jets vs. Bears 1 p.m. |
Under 42.5 Ed Scimia |
| Packers vs. Buccaneers 1 p.m. |
Packers -3.5 Quinn Allen |
| Patriots vs. Bills 1 p.m. |
Bills -6.5 Dustin Saracini |
| Rams vs. Eagles 1 p.m. |
Eagles +3.5 Nick Galaida |
| Titans vs. Ravens 1 p.m. |
Titans +11.5 Geoff Clark |
| Dolphins vs. Vikings 4:05 p.m. |
Vikings -10.5 Quinn Allen |
| Broncos vs. 49ers 4:25 p.m. |
49ers -2.5 Geoff Clark |
| Chargers vs. Seahawks 4:25 p.m. |
Over 42.5 Geoff Clark |
| Chiefs vs. Raiders 4:25 p.m. |
Chiefs -4.5 Neil Parker |
| Lions vs. Panthers 8:20 p.m. |
Lions -3.5 Jason Logan |
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1 p.m. kickoffs
Cardinals vs. Giants
- Kickoff: 1 p.m.
- TV: CBS
- Analyst: Neil Parker
Top pick: Cardinals moneyline
Neil Parker is sticking with Arizona even after heavy line movement. His Cardinals vs. Giants prediction and picks point to a Giants defense that ranks last in pressure percentage and 26th in pass rush win rate, with an inexperienced secondary behind it. He also expects tight end Trey McBride to have a big day.
Cowboys vs. Texans
- Kickoff: 1 p.m.
- TV: FOX
- Analyst: Jason Logan
Top pick: Jake Ferguson 25+ receiving yards
Jason Logan’s Cowboys vs. Texans prediction and picks target the Dallas tight end. Houston has let opposing tight ends catch 18 of 21 targets for 213 yards, and several of its top coverage linebackers are injured or out. Logan also expects a shootout and likes the Over.
Jaguars vs. Bengals
- Kickoff: 1 p.m.
- TV: CBS
- Analyst: Tom Oldfield
Top pick: Over 51.5
Tom Oldfield expects fireworks. His Jaguars vs. Bengals prediction and picks note the Bengals and Jaguars are scoring 26.7 and 27.3 points per game, Trevor Lawrence has 65 completions of 20-plus yards since the start of 2025, and the Over is 7-2-1 in the last 10 meetings.
Jets vs. Bears
- Kickoff: 1 p.m.
- TV: FOX
- Analyst: Ed Scimia
Top pick: Under 42.5
Both teams are missing key offensive weapons, which is why Ed Scimia’s Jets vs. Bears prediction and picks go Under. Chicago has allowed just 16 points over the last two weeks, and New York averages only 3.3 yards per carry. His touchdown pick is Bears running back Kyle Monangai.
Packers vs. Buccaneers
- Kickoff: 1 p.m.
- TV: FOX
- Analyst: Quinn Allen
Top pick: Packers -3.5
With Baker Mayfield sidelined, Tampa Bay is turning to rookie Jalon Daniels. Quinn Allen’s Packers vs. Buccaneers prediction and picks argue that gap is too big to ignore and have Green Bay bouncing back to cover. His touchdown pick is Packers receiver Christian Watson.
Patriots vs. Bills
- Kickoff: 1 p.m.
- TV: CBS
- Analyst: Dustin Saracini
Top pick: Bills -6.5
Dustin Saracini isn’t touching New England. His Patriots vs. Bills prediction and picks note that Drake Maye hasn’t thrown a touchdown since Week 1, has six interceptions, and leads an offense averaging an NFL-worst 12 points per game. Buffalo is a perfect 3-0 against the spread, and Saracini also likes James Cook to score.
Rams vs. Eagles
- Kickoff: 1 p.m.
- TV: FOX
- Analyst: Nick Galaida
Top pick: Eagles +3.5
Nick Galaida calls this a brutal schedule spot for Los Angeles. His Rams vs. Eagles prediction and picks note the Rams have dropped two of three, will be without cornerback Jaylen Watson and tight end Terrance Ferguson, and got their lone convincing win against a backup quarterback. He expects Philadelphia to show fight despite a long injury report.
Titans vs. Ravens
- Kickoff: 1 p.m.
- TV: CBS
- Analyst: Geoff Clark
Top pick: Titans +11.5
The Titans are 0-3, but Geoff Clark says their numbers don’t look like an 11.5-point underdog’s. His Titans vs. Ravens prediction and picks cite Tennessee’s 14th-place ranking in net yards per play, two one-score losses decided in the final seconds, and a run defense allowing just 3.6 yards per carry against Baltimore’s biggest strength. He’d play it down to +9.5.
4:05 p.m. kickoff
Dolphins vs. Vikings
- Kickoff: 4:05 p.m.
- TV: FOX
- Analyst: Quinn Allen
Top pick: Vikings -10.5
Quinn Allen’s Dolphins vs. Vikings prediction and picks back the unbeaten hosts. Minnesota is second in scoring defense at 13.7 points per game and leads the league in third-down conversion rate, while Miami carries a minus-50 point differential and allows 28.7 per game. His touchdown pick is Vikings receiver Jordan Addison.
4:25 p.m. kickoffs
Broncos vs. 49ers
- Kickoff: 4:25 p.m.
- TV: CBS
- Analyst: Geoff Clark
Top pick: 49ers -2.5
Geoff Clark’s power ratings rate the 3-0 49ers as the best team in the NFL, and he considers them tradable up to -4. His Broncos vs. 49ers prediction and picks tie the top play to San Francisco’s early-down dominance, and he adds a combo, a touchdown scorer and a player prop.
Chargers vs. Seahawks
- Kickoff: 4:25 p.m.
- TV: CBS
- Analyst: Geoff Clark
Top pick: Over 42.5
Geoff Clark sees a buy-low spot on the winless Chargers, whose offense ranks 31st in EPA per play despite Justin Herbert and offensive coordinator Mike McDaniel. His Chargers vs. Seahawks prediction and picks note that Washington scored 33 on Seattle last week, and Seattle is 7-2 to the Over as a favorite of seven or more under Mike Macdonald. He has Seattle winning 26-21 and plays the total up to 44.5.
Chiefs vs. Raiders
- Kickoff: 4:25 p.m.
- TV: CBS
- Analyst: Neil Parker
Top pick: Chiefs -4.5
Both teams are 3-0, but Neil Parker thinks the step up in class is too much for Las Vegas. His Chiefs vs. Raiders prediction and picks credit the Raiders’ league-leading takeaway total for their hot start, but note an offense that ranks only 15th in EPA per play. He expects Kansas City to cover and improve to 4-0.
Sunday Night Football
Lions vs. Panthers
- Kickoff: 8:20 p.m.
- TV: NBC
- Analyst: Jason Logan
Top pick: Lions -3.5
Jason Logan expects Detroit to cruise past a banged-up Carolina team. His Lions vs. Panthers prediction and picks note injuries at running back, receiver and offensive line for the Panthers, who also rank 25th in pass block win rate. The Lions blitz at the sixth-highest rate and have 12 sacks, second in the league, against a Bryce Young who is dealing with a knee issue. He also singles out one Carolina weapon.
More Week 4 NFL picks
Want to build a bigger card? These Covers roundups cover every bet type for the weekend:
- NFL Picks Against the Spread for Every Week 4 Game
- NFL Week 4 Moneyline Picks
- Expert Touchdown Picks for NFL Week 4
- NFL Anytime Touchdown Picks: Week 4
- Expert NFL Combo Picks for Week 4
- NFL Week 4 Survivor Pool Rankings
- NFL Week 4 Odds and Opening Betting Lines
Check the NFL weather report and the NFL injury report, compare numbers across football betting sites, and brush up with our guide to betting on football before finalizing today’s picks.
All of today’s matchups are also on the NFL scores and matchups page, and the full pick archive lives in free NFL picks.
Odds are correct at the time of publishing and are subject to change.
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