Cardinals 4th NFC West3-14

49ers 3rd NFC West12-5

4:25PM ET Sep 21, 2025

FOX

Cardinals @ 49ers Odds

Game Odds

Game Odds Arizona Cardinals vs. San Francisco 49ers
	Spread	Total	Moneyline
Sports.OddsComparison.BettingLines.Models.BettingSide.SpreadBettingSideVm Arizona	+1.5 -110	o44.5 -110	+110
Sports.OddsComparison.BettingLines.Models.BettingSide.SpreadBettingSideVm San Francisco	-1.5 -104	u44.5 -110	-115

Spread

Game Odds Arizona Cardinals vs. San Francisco 49ers
	ARI	SF
	+1.5 -110	-1.5 -104

Odds Comparison

ALL BOOKS	ARI	SF
DraftKings logo	+1.5 -125	-1.5 -105
bet365 logo	+1.5 -110	-1.5 -110
FanDuel logo	+1.5 -128	-1.5 -104
BetMGM logo	+1.5 -110	-1.5 -110
Caesars logo	+1.5 -110	-1.5 -110

Total

Game Odds vs.
	OVER	UNDER
	o44.5 -110	u44.5 -110

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o44.5 -115	u44.5 -115
bet365 logo	o44.5 -110	u44.5 -110
FanDuel logo	o44.5 -114	u44.5 -114
BetMGM logo	o44.5 -110	u44.5 -110
Caesars logo	o44.5 -110	u44.5 -110

Moneyline

Game Odds Arizona Cardinals vs. San Francisco 49ers
	ARI	SF
	+110	-115

Odds Comparison

ALL BOOKS	ARI	SF
DraftKings logo	-105	-125
bet365 logo	+105	-125
FanDuel logo	-111	-115
BetMGM logo	+105	-125
Caesars logo	+110	-130

Passing Yards

Kyler Murray Projection 220.21

Game Odds vs.
OVER	UNDER
o215.5 -112	u217.5 -113

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o217.5 -111	u217.5 -113
bet365 logo	-	-
FanDuel logo	o215.5 -112	u215.5 -112
BetMGM logo	o217.5 -115	u217.5 -115
Caesars logo	o215.5 -115	u215.5 -115

Mac Jones Projection 219.75

Game Odds vs.
OVER	UNDER
o219.5 -111	u222.5 -112

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o219.5 -111	u219.5 -113
bet365 logo	-	-
FanDuel logo	o222.5 -112	u222.5 -112
BetMGM logo	o220.5 -115	u220.5 -115
Caesars logo	o219.5 -125	u219.5 -110

Rushing Yards

Christian McCaffrey Projection 63.53

Game Odds vs.
OVER	UNDER
o68.5 -112	u74.5 -115

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o71.5 -110	u71.5 -114
bet365 logo	-	-
FanDuel logo	o68.5 -112	u68.5 -112
BetMGM logo	o74.5 -115	u74.5 -115
Caesars logo	o70.5 -115	u70.5 -115

James Conner Projection 60.84

Game Odds vs.
OVER	UNDER
o48.5 -118	u54.5 -112

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o53.5 -109	u53.5 -115
bet365 logo	-	-
FanDuel logo	o54.5 -112	u54.5 -112
BetMGM logo	o48.5 -118	u48.5 -110
Caesars logo	o53.5 -114	u53.5 -118

Kyler Murray Projection 29.58

Game Odds vs.
OVER	UNDER
o27.5 -110	u28.5 -110

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o28.5 -109	u28.5 -116
bet365 logo	-	-
FanDuel logo	o28.5 -112	u28.5 -112
BetMGM logo	o27.5 -110	u27.5 -118
Caesars logo	o28.5 -125	u28.5 -110

Mac Jones Projection 12.92

Game Odds vs.
OVER	UNDER
o6.5 -112	u7.5 -105

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o7.5 -115	u7.5 -109
bet365 logo	-	-
FanDuel logo	o6.5 -112	u6.5 -112
BetMGM logo	o7.5 -115	u7.5 -105
Caesars logo	o7.5 -118	u7.5 -114

Brian Robinson Jr.

Game Odds vs.
OVER	UNDER
o21.5 -109	u22.5 -112

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o21.5 -109	u21.5 -116
bet365 logo	-	-
FanDuel logo	o22.5 -112	u22.5 -112
BetMGM logo	o21.5 -120	u21.5 -110
Caesars logo	o21.5 -114	u21.5 -118

Game Odds vs.
OVER	UNDER
o23.5 -111	u25.5 -112

Odds Comparison

ALL BOOKS	OVER	UNDER
DraftKings logo	o23.5 -111	u23.5 -113
bet365 logo	-	-
FanDuel logo	o25.5 -112	u25.5 -112
BetMGM logo	o25.5 -115	u25.5 -115
Caesars logo	o25.5 -114	u25.5 -118

Receiving Yards

Receptions Made

Rushing Attempts

Passing Attempts

Passing Completions

Interceptions Thrown

Rush and Rec Yards

Passing and Rushing Yards

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